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  • 1
    Publication Date: 2018-03-16
    Description: One research objective in the Priority Program 1897 “Calm, Smooth and Smart” of the German Research Foundation (DFG – SPP 1897) is the development of model order reduction techniques for parametric non-linear mechanical systems to enable efficient design, simulation, analysis, optimization and control of those. As a starting point for our research, this contribution provides an overview of the main challenges and well-established reduction techniques in this research area, at that stage, neglecting parameter dependencies. This includes simulation-based as well as simulation-free reduction bases generation and hyperreduction of the non-linear force terms. An extension of the Krylov directions in moment matching based on the concept of modal derivatives is also sketched. (© 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim)
    Electronic ISSN: 1617-7061
    Topics: Mathematics , Physics , Technology
    Published by Wiley-Blackwell
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  • 2
    Publication Date: 2017-03-22
    Description: Purpose To develop a single-shot spiral perfusion pulse sequence with outer-volume suppression (OVS) to achieve whole-heart coverage with a short temporal footprint of 10 ms per slice location. Methods A highly accelerated single-shot variable density spiral pulse sequence with an integrated OVS module for reduced field of view (rFOV) perfusion imaging with 2 mm spatial resolution was developed and evaluated in simulations, phantom experiments and in clinical patients with (n = 8) or without (n = 8) OVS. Images were reconstructed by block low-rank sparsity with motion guidance (BLOSM) and graded by two cardiologists on a 5-point scale (1, excellent; 5, poor). Results Simulation and phantom results showed that OVS effectively suppressed the signal outside the desired field of view (FOV). Clinical patient data demonstrated high quality perfusion images with rFOV. The average image quality scores of full FOV cases and rFOV cases were 3.1 ± 0.64 and 2.3 ± 0.46, respectively, ( P  = 0.02) from cardiologist 1 and 2.5 ± 0.54 and 1.8 ± 0.47, respectively, ( P  = 0.04) from cardiologist 2, showing superior image quality for the rFOV images compared with the full FOV images. Conclusion A single-shot spiral perfusion sequence that uses OVS and BLOSM performs perfusion imaging with a very short temporal footprint per image supporting whole-heart coverage with good image quality. Magn Reson Med, 2017. © 2017 International Society for Magnetic Resonance in Medicine.
    Print ISSN: 0740-3194
    Electronic ISSN: 1522-2594
    Topics: Medicine
    Published by Wiley-Blackwell
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