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  • 1
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    Rapid adaptation to controlling new microbial epibionts in the invaded range promotes invasiveness of an exotic seaweed (2016)
    Wiley
    In:  Journal of Ecology, 104 (4). pp. 969-978.
    Details
    Publication Date: 2019-02-01
    Description: Rapid adaptation to novel biotic interactions and abiotic factors in introduced ranges can be critical to invasion success of both exotic terrestrial and aquatic plants. Seaweeds are extremely successful biological invaders in marine environments. Along with herbivores, foulers − ubiquitous enemies in the marine environment − have the potential to determine the success or failure of invasive seaweeds. However, research on the topic of rapid adaptation of seaweeds to biotic challenges is still in its nascent stages and rapid adaptation of seaweeds to fouling is unexplored. We tested whether the impressive invasion success of the red macroalga Gracilaria vermiculophylla may be enhanced by the rapid adaptation of chemical control (defence) of new bacterial epibionts in the invaded range. The native and invasive G. vermiculophylla populations investigated were equally well defended against currently co-occurring bacterial epibionts isolated from their respective ranges. In contrast, the native populations were weakly defended against bacterial epibionts from the invaded range, whereas the invasive populations were weakly defended against bacterial epibionts from their native range. Apparently during the invasion process, invasive populations have adapted their control capacity to cope with the new epibionts but have lost the capacity to fend off old epibionts. Synthesis. These results provide the first evidence that a change in habitat and, thus, confrontation by new enemies, may trigger rapid defence adaptation of seaweeds, which could be necessary for invasiveness. Such adaptation dynamics as found in the current study could be also applicable to other types of host plant – enemy interaction e.g. plant root – microbe interactions, freshwater plant – fouler interactions in general and for cases of shifting plant – enemy interactions in course of climate change.
    Type: Article , PeerReviewed
    Format: text
    Format: text
    DOI: 10.1111/1365-2745.12590
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    OceanRep: Article in a Scientific Journal - peer-reviewed
  • 2
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    Synthesis and Cytotoxic Activity of a Small Naphthoquinone Library: First Synthesis of Juglonbutin (2014)
    Wiley
    In:  European Journal of Organic Chemistry, 2014 (24). pp. 5318-5330.
    Details
    Publication Date: 2018-06-20
    Description: A synthetic protocol has been designed to synthesize grecoketidone (2k), 5-hydroxylapachol (2g), and the recently discovered natural products juglonbutin (2o) and its derivatives, leading to a small library of different 1,4-naphthoquinones with the intention of finding new active compounds. Within our collection, 2-O-alkylated naphthoquinones with an ester functionality in the side-chain and a free OH group at C-5 showed the best activities. Compounds 2f, 2m, and 2n showed GI50 values against 12 tumor cell lines in the lower micromolar range and juglonbutin (2o) showed remarkably efficient inhibition of the glycogen synthase kinase 3β with an IC50 value of 2.03 μM. Furthermore, studies on the mode of action of the most active cytotoxic compounds have been carried out. To the best of our knowledge, this is the first report on the synthesis of juglonbutin (2o) and its biological activity.
    Type: Article , PeerReviewed
    Format: text
    DOI: 10.1002/ejoc.201402272
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    OceanRep: Article in a Scientific Journal - peer-reviewed
  • 3
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    Engyodontochones, Antibiotic Polyketides from the Marine FungusEngyodontium albumStrain LF069 (2016)
    Wiley
    In:  Chemistry - a European Journal, 22 (22). pp. 7452-7462.
    Details
    Publication Date: 2019-02-01
    Description: Six new (2, 4–8) and two known polyketides with a basic structure of an anthraquinone-xanthone were isolated from mycelia and culture broth of the fungus Engyodontium album strain LF069. The structures and relative configurations of these compounds were established by spectroscopic means, and their absolute configurations were defined mainly by comparison of quantum chemical TDDFT calculated and experimental ECD spectra. Compounds 2 and 4–8 were given the trivial names engyodontochone A (2) and B–F (4–8). Compounds 5–8 represent the first example of a 23,28 seco-beticolin carbon skeleton. The relative and absolute configurations of two known substances JBIR-97/98 (1) and JBIR-99 (3) were determined for the first time. All isolated compounds were subjected to bioactivity assays. Compounds 1–4 exhibited inhibitory activity against methicillin-resistant Staphylococcus aureus (MRSA) that was 10-fold stronger than chloramphenicol.
    Type: Article , PeerReviewed
    Format: text
    Format: text
    DOI: 10.1002/chem.201600430
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    OceanRep: Article in a Scientific Journal - peer-reviewed
  • 4
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    Marine bacteria and fungi as promising source for new antibiotics (2019)
    Wiley
    In:  Drug Development Research, 80 (1). pp. 24-27.
    Details
    Publication Date: 2022-01-31
    Description: Natural products and derivatives thereof are of considerable importance in the discovery of new pharmaceuticals, for example, for the treatment of cancer, diabetes, inflammation diseases, and infection diseases caused by bacteria, fungi, viruses, or parasites. The great biodiversity of marine microorganisms is reflected in their huge chemical diversity, which provides a rich source of biologically active compounds. An increasing interest in marine microorganisms as promising producers of new compounds with potential medical applications has raised increasing interest in the sustainable exploration of marine microbial resources for the discovery of new antibiotics, which is highlighted. The bottlenecks in the development of drugs using the large marine natural product pipeline are also discussed.
    Type: Article , PeerReviewed , info:eu-repo/semantics/article
    Format: text
    DOI: 10.1002/ddr.21482
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    OceanRep: Article in a Scientific Journal - peer-reviewed
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