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  • Wiley  (365)
  • 1
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    Applications of scanning ion conductance microscope in biomedical fields
    Wiley ; 2023
    In:  MedComm – Biomaterials and Applications Vol. 2, No. 1 ( 2023-03)
    Details
    In: MedComm – Biomaterials and Applications, Wiley, Vol. 2, No. 1 ( 2023-03)
    Abstract: Scanning ion conductance microscopy (SICM) is a scanning probe technique to reflect the surface morphology of the sample with the probe's motion trajectory through measuring the current between the probe and the surface of the sample. Since the surface of the sample can be scanned noncontact and the morphological characteristics of the living cell can be obtained under physiological conditions, SICM is particularly important in the field of biomedicine. SICM has strong potentials in various applications, such as the real‐time and high‐resolution imaging of living cells, monitoring the volume and movements of living cells. In addition, SICM combines with various technologies such as patch clamp and nanopipette to study the physical properties of cells. Furthermore, using SICM to observe cell and tissue structure provides more directions for studying the mechanism of disease. This review briefly introduces the principles and imaging modes of SICM and outlines the recent applications and development of SICM in biomedical research. We also introduce the limitations of the existing SICM technology and make a perspective on its future development.
    Type of Medium: Online Resource
    ISSN: 2769-643X , 2769-643X
    URL: Issue
    URL: Article
    DOI: 10.1002/mba2.v2.1
    DOI: 10.1002/mba2.26
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 3147847-5
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  • 2
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    Ginsenoside Rg1 Ameliorates Acute Renal Ischemia/Reperfusion Injury via Upregulating AMPKα1 Expression
    Wiley ; 2022
    In:  Oxidative Medicine and Cellular Longevity Vol. 2022 ( 2022-9-1), p. 1-18
    Details
    In: Oxidative Medicine and Cellular Longevity, Wiley, Vol. 2022 ( 2022-9-1), p. 1-18
    Abstract: Acute renal ischemia/reperfusion (I/R) injury often occurs during kidney transplantation and other kidney surgeries, and the molecular mechanism involves oxidative stress. We hypothesized that ginsenoside Rg1 (Rg1), a saponin derived from ginseng, would protect the renal tissue against acute renal I/R injury by upregulating 5 ′ adenosine monophosphate-activated protein kinase α1 (AMPKα1) expression and inhibiting oxidative stress. The models of acute anoxia/reoxygenation (A/R) damage in normal rat kidney epithelial cell lines (NRK-52E) and acute renal I/R injury in mice were constructed. The results revealed that pretreatment with 25 μM Rg1 significantly increased NRK-52E viability, decreased lactate dehydrogenase (LDH) activity and apoptosis, suppressed reactive oxygen species generation and oxidative stress, stabilized mitochondrial membrane potential and reduced mitochondria permeability transition pore openness, decreased adenosine monophosphate/adenosine triphosphate ratio, and upregulated the expression of AMPKα1, cytochrome b-c1 complex subunit 2, NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 8, and B-cell lymphoma 2, while downregulating BCL2-associated X protein expression. The effects of Rg1 pretreatment were similar to those of pAD/Flag-AMPKα1. After acute renal I/R injury, serum creatinine, blood urea nitrogen, LDH activity, and oxidative stress in renal tissue significantly increased. Rg1 pretreatment upregulated AMPKα1 expression, which protects against acute renal I/R injury by maintaining renal function homeostasis, inhibiting oxidative stress, and reducing apoptosis. Compound C, a specific inhibitor of AMPK, reversed the effects of Rg1. In summary, Rg1 pretreatment upregulated AMPKα1 expression, inhibited oxidative stress, maintained mitochondrial function, improved energy metabolism, reduced apoptosis, and ultimately protected renal tissue against acute renal I/R injury.
    Type of Medium: Online Resource
    ISSN: 1942-0994 , 1942-0900
    URL: Article
    DOI: 10.1155/2022/3737137
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2455981-7
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  • 3
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    A Tensile‐Strained Pt–Rh Single‐Atom Alloy Remarkably Boosts Ethanol Oxidation
    Wiley ; 2021
    In:  Advanced Materials Vol. 33, No. 17 ( 2021-04)
    Details
    In: Advanced Materials, Wiley, Vol. 33, No. 17 ( 2021-04)
    Abstract: The rational design and control of electrocatalysts at single‐atomic sites could enable unprecedented atomic utilization and catalytic properties, yet it remains challenging in multimetallic alloys. Herein, the first example of isolated Rh atoms on ordered PtBi nanoplates (PtBi‐Rh 1 ) by atomic galvanic replacement, and their subsequent transformation into a tensile‐strained Pt–Rh single‐atom alloy (PtBi@PtRh 1 ) via electrochemical dealloying are presented. Benefiting from the Rh 1 ‐tailored Pt (110) surface with tensile strain, the PtBi@PtRh 1 nanoplates exhibit record‐high and all‐round superior electrocatalytic performance including activity, selectivity, stability, and anti‐poisoning ability toward ethanol oxidation in alkaline electrolytes. Density functional theory calculations reveal the synergism between effective Rh 1 and tensile strain in boosting the adsorption of ethanol and key surface intermediates and the CC bond cleavage of the intermediates. The facile synthesis of the tensile‐strained single‐atom alloy provides a novel strategy to construct model nanostructures, accelerating the development of highly efficient electrocatalysts.
    Type of Medium: Online Resource
    ISSN: 0935-9648 , 1521-4095
    URL: Issue
    URL: Article
    DOI: 10.1002/adma.v33.17
    DOI: 10.1002/adma.202008508
    RVK:
    UA 1538
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 1012489-5
    detail.hit.zdb_id: 1474949-X
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  • 4
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    Avian influenza A virus H7N9 in China, a role reversal from reassortment receptor to the donator
    Wiley ; 2023
    In:  Journal of Medical Virology Vol. 95, No. 1 ( 2023-01)
    Details
    In: Journal of Medical Virology, Wiley, Vol. 95, No. 1 ( 2023-01)
    Abstract: Reassortment can introduce one or more gene segments of influenza A viruses (IAVs) into another, resulting in novel subtypes. Since 2013, a new outbreak of human highly pathogenic avian influenza has emerged in the Yangtze River Delta (YRD) and South‐Central regions of China. In this study, using Anhui province as an example, we discuss the possible impact of H7N9 IAVs on future influenza epidemics through a series of gene reassortment events. Sixty‐one human H7N9 isolates were obtained from five outbreaks in Anhui province from 2013 to 2019. Bioinformatics analyses revealed that all of them were characterized by low pathogenicity and high human or mammalian tropism and had introduced novel avian influenza A virus (AIV) subtypes such as H7N2, H7N6, H9N9, H5N6, H6N6, and H10N6 through gene reassortment. In reassortment events, Anhui isolates may donate one or more segments of HA, NA, and the six internal protein‐coding genes for the novel subtype AIVs. Our study revealed that H7N9, H9N2, and H5N1 can serve as stable and persistent gene pools for AIVs in the YRD and South‐Central regions of China. Novel AIV subtypes might be generated continuously by reassortment. These AIVs may have obtained human‐type receptor‐binding abilities from their donors and prefer binding to them, which can cause human epidemics through accidental spillover infections. Facing the continual threat of emerging avian influenza, constant monitoring of AIVs should be conducted closely for agricultural and public health.
    Type of Medium: Online Resource
    ISSN: 0146-6615 , 1096-9071
    URL: Issue
    URL: Article
    DOI: 10.1002/jmv.v95.1
    DOI: 10.1002/jmv.28392
    RVK:
    XA 10000
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 752392-0
    detail.hit.zdb_id: 1475090-9
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  • 5
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    Enhanced Electrical Performance and Stability of La‐Doped Indium Oxide‐Based Thin‐Film Transistors and Application Explorations
    Wiley ; 2022
    In:  physica status solidi (a) Vol. 219, No. 3 ( 2022-02)
    Details
    In: physica status solidi (a), Wiley, Vol. 219, No. 3 ( 2022-02)
    Abstract: Metal‐oxide‐based thin‐film transistors (TFTs) fabricated by aqueous solution method are attracting more attention due to their potential applications in large‐scale display devices. Herein, solution‐processed TFTs with InLaO as channel layer are prepared as a function of lanthanum (La) doping molar ratio (La/In). Compared with In 2 O 3 TFT, InLaO‐0.5 TFT demonstrates improved electrical performance, including a large μ FE of 21.35 cm 2  V −1 s −1 , a higher I on / I off of ≈10 8 , a smaller interfacial trap states ( D it ) of 5.01 × 10 11  cm −2 , and a smaller subthreshold slope of 0.076 V decade −1 . Low‐frequency noise tests are also carried out and conclude that the interfacial trap density of In 2 O 3 TFTs can be modulated by La doping. Meanwhile, InLaO‐0.5 TFT also represents excellent bias stress stability, including threshold voltage shift (Δ V TH ) of 0.13 and −0.03 V under positive and negative bias stress for 3600 s, respectively. Finally, a low‐voltage resistor‐loaded inverter has been built based on InLaO‐0.5 TFT, exhibiting full‐swing characteristics and a maximum gain of 10.2. All experimental results demonstrate the potential application of aqueous solution technology for future low‐cost, energy‐efficient, large‐scale, and high‐performance electronics.
    Type of Medium: Online Resource
    ISSN: 1862-6300 , 1862-6319
    URL: Issue
    URL: Article
    DOI: 10.1002/pssa.v219.3
    DOI: 10.1002/pssa.202100590
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 1481091-8
    detail.hit.zdb_id: 208850-2
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  • 6
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    PERK‐Mediated Cholesterol Excretion from IDH Mutant Glioma Determines Anti‐Tumoral Polarization of Microglia
    Wiley ; 2023
    In:  Advanced Science Vol. 10, No. 20 ( 2023-07)
    Details
    In: Advanced Science, Wiley, Vol. 10, No. 20 ( 2023-07)
    Abstract: Isocitrate dehydrogenase (IDH) mutation, a known pathologic classifier, initiates metabolic reprogramming in glioma cells and has been linked to the reaction status of glioma‐associated microglia/macrophages (GAMs). However, it remains unclear how IDH genotypes contribute to GAM phenotypes. Here, it is demonstrated that gliomas expressing mutant IDH determine M1‐like polarization of GAMs, while archetypal IDH induces M2‐like polarization. Intriguingly, IDH‐mutant gliomas secrete excess cholesterol, resulting in cholesterol‐rich, pro‐inflammatory GAMs without altering their cholesterol biosynthesis, and simultaneously exhibiting low levels of tumoral cholesterol due to expression remodeling of cholesterol transport molecules, particularly upregulation of ABCA1 and downregulation of LDLR. Mechanistically, a miR‐19a/LDLR axis‐mediated novel post‐transcriptional regulation of cholesterol uptake is identified, modulated by IDH mutation, and influencing tumor cell proliferation and invasion. IDH mutation‐induced PERK activation enhances cholesterol export from glioma cells via the miR‐19a/LDLR axis and ABCA1/APOE upregulation. Further, a synthetic PERK activator, CCT020312 is introduced, which markedly stimulates cholesterol efflux from IDH wild‐type glioma cells, induces M1‐like polarization of GAMs, and consequently suppresses glioma cell invasion. The findings reveal an essential role of the PERK/miR‐19a/LDLR signaling pathway in orchestrating gliomal cholesterol transport and the subsequent phenotypes of GAMs, thereby highlighting a novel potential target pathway for glioma therapy.
    Type of Medium: Online Resource
    ISSN: 2198-3844 , 2198-3844
    URL: Issue
    URL: Article
    DOI: 10.1002/advs.v10.20
    DOI: 10.1002/advs.202205949
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2808093-2
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  • 7
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    PERK‐Mediated Cholesterol Excretion from IDH Mutant Glioma Determines Anti‐Tumoral Polarization of Microglia (Adv. Sci. 20/2023)
    Wiley ; 2023
    In:  Advanced Science Vol. 10, No. 20 ( 2023-07)
    Details
    In: Advanced Science, Wiley, Vol. 10, No. 20 ( 2023-07)
    Type of Medium: Online Resource
    ISSN: 2198-3844 , 2198-3844
    URL: Issue
    URL: Article
    DOI: 10.1002/advs.v10.20
    DOI: 10.1002/advs.202370127
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2808093-2
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  • 8
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    Engineered Cell‐Derived Microparticles Bi 2 Se 3 /DOX@MPs for Imaging Guided Synergistic Photothermal/Low‐Dose Chemotherapy of Cancer
    Wiley ; 2020
    In:  Advanced Science Vol. 7, No. 3 ( 2020-02)
    Details
    In: Advanced Science, Wiley, Vol. 7, No. 3 ( 2020-02)
    Abstract: Cell‐derived microparticles, which are recognized as nanosized phospholipid bilayer membrane vesicles, have exhibited great potential to serve as drug delivery systems in cancer therapy. However, for the purpose of comprehensive therapy, microparticles decorated with multiple therapeutic components are needed, but effective engineering strategies are limited and still remain enormous challenges. Herein, Bi 2 Se 3 nanodots and doxorubicin hydrochloride (DOX) co‐embedded tumor cell‐derived microparticles (Bi 2 Se 3 /DOX@MPs) are successfully constructed through ultraviolet light irradiation‐induced budding of parent cells which are preloaded with Bi 2 Se 3 nanodots and DOX via electroporation. The multifunctional microparticles are obtained with high controllability and drug‐loading capacity without unfavorable membrane surface destruction, maintaining their excellent intrinsic biological behaviors. Through membrane fusion cellular internalization, Bi 2 Se 3 /DOX@MPs show enhanced cellular internalization and deepened tumor penetration, resulting in extreme cell damage in vitro without considering endosomal escape. Because of their distinguished photothermal performance and tumor homing target capability, Bi 2 Se 3 /DOX@MPs exhibit admirable dual‐modal imaging capacity and outstanding tumor suppression effect. Under 808 nm laser irradiation, intravenous injection of Bi 2 Se 3 /DOX@MPs into H22 tumor‐bearing mice results in remarkably synergistic antitumor efficacy by combining photothermal therapy with low‐dose chemotherapy in vivo. Furthermore, the negligible hemolytic activity, considerable metabolizability, and low systemic toxicity of Bi 2 Se 3 /DOX@MPs imply their distinguished biocompatibility and great potential for tumor theranostics.
    Type of Medium: Online Resource
    ISSN: 2198-3844 , 2198-3844
    URL: Issue
    URL: Article
    DOI: 10.1002/advs.v7.3
    DOI: 10.1002/advs.201901293
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2808093-2
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  • 9
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    Long‐term functional prognosis and related factors of spinal cord stimulation in patients with disorders of consciousness
    Wiley ; 2022
    In:  CNS Neuroscience & Therapeutics Vol. 28, No. 8 ( 2022-08), p. 1249-1258
    Details
    In: CNS Neuroscience & Therapeutics, Wiley, Vol. 28, No. 8 ( 2022-08), p. 1249-1258
    Abstract: The treatment of patients with disorders of consciousness (DoC) remains a challenging issue, and spinal cord stimulation (SCS) has been reported to be a promising treatment for DoC in some studies. Aims This study explores the efficiency of SCS in treating patients with DoC at different consciousness levels, including the vegetative state/unresponsive wakefulness syndrome (VS/UWS) and the minimally conscious state (MCS) and summarizes and analyzes the long‐term effect and related factors of SCS in patients with DoC. Results An overall positive outcome was reached in 35 of 110 patients (31.8%). Among patients with positive outcomes, the MCS group improved 45.53% more than VS/UWS group, and this difference was statistically significant. In terms of the recommendation standard, positive outcomes occurred in 33 patients (94.3%) in the highly recommended group and 2 patients (5.7%) in the weakly recommended group ( p   〈  0.001). After adjustment for potential covariables, young age (age ≤ 19 years old) ( p  = 0.045) and MCS ( p   〈  0.001) were significantly correlated with positive outcome. A nomogram based on age, state of consciousness, and pathogeny showed good predictive performance, with a c‐index of 0.794. The Hosmer–Lemeshow goodness‐of‐fit test showed that the model was well calibrated ( χ 2  = 3.846, p  = 0.871). Conclusions SCS is one of the most feasible treatments for patients with DoC, especially for patients with MCS. Younger age is significantly associated with better outcomes and could therefore serve as a basis for preoperative screening. However, more evidence‐based randomized controlled trials are needed to confirm the efficacy of the treatment.
    Type of Medium: Online Resource
    ISSN: 1755-5930 , 1755-5949
    URL: Article
    DOI: 10.1111/cns.13870
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2423467-9
    detail.hit.zdb_id: 2423461-8
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  • 10
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    Nutritional changes in trees during drought‐induced mortality: A comprehensive meta‐analysis and a field study
    Wiley ; 2024
    In:  Global Change Biology Vol. 30, No. 1 ( 2024-01)
    Details
    In: Global Change Biology, Wiley, Vol. 30, No. 1 ( 2024-01)
    Abstract: Both macronutrients and micronutrients are essential for tree growth and development through participating in various ecophysiological processes. However, the impact of the nutritional status of trees on their ability to withstand drought‐induced mortality remains inconclusive. We thus conducted a comprehensive meta‐analysis, compiling data on 11 essential nutrients from 44 publications (493 independent observations). Additionally, a field study was conducted on Pinus sylvestris L. trees with varying drought‐induced vitality loss in the “Visp” forest in southern Switzerland. No consistent decline in tree nutritional status was observed during tree mortality. The meta‐analysis revealed significantly lower leaf potassium (K), iron (Fe), and copper (Cu) concentrations with tree mortality. However, the field study showed no causal relationships between nutritional levels and the vitality status of trees. This discrepancy is mainly attributed to the intrinsic differences in the two types of experimental designs and the ontogenetic stages of target trees. Nutrient reductions preceding tree mortality were predominantly observed in non‐field conditions, where the study was conducted on seedlings and saplings with underdeveloped root systems. It limits the nutrient uptake capacity of these young trees during drought. Furthermore, tree nutritional responses are also influenced by many variables. Specifically, (a) leaf nutrients are more susceptible to drought stress than other organs; (b) reduced tree nutrient concentrations are more prevalent in evergreen species during drought‐induced mortality; (c) of all biomes, Mediterranean forests are most vulnerable to drought‐induced nutrient deficiencies; (d) soil types affect the direction and extent of tree nutritional responses. We identified factors that influence the relationship between tree nutritional status and drought survival, and proposed potential early‐warning indicators of impending tree mortality, for example, decreased K concentrations with declining vitality. These findings contribute to our understanding of tree responses to drought and provide practical implications for forest management strategies in the context of global change.
    Type of Medium: Online Resource
    ISSN: 1354-1013 , 1365-2486
    URL: Issue
    URL: Article
    DOI: 10.1111/gcb.v30.1
    DOI: 10.1111/gcb.17133
    Language: English
    Publisher: Wiley
    Publication Date: 2024
    detail.hit.zdb_id: 1281439-8
    detail.hit.zdb_id: 2020313-5
    SSG: 12
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