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  • 1
    Online Resource
    Online Resource
    Hydrogel with Robust Adhesion in Various Liquid Environments by Electrostatic‐Induced Hydrophilic and Hydrophobic Polymer Chains Migration and Rearrangement
    Wiley ; 2023
    In:  Advanced Materials
    Details
    In: Advanced Materials, Wiley
    Type of Medium: Online Resource
    ISSN: 0935-9648 , 1521-4095
    URL: Article
    DOI: 10.1002/adma.202211237
    RVK:
    UA 1538
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 1474949-X
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  • 2
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    Online Resource
    FoxA2 inhibits the proliferation of hepatic progenitor cells by reducing PI3K/Akt/HK2‐mediated glycolysis
    Wiley ; 2020
    In:  Journal of Cellular Physiology Vol. 235, No. 12 ( 2020-12), p. 9524-9537
    Details
    In: Journal of Cellular Physiology, Wiley, Vol. 235, No. 12 ( 2020-12), p. 9524-9537
    Abstract: FoxA2 is an essential transcription factor for liver organogenesis and homeostasis. Although reduced expression of FoxA2 has been associated with chronic liver diseases, hepatic progenitor cells (HPCs) that are activated in these circumstances express FoxA2. However, the functional effects and underlying mechanism of FoxA2 in HPCs are still unknown. As revealed by immunostaining, HPCs expressed FoxA2 in human cirrhotic livers and in the livers of choline‐deficient diet supplemented with ethionine (CDE) rats. Knocking down FoxA2 in HPCs isolated from CDE rats significantly increased cell proliferation and aerobic glycolysis. Moreover, gene transcription, protein expression, and the enzyme activities of hexokinase 2 (HK2) were upregulated, and blocking HK2 activities via 2‐deoxyglucose markedly reduced cell proliferation and aerobic glycolysis. Kyoto Encyclopedia of Genes and Genomes analysis revealed that FoxA2 knockdown enhanced the transcription of genes involved in the phosphatidylinositol 3‐kinase (PI3K)/protein kinase B (Akt) pathway and triggered downstream Akt phosphorylation. Blocking the PI3K/Akt pathway by Ly294002 inhibited HK2 activities, aerobic glycolysis, and cell proliferation in FoxA2‐knockdown cells. Therefore, FoxA2 plays an important role in the proliferation and inhibition of HPCs by suppressing PI3K/Akt/HK2‐regulated aerobic glycolysis.
    Type of Medium: Online Resource
    ISSN: 0021-9541 , 1097-4652
    URL: Issue
    URL: Article
    DOI: 10.1002/jcp.v235.12
    DOI: 10.1002/jcp.29759
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 1478143-8
    SSG: 12
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  • 3
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    Online Resource
    NNMT‐DNMT1 Axis is Essential for Maintaining Cancer Cell Sensitivity to Oxidative Phosphorylation Inhibition
    Wiley ; 2023
    In:  Advanced Science Vol. 10, No. 1 ( 2023-01)
    Details
    In: Advanced Science, Wiley, Vol. 10, No. 1 ( 2023-01)
    Abstract: Lacking a clear understanding of the molecular mechanism determining cancer cell sensitivity to oxidative phosphorylation (OXPHOS) inhibition limits the development of OXPHOS‐targeting cancer treatment. Here, cancer cell lines sensitive or resistant to OXPHOS inhibition are identified by screening. OXPHOS inhibition‐sensitive cancer cells possess increased OXPHOS activity and silenced nicotinamide N ‐methyltransferase (NNMT) expression. NNMT expression negatively correlates with OXPHOS inhibition sensitivity and functionally downregulates the intracellular levels of S‐adenosyl methionine (SAM). Expression of DNA methyltransferase 1 (DNMT1), a SAM consumer, positively correlates with OXPHOS inhibition sensitivity. NNMT overexpression and DNMT1 inhibition render OXPHOS inhibition‐sensitive cancer cells resistant. Importantly, treatments of OXPHOS inhibitors (Gboxin and Berberine) hamper the growth of mouse tumor xenografts by OXPHOS inhibition sensitive but not resistant cancer cells. What's more, the retrospective study of 62 tumor samples from a clinical trial demonstrates that administration of Berberine reduces the tumor recurrence rate of NNMT low /DNMT1 high but not NNMT high /DNMT1 low colorectal adenomas (CRAs). These results thus reveal a critical role of the NNMT‐DNMT1 axis in determining cancer cell reliance on mitochondrial OXPHOS and suggest that NNMT and DNMT1 are faithful biomarkers for OXPHOS‐targeting cancer therapies.
    Type of Medium: Online Resource
    ISSN: 2198-3844 , 2198-3844
    URL: Issue
    URL: Article
    DOI: 10.1002/advs.v10.1
    DOI: 10.1002/advs.202202642
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2808093-2
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  • 4
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    Online Resource
    Learners' interaction patterns in asynchronous online discussions: An integration of the social and cognitive interactions
    Wiley ; 2022
    In:  British Journal of Educational Technology Vol. 53, No. 1 ( 2022-01), p. 23-40
    Details
    In: British Journal of Educational Technology, Wiley, Vol. 53, No. 1 ( 2022-01), p. 23-40
    Abstract: Studying the networked nature of social and cognitive aspects of learner interactions is the key to understanding how successful collaborative learning occurs in asynchronous online discussion forums (AODFs). Guided by network science and multiplex network analysis, this study compared the differences of network structure and properties between the social (learners as nodes and commenting on the others' contributions as edges) and cognitive (learners as nodes and explicitly quoting the others' contributions as edges) networks within an AODF. It additionally examined the differences of individual measures between these two monolayer networks and their integrated two multiplex networks. The two multiplex networks were respectively framed in superimposed and unfold approaches. Moreover, correlation analysis was conducted to examine the relationships between individual measures and learning performance across the four networks. Results showed key differences at the network and individual levels between the social and cognitive networks. The two networks had different compositions of participants, and students in the cognitive network occupied more central positions in general. Besides, certain individual measures in the multiplex networks were relatively higher and more related to learning performance than those in the monolayer networks. These results indicate that integrating multi‐aspect information of collaboration may be more conducive to unveiling learners' interaction patterns in asynchronous online discussions. Practitioner notes What is already known about this topic? Studying the networked nature of the social and cognitive aspects of learner interactions is the key to understanding how successful collaborative learning occurs. Social network analysis and content analysis are two commonly used methods to analyse learner interactions in asynchronous online discussions. There is a lack of research examining learners' overall interaction patterns by integrating social and cognitive interactions. What this paper adds? This study framed cognitive interactions as a networked phenomenon to unveil the way learners participate in the cognitive aspect of learner interactions. Multiplex network analysis (MNA) was introduced to integrate social and cognitive interactions to understand learners' overall interaction patterns. Integrating social and cognitive interactions led to a more closer relationship between learner interactions and learning performance. Implications for practice and/or policy? The proposed approach for framing the cognitive network and the introduced approach of MNA could be jointly employed to discern learners' overall interaction pattern in asynchronous online discussions. Course facilitators and instructors should be aware of the inconsistencies in social and cognitive interactions and then simultaneously examine them so as to acquire an accurate understanding of learners' diverse interactions. Pedagogical strategies for simultaneously facilitating social and cognitive interactions could be used to better improve learning performance.
    Type of Medium: Online Resource
    ISSN: 0007-1013 , 1467-8535
    URL: Issue
    URL: Article
    DOI: 10.1111/bjet.v53.1
    DOI: 10.1111/bjet.13147
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 1479099-3
    SSG: 5,3
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  • 5
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    Online Resource
    Advances in surface‐enhanced Raman spectroscopy technology for detection of foodborne pathogens
    Wiley ; 2023
    In:  Comprehensive Reviews in Food Science and Food Safety Vol. 22, No. 3 ( 2023-05), p. 1466-1494
    Details
    In: Comprehensive Reviews in Food Science and Food Safety, Wiley, Vol. 22, No. 3 ( 2023-05), p. 1466-1494
    Abstract: Rapid control and prevention of diseases caused by foodborne pathogens is one of the existing food safety regulatory issues faced by various countries and has received wide attention from all sectors of society. The development of rapid and reliable detection methods for foodborne pathogens remains a hot research area for food safety and public health because of the limitations of complex steps, time‐consuming, low sensitivity, or poor selectivity of commonly used methods. Surface‐enhanced Raman spectroscopy (SERS), as a novel spectroscopic technique, has the advantages of high sensitivity, selectivity, rapid and nondestructive detection and has exhibited broad application prospects in the determination of pathogenic bacteria. In this study, the enhancement mechanisms of SERS are briefly introduced, then the characteristics and properties of liquid‐phase, rigid solid‐phase, and flexible solid‐phase are categorized. Furthermore, a comprehensive review of the advances in label‐free or label‐based SERS strategies and SERS‐compatible techniques for the detection of foodborne pathogens is provided, and the advantages and disadvantages of these methods are reviewed. Finally, the current challenges of SERS technology applied in practical applications are listed, and the possible development trends of SERS in the field of foodborne pathogens detection in the future are discussed.
    Type of Medium: Online Resource
    ISSN: 1541-4337 , 1541-4337
    URL: Issue
    URL: Article
    DOI: 10.1111/crf3.v22.3
    DOI: 10.1111/1541-4337.13118
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2185829-9
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  • 6
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    Online Resource
    Chemical Exchange Saturation Transfer (CEST) Agents: Quantum Chemistry and MRI
    Wiley ; 2016
    In:  Chemistry – A European Journal Vol. 22, No. 1 ( 2016-01-04), p. 264-271
    Details
    In: Chemistry – A European Journal, Wiley, Vol. 22, No. 1 ( 2016-01-04), p. 264-271
    Abstract: Diamagnetic chemical exchange saturation transfer (CEST) contrast agents offer an alternative to Gd 3+ ‐based contrast agents for MRI. They are characterized by containing protons that can rapidly exchange with water and it is advantageous to have these protons resonate in a spectral window that is far removed from water. Herein, we report the first results of DFT calculations of the 1 H nuclear magnetic shieldings in 41 CEST agents, finding that the experimental shifts can be well predicted ( R 2 =0.882). We tested a subset of compounds with the best MRI properties for toxicity and for activity as uncouplers, then obtained mice kidney CEST MRI images for three of the most promising leads finding 16 (2,4‐dihydroxybenzoic acid) to be one of the most promising CEST MRI contrast agents to date. Overall, the results are of interest since they show that 1 H NMR shifts for CEST agents—charged species—can be well predicted, and that several leads have low toxicity and yield good in vivo MR images.
    Type of Medium: Online Resource
    ISSN: 0947-6539 , 1521-3765
    URL: Issue
    URL: Article
    DOI: 10.1002/chem.v22.1
    DOI: 10.1002/chem.201503942
    RVK:
    VA 1120 ; VA 3507
    Language: English
    Publisher: Wiley
    Publication Date: 2016
    detail.hit.zdb_id: 1478547-X
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  • 7
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    3D MR Elastography of Hepatocellular Carcinomas as a Potential Biomarker for Predicting Tumor Recurrence
    Wiley ; 2019
    In:  Journal of Magnetic Resonance Imaging Vol. 49, No. 3 ( 2019-03), p. 719-730
    Details
    In: Journal of Magnetic Resonance Imaging, Wiley, Vol. 49, No. 3 ( 2019-03), p. 719-730
    Abstract: Preoperative prediction of tumor recurrence is important in the management of patients with hepatocellular carcinoma (HCC). Purpose To investigate whether tumor stiffness derived by magnetic resonance elastography (MRE) could predict early recurrence of HCC after hepatic resection. Study Type Retrospective. Population In all, 99 patients with pathologically confirmed HCCs after surgical resection. Field Strength/Sequence 3.0T; preoperative MRE with 60‐Hz mechanical vibrations using an active acoustic driver. Assessment Regions of interest (ROIs) were manually drawn in the tumors to measure mean tumor stiffness. Surgical specimens were reviewed for histological grade, capsule, vascular invasion, and surgical margins. The early recurrence of HCC was defined as that occurring within 2 years after resection. Statistical Tests Cox proportional hazard models were used to evaluate risk factors associated with the time to early recurrence. Results HCCs with recurrence had higher tumor stiffness, higher rate of advanced T stage, vascular invasion, lower rate of capsule formation, larger tumor size, higher aspartate aminotransferase (AST), and hepatitis B virus (HBV)‐DNA level and aspartate aminotransferase / alanine aminotransferase ratio ( P  = 0.031, 0.007, 0.01, 〈 0.001, 0.015, 0.034, 0.01, and 0.014, respectively) than HCCs without recurrence. Vascular invasion (hazard ratio [HR] = 2.922; 95% confidence interval [CI] : [1.079, 7.914], P  = 0.035) and mean tumor stiffness (HR = 1.163; 95% CI: [1.055, 1.282], P  = 0.002) were risk factors associated with early recurrence. Each 1‐kPa increase in tumor stiffness was associated with a 16.3% increase in the risk for tumor recurrence. Data Conclusion The mean stiffness of HCCs may be a useful, noninvasive, quantitative biomarker for the prediction of early HCC recurrence after hepatic resection. Level of Evidence: 4 Technical Efficacy: Stage 5 J. Magn. Reson. Imaging 2019;49:719–730.
    Type of Medium: Online Resource
    ISSN: 1053-1807 , 1522-2586
    URL: Issue
    URL: Article
    DOI: 10.1002/jmri.v49.3
    DOI: 10.1002/jmri.26250
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 1497154-9
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  • 8
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    Online Resource
    miR‐30d is related to asbestos exposure and inhibits migration and invasion in NCI ‐H2452 cells
    Wiley ; 2017
    In:  FEBS Open Bio Vol. 7, No. 10 ( 2017-10), p. 1469-1479
    Details
    In: FEBS Open Bio, Wiley, Vol. 7, No. 10 ( 2017-10), p. 1469-1479
    Abstract: Pleural malignant mesothelioma ( MM ) is a highly aggressive tumor that is typically related to asbestos exposure and has a latency of 20–60 years. Several micro RNA contribute to MM initiation and progression, but the mechanisms are not clear. Here, we found that miR‐30d is downregulated in the pleural MM cell line NCI ‐H2452, in the plasma of asbestos‐exposed individuals, and in asbestos‐exposed mesothelial cells. Furthermore, we investigated the influence of the overexpression of miR‐30d in pleural MM cells. We demonstrated that miR‐30d overexpression could suppress pleural MM cell proliferation, migration, and invasion in vitro and could promote cell apoptosis but could not significantly influence cell cycle. The mRNA and protein expression of vimentin and TWIST 1 decreased, and the mRNA expression of CDH 1 increased in NCI ‐H2452 cells that overexpressed miR‐30d. We therefore conclude that miR‐30d is related to asbestos exposure and inhibits cell migration and invasion by regulating the epithelial–mesenchymal transition in NCI ‐H2452 cells.
    Type of Medium: Online Resource
    ISSN: 2211-5463 , 2211-5463
    URL: Issue
    URL: Article
    DOI: 10.1002/feb4.2017.7.issue-10
    DOI: 10.1002/2211-5463.12274
    Language: English
    Publisher: Wiley
    Publication Date: 2017
    detail.hit.zdb_id: 2651702-4
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  • 9
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    Online Resource
    Bone morphogenetic protein 6 inhibit stress-induced breast cancer cells apoptosis via both smad and P38 pathways
    Wiley ; 2008
    In:  Journal of Cellular Biochemistry Vol. 103, No. 5 ( 2008-04-01), p. 1584-1597
    Details
    In: Journal of Cellular Biochemistry, Wiley, Vol. 103, No. 5 ( 2008-04-01), p. 1584-1597
    Type of Medium: Online Resource
    ISSN: 0730-2312 , 1097-4644
    URL: Issue
    URL: Journal
    URL: Article
    DOI: 10.1002/jcb.v103:5
    DOI: 10.1002/(ISSN)1097-4644
    DOI: 10.1002/jcb.21547
    Language: English
    Publisher: Wiley
    Publication Date: 2008
    detail.hit.zdb_id: 1479976-5
    SSG: 12
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  • 10
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    Post‐transcriptional regulation of Ghd7 protein stability by phytochrome and Os GI in photoperiodic control of flowering in rice
    Wiley ; 2019
    In:  New Phytologist Vol. 224, No. 1 ( 2019-10), p. 306-320
    Details
    In: New Phytologist, Wiley, Vol. 224, No. 1 ( 2019-10), p. 306-320
    Abstract: Rice ( Oryza sativa ) is a facultative short‐day ( SD ) plant, flowering early under SD and late under long‐day ( LD ) conditions. Ghd7 is a major regulator of flowering time in rice, which strongly delays flowering under LD . Induction of Ghd7 expression by phytochromes has been shown to contribute to photoperiodic regulation of flowering in rice. Here, we show that Ghd7 also is regulated by phytochromes at a post‐transcriptional level. We found that constitutive expression of Ghd7 delays flowering in the wild‐type (WT) background, but not in the se5 mutant background (deficient in functional phytochromes) under LD and that Ghd7 protein fails to accumulate in the se5 mutant. We also found that co‐expressing OsGIGANTEA ( Os GI ) with Ghd7 causes reduced accumulation of Ghd7 protein and partially suppresses the delayed flowering phenotype in the WT background, suggesting that phytochromes and Os GI play antagonist roles in regulating Ghd7 protein stability and flowering time. We show that Os PHYA , Os PHYB and Os GI could directly interact with Ghd7. Interestingly, Os PHYA and Os PHYB could inhibit the interaction between Os GI and Ghd7, thus helping to stabilize Ghd7 protein. Our results revealed a new level of Ghd7 regulation by phytochromes and Os GI in photoperiodic control of flowering in rice.
    Type of Medium: Online Resource
    ISSN: 0028-646X , 1469-8137
    URL: Issue
    URL: Article
    DOI: 10.1111/nph.v224.1
    DOI: 10.1111/nph.16010
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 208885-X
    detail.hit.zdb_id: 1472194-6
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