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  • 1
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    Online Resource
    Diagnostic value of nerve conduction study in NOTCH2NLC ‐related neuronal intranuclear inclusion disease
    Wiley ; 2023
    In:  Journal of the Peripheral Nervous System
    Details
    In: Journal of the Peripheral Nervous System, Wiley
    Abstract: Neuronal intranuclear inclusion disease (NIID) is a rare progressive neurodegenerative disorder mainly caused by abnormally expanded GGC repeats within the NOTCH2NLC gene. Most patients with NIID show polyneuropathy. Here, we aim to investigate diagnostic electrophysiological markers of NIID. Methods In this retrospective dual‐center study, we reviewed 96 patients with NOTCH2NLC ‐related NIID, 94 patients with genetically confirmed Charcot–Marie‐Tooth (CMT) disease, and 62 control participants without history of peripheral neuropathy, who underwent nerve conduction studies between 2018 and 2022. Results Peripheral nerve symptoms were presented by 53.1% of patients with NIID, whereas 97.9% of them showed peripheral neuropathy according to electrophysiological examinations. Patients with NIID were characterized by slight demyelinating sensorimotor polyneuropathy; some patients also showed mild axonal lesions. Motor nerve conduction velocity (MCV) of the median nerve usually exceeded 35 m/s, and were found to be negatively correlated with the GGC repeat sizes. Regarding the electrophysiological differences between muscle weakness type ( n  = 27) and non‐muscle weakness type ( n  = 69) of NIID, nerve conduction abnormalities were more severe in the muscle weakness type involving both demyelination and axonal impairment. Notably, specific DWI subcortical lace sign was presented in only 33.3% of muscle weakness type, thus it was difficult to differentiate them from CMT. Combining age of onset, distal motor latency, and compound muscle action potential of the median nerve showed the optimal diagnostic performance to distinguish NIID from major CMT (AUC = 0.989, sensitivity = 92.6%, specificity = 97.4%). Interpretation Peripheral polyneuropathy is common in NIID. Our study suggest that nerve conduction study is useful to discriminate NIID.
    Type of Medium: Online Resource
    ISSN: 1085-9489 , 1529-8027
    URL: Article
    DOI: 10.1111/jns.12599
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2030613-1
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  • 2
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    Effect of steam explosion‐assisted extraction on phenolic acid profiles and antioxidant properties of wheat bran
    Wiley ; 2016
    In:  Journal of the Science of Food and Agriculture Vol. 96, No. 10 ( 2016-08), p. 3484-3491
    Details
    In: Journal of the Science of Food and Agriculture, Wiley, Vol. 96, No. 10 ( 2016-08), p. 3484-3491
    Abstract: The majority of phenolic acids in wheat bran are bound to the cell walls. Hence, a high proportion of phenolic acids cannot be extracted with conventional extraction methods. This study aimed to investigate the efficiency of steam explosion pre‐treatment in increasing the extractability of phenolic compounds from wheat bran. RESULTS Bound phenolic acids ( BPA ) can be released by steam explosion‐assisted extraction. Within the experimental range, soluble free phenolic acids ( FPA ) and soluble conjugated phenolic acids ( CPA ) increased gradually with residence time and temperature. After steam explosion at 215 °C for 120 s, the total FPA and CPA reached 6671.8 and 2578.6 µg GAE g −1 bran, respectively, which was about 39‐fold and seven‐fold higher than that of the untreated sample. Ferulic acid, the major individual phenolic acids in bran, increased from 55.7 to 586.3 µg g −1 for FPA , and from 44.9 to 1108.4 µg g −1 for CPA . The antioxidant properties of FPA and CPA extracts were significantly improved after treated. Correlation analysis indicated that the antioxidant capacity was in close relationship with phenolic content in FPA and CPA . CONCLUSION Steam explosion pre‐treatment could be effectively used to release of BPA and enhance the antioxidant capacity of wheat bran. © 2015 Society of Chemical Industry
    Type of Medium: Online Resource
    ISSN: 0022-5142 , 1097-0010
    URL: Issue
    URL: Article
    DOI: 10.1002/jsfa.2016.96.issue-10
    DOI: 10.1002/jsfa.7532
    Language: English
    Publisher: Wiley
    Publication Date: 2016
    detail.hit.zdb_id: 2001807-1
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  • 3
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    Characterization of a phospholipase D from Streptomyces cinnamoneum SK43.003 suitable for phosphatidylserine synthesis
    Wiley ; 2022
    In:  Biotechnology and Applied Biochemistry Vol. 69, No. 5 ( 2022-10), p. 1917-1928
    Details
    In: Biotechnology and Applied Biochemistry, Wiley, Vol. 69, No. 5 ( 2022-10), p. 1917-1928
    Abstract: A phospholipase D high producing strain with transphosphatidylation activity that is suitable for phosphatidylserine synthesis was screened by our laboratory and named as Streptomyces cinnamoneum SK43.003. The enzyme structural and biochemical properties were investigated using the molecular biology method. A 1521‐bp fragment of the phospholipase D gene from Streptomyces cinnamoneum SK43.003 was amplified by PCR and encoded for 506 amino acids. The primary structure contained two conserved HKD and GG/S motifs. The pld gene was cloned and expressed in Escherichia coli . The purified enzyme exhibited the highest activity at a pH value of 6.0 andtemperature of 60°C. The enzyme was stable within a pH range of 4–7 for 24 h or at temperatures below 50°C. In addition, Triton X‐100, Fe 2+ , and Al 3+ were beneficial to the enzyme activity, whereas Zn 2+ and Cu 2+ dramatically inhibited its activity. In a two‐phase system, the enzyme could convert phosphatidylcholine to phosphatidylserine with a 92% transformation rate.
    Type of Medium: Online Resource
    ISSN: 0885-4513 , 1470-8744
    URL: Issue
    URL: Article
    DOI: 10.1002/bab.v69.5
    DOI: 10.1002/bab.2257
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 1496341-3
    SSG: 12
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  • 4
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    Ultrasound‐guided percutaneous metal‐organic frameworks based codelivery system of doxorubicin/acetazolamide for hepatocellular carcinoma therapy
    Wiley ; 2021
    In:  Clinical and Translational Medicine Vol. 11, No. 10 ( 2021-10)
    Details
    In: Clinical and Translational Medicine, Wiley, Vol. 11, No. 10 ( 2021-10)
    Type of Medium: Online Resource
    ISSN: 2001-1326 , 2001-1326
    URL: Issue
    URL: Article
    DOI: 10.1002/ctm2.v11.10
    DOI: 10.1002/ctm2.600
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2697013-2
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  • 5
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    Online Resource
    Application of deep brief network in transmission spectroscopy detection of pesticide residues in lettuce leaves
    Wiley ; 2019
    In:  Journal of Food Process Engineering Vol. 42, No. 3 ( 2019-05)
    Details
    In: Journal of Food Process Engineering, Wiley, Vol. 42, No. 3 ( 2019-05)
    Abstract: To realize the quick, nondestructive detection of pesticide residues in lettuce leaves, a new method based on deep brief network (DBN) combined with near‐infrared transmission spectroscopy, was studied in this article. Two kinds of pesticide residues (fenvalerate and triazoline) and distilled water were sprayed on the surface of lettuce leaves, respectively. In addition, near infrared transmission spectroscopy was used for collecting spectral data of 240 lettuce samples. Furthermore, Savitzky–Golay combined with multiplicative scatter correction was used to denoise the raw spectral data. Then, after preprocessing spectral data, DBN was used to extract features and identify kinds of pesticide residues in lettuce leaves. Moreover，successive projection algorithm (SPA) was used to select characteristic wavelengths. After all, support vector machine (SVM), PLS‐DA, and k ‐nearest neighbor were carried out to establish classification models based on full spectral data, data extracted by DBN and data extracted by SPA. Consequently, DBN–SVM performed best and the accuracy of training set and test set reached 98.89 and 95.00%, respectively. Hence, the method of near infrared transmission spectroscopy combined with DBN–SVM is practical for the qualitative analysis of pesticide residues in lettuce leaves. Practical applications Using near infrared spectroscopy could detect the kinds of pesticide residues in lettuce leaves quickly and effectively. A new method involving deep brief network (DBN) was proposed to extract the features of spectral data. Results in this study showed that the DBN is feasible and effective for building classification models of different pesticide residues.
    Type of Medium: Online Resource
    ISSN: 0145-8876 , 1745-4530
    URL: Issue
    URL: Article
    DOI: 10.1111/jfpe.2019.42.issue-3
    DOI: 10.1111/jfpe.13005
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 2175259-X
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  • 6
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    Pyrethrins elicit olfactory response and spatial repellency in Aedes albopictus
    Wiley ; 2021
    In:  Pest Management Science Vol. 77, No. 8 ( 2021-08), p. 3706-3712
    Details
    In: Pest Management Science, Wiley, Vol. 77, No. 8 ( 2021-08), p. 3706-3712
    Abstract: Pyrethrum from dry flowers of Chrysanthemum is a well‐known botanical insecticide and repellent. Its insecticidal activity attributes to its six insecticidal esters, collectively known as pyrethrins. Pyrethrins and its synthetic analogs pyrethroids exert their toxic action by modifying the function of voltage‐gated sodium channels. Aside from insecticidal activity, pyrethrum has also been used to repel mosquitoes for centuries. Today, pyrethrum continues to be used as an active ingredient in mosquito coils and other mosquito‐repellent devices globally. However, the mechanism of pyrethrum repellency remains largely unknown. RESULTS Here we report that pyrethrum vapor induced spatial (non‐contact) repellency in Aedes albopictus , a major vector of dengue and West Nile viruses. Using electroantennogram (EAG) recordings from adult antennae, we found that pyrethrum elicited EAG response in a dose‐dependent manner. We then isolated the six insecticidal esters, pyrethrins I and II, cinerins I and II, jasmolins I and II from pyrethrum extract and discovered that five of the six esters, except jasmolin I, all elicited EAG responses. Furthermore, pyrethrins I and II, cinerin II and jasmolin II induced repellency, whereas cinerin I and jasmolin I did not. CONCLUSION Of the six pyrethrins, four of them, pyrethrins I and II, cinerin II and jasmolin II, activate olfactory‐receptor neurons and elicit spatial repellency in Ae. albopictus . Our study provided a foundation for future structure–function studies of pyrethrins, their cognate olfactory receptors and efficacies of repellency and for the development of new and more effective mosquito repellents for controlling vector‐borne human diseases. © 2021 Society of Chemical Industry.
    Type of Medium: Online Resource
    ISSN: 1526-498X , 1526-4998
    URL: Issue
    URL: Article
    DOI: 10.1002/ps.v77.8
    DOI: 10.1002/ps.6390
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2003455-6
    SSG: 12
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  • 7
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    Citri Reticulatae Pericarpium alleviates postmyocardial infarction heart failure by upregulating PPARγ expression
    Wiley ; 2022
    In:  Clinical and Experimental Pharmacology and Physiology Vol. 49, No. 6 ( 2022-06), p. 661-673
    Details
    In: Clinical and Experimental Pharmacology and Physiology, Wiley, Vol. 49, No. 6 ( 2022-06), p. 661-673
    Abstract: Heart failure after myocardial infarction (MI) is the leading cause of death worldwide. Citri Reticulatae Pericarpium (CRP) is a traditional Chinese herbal medicine that has been used in the clinic for centuries. In this study, we aimed to investigate the roles of CRP in cardiac remodelling and heart failure after MI, as well as the molecular mechanisms involved. Male C57BL/6 mice aged 8 weeks were subjected to coronary artery ligation to mimic the clinical situation in vivo. Echocardiography was used to assess the systolic function of the mouse heart. Masson trichrome staining and Wheat germ agglutinin (WGA) staining were utilised to determine the fibrotic area and cross‐sectional area of the mouse heart, respectively. Cardiomyocytes and fibroblasts were isolated from neonatal rats aged 0–3 days in vitro using enzyme digestion. TUNEL staining and EdU staining were performed to evaluate apoptosis and proliferation, respectively. Gene expression changes were analysed by qRT–PCR, and protein expression changes were assessed by Western blotting. Our findings revealed that CRP attenuated cardiac hypertrophy, fibrosis and apoptosis and alleviated heart failure after MI in vivo. Furthermore, CRP mitigated cardiomyocyte apoptosis and fibroblast proliferation and differentiation into myofibroblasts. In addition, the PPARγ inhibitor T0070907 completely abolished the abovementioned beneficial effects of CRP, and the PPARγ activator rosiglitazone failed to further ameliorate cardiac apoptosis and fibrosis in vitro. CRP alleviates cardiac hypertrophy, fibrosis, and apoptosis and can ameliorate heart failure after MI via activation of PPARγ.
    Type of Medium: Online Resource
    ISSN: 0305-1870 , 1440-1681
    URL: Issue
    URL: Article
    DOI: 10.1111/cep.v49.6
    DOI: 10.1111/1440-1681.13642
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2020033-X
    SSG: 15,3
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  • 8
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    High‐Throughput Cellular Heterogeneity Analysis in Cell Migration at the Single‐Cell Level
    Wiley ; 2023
    In:  Small Vol. 19, No. 6 ( 2023-02)
    Details
    In: Small, Wiley, Vol. 19, No. 6 ( 2023-02)
    Abstract: Cancer cell migration represents an essential step toward metastasis and cancer deaths. However, conventional drug discovery focuses on cytotoxic and growth‐inhibiting compounds rather than inhibitors of migration. Drug screening assays generally measure the average response of many cells, masking distinct cell populations that drive metastasis and resist treatments. Here, this work presents a high‐throughput microfluidic cell migration platform that coordinates robotic liquid handling and computer vision for rapidly quantifying individual cellular motility. Using this innovative technology, 172 compounds were tested and a surprisingly low correlation between migration and growth inhibition was found. Notably, many compounds were found to inhibit migration of most cells while leaving fast‐moving subpopulations unaffected. This work further pinpoints synergistic drug combinations, including Bortezomib and Danirixin, to stop fast‐moving cells. To explain the observed cell behaviors, single‐cell morphological and molecular analysis were performed. These studies establish a novel technology to identify promising migration inhibitors for cancer treatment and relevant applications.
    Type of Medium: Online Resource
    ISSN: 1613-6810 , 1613-6829
    URL: Issue
    URL: Article
    DOI: 10.1002/smll.v19.6
    DOI: 10.1002/smll.202206754
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2168935-0
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  • 9
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    Organic–Inorganic Hybrid Cathode with Dual Energy‐Storage Mechanism for Ultrahigh‐Rate and Ultralong‐Life Aqueous Zinc‐Ion Batteries
    Wiley ; 2022
    In:  Advanced Materials Vol. 34, No. 6 ( 2022-02)
    Details
    In: Advanced Materials, Wiley, Vol. 34, No. 6 ( 2022-02)
    Abstract: The exploitation of cathode materials with high capacity as well as high operating voltage is extremely important for the development of aqueous zinc‐ion batteries (ZIBs). Yet, the classical high‐capacity materials (e.g., vanadium‐based materials) provide a low discharge voltage, while organic cathodes with high operating voltage generally suffer from a low capacity. In this work, organic (ethylenediamine)–inorganic (vanadium oxide) hybrid cathodes, that is, EDA‐VO, with a dual energy‐storage mechanism, are designed for ultrahigh‐rate and ultralong‐life ZIBs. The embedded ethylenediamine (EDA) can not only increase the layer spacing of the vanadium oxide, with improved mobility of Zn ions in the V–O layered structure, but also act as a bidentate chelating ligand participating in the storage of Zn ions. This hybrid provides a high specific capacity (382.6 mA h g −1 at 0.5 A g −1 ), elevated voltage (0.82 V) and excellent long‐term cycle stability (over 10 000 cycles at 5 A g −1 ). Assistant density functional theory (DFT) calculations indicate the cathode has remarkable electronic conductivity, with an ultralow diffusion barrier of 0.78 eV for an optimal Zn‐ion diffusion path in the EDA‐VO. This interesting idea of building organic–inorganic hybrid cathode materials with a dual energy‐storage mechanism opens a new research direction toward high‐energy secondary batteries.
    Type of Medium: Online Resource
    ISSN: 0935-9648 , 1521-4095
    URL: Issue
    URL: Article
    DOI: 10.1002/adma.v34.6
    DOI: 10.1002/adma.202105452
    RVK:
    UA 1538
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 1474949-X
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  • 10
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    Is it beneficial for patients with pT1‐2N1M0 breast cancer to receive p ostmastectomy radiotherapy? An analysis based on RecurIndex assay
    Wiley ; 2021
    In:  International Journal of Cancer Vol. 149, No. 10 ( 2021-11-15), p. 1801-1808
    Details
    In: International Journal of Cancer, Wiley, Vol. 149, No. 10 ( 2021-11-15), p. 1801-1808
    Abstract: What's new? The benefit of post‐mastectomy radiotherapy in pT1‐2N1M0 breast cancer patients remains controversial. RecurIndex is a risk assessment model based on Chinese genes and clinicopathological features. Here, the authors retrospectively assessed the value of RecurIndex in informing the decision‐making process for post‐mastectomy radiotherapy in pT1‐2N1M0 breast cancer patients. The results show that RecurIndex can potentially stratify pT1‐2N1M0 breast cancer patients into low‐ and high‐risk groups for recurrence and metastasis. While there was little evidence that post‐mastectomy radiotherapy is beneficial in low‐risk patients, post‐mastectomy radiotherapy may produce survival benefits in high‐risk pT1‐2N1M0 breast cancer patients.
    Type of Medium: Online Resource
    ISSN: 0020-7136 , 1097-0215
    URL: Issue
    URL: Article
    DOI: 10.1002/ijc.v149.10
    DOI: 10.1002/ijc.33730
    RVK:
    XA 10000
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 218257-9
    detail.hit.zdb_id: 1474822-8
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