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  • Wiley  (33)
  • 1
    Online Resource
    Online Resource
    Densely Populated Bismuth Nanosphere Semi‐Embedded Carbon Felt for Ultrahigh‐Rate and Stable Vanadium Redox Flow Batteries
    Wiley ; 2020
    In:  Small Vol. 16, No. 37 ( 2020-09)
    Details
    In: Small, Wiley, Vol. 16, No. 37 ( 2020-09)
    Abstract: The elaborate spatial arrangement and immobilization of highly active electrocatalysts inside porous substrates are crucial for vanadium redox flow batteries capable of high‐rate charging/discharging and stable operation. Herein, a type of bismuth nanosphere/carbon felt is devised and fabricated via the carbothermic reduction of nanostructured bismuth oxides. The bismuth nanospheres with sizes of ≈25 nm are distributed on carbon fiber surfaces in a highly dispersed manner and its density reaches up to ≈500 pcs µm −2 , providing abundant active sites. Besides, a unique bismuth nanosphere semi‐embedded carbon fiber structure with strong interfacial BiC chemical bonding is spontaneously formed during carbothermic reactions, offering an excellent mechanical stability under flowing electrolytes. It shows that the bismuth nanosphere semi‐embedded carbon felt can effectively promote V(II)/V(III) redox reactions with appreciable catalytic activity. The battery with the present electrode sustains an energy efficiency of 77.1 ± 0.2% and an electrolyte utilization of 57.2 ± 0.2% even when a current density up to 480 mA cm −2 is applied, which are remarkably higher than those of batteries with the bismuth nanoparticle/carbon felt synthesized by the electrodeposition method (62.6 ± 0.1%, 23.6 ± 0.2%). Further, the battery with the present electrode demonstrates a stable energy efficiency retention of 98.2% after 1000 cycles.
    Type of Medium: Online Resource
    ISSN: 1613-6810 , 1613-6829
    URL: Issue
    URL: Article
    DOI: 10.1002/smll.v16.37
    DOI: 10.1002/smll.201907333
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2168935-0
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  • 2
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    Online Resource
    Phase Transition Induced Thermal Reversible Luminescent of Perovskite Quantum Dots Fibers
    Wiley ; 2023
    In:  Advanced Functional Materials Vol. 33, No. 32 ( 2023-08)
    Details
    In: Advanced Functional Materials, Wiley, Vol. 33, No. 32 ( 2023-08)
    Abstract: Converting and patterning high‐quality perovskite quantum dots (PQDs) into flexible thin films is of great significance for high‐performance solid‐state optical applications. However, the poor stability and low quantum efficiency of PQDs after film formation is a big challenge hindering their usability. Here, an in situ synthesis strategy to prepare ligand‐free long‐term stable CsPb(Br 0.3 I 0.7 ) 3 @poly(methylmethacrylate) (PMMA) PQDs fibers with thermal responsive fluorescence performance is demonstrated. The luminescence of the CsPb(Br 0.3 I 0.7 ) 3 @PMMA PQDs fibers can rapidly and reversibly quench and recover between heating and cooling cycles. It reveals that the thermally induced phase transition of CsPb(Br 0.3 I 0.7 ) 3 results in this thermally reversible luminescence phenomenon. This temperature‐reversible luminescence characteristic not only deepens the comprehension of the temperature‐dependent phase transition behavior of perovskite materials but also broadens their applications in the fields of information encryption storage, anti‐counterfeiting, temperature warning, and other temperature‐responsive fields.
    Type of Medium: Online Resource
    ISSN: 1616-301X , 1616-3028
    URL: Issue
    URL: Article
    DOI: 10.1002/adfm.v33.32
    DOI: 10.1002/adfm.202300607
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2029061-5
    detail.hit.zdb_id: 2039420-2
    SSG: 11
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  • 3
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    Stem density induces differential effects of litter on native and invasive plants
    Wiley ; 2022
    In:  Ecological Research Vol. 37, No. 4 ( 2022-07), p. 495-504
    Details
    In: Ecological Research, Wiley, Vol. 37, No. 4 ( 2022-07), p. 495-504
    Abstract: Litter plays an important role in plant invasion. Our previous studies have found that litter had two opposite effects as Spartina alterniflora invading native plant Phragmites australis community. Litter stimulated the growth of S. alterniflora on the edge of the community, while it inhibited the growth in the old community. Accordingly, we hypothesized that litter may play different roles in different stages of plant invasions. We selected three types of communities: P. australis monoculture (PAM), S. alterniflora monoculture (SAM), S. alterniflora – P. australis mixture (SPM) and conducted a comparative study by keeping and removing litter at Chongming Dongtan in the Yangtze River estuary, China. Our results revealed that litter removal significantly increased light intensity in SAM, and enhanced it in SPM, but had no significant influence on it in PAM. The effect of litter on light intensity resulted in a higher chlorophyll content and higher plant height of S. alterniflora monoculture after litter removal, which eventually led to a higher single weight and aboveground biomass for PAM and SAM after litter removal, and to a higher aboveground biomass for S. alterniflora in SPM. Litter removal significantly enhanced the dominance of S. alterniflora relative to P. australis in SPM. We concluded that the effects of invasive plants' litter on the invasion processes depend on the stem density of invasive plants relative to native plants. If an invasive species had a higher plant density, its litter may not have a shelter effect on native species, but could restrict its own growth.
    Type of Medium: Online Resource
    ISSN: 0912-3814 , 1440-1703
    URL: Issue
    URL: Article
    DOI: 10.1111/ere.v37.4
    DOI: 10.1111/1440-1703.12322
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2023900-2
    SSG: 12
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  • 4
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    A spatiotemporal gene expression and cell atlases of the developing rat ovary
    Wiley ; 2023
    In:  Cell Proliferation
    Details
    In: Cell Proliferation, Wiley
    Abstract: Normal ovarian development is necessary for the production of healthy oocytes. However, the characteristics of oocytes development at different stages and the regulatory relationship between oocytes and somatic cells remain to be fully explained. Here, we combined scRNA‐seq and spatial transcriptomic sequencing to profile the transcriptomic atlas of developing ovarian of the rat. We identified four components from developing granulosa cells including cumulus, primitive, mural, and luteal cells, and constructed their differential transcriptional regulatory networks. Several novel growth signals from oocytes to cumulus cells were identified, such as JAG1‐NOTCH2 and FGF9‐FGFR2. Moreover, we observed three cumulus sequential phases during follicle development determined by the key transcriptional factors in each cumulus phase ( Bckaf1 , Gata6 , Cebpb , etc.), as well as the potential pinpointed roles of macrophages in luteal regression. Altogether, the single‐cell spatial transcriptomic profile of the ovary provides not only a new research dimension for temporal and spatial analysis of ovary development, but also valuable data resources and a research basis for in‐depth excavation of the mechanisms of mammalian ovary development.
    Type of Medium: Online Resource
    ISSN: 0960-7722 , 1365-2184
    URL: Article
    DOI: 10.1111/cpr.13516
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2019986-7
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  • 5
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    Novel Development-Related Alternative Splices in Human Testis Identified by cDNA Microarrays
    Wiley ; 2005
    In:  Journal of Andrology Vol. 26, No. 2 ( 2005-03-04), p. 189-196
    Details
    In: Journal of Andrology, Wiley, Vol. 26, No. 2 ( 2005-03-04), p. 189-196
    Type of Medium: Online Resource
    ISSN: 0196-3635
    URL: Article
    DOI: 10.1002/j.1939-4640.2005.tb01085.x
    Language: English
    Publisher: Wiley
    Publication Date: 2005
    detail.hit.zdb_id: 2078091-6
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  • 6
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    Goat Milk Improves Glucose Homeostasis via Enhancement of Hepatic and Skeletal Muscle AMP‐Activated Protein Kinase Activation and Modulation of Gut Microbiota in Streptozocin‐Induced Diabetic Rats
    Wiley ; 2021
    In:  Molecular Nutrition & Food Research Vol. 65, No. 6 ( 2021-03)
    Details
    In: Molecular Nutrition & Food Research, Wiley, Vol. 65, No. 6 ( 2021-03)
    Abstract: Previously, the metabolic benefits of goat milk consumption in high‐fat diet‐fed rats are demonstrated. However, the effects are only reported in one animal model and the involvement of gut microbiota is not investigated. The aim of this study is to investigate the effects of goat milk consumption on glucose homeostasis and gut microbiota in streptozocin (STZ)‐induced diabetic rats. Methods and Results STZ‐induced diabetic rats are fed with three dosages of goat milk: 2.5, 5, and 10 g kg −1 . Parameters related to glucose homeostasis, hepatic and skeletal muscle AMP‐activated protein kinase (AMPK) activation, and gut microbiota are investigated. The dose of 10 g kg −1 exerts more metabolic benefits. Goat milk consumption improves fasting glucose levels, glucose tolerance, insulin sensitivity, and promotes hepatic and skeletal muscle AMPK activation in STZ‐injected diabetic rats. Goat milk modulates gut microbiota, increases the relative abundance of Lactobacillus , and augments levels of propionic and butyric acids. Conclusion This study demonstrates the metabolic benefits of goat milk consumption in STZ‐induced diabetic rats, which is consistent with the previous observations in high‐fat diet‐induced diabetic rats. Furthermore, this study elucidates the modulation of gut microbiota by goat milk, which likely mediates the metabolic effects of goat milk.
    Type of Medium: Online Resource
    ISSN: 1613-4125 , 1613-4133
    URL: Issue
    URL: Article
    DOI: 10.1002/mnfr.v65.6
    DOI: 10.1002/mnfr.202000888
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2160372-8
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  • 7
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    Micro RNA ‐503 promotes angiotensin II‐induced cardiac fibrosis by targeting Apelin‐13
    Wiley ; 2016
    In:  Journal of Cellular and Molecular Medicine Vol. 20, No. 3 ( 2016-03), p. 495-505
    Details
    In: Journal of Cellular and Molecular Medicine, Wiley, Vol. 20, No. 3 ( 2016-03), p. 495-505
    Abstract: Cardiac fibrosis is a major cause of heart failure. Micro RNA s (miRs) are important epigenetic regulators of cardiac function and cardiovascular diseases, including cardiac fibrosis. This study aimed to explore the role of miR‐503 and its mechanisms in regulating cardiac fibrosis. miR‐503 was found up‐regulated in the mouse LV tissues subjected to transverse aortic constriction ( TAC ) and in neonatal cardiac fibroblasts ( CF s) cultured with Angiotension II. The role of miR‐503 in regulating CF cell proliferation and/or collagen production in mice neonatal CF s were determined using an MTT assay and RT ‐ PCR respectively. Forced expression of miR‐503 increased the cellular proliferation and collagen production in mice neonatal CF s. The effects were abrogated by cotransfection with AMO ‐503 (a specific inhibitor of miR‐503). Injection of antagomiR‐503 elevated cardiac function and inhibited the expression of connective tissue growth factor ( CTGF ) and transforming growth factor ( TGF )‐β in the TAC mice. Additional analysis revealed that Apelin‐13 is a direct target of miR‐503, as the overexpression of miR‐503 decreased the protein and mRNA expression levels of Apelin‐13. In the CF s with pre‐treatment of AngII, we transfected AMO‐503 into the cells treated with si RNA ‐ APLN . si RNA ‐ APLN abolished the effects of AMO ‐503 on the production of collagen I and III and the expression of TGF ‐β and CTGF . Furthermore, pre‐treatment of CF s with Apelin‐13 (1–100 nmol/l) inhibited angiotensin II‐mediated collagen production and activation of CTGF and TGF ‐β. So we conclude that miR‐503 promotes cardiac fibrosis via miR‐503‐Apelin‐13‐ TGF ‐β‐ CTGF ‐collagen production pathway. Thus, miR‐503 is a promising therapeutic target for reducing cardiac fibrosis.
    Type of Medium: Online Resource
    ISSN: 1582-1838 , 1582-4934
    URL: Issue
    URL: Article
    DOI: 10.1111/jcmm.2016.20.issue-3
    DOI: 10.1111/jcmm.12754
    Language: English
    Publisher: Wiley
    Publication Date: 2016
    detail.hit.zdb_id: 2076114-4
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  • 8
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    Design, synthesis, and antiviral evaluation of novel hydrazone‐substituted thiophene[3,2‐ d ]pyrimidine derivatives as potent human immunodeficiency virus‐1 inhibitors
    Wiley ; 2018
    In:  Chemical Biology & Drug Design Vol. 92, No. 6 ( 2018-12), p. 2009-2021
    Details
    In: Chemical Biology & Drug Design, Wiley, Vol. 92, No. 6 ( 2018-12), p. 2009-2021
    Abstract: In the previous studies of our laboratory, the thiophene[3,2‐ d ]pyrimidine was identified as a promising scaffold for seeking highly potent HIV ‐1 non‐nucleoside reverse transcriptase inhibitors ( NNRTI s). In this study, we designed, synthesized, and biologically evaluated a series of thiophene[3,2‐ d ]pyrimidine derivatives with changed linker between the thiophenepyrimidine core and the right wing. Some of the synthesized compounds exhibited excellent HIV ‐1 inhibitory potency with low (double‐digit) nanomolar 50% effective concentration ( EC 50 ) values. Among them, compound 13a exhibited the most potent anti‐ HIV ‐1 activity ( EC 50  = 21.2 nM), which was 10‐fold greater than that of NVP ( EC 50  = 281 nM). Moreover, 13a showed much lower cytotoxicity ( CC 50  = 183 μM) and higher selection index ( SI  = 8,632) than NVP , ETV , and AZT . Besides, some physicochemical properties and water solubility were calculated or measured. The preliminary structure–activity relationships and molecular simulation studies of these compounds were also discussed comprehensively to provide valuable direction for further design and optimization.
    Type of Medium: Online Resource
    ISSN: 1747-0277 , 1747-0285
    URL: Issue
    URL: Article
    DOI: 10.1111/cbdd.2018.92.issue-6
    DOI: 10.1111/cbdd.13373
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2216600-2
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  • 9
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    Stem Cell‐Niche Engineering via Multifunctional Hydrogel Potentiates Stem Cell Therapies for Inflammatory Bone Loss
    Wiley ; 2023
    In:  Advanced Functional Materials Vol. 33, No. 2 ( 2023-01)
    Details
    In: Advanced Functional Materials, Wiley, Vol. 33, No. 2 ( 2023-01)
    Abstract: Effective therapies capable of simultaneously inhibiting inflammation and promoting bone healing remain to be developed for inflammatory bone disease. Stem cell therapies hold great promise for a variety of diseases, but their translation is hampered by low cell survival, rapid clearance, and limited functional integration of transplanted stem cells in target tissues. Herein, a multifunctional hydrogel‐based stem cell niche engineering strategy is reported for the treatment of inflammatory bone loss. By rationally integrating different functional modules, an injectable hydrogel‐based stem niche is engineered, which possesses temperature‐triggered gelling performance, inflammation/oxidative stress‐resolving activity, stem‐cell binding and survival‐enhancing capacity, and osteogenesis‐promoting capability. Using ectomesenchymal stem cells (EMSCs), effectiveness of this functionally advanced synthetic stem cell niche is demonstrated in rats with periodontitis, a representative inflammatory bone loss disease. Synergistic effects of the multifunctional hydrogel and EMSCs are also confirmed, with respect to normalizing the pathological microenvironment and improving alveolar bone regeneration in the periodontal tissue. Mechanistically, inflammation/oxidative stress‐resolving and osteogenic differentiation promoting capacities of the synthetic stem cell niche are mainly achieved by an incorporated nanotherapy via the GDF15/Atf3/c‐Fos axis of the MAPK signaling pathway. Besides periodontitis, the newly engineered hydrogel‐stem cell therapies are promising for the treatment of other inflammatory bone defects.
    Type of Medium: Online Resource
    ISSN: 1616-301X , 1616-3028
    URL: Issue
    URL: Article
    DOI: 10.1002/adfm.v33.2
    DOI: 10.1002/adfm.202209466
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2029061-5
    detail.hit.zdb_id: 2039420-2
    SSG: 11
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  • 10
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    In Situ Photocatalyzed Oxygen Generation with Photosynthetic Bacteria to Enable Robust Immunogenic Photodynamic Therapy in Triple‐Negative Breast Cancer
    Wiley ; 2020
    In:  Advanced Functional Materials Vol. 30, No. 10 ( 2020-03)
    Details
    In: Advanced Functional Materials, Wiley, Vol. 30, No. 10 ( 2020-03)
    Abstract: Hypoxia in the tumor microenvironment is a major hurdle dampening the antitumor effect of photodynamic therapy (PDT). Herein, active photosynthetic bacteria ( Synechococcus 7942, Syne ) are utilized for tumor‐targeted photosensitizer delivery and in situ photocatalyzed oxygen generation to achieve photosynthesis‐boosted PDT. Photosensitizer‐encapsulated nanoparticles (HSA/ICG) are assembled by intermolecular disulfide crosslinking and attached to the surface of Syne with amide bonds to form a biomimetic system (S/HSA/ICG). S/HSA/ICG combined the photosynthetic capability of Syne and the theranostic effect of HSA/ICG. Syne capable of photoautotrophy exhibit a moderate immune stimulation effect and a certain photodynamic role under 660 nm laser irradiation. Upon intravenous injection into tumor‐bearing mice, S/HSA/ICG can effectively accumulate in tumors and generate oxygen continuously under laser irradiation through photosynthesis, which remarkably relieve tumor hypoxia and enhance reactive oxygen species production, thereby completely eliminating primary tumors. This photosynthesis‐boosted PDT can also effectively reverse the tumor immunosuppressive microenvironment and robustly evoke systematic antitumor immune responses, which exhibit excellent effect on preventing tumor recurrence and metastasis inhibition in a metastatic triple‐negative breast cancer mouse model. Hence, this photosynthetic bacteria‐based photosynthesis‐boosted immunogenic PDT offers a promising approach to eliminate both local and metastatic tumors.
    Type of Medium: Online Resource
    ISSN: 1616-301X , 1616-3028
    URL: Issue
    URL: Article
    DOI: 10.1002/adfm.v30.10
    DOI: 10.1002/adfm.201910176
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2029061-5
    detail.hit.zdb_id: 2039420-2
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