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  • Wiley  (16)
  • 1
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    Function and prognostic value of N6‐methyladenosine‐modified RNAs in lung adenocarcinoma
    Wiley ; 2023
    In:  The Journal of Gene Medicine Vol. 25, No. 1 ( 2023-01)
    Details
    In: The Journal of Gene Medicine, Wiley, Vol. 25, No. 1 ( 2023-01)
    Abstract: Aberrant regulation of N6‐methyladenosine (m6A) modification is reportedly vital for cancer progression, including lung adenocarcinoma (LUAD). However, current studies mainly focus on the function and mechanism of m6A‐modified regulators, such as m6A writers (METTL3 and METTL14), erasers (ALKBH5 and FTO), and readers (YTHDF1 and YTHDF2). The landscape, function, and prognostic value of RNAs by m6A‐modified have not been fully clarified until now. Methods The present study identified 57 RNAs with significantly different m6A‐methylation levels in LUAD tissues using epitranscriptomic microarray analysis. Results Among the 57 RNAs, 28 and 29 were hypermethylated and hypomethylated, respectively. The m6A‐methylation level increased in mRNA and long non‐coding RNA (lncRNA) but decreased in small non‐coding RNA. After pathway enrichment analyses, RNA metabolism‐associated pathways such as nucleotide metabolism were enriched in total and m6A‐hypermethylated mRNAs. Furthermore, lncRNA networks were built using miRNet tools, revealing that the immune system was closed to m6A‐modified lncRNAs. To evaluate the prognostic value of mRNAs with hypermethylated or hypomethylated, we calculated the risk scores, and constructed signatures to predict the survival time of patients with LUAD using multicox regression analysis. In addition, hypermethylated‐mRNA and hypomethylated‐mRNA signatures were established. The survival plotter showed that these two signatures effectively predicted the survival time of patients with LUAD. Conclusions The results of the present study support the evidence for understanding the expression, function, and potential prognostic values of m6A‐modified RNAs, possibly promoting effective therapies for patients with LUAD.
    Type of Medium: Online Resource
    ISSN: 1099-498X , 1521-2254
    URL: Issue
    URL: Article
    DOI: 10.1002/jgm.v25.1
    DOI: 10.1002/jgm.3454
    Language: English
    Publisher: Wiley
    Publication Date: 2023
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    detail.hit.zdb_id: 1458024-X
    SSG: 12
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  • 2
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    Controllable exfoliation of hexagonal boron nitride and tailored three‐dimensional network for highly thermally conductive polymer composites
    Wiley ; 2024
    In:  Journal of Applied Polymer Science Vol. 141, No. 10 ( 2024-03-10)
    Details
    In: Journal of Applied Polymer Science, Wiley, Vol. 141, No. 10 ( 2024-03-10)
    Abstract: Thermally conductive but electrically insulating composites have become significant components for efficient thermal dissipation in electronic devices due to their miniaturization, integration, and functionalization. Over the past decade, extensive efforts have been dedicated to improving the thermal conductivity of polymer‐based composites through incorporating various thermally conductive fillers. In particular, boron nitride nanosheets (BNNS) with outstanding intrinsic thermal conductivity, electrical insulation, and chemical stability, have sparked intensive interest from researchers. However, BNNS usually suffers from severe aggregation in polymer matrices, leading to high interfacial thermal resistance. Rational construction of three‐dimensional (3D) BNNS continuous networks is crucial for efficient thermal transport and has also been established as a feasible and effective approach to achieve significant enhancement of thermal conductivity for polymer/BNNS composites. In this brief review, we summarized and introduced recent progress on the controllable exfoliation of h‐BN and tailored three‐dimensional networks for highly thermally conductive polymer composites. The fabrication strategies for 3D BNNS networks and the structure–properties relationships of polymer/BNNS composites are highlighted. Finally, the opportunities and challenges for polymer/BNNS composites based on 3D thermally conductive networks are prospected.
    Type of Medium: Online Resource
    ISSN: 0021-8995 , 1097-4628
    URL: Issue
    URL: Article
    DOI: 10.1002/app.v141.10
    DOI: 10.1002/app.55094
    Language: English
    Publisher: Wiley
    Publication Date: 2024
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    detail.hit.zdb_id: 1491105-X
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  • 3
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    Chemical composition of the volatiles of three wild Bergenia species from western China
    Wiley ; 2006
    In:  Flavour and Fragrance Journal Vol. 21, No. 3 ( 2006-05), p. 431-434
    Details
    In: Flavour and Fragrance Journal, Wiley, Vol. 21, No. 3 ( 2006-05), p. 431-434
    Abstract: Volatiles were distilled from leaves of three Bergenia species collected from Yunnan, Xinjiang and Tibet in western China and analyzed using GC/MS instrumentation. The contents of extractable volatiles varied substantially among the three species with B. crassifolia having approximately 0.05% dry wt (v/w), B. purpurscens 0.01% (v/w) and B. stracheyi 0.13% (v/w), respectively. In B. crassifolia , the main components were present as 3‐methyl‐2‐buten‐1‐ol (26.56%), hexadecanoic acid (16.06%), dodecanoic acid (9.99%), linalool (5.63%) and octadecadienoic acid (4.10%). In B. purpurascens , the main components were β ‐eudesmol (18.63%), phytol (14.50%), hexadecanoic acid (13.05%), n ‐nonacosane (9.19%) and 3‐methyl‐2‐buten‐1‐ol (7.52%). In B. stracheyi , 3‐methyl‐2‐buten‐1‐ol was the dominant sort of volatile (52.71%), whereas detected major constituents included β ‐eudesmol (7.44%), damascenone (3.22%), caryophyllene (2.75%) and phytol (2.57%). Copyright © 2006 John Wiley & Sons, Ltd.
    Type of Medium: Online Resource
    ISSN: 0882-5734 , 1099-1026
    URL: Issue
    URL: Article
    DOI: 10.1002/ffj.v21:3
    DOI: 10.1002/ffj.1689
    Language: English
    Publisher: Wiley
    Publication Date: 2006
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    detail.hit.zdb_id: 1483463-7
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  • 4
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    Virtual bronchoscopic navigation and endobronchial ultrasound with a guide sheath without fluoroscopy for diagnosing peripheral pulmonary lesions with a bronchus leading to or adjacent to the lesion: A randomized non‐inferiority trial
    Wiley ; 2023
    In:  Respirology Vol. 28, No. 4 ( 2023-04), p. 389-398
    Details
    In: Respirology, Wiley, Vol. 28, No. 4 ( 2023-04), p. 389-398
    Abstract: Transbronchial sampling of peripheral pulmonary lesions (PPLs) is routinely performed under fluoroscopy. However, advanced ancillary techniques have become available, such as virtual bronchoscopic navigation (VBN) and radial endobronchial ultrasound with a guide sheath (rEBUS‐GS). This study was performed to determine whether the diagnostic utility of VBN and rEBUS with a GS is similar with or without fluoroscopy. Methods This multicenter non‐inferiority trial randomized patients to a VBN‐rEBUS‐GS with or without fluoroscopy group at three centres. The primary endpoint was the diagnostic yield. The secondary endpoints were the time for rEBUS, GS, and the total operation. Complications were also recorded. Results Four hundred and ninety‐six subjects were assessed and 426 subjects were included in the analysis (212 in non‐fluoroscopy‐guided‐group and 214 in fluoroscopy‐guided‐group). The diagnostic yield in the non‐fluoroscopy‐guided‐group (84.0%) was not inferior to that in the fluoroscopy‐guided‐group (84.6%), with a diagnostic difference of −0.6% (95% CI: −6.4%, 5.2%). Multivariable analysis confirmed that bronchus sign and lesion nature were valuable diagnostic predictors in non‐fluoroscopy‐guided‐group. The non‐fluoroscopy‐guided‐group had shorter rEBUS, GS, and total operation time. No severe complications occurred in either group. Conclusion Transbronchial diagnosis of PPLs suspicious of malignancy and presence of a bronchus leading to or adjacent to lesions using VBN‐rEBUS‐GS without fluoroscopy is a safe and effective method that is non‐inferior to VBN‐rEBUS‐GS with fluoroscopy. Bronchus leading to lesions and malignant nature are associated with high diagnostic yield in VBN‐rEBUS‐GS without fluoroscopy for the diagnosis of PPLs.
    Type of Medium: Online Resource
    ISSN: 1323-7799 , 1440-1843
    URL: Issue
    URL: Article
    DOI: 10.1111/resp.v28.4
    DOI: 10.1111/resp.14405
    Language: English
    Publisher: Wiley
    Publication Date: 2023
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    detail.hit.zdb_id: 1435849-9
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  • 5
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    Outer membrane vesicles from X‐ray‐irradiated Pseudomonas aeruginosa alleviate lung injury caused by P. aeruginosa infection‐mediated sepsis
    Wiley ; 2024
    In:  APMIS
    Details
    In: APMIS, Wiley
    Abstract: Pseudomonas aeruginosa infection causes pneumonia and sepsis. Previous research found that X‐ray radiation can induce P. aeruginosa to release outer membrane vesicles (OMVs) of relatively consistent sizes. This study found that OMVs derived from X‐ray‐irradiated P. aeruginosa can significantly inhibit lung leakage, inflammatory cell infiltrating into lung, and the production of pro‐inflammatory cytokines, IL‐1β and TNFα caused by P. aeruginosa infection under preventive and therapeutic administration conditions. Under the same conditions, OMVs also significantly alleviated pathological characteristics of lung injury, including pulmonary edema, pulmonary hemorrhage, and alveolar wall thickening. OMVs also significantly reduced bacterial burdens in peritoneal cavity, accompanied by a reduction in the number of viable bacteria capable of forming bacterial colonies. Pretreating macrophages and neutrophils with OMVs enhances their bactericidal ability. When bacteria were cocultured with treated cells, the number of viable bacteria capable of forming bacterial colonies was significantly reduced. OMVs themselves have not been shown to cause any lung injury or affect bacterial viability. Therefore, OMVs derived from X‐ray‐irradiated P. aeruginosa may not only be applied in prevention and treatment of diseases associated with P. aeruginosa infection, but also served as an excellent vaccine development platform.
    Type of Medium: Online Resource
    ISSN: 0903-4641 , 1600-0463
    URL: Article
    DOI: 10.1111/apm.13444
    RVK:
    XA 13160
    Language: English
    Publisher: Wiley
    Publication Date: 2024
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    detail.hit.zdb_id: 913841-9
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  • 6
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    ROS‐Dependent Activation of Autophagy through the PI3K/Akt/mTOR Pathway Is Induced by Hydroxysafflor Yellow A‐Sonodynamic Therapy in THP‐1 Macrophages
    Wiley ; 2017
    In:  Oxidative Medicine and Cellular Longevity Vol. 2017, No. 1 ( 2017-01)
    Details
    In: Oxidative Medicine and Cellular Longevity, Wiley, Vol. 2017, No. 1 ( 2017-01)
    Abstract: Monocyte‐derived macrophages participate in infaust inflammatory responses by secreting various types of proinflammatory factors, resulting in further inflammatory reactions in atherosclerotic plaques. Autophagy plays an important role in inhibiting inflammation; thus, increasing autophagy may be a therapeutic strategy for atherosclerosis. In the present study, hydroxysafflor yellow A‐mediated sonodynamic therapy was used to induce autophagy and inhibit inflammation in THP‐1 macrophages. Following hydroxysafflor yellow A‐mediated sonodynamic therapy, autophagy was induced as shown by the conversion of LC3‐II/LC3‐I, increased expression of beclin 1, degradation of p62, and the formation of autophagic vacuoles. In addition, inflammatory factors were inhibited. These effects were blocked by Atg5 siRNA, the autophagy inhibitor 3‐methyladenine, and the reactive oxygen species scavenger N‐acetyl cysteine. Moreover, AKT phosphorylation at Ser473 and mTOR phosphorylation at Ser2448 decreased significantly after HSYA‐SDT. These effects were inhibited by the PI3K inhibitor LY294002, the AKT inhibitor triciribine, the mTOR inhibitor rapamycin, mTOR siRNA, and N‐acetyl cysteine. Our results demonstrate that HSYA‐SDT induces an autophagic response via the PI3K/Akt/mTOR signaling pathway and inhibits inflammation by reactive oxygen species in THP‐1 macrophages.
    Type of Medium: Online Resource
    ISSN: 1942-0900 , 1942-0994
    URL: Issue
    URL: Article
    DOI: 10.1155/omcl.v2017.1
    DOI: 10.1155/2017/8519169
    Language: English
    Publisher: Wiley
    Publication Date: 2017
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  • 7
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    Signature and Molecular Mechanism of Mitochondrial Energy Metabolism Pathway-Related Genes in Lung Adenocarcinoma
    Wiley ; 2022
    In:  Disease Markers Vol. 2022 ( 2022-8-22), p. 1-19
    Details
    In: Disease Markers, Wiley, Vol. 2022 ( 2022-8-22), p. 1-19
    Abstract: Objective. The mitochondrial energy metabolic pathway (MEMP) is the primary energy metabolism of tumor cells, and its disruption may promote cancer emergence, spreading, and immune escape. However, there is a lack of studies to determine the relationship between relevant functional mechanisms and lung adenocarcinoma (LUAD) prognosis. Methods. Gene set enrichment analysis (GSEA) was employed to determine MEMP pathway-related genes. Then, a prognostic model was created using the MEMP key genes that were found by LASSO-Cox regression analysis. The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases provided the training and validation sets. Furthermore, the infiltration of immune cells was examined by ssGSEA. Finally, a screening of candidate therapeutic compounds for LUAD patients was performed using DrugBank, Protein Data Bank (PDB), and AutoDock Vina databases. Results. First, 266 MEMP pathway-related genes that exhibited aberrant activity in tumors were identified. Then, 19 MEMP key genes were used to build a prognostic model, which can successfully predict the survival rates of LUAD patients after 1, 3, and 5 years, respectively. The Kaplan-Meier curve showed that patients in the high-risk group had considerably lower survival outcomes than those in the low-risk group. Furthermore, it was discovered that the high-risk group had the majority of activated T cells, while the low-risk group tended to have more other activated immune cells. The majority of immunological checkpoints expressed themselves more strongly in the high-risk group as well. Finally, 11 prospective medication small molecules were obtained from the projected potential therapeutic drugs, with DB0980 being regarded as the most promising of them for the treatment of LUAD. Conclusion. This current study developed reliable prognostic signature, called MEMP score, which provides new guidance for prognostic assessment, immunotherapy, and drug development in LUAD. Thereby, DB0980 appears to be the most likely approach for the treatment of LUAD.
    Type of Medium: Online Resource
    ISSN: 1875-8630 , 0278-0240
    URL: Article
    DOI: 10.1155/2022/3201600
    Language: English
    Publisher: Wiley
    Publication Date: 2022
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    detail.hit.zdb_id: 2033253-1
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  • 8
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    Tailoring crystal facet microenvironments for simultaneous electrochemical ozone and hydrogen peroxide production
    Wiley ; 2023
    In:  AIChE Journal Vol. 69, No. 10 ( 2023-10)
    Details
    In: AIChE Journal, Wiley, Vol. 69, No. 10 ( 2023-10)
    Abstract: Developing a bifunctional electrocatalyst that can effectively produce O 3 and H 2 O 2 is significant for the electrochemical synthesis of O 3 and H 2 O 2 for the synergistic oxidative degradation of organic pollutants. In this study, SnO with various exposed facets was synthesized by tailoring the crystal facet microenvironment for oxygen intermediates adsorption for electrochemical ozone production (EOP) and two‐electron oxygen reduction reaction (2 e − ORR). The Faraday efficiency of SnO‐1 with a high (110) facet ratio for O 3 was 22.0%, while SnO‐4 with a high (002) facet ratio achieved a selectivity of 93.6% for H 2 O 2 . The theoretical calculation indicates that their excellent performances originated from the strong adsorption of the (110) facet on O* and O 2 * and the suitable adsorption and desorption strength of the (002) facet on OOH*, respectively. This study provides an attractive strategy for the development of a bifunctional electrocatalyst for advanced electrochemical oxidation by tailoring the crystal facet microenvironment.
    Type of Medium: Online Resource
    ISSN: 0001-1541 , 1547-5905
    URL: Issue
    URL: Article
    DOI: 10.1002/aic.v69.10
    DOI: 10.1002/aic.18152
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2020333-0
    detail.hit.zdb_id: 240008-X
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  • 9
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    Rationale and design of the AUGUST‐AHF Study
    Wiley ; 2020
    In:  ESC Heart Failure Vol. 7, No. 5 ( 2020-10), p. 3124-3133
    Details
    In: ESC Heart Failure, Wiley, Vol. 7, No. 5 ( 2020-10), p. 3124-3133
    Abstract: We aim to assess the effect of a lyophilized herbal injection on 90 day mortality and readmission rates in patients with acute heart failure (AHF). Methods and results The AUGUST‐AHF study is a multicentre, randomized, double‐blind, placebo‐controlled trial enrolling 1270 hospitalized patients for AHF. Patients are randomized to receive YiqiFumai lyophilized injection (5.2 g/day) or placebo for 10 days, in addition to standard therapy, using a 1:1 ratio via an interactive web response system. The primary endpoint is the 90 day all‐cause mortality or AHF readmission rates. Secondary endpoints include 180 day all‐cause mortality or heart failure readmission rates, length of hospital stay for the indexed AHF, 90 day cardiac‐specific mortality rate, occurrence of worsening heart failure through Day 10, changes in the Minnesota Living with Heart Failure Quality of Life scale score through Day 180, and 90 day major adverse cardiac events. Additional secondary endpoints include change in dyspnoea via visual analogue scale (VAS) and Likert 7‐point comparator scale, N terminal pro‐B‐type natriuretic peptide value and New York Heart Association functional class, and the total amount of diuretics for the indexed AHF hospitalization. Study recruitment is expected to be completed by March 2021, and follow‐up will end in September 2021. In an optional sub‐study, patients will be followed up for 3 years. Conclusions To our best knowledge, AUGUST‐AHF is the first study assessing the efficacy of a Chinese herbal injection in patients with AHF. The results will be valuable to guide clinicians in using YiqiFumai lyophilized injection, which was included in the latest Chinese Health Insurance Catalog.
    Type of Medium: Online Resource
    ISSN: 2055-5822 , 2055-5822
    URL: Issue
    URL: Article
    DOI: 10.1002/ehf2.v7.5
    DOI: 10.1002/ehf2.12787
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2814355-3
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  • 10
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    The Application of Traditional Chinese Medicine Injection on Patients with Acute Coronary Syndrome during the Perioperative Period of Percutaneous Coronary Intervention: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
    Wiley ; 2020
    In:  Evidence-Based Complementary and Alternative Medicine Vol. 2020 ( 2020-05-19), p. 1-30
    Details
    In: Evidence-Based Complementary and Alternative Medicine, Wiley, Vol. 2020 ( 2020-05-19), p. 1-30
    Abstract: Introduction . TCMI with the effect of Liqihuoxue and Yiqihuoxue has been applied as complementary therapies during the perioperative period of PCI for patients with ACS, while the recommended time points and plans of TCMI are still short of the support of evidence-based medicine. Methods . A systematic review and meta-analysis was conducted to evaluate the clinical efficacy and safety of TCMI on patients with ACS during the perioperative period of PCI. RCTs were searched based on standardized searching rules in seven medical databases from the inception up to August 2019. Two reviewers conducted the study selection, data extraction, and quality analysis independently. Data were analysed with the support of software RevMan and Stata . Results . A total of 68 articles with 6,043 patients were enrolled. The result of meta-analysis showed that the TCMI combined with western medicine was superior to the western medicine alone on clinical efficiency (before the PCI, before and after the PCI, or overall, P 〈 0.05 ), the occurrence of MACE (myocardial infarction and stenocardia: before the PCI, before and after the PCI, or overall, P 〈 0.05 ; arrhythmia: before and after the PCI, P 〈 0.05 ), and the level of inflammatory factors (hs-CRP: before the PCI, before and after the PCI, or overall, P 〈 0.05 ; IL-6: after the PCI, P 〈 0.05 ). The TCMI with the effect of Liqihuoxue obtained more support compared with Yiqihuoxue based on the result of meta-analysis. Conclusions . TCMI with the effect of Liqihuoxue or Yiqihuoxue combined with western medicine generally showed the potential advantage on the treatment of ACS during the perioperative period of PCI. However, the optimal time point of intervention and recommended plan based on the effect still needs more clinical evidence. We consider that the research of precise and standardized application of TCMI will be a promising direction for TCM in the future.
    Type of Medium: Online Resource
    ISSN: 1741-427X , 1741-4288
    URL: Article
    DOI: 10.1155/2020/3834128
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2171158-6
    detail.hit.zdb_id: 2148302-4
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