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  • 1
    Online Resource
    Online Resource
    Adverse drug reactions linked to Ciwujia injection: a systematic review of 521 cases
    Wiley ; 2010
    In:  Journal of Evidence-Based Medicine Vol. 3, No. 1 ( 2010-02), p. 37-43
    Details
    In: Journal of Evidence-Based Medicine, Wiley, Vol. 3, No. 1 ( 2010-02), p. 37-43
    Abstract: Objective To analyze adverse drug reactions (ADRs) associated with Ciwujia injection and possible contributing factors. Methods We searched all clinical studies and ADR reports of Ciwujia injection from the China National Knowledge Infrastructure (CNKI) database. Relevant information such as disease treated; menstruum and compatibility of the Ciwujia injection; age, gender, and allergic history of ADR cases; and the types, occurrence time and severity of the ADRs were collected and analyzed. Results In the 800 clinical studies of Ciwujia injection's efficacy and safety, 97 (12.1%) reported 285 ADR cases. There were 144 ADR reports for the drug describing a total of 236 ADR cases. Most of the ADR reports described cases of anaphylactic shock, while the most common ADR reported in clinical studies was local pain; 27.7% of ADR cases were I to II class in all 521 cases, and four anaphylactic shock cases died. Conclusion The relevant information of ADRs for Ciwujia injection was insufficiently reported in included studies. The ADR type distribution between clinical studies and ADR reports was inconsistency. Most of the reported ADRs were mild, and were treated successfully by slowing down the drip velocity or by withdrawing the drug and treating the symptoms. As Ciwujia injection was one of the highest numbers of ADR reports of traditional Chinese medicine injections, high quality ADR monitoring, standardized ADR reporting, and timely analysis risk factors of ADRs are extremely urgent.
    Type of Medium: Online Resource
    ISSN: 1756-5383 , 1756-5391
    URL: Issue
    URL: Article
    DOI: 10.1111/jebm.2010.3.issue-1
    DOI: 10.1111/j.1756-5391.2010.01066.x
    Language: English
    Publisher: Wiley
    Publication Date: 2010
    detail.hit.zdb_id: 2474496-7
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  • 2
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    Online Resource
    Thermophysical and electrical properties of rare‐earth‐cerate high‐entropy ceramics
    Wiley ; 2022
    In:  Journal of the American Ceramic Society Vol. 105, No. 7 ( 2022-07), p. 4910-4920
    Details
    In: Journal of the American Ceramic Society, Wiley, Vol. 105, No. 7 ( 2022-07), p. 4910-4920
    Abstract: A new series of rare‐earth‐cerate high‐entropy ceramics with compositions of (La 0.2 Nd 0.2 Sm 0.2 Gd 0.2 Dy 0.2 ) 2 Ce 2 O 7 (HEC1), (La 0.2 Nd 0.2 Sm 0.2 Gd 0.2 Yb 0.2 ) 2 Ce 2 O 7 (HEC2), (La 0.2 Nd 0.2 Sm 0.2 Yb 0.2 Dy 0.2 ) 2 Ce 2 O 7 (HEC3), (La 0.2 Nd 0.2 Yb 0.2 Gd 0.2 Dy 0.2 ) 2 Ce 2 O 7 (HEC4), (La 0.2 Yb 0.2 Sm 0.2 Gd 0.2 Dy 0.2 ) 2 Ce 2 O 7 (HEC5) as well as a single component of Nd 2 Ce 2 O 7 are fabricated via sintering the corresponding sol–gel‐derived powders at 1600°C for 10 h. HEC1–5 samples exhibit a single‐cerate phase with fluorite structure and high configurational entropy. Compared with Nd 2 Ce 2 O 7 , HEC1–5 samples have a lower grain growth rate owing to the sluggish diffusion effect. The chemical compositional uniformity of HEC1–5 as well as Nd 2 Ce 2 O 7 does not apparently change after annealing at 1500°C for different time intervals (1, 6, 12, and 18 h). Compared with 8YSZ, HEC1–5 samples display the decreased thermal conductivity and increased thermal expansion coefficient. The lattice size disorder parameter of HEC1–5 is negatively related to the thermal conductivity in 26–450°C. Furthermore, HEC1–5 and Nd 2 Ce 2 O 7 exhibit lower oxygen‐ion conductivity, meaning an increased resistance to oxygen diffusion.
    Type of Medium: Online Resource
    ISSN: 0002-7820 , 1551-2916
    URL: Issue
    URL: Article
    DOI: 10.1111/jace.v105.7
    DOI: 10.1111/jace.18457
    RVK:
    VA 1120
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2008170-4
    detail.hit.zdb_id: 219232-9
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  • 3
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    Online Resource
    D‐mannose alleviates osteoarthritis progression by inhibiting chondrocyte ferroptosis in a HIF‐2α‐dependent manner
    Wiley ; 2021
    In:  Cell Proliferation Vol. 54, No. 11 ( 2021-11)
    Details
    In: Cell Proliferation, Wiley, Vol. 54, No. 11 ( 2021-11)
    Abstract: Chondrocyte ferroptosis contributes to osteoarthritis (OA) progression, and D‐mannose shows therapeutic value in many inflammatory conditions. Here, we investigated whether D‐mannose interferes in chondrocyte ferroptotic cell death during osteoarthritic cartilage degeneration. Materials and methods In vivo anterior cruciate ligament transection (ACLT)‐induced OA mouse model and an in vitro study of chondrocytes in an OA microenvironment induced by interleukin‐1β (IL‐1β) exposure were employed. Combined with Epas1 gene gain‐ and loss‐of‐function, histology, immunofluorescence, quantitative RT‐PCR, Western blot, cell viability and flow cytometry experiments were performed to evaluate the chondroprotective effects of D‐mannose in OA progression and the role of hypoxia‐inducible factor 2 alpha (HIF‐2 α) in D‐mannose‐induced ferroptosis resistance of chondrocytes. Results D‐mannose exerted a chondroprotective effect by attenuating the sensitivity of chondrocytes to ferroptosis and alleviated OA progression. HIF‐2α was identified as a central mediator in D‐mannose‐induced ferroptosis resistance of chondrocytes. Furthermore, overexpression of HIF‐2α in chondrocytes by Ad‐ Epas1 intra‐articular injection abolished the chondroprotective effect of D‐mannose during OA progression and eliminated the role of D‐mannose as a ferroptosis suppressor. Conclusions D‐mannose alleviates osteoarthritis progression by suppressing HIF‐2α‐mediated chondrocyte sensitivity to ferroptosis, indicating D‐mannose to be a potential therapeutic strategy for ferroptosis‐related diseases.
    Type of Medium: Online Resource
    ISSN: 0960-7722 , 1365-2184
    URL: Issue
    URL: Article
    DOI: 10.1111/cpr.v54.11
    DOI: 10.1111/cpr.13134
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2019986-7
    SSG: 12
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  • 4
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    Online Resource
    Influences of Bi 0.75 Y 0.25 O 1.5 addition on the microstructure and ionic conductivity of Ce 0.8 Y 0.2 O 1.9 ceramics
    Wiley ; 2021
    In:  International Journal of Applied Ceramic Technology Vol. 18, No. 4 ( 2021-07), p. 1153-1163
    Details
    In: International Journal of Applied Ceramic Technology, Wiley, Vol. 18, No. 4 ( 2021-07), p. 1153-1163
    Abstract: A second phase of Y 2 O 3 ‐stabilized Bi 2 O 3 (Bi 0.75 Y 0.25 O 1.5 ,YSB) is introduced into Y 2 O 3 ‐doped CeO 2 (Ce 0.8 Y 0.2 O 1.9 ,YDC) as a sintering additive and the composite ceramics of YDC‐xYSB (x = 0, 5, 10, 20, 30, 40 wt%) are prepared through sintering at 1100°C for 6 h in air atmosphere. The YDC‐xYSB ceramics are composed of both YDC and YSB with cubic fluorite structure, and no other impurity phases are detected in XRD patterns. The relative density of YDC‐xYSB rises firstly for x ≤5 wt%, and then it declines with YSB addition from 5 to 40 wt%. The average grain size of YDC decreases from 270 nm to 85.7 nm with YSB addition from 0 to 40 wt%. The YSB phase segregates at the grain boundaries of YDC based on the TEM analysis result. The ionic conductivity of YDC‐xYSB (x ≥5 wt%) is lower than that of YDC in the test temperature of 200°C–500°C, while it gradually exceeds that of YDC in 500°C–750°C. At 750°C, the conductivity of YDC‐30%YSB (6.22 × 10 −2  S/cm) is 1.35 times higher than that of YDC (4.6 × 10 −2  S/cm). The YSB addition can improve the ionic conductivity of YDC in 500°C–750°C and decrease its sintering temperature.
    Type of Medium: Online Resource
    ISSN: 1546-542X , 1744-7402
    URL: Issue
    URL: Article
    DOI: 10.1111/ijac.v18.4
    DOI: 10.1111/ijac.13746
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2167226-X
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  • 5
    Online Resource
    Online Resource
    Adverse drug reactions of Shenmai injection: a systematic review
    Wiley ; 2010
    In:  Journal of Evidence-Based Medicine Vol. 3, No. 3 ( 2010-08), p. 177-182
    Details
    In: Journal of Evidence-Based Medicine, Wiley, Vol. 3, No. 3 ( 2010-08), p. 177-182
    Abstract: Objective To analyze adverse drug reactions (ADRs) associated with Shenmai injection and possible contributing factors. Methods We searched all clinical studies and ADR reports of Shenmai injection from the China National Knowledge Infrastructure (CNKI) database, the Data Bank of Chinese Scientific Journals (VIP), and Chinese Biomedical (CBM) database. We collected relevant information such as gender, age, allergic history, and diseases treated in ADR cases; types, occurrence times, and severity of ADRs; and menstruum and compatibility of Shenmai injection. Results Of the 1828 clinical studies of Shenmai injection, 146 (7.99%) mentioned 576 ADR cases; 181 ADR reports mentioned 246 ADR cases. The most commonly affected age group was 40 to 69 (57.32%). In 36 (14.63%) cases, patients were described as having an allergic history. The diseases treated in ADR cases were principally heart failure and coronary artery heart disease. Thirty‐eight (15.45%) of the 246 ADR cases in ADR reports described anaphylactic shock, while the most common ADR reported in clinical studies was headache/dizziness. Of the 822 total reported ADR cases, 99 (12.04%) were class III, and 637 (77.50%) were class IV, and there were no fatalities. The menstruum of most Shenmai injections was 5% glucose. Incompatible drugs were given in 68 ADR cases. In ADR cases, the most common dosage of Shenmai injection was 40 to 60 ml; 215 (80.90%) ADR cases occurred in first time medication, mainly in the first 30 minutes after injection. Conclusions Current evidence shows that Shenmai injection had lower ADR occurrence, but some potential factors such as irrational compatibility, dosages may lead to a high risk of ADR. In future, clinicians should follow indications or functions to promote rational use of Chinese Medicine Injections .
    Type of Medium: Online Resource
    ISSN: 1756-5383 , 1756-5391
    URL: Issue
    URL: Article
    DOI: 10.1111/jebm.2010.3.issue-3
    DOI: 10.1111/j.1756-5391.2010.01089.x
    Language: English
    Publisher: Wiley
    Publication Date: 2010
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  • 6
    Online Resource
    Online Resource
    Evidence‐based traditional Chinese medicine research: Beijing Declaration
    Wiley ; 2020
    In:  Journal of Evidence-Based Medicine Vol. 13, No. 2 ( 2020-05), p. 91-92
    Details
    In: Journal of Evidence-Based Medicine, Wiley, Vol. 13, No. 2 ( 2020-05), p. 91-92
    Type of Medium: Online Resource
    ISSN: 1756-5383 , 1756-5391
    URL: Issue
    URL: Article
    DOI: 10.1111/jebm.v13.2
    DOI: 10.1111/jebm.12389
    Language: English
    Publisher: Wiley
    Publication Date: 2020
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  • 7
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    Qingjin Yiqi granules for post‐COVID‐19 condition: A randomized clinical trial
    Wiley ; 2022
    In:  Journal of Evidence-Based Medicine Vol. 15, No. 1 ( 2022-03), p. 30-38
    Details
    In: Journal of Evidence-Based Medicine, Wiley, Vol. 15, No. 1 ( 2022-03), p. 30-38
    Abstract: To evaluate the effectiveness and safety of Qingjin Yiqi granules (QJYQ) on post‐COVID‐19 condition (PCC). Method Patients who met the inclusion criteria were randomly assigned to two groups, the QJYQ group received QJYQ combined with standard rehabilitation treatments (SRTs) and the control group only received SRTs. The treatment course was 14 days. The primary outcomes were modified Medical Research Council (mMRC) scale and Borg scale, while the secondary outcomes included symptoms score and 6‐minute walking distance (6MWD). The safety outcome was the incidence of adverse events. Results A total of 388 patients with PCC were enrolled and randomly assigned to the QJYQ group ( n  = 194) and the control group ( n  = 194). Compared to the controls, the mMRC scale was improved in the QJYQ group, which was better than that of the control group [β (95%CI): –0.626 (–1.101, –0.151), p  = 0.010]. A significant improvement in Borg scale was also observed in the QJYQ group compared to the control group [β (95%CI): –0.395(–0.744, –0.046), p  = 0.026]. There was no statistically significant difference in symptoms score and 6MWD between the two groups ( p = 0.293, p = 0.724). No treatment‐related adverse events were observed in either group. Conclusions QJYQ can bring benefits to patients with PCC, mainly in the improvement of breathlessness and fatigue.
    Type of Medium: Online Resource
    ISSN: 1756-5383 , 1756-5391
    URL: Issue
    URL: Article
    DOI: 10.1111/jebm.v15.1
    DOI: 10.1111/jebm.12465
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2474496-7
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  • 8
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    Online Resource
    Systematic review on the compatibility of Shuanghuanglian injection combined with western medical injections
    Wiley ; 2010
    In:  Journal of Evidence-Based Medicine Vol. 3, No. 1 ( 2010-02), p. 27-36
    Details
    In: Journal of Evidence-Based Medicine, Wiley, Vol. 3, No. 1 ( 2010-02), p. 27-36
    Abstract: Objectives Shuanghuanglian injection (SHLI) is a typical Chinese herbal injection which has been used for more than 20 years. This study aims to investigate the compatibility of SHLI with western intravenous agents. Methods An extensive literature search was executed to identify all experimental tests and clinical reports on the topics. Data on the types of infusion solutions and western medical injections, usage and dosage, outcome measures for physical and chemical properties, and changes of drug effect were searched for. The included data was analyzed and described by the category of included western drugs. Compatibility was tested through integrating the evaluations of physical properties, chemical composition, drug metabolism, and safety. Results Sixty articles (38 experimental tests and 22 clinical reports) were included after screening. Fifty–three western medical injections were identified from all the included articles. Most of the research was about the compatibility of SHLI with different types of antibiotics, including β‐lactam, aminoglycoside, and quinolone etc. Thirty‐one western medical injections were not recommended to be combined with SHLI. The quality of the experimental test design was low because of unbalanced evaluation indicators: more attention to physical changes than drug metabolism, effect, and safety. Conclusions A broad incompatibility existed in the combination of SHLI with western medical injections. Some results were still uncertain, but the combinations should still be avoided until researched clearly. The compatibility and interaction of Chinese herbal injections and western medicines is still a weak area. The pharmaceutical sector should strengthen post‐market research to update evidence and improve its distribution.
    Type of Medium: Online Resource
    ISSN: 1756-5383 , 1756-5391
    URL: Issue
    URL: Article
    DOI: 10.1111/jebm.2010.3.issue-1
    DOI: 10.1111/j.1756-5391.2010.01068.x
    Language: English
    Publisher: Wiley
    Publication Date: 2010
    detail.hit.zdb_id: 2474496-7
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