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  • 1
    Online Resource
    Online Resource
    Wiley ; 2010
    In:  Journal of the Science of Food and Agriculture Vol. 90, No. 4 ( 2010-03-15), p. 635-640
    In: Journal of the Science of Food and Agriculture, Wiley, Vol. 90, No. 4 ( 2010-03-15), p. 635-640
    Abstract: BACKGROUND: Fish skin, a by‐product of the food industry, contains a large amount of collagen. However, only a small proportion of fish skin is used in the production of leather materials and animal feedstuffs, most of it being discarded. The aims of this study were to prepare peptides from Alaska pollack ( Theragra chalcogramma ) skin by enzymatic hydrolysis and to evaluate the antioxidant activity of the resulting hydrolysate. RESULTS: Protamex was the most efficient enzyme for preparing antioxidant peptides from Alaska pollack skin. The optimal hydrolysis conditions were as follows: hydrolysis time 8 h; enzyme/substrate ratio 2:1000; skin/water ratio 1:6; temperature 55 °C; pH 6.0. Under these conditions the highest yield of peptides was 83.44%, with 85.95% of the hydrolysate being mainly composed of oligopeptides with molecular weights ranging from 180 to 1000 Da. The hydrolysate showed 2,2‐diphenyl‐1‐picrylhydrazyl radical‐scavenging activity, with an IC 50 value of 2.5 mg mL −1 , and its reducing power was 0.14 at 1 mg mL −1 , 53.8% of that of reduced glutathione at the same concentration. CONCLUSION: This study demonstrated that the hydrolysate of Alaska pollack skin was mainly composed of oligopeptides with two to eight amino acid residues and possessed antioxidant activity. Copyright © 2010 Society of Chemical Industry
    Type of Medium: Online Resource
    ISSN: 0022-5142 , 1097-0010
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2010
    detail.hit.zdb_id: 2001807-1
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  • 2
    Online Resource
    Online Resource
    Wiley ; 2017
    In:  Geostandards and Geoanalytical Research Vol. 41, No. 3 ( 2017-09), p. 359-365
    In: Geostandards and Geoanalytical Research, Wiley, Vol. 41, No. 3 ( 2017-09), p. 359-365
    Abstract: In this study (U‐Th)/He dating of the Penglai zircons, which occur as abundant megacrysts in Neogene alkaline basalts in northern Hainan Province, south‐eastern China, was undertaken. A weighted mean age of 4.06 ± 0.35 Ma (2 s ) with a mean square weighted deviation ( MSWD ) of 1.79 was obtained from eighteen fragments of four zircon megacrysts using single‐crystal laser fusion He determinations and the U‐Th isotope dilution ( ID ) method. The (U‐Th)/He ages are consistent, homogeneous and systematically slightly younger than the preferred 206 Pb/ 238 U age of 4.4 ± 0.1 Ma (95% confidence interval) determined by ID ‐ TIMS and subsequently published U‐Pb results. The U‐Pb isotopic system in zircon has a high closure temperature of ~ 900 °C, and the preferred U‐Pb age may record both the time since eruption and the zircon residence time in the magma chamber. In contrast, the closure temperature of the zircon (U‐Th)/He system is ~ 190 °C and the zircon megacrysts were brought quickly to the surface by the host basaltic magma. Thus, the (U‐Th)/He age represents the timing of the eruption. Based on the unlimited quantity, large grain size, mostly weak broad zoning, rapid cooling and homogenous (U‐Th)/He ages, we consider the Penglai zircons suitable for use as a reference material in (U‐Th)/He isotope geochronology.
    Type of Medium: Online Resource
    ISSN: 1639-4488 , 1751-908X
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2017
    detail.hit.zdb_id: 2276474-4
    detail.hit.zdb_id: 2595219-5
    detail.hit.zdb_id: 2134777-3
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  • 3
    In: Basin Research, Wiley, Vol. 33, No. 6 ( 2021-12), p. 3212-3230
    Abstract: The development history of high topography in the northeastern (NE) Tibetan Plateau is essential to test various plateau growth models and understand plateau construction. We present integrated provenance data from the NE Qaidam Basin, south of the Qilian Shan. Results show an increase in carbonate lithics, an increase in Al 2 O 3 /SiO 2 ratios, a negative shift in ε Nd values and an appearance of large amounts of Precambrian zircon grains in the period of ca. 13–8 Ma, arguing that the sediment source of the NE Qaidam Basin may have shifted from the East Kunlun Shan to the Qilian Shan during this time interval. We infer that significant topographic growth of the southern Qilian Shan occurred during the middle‐late Miocene. Along with widespread middle to late Miocene deformation records across the Qilian Shan and abruptly shifts on provenance, sedimentary facies and climate indexes in its surrounding basins, present high topography of the NE Tibetan Plateau may have been established since the middle‐late Miocene.
    Type of Medium: Online Resource
    ISSN: 0950-091X , 1365-2117
    URL: Issue
    RVK:
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2019914-4
    SSG: 16,13
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  • 4
    Online Resource
    Online Resource
    Wiley ; 1999
    In:  The Canadian Journal of Chemical Engineering Vol. 77, No. 2 ( 1999-04), p. 284-290
    In: The Canadian Journal of Chemical Engineering, Wiley, Vol. 77, No. 2 ( 1999-04), p. 284-290
    Type of Medium: Online Resource
    ISSN: 0008-4034 , 1939-019X
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 1999
    detail.hit.zdb_id: 240250-6
    detail.hit.zdb_id: 2119520-1
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  • 5
    In: Journal of Periodontal Research, Wiley, Vol. 56, No. 4 ( 2021-08), p. 656-666
    Abstract: The application of curcumin is limited by its instability. Mono‐carbonyl analogues of curcumin (MCACs) are structurally stable, yet the intermediate bridging ketones in their skeletons account for increased toxicity. This study aimed to synthesize and screen MCACs that exhibit low cytotoxicity and high antioxidant ability, and the effects of MCACs on experimental periodontitis were also investigated. Materials and methods The cytotoxicity of MCACs on MC3 T3‐E1 was determined by MTT assay. The antioxidant capacity was investigated by the cell viability against H 2 O 2 ‐induced damage and the level of reactive oxygen species (ROS) and malondialdehyde (MDA). The localization and protein expression of nuclear factor erythroid 2‐related factor 2 (Nrf2) and heme oxygenase‐1 (HO‐1) was detected by immunofluorescence and western blot, respectively. In addition, MCAC was intragastrically administrated in rats with ligature‐induced experimental periodontitis. The effects were assessed by bone resorption, as well as the immunohistology staining of inflammatory and oxidative stress markers. Results MCACs with cyclopentanone and containing pyrone showed lower toxicity than natural curcumin were synthesized ( 1A ‐ 10A , 1H ‐ 10H ), among which, 1A exhibited the most potent cytoprotective effect against H 2 O 2 ‐induced damage. Such effects could be explained by the reduced MDA and ROS level, possibly through the nucleus translocation of Nrf2 and the induction of HO‐1. Micro‐CT results further indicated that 1A significantly reduced bone loss, along with an increased level of Nrf2 and HO‐1, and decreased TNF‐α and IL‐1β. Conclusion The present study has synthesized a novel antioxidant MCAC 1A with good biosafety and stability. MCAC 1A could serve as a host response modulator with preventive and protective effects on periodontitis.
    Type of Medium: Online Resource
    ISSN: 0022-3484 , 1600-0765
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2025633-4
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  • 6
    In: Journal of Food Process Engineering, Wiley, Vol. 44, No. 12 ( 2021-12)
    Abstract: This research aimed to explore the digestion properties of oil embedded in the soybean protein–phospholipid (PC) nanocomposite aggregate particles through gastrointestinal digestion model. Soybean protein isolate (SPI), before and after enzymatically hydrolyzed, was combined with PC to form SPI‐PC and enzymatically hydrolyzed SPI‐PC (EHSPI‐PC) nanocomposite aggregate particles. In the process of stomach dynamic digestion, the zeta potential of SPI‐PC changed from −23.50 to 0.40 mV and the Z‐average particle size reached 1,452.00 nm at 70 min while the zeta potential of EHSPI‐PC changed from −45.63 to 6.13 mV and the Z‐average particle size was 594.77 nm. EHSPI‐PC had larger zeta‐potential absolute value and smaller particle size compared with SPI‐PC. It indicated EHSPI‐PC nanocomposite aggregate particles were good gastrointestinal protective carriers. After adding soybean oil, EHSPI‐PC showed denser and smaller droplet morphologies and more surface charge during the digestion process. Compared with SPI‐PC, it also had better emulsification activity and emulsification stability. In conclusion, EHSPI‐PC is more suitable for embedding soybean oil to release in the small intestine. Practical Applications Nano‐aggregate particles are widely used in food, medicine, and chemical industries due to their unique physical and chemical properties and functional properties. However, nano‐aggregate particles have unsatisfactory packaging of emulsifiers and leakage of embedded materials. Enzymatically hydrolyzed soybean protein isolate–phospholipid (EHSPI‐PC) nanocomposite aggregate particles have good emulsification and long‐lasting stability. The results showed that it is feasible for EHSPI‐PC nanocomposite aggregate particles to embed oily substances to ensure that the substances perform their functions in the intestinal tract. Therefore, the delivery system based on the EHSPI‐PC nanocomposite aggregate particles has good development potential in the food and pharmaceutical industries for encapsulation, protection, and release of nonpolar substances.
    Type of Medium: Online Resource
    ISSN: 0145-8876 , 1745-4530
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2175259-X
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  • 7
    In: Chemical Biology & Drug Design, Wiley, Vol. 94, No. 1 ( 2019-07), p. 1368-1377
    Abstract: As NF ‐κB signaling pathway is constitutively activated in lung cancer, targeting NF ‐κB has a potential for the treatment. EF 24 has been proved to be a NF ‐κB inhibitor with good antitumor activity, while whose toxicity possibly became one of the obstacles to enter into clinical application. In order to find high efficiency and low toxicity NF ‐κB inhibitors, EF 24 was modified and 13d was screened out. It was proved that 13d possessed an effective combination of inhibiting NF ‐κB pathway and showing lower cytotoxicity on normal cells as well as less toxicity in acute toxicity experiment compared with the lead compound of EF 24. In addition, 13d was found to inhibit cell vitality, arrest cell cycle in G2/M phase, promote cell apoptosis, and suppress the xenograft tumor growth. Furthermore, 13d was elucidated to induce pyroptosis developing from apoptosis, which was associated with the inhibition of NF ‐κB. Taken together, it was suggested that 13d was a potent antitumor agent.
    Type of Medium: Online Resource
    ISSN: 1747-0277 , 1747-0285
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 2216600-2
    SSG: 12
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  • 8
    In: Cereal Chemistry, Wiley, Vol. 100, No. 2 ( 2023-03), p. 393-413
    Abstract: Cold plasma (CP) treatment is a promising way to remove mycotoxins from cereal kernels, although its effects on nutrient contents remain unclear. This study evaluates the biochemical parameters, gelatinization properties, and fatty acid profile of Chinese hard‐white wheat flour treated with low‐pressure radio‐frequency (RF) CP (13.56 MHz, 140 Pa, helium or oxygen, 120 W, 0–180 s, 70 g sample). Findings 120 W oxygen and helium plasma respectively required 90 and 120 s treatment to remove 50% deoxynivalenol (DON) from hard‐white wheat flour samples with 1.22 μg/g DON. A General Linear Model–Univariate analysis shows that oxygen and helium plasma both significantly increased water absorption rate, conductivity, and contents of reducing sugars, amylose, soluble protein, and saturated fatty acids in wheat flours but decreased the contents of soluble amino acids, total, unsaturated, mono‐unsaturated and poly‐unsaturated fatty acids, and enthalpy of gelatinization, and kept gelatinization peak temperature. At the same treatment time, helium plasma induced a higher water absorption rate, conductivity, and contents of pentosan and sulfhydryl groups in wheat flours than oxygen plasma. Oxygen plasma induced more reductions in mono‐ and poly‐unsaturated fatty acids in wheat flours than helium plasma. Compared with the untreated samples, helium plasma increased the values of water SRC, NaHCO 3 SRC, and sucrose SRC, but decreased the lactic acid SRC, suggesting that the flour functional polymers were modified by helium plasma treatment, but oxygen plasma kept these four SRC values and did not significantly alter the functional polymers in wheat flour. Conclusion The treatment with low‐pressure RF CP can increase hydrophilicity, and unsaturated fatty acid oxidation in wheat flours while kept starch gelatinization, and helium plasma can modify the flour's functional polymers. Significance and Novelty The suitable helium CP treatment (low‐pressure RF, 120 W, and 90–120 s) is a promising way to reduce the contaminants of wheat flours and improve their functional properties.
    Type of Medium: Online Resource
    ISSN: 0009-0352 , 1943-3638
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2016053-7
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  • 9
    Online Resource
    Online Resource
    Wiley ; 2013
    In:  The Journal of Wildlife Management Vol. 77, No. 3 ( 2013-04), p. 555-566
    In: The Journal of Wildlife Management, Wiley, Vol. 77, No. 3 ( 2013-04), p. 555-566
    Abstract: The Dybowski's frog ( Rana dybowskii ) is mainly distributed in northeast China and the Russian Far East. Its dried oviduct, or frog oil, has been used in traditional Chinese medicine for thousands of years. Frogs from different geographic regions exhibit variations in their body mass and oil productivity. As a result, farmers usually import high quality breeding stock from different areas to increase oviduct productivity. This practice could alter the genetic structure of the frog populations. We used 10 microsatellite loci to investigate the level of genetic variation for 10 frog populations in the context of human‐mediated disturbance. The study populations comprised the following: the Hebei, Tieli, and Jiamusi populations from the Lesser Khingan Mountains; the Mudanjiang, Jilin, Jiaohe, and Huadian populations from the north central Changbai Mountains; and the Tonghua, Benxi, and Xiuyan populations from the southern Changbai Mountains. Our results showed that the 3 Lesser Khingan Mountain populations exhibited highly significant differentiation values ( F ST  = 0.047–0.071, P   〈  0.001). In addition, the Tonghua population differentiated significantly from the other 6 populations of the Changbai Mountains ( P   〈  0.001). The genetic differentiation coefficient ( F ST ) and gene flow ( N e m) estimates showed that the Benxi and Jiaohe populations had a high degree of genetic similarity despite being geographically separated by mountains and river systems. We obtained similar results for the Xiuyan and Tieli populations. Furthermore, the degree of gene flow between the Jiamusi and the north central Changbai Mountain populations was greater than that observed between the Jiamusi and the other Lesser Khingan Mountain populations. These results therefore suggest that the Benxi, Xiuyan, and Jiamusi populations have undergone substantial intermixing because of human‐mediated relocation. Economic demands make completely stopping the geographical relocation of Dybowski's frog in northeast China virtually impossible. Consequently, effective management strategies are now a high priority to ensure that conservationists and local economies can work together to guarantee the long‐term survival of this species. © 2013 The Wildlife Society.
    Type of Medium: Online Resource
    ISSN: 0022-541X , 1937-2817
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2013
    detail.hit.zdb_id: 2066663-9
    SSG: 12
    SSG: 23
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