GLORIA

GEOMAR Library Ocean Research Information Access

X

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Online Resource
    Online Resource
    Imatinib compared with second‐generation tyrosine kinase‐inhibitors in persons with chronic myeloid leukemia presenting in accelerated phase
    Wiley ; 2023
    In:  American Journal of Hematology Vol. 98, No. 7 ( 2023-07)
    Details
    In: American Journal of Hematology, Wiley, Vol. 98, No. 7 ( 2023-07)
    Type of Medium: Online Resource
    ISSN: 0361-8609 , 1096-8652
    URL: Issue
    URL: Article
    DOI: 10.1002/ajh.v98.7
    DOI: 10.1002/ajh.26943
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 1492749-4
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 2
    Online Resource
    Online Resource
    The neutrophil‐to‐lymphocyte ratio represents a systemic inflammation marker and reflects the relationship with 90‐day mortality in non‐cirrhotic chronic severe hepatitis
    Wiley ; 2022
    In:  Journal of Digestive Diseases Vol. 23, No. 10 ( 2022-10), p. 587-596
    Details
    In: Journal of Digestive Diseases, Wiley, Vol. 23, No. 10 ( 2022-10), p. 587-596
    Abstract: To investigate the relationship between systemic inflammatory response and short‐term mortality in patients with non‐cirrhotic chronic severe hepatitis (CSH) by using several indicators of inflammation including neutrophil‐to‐lymphocyte ratio (NLR), neutrophil (NEU), white blood cell (WBC), platelet‐to lymphocyte ratio (PLR), and monocyte‐to‐lymphocyte ratio (MLR). Methods Data were collected from two prospectively enrolled CATCH‐LIFE noncirrhotic cohorts. Cox regression analysis was used to investigate the association between systemic inflammatory biomarkers and 90‐day liver transplant (LT)‐free mortality. A generalized additive model (GAM) was used to illustrate the quantitative curve relationship between NLR and 90‐day LT‐free mortality. Kaplan–Meier method was used to estimate the 90‐year LT‐free survival. Results The prevalence of CSH was 20.5% (226/1103). The 28‐day and 90‐day LT‐free mortality rates were 17.7% and 26.1%, respectively, for patients with non‐cirrhotic CSH. Patients with no infection accounted for 75.0% of all CSH patients, and NLR was independently associated with 90‐day LT‐free mortality. NLR of 2.9 might be related to disease deterioration in CSH patients without infection. Conclusions NLR may be an independent risk factor for 90‐day LT‐free mortality in patients with non‐cirrhotic chronic liver disease. A NLR of 2.9 as the cut‐off value can be used to predict disease aggravation in CSH patients without infection.
    Type of Medium: Online Resource
    ISSN: 1751-2972 , 1751-2980
    URL: Issue
    URL: Article
    DOI: 10.1111/cdd.v23.10
    DOI: 10.1111/1751-2980.13143
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2317117-0
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 3
    Online Resource
    Online Resource
    The Phenotypic and Genetic Spectrum of Paroxysmal Kinesigenic Dyskinesia in China
    Wiley ; 2020
    In:  Movement Disorders Vol. 35, No. 8 ( 2020-08), p. 1428-1437
    Details
    In: Movement Disorders, Wiley, Vol. 35, No. 8 ( 2020-08), p. 1428-1437
    Abstract: Paroxysmal kinesigenic dyskinesia is a spectrum of involuntary dyskinetic disorders with high clinical and genetic heterogeneity. Mutations in proline‐rich transmembrane protein 2 have been identified as the major pathogenic factor. Objectives We analyzed 600 paroxysmal kinesigenic dyskinesia patients nationwide who were identified by the China Paroxysmal Dyskinesia Collaborative Group to summarize the clinical phenotypes and genetic features of paroxysmal kinesigenic dyskinesia in China and to provide new thoughts on diagnosis and therapy. Methods The China Paroxysmal Dyskinesia Collaborative Group was composed of departments of neurology from 22 hospitals. Clinical manifestations and proline‐rich transmembrane protein 2 screening results were recorded using unified paroxysmal kinesigenic dyskinesia registration forms. Genotype‐phenotype correlation analyses were conducted in patients with and without proline‐rich transmembrane protein 2 mutations. High‐knee exercises were applied in partial patients as a new diagnostic test to induce attacks. Results Kinesigenic triggers, male predilection, dystonic attacks, aura, complicated forms of paroxysmal kinesigenic dyskinesia, clustering in patients with family history, and dramatic responses to antiepileptic treatment were the prominent features in this multicenter study. Clinical analysis showed that proline‐rich transmembrane protein 2 mutation carriers were prone to present at a younger age and have longer attack duration, bilateral limb involvement, choreic attacks, a complicated form of paroxysmal kinesigenic dyskinesia, family history, and more forms of dyskinesia. The new high‐knee‐exercise test efficiently induced attacks and could assist in diagnosis. Conclusions We propose recommendations regarding diagnostic criteria for paroxysmal kinesigenic dyskinesia based on this large clinical study of paroxysmal kinesigenic dyskinesia. The findings offered some new insights into the diagnosis and treatment of paroxysmal kinesigenic dyskinesia and might help in building standardized paroxysmal kinesigenic dyskinesia clinical evaluations and therapies. © 2020 International Parkinson and Movement Disorder Society
    Type of Medium: Online Resource
    ISSN: 0885-3185 , 1531-8257
    URL: Issue
    URL: Article
    DOI: 10.1002/mds.v35.8
    DOI: 10.1002/mds.28061
    RVK:
    XA 10000
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2041249-6
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 4
    Online Resource
    Online Resource
    Impaired robust interhemispheric function integration of depressive brain from REST‐meta‐MDD database in China
    Wiley ; 2022
    In:  Bipolar Disorders Vol. 24, No. 4 ( 2022-06), p. 400-411
    Details
    In: Bipolar Disorders, Wiley, Vol. 24, No. 4 ( 2022-06), p. 400-411
    Abstract: Recently, functional homotopy (FH) architecture, defined as robust functional connectivity (FC) between homotopic regions, has been frequently reported to be altered in MDD patients (MDDs) but with divergent locations. Methods In this study, we obtained resting‐state functional magnetic resonance imaging (R‐fMRI) data from 1004 MDDs (mean age, 33.88 years; age range, 18–60 years) and 898 matched healthy controls (HCs) from an aggregated dataset from 20 centers in China. We focused on interhemispheric function integration in MDDs and its correlation with clinical characteristics using voxel‐mirrored homotopic connectivity (VMHC) devised to inquire about FH patterns. Results As compared with HCs, MDDs showed decreased VMHC in visual, motor, somatosensory, limbic, angular gyrus, and cerebellum, particularly in posterior cingulate gyrus/precuneus (PCC/PCu) (false discovery rate [FDR] q  〈  0.002, z = −7.07). Further analysis observed that the reduction in SMG and insula was more prominent with age, of which SMG reflected such age‐related change in males instead of females. Besides, the reduction in MTG was found to be a male‐special abnormal pattern in MDDs. VMHC alterations were markedly related to episode type and illness severity. The higher Hamilton Depression Rating Scale score, the more apparent VMHC reduction in the primary visual cortex. First‐episode MDDs revealed stronger VMHC reduction in PCu relative to recurrent MDDs. Conclusions We confirmed a significant VMHC reduction in MDDs in broad areas, especially in PCC/PCu. This reduction was affected by gender, age, episode type, and illness severity. These findings suggest that the depressive brain tends to disconnect information exchange across hemispheres.
    Type of Medium: Online Resource
    ISSN: 1398-5647 , 1399-5618
    URL: Issue
    URL: Article
    DOI: 10.1111/bdi.v24.4
    DOI: 10.1111/bdi.13139
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2001157-X
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 5
    Online Resource
    Online Resource
    Clinical definition of secondary resistance to immunotherapy in non‐small cell lung cancer
    Wiley ; 2023
    In:  Thoracic Cancer Vol. 14, No. 34 ( 2023-12), p. 3421-3429
    Details
    In: Thoracic Cancer, Wiley, Vol. 14, No. 34 ( 2023-12), p. 3421-3429
    Abstract: Immune checkpoint inhibitors (PD‐1/PD‐L1 and CTLA‐4 blockade) have revolutionized the treatment landscape in non‐small cell lung cancer (NSCLC). Secondary resistance to immunotherapy (IO), which poses a substantial challenge in clinical settings, occurs in several initial responders. Currently, new treatment approaches have been extensively evaluated in investigational studies for these patients to tackle this difficult problem; however, the lack of consistency in clinical definition, uniform criteria for enrollment in clinical trials, and interpretation of results remain significant hurdles to progress. Thus, our expert panel comprehensively synthesized data from current studies to propose a practical clinical definition of secondary resistance to immunotherapy in NSCLC in metastatic and neoadjuvant settings. In addition to patients who received IO alone (including IO‐IO combinations), we also generated a definition for patients treated with chemotherapy plus IO. This consensus aimed to provide guidance for clinical trial design and facilitate future discussions with investigators. It should be noted that additional updates in this consensus are required when new data is available.
    Type of Medium: Online Resource
    ISSN: 1759-7706 , 1759-7714
    URL: Issue
    URL: Article
    DOI: 10.1111/tca.v14.34
    DOI: 10.1111/1759-7714.15157
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2559245-2
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 6
    Online Resource
    Online Resource
    Antiphospholipid Antibodies in Critically Ill Patients With COVID‐19
    Wiley ; 2020
    In:  Arthritis & Rheumatology Vol. 72, No. 12 ( 2020-12), p. 1998-2004
    Details
    In: Arthritis & Rheumatology, Wiley, Vol. 72, No. 12 ( 2020-12), p. 1998-2004
    Abstract: Coagulopathy is one of the characteristics observed in critically ill patients with coronavirus disease 2019 (COVID‐19). Antiphospholipid antibodies (aPLs) contribute to coagulopathy, though their role in COVID‐19 remains unclear. This study was undertaken to determine the prevalence and characteristics of aPLs in patients with COVID‐19. Methods Sera collected from 66 COVID‐19 patients who were critically ill and 13 COVID‐19 patients who were not critically ill were tested by chemiluminescence immunoassay for anticardiolipin antibodies (aCLs), anti–β 2 ‐glycoprotein I (anti‐β 2 GPI) (IgG, IgM, and IgA), and IgG anti‐β 2 GPI–domain 1 (anti‐β 2 GPI–D1) and IgM and IgG anti–phosphatidylserine/prothrombin (anti‐PS/PT) antibodies were detected in the serum by enzyme‐linked immunosorbent assay. Results Of the 66 COVID‐19 patients in critical condition, aPLs were detected in 31 (47% ). Antiphospholipid antibodies were not present among COVID‐19 patients who were not in critical condition. The IgA anti‐β 2 GPI antibody was the most commonly observed aPL in patients with COVID‐19 and was present in 28.8% (19 of 66) of the critically ill patients, followed by IgA aCLs (17 of 66, or 25.8%) and IgG anti‐β 2 GPI (12 of 66, or 18.2%). For multiple aPLs, IgA anti‐β 2 GPI + IgA aCLs was the most common antibody profile observed (15 of 66, or 22.7%), followed by IgA anti‐β 2 GPI + IgA aCL + IgG anti‐β 2 GPI (10 of 66, or 15.2%). Antiphospholipid antibodies emerge ~35–39 days after disease onset. A dynamic analysis of aPLs revealed 4 patterns based on the persistence or transient appearance of the aPLs. Patients with multiple aPLs had a significantly higher incidence of cerebral infarction compared to patients who were negative for aPLs ( P = 0.023). Conclusion Antiphospholipid antibodies were common in critically ill patients with COVID‐19. Repeated testing demonstrating medium to high titers of aPLs and the number of aPL types a patient is positive for may help in identifying patients who are at risk of developing cerebral infarction. Antiphospholipid antibodies may be transient and disappear within a few weeks, but in genetically predisposed patients, COVID‐19 may trigger the development of an autoimmune condition similar to the antiphospholipid syndrome (APS), referred to as “COVID‐19–induced APS‐like syndrome.” Long‐term follow‐up of COVID‐19 patients who are positive for aPLs would be of great importance in understanding the pathogenesis of this novel coronavirus.
    Type of Medium: Online Resource
    ISSN: 2326-5191 , 2326-5205
    URL: Issue
    URL: Article
    DOI: 10.1002/art.v72.12
    DOI: 10.1002/art.41425
    RVK:
    XA 10000
    RVK:
    XA 30325
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2754614-7
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 7
    Online Resource
    Online Resource
    Prediction of postpartum hemorrhage in pregnant women with immune thrombocytopenia: Development and validation of the MONITOR model in a nationwide multicenter study
    Wiley ; 2021
    In:  American Journal of Hematology Vol. 96, No. 5 ( 2021-05), p. 561-570
    Details
    In: American Journal of Hematology, Wiley, Vol. 96, No. 5 ( 2021-05), p. 561-570
    Abstract: Globally, postpartum hemorrhage (PPH) is the leading cause of maternal death. Women with immune thrombocytopenia (ITP) are at increased risk of developing PPH. Early identification of PPH helps to prevent adverse outcomes, but is underused because clinicians do not have a tool to predict PPH for women with ITP. We therefore conducted a nationwide multicenter retrospective study to develop and validate a prediction model of PPH in patients with ITP. We included 432 pregnant women (677 pregnancies) with primary ITP from 18 academic tertiary centers in China from January 2008 to August 2018. A total of 157 (23.2%) pregnancies experienced PPH. The derivation cohort included 450 pregnancies. For the validation cohort, we included 117 pregnancies in the temporal validation cohort and 110 pregnancies in the geographical validation cohort. We assessed 25 clinical parameters as candidate predictors and used multivariable logistic regression to develop our prediction model. The final model included seven variables and was named MONITOR ( m aternal complication, WH O bleeding score, a n tepartum platelet transfusion, placental abnormal i ties, pla t elet count, previ o us uterine surgery, and p r imiparity). We established an easy‐to‐use risk heatmap and risk score of PPH based on the seven risk factors. We externally validated this model using both a temporal validation cohort and a geographical validation cohort. The MONITOR model had an AUC of 0.868 (95% CI 0.828–0.909) in internal validation, 0.869 (95% CI 0.802–0.937) in the temporal validation, and 0.811 (95% CI 0.713–0.908) in the geographical validation. Calibration plots demonstrated good agreement between MONITOR‐predicted probability and actual observation in both internal validation and external validation. Therefore, we developed and validated a very accurate prediction model for PPH. We hope that the model will contribute to more precise clinical care, decreased adverse outcomes, and better health care resource allocation.
    Type of Medium: Online Resource
    ISSN: 0361-8609 , 1096-8652
    URL: Issue
    URL: Article
    DOI: 10.1002/ajh.v96.5
    DOI: 10.1002/ajh.26134
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 1492749-4
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 8
    Online Resource
    Online Resource
    Germline mutations in 40 cancer susceptibility genes among C hinese patients with high hereditary risk breast cancer
    Wiley ; 2019
    In:  International Journal of Cancer Vol. 144, No. 2 ( 2019-01-15), p. 281-289
    Details
    In: International Journal of Cancer, Wiley, Vol. 144, No. 2 ( 2019-01-15), p. 281-289
    Abstract: What's new? The prevalence of mutations in breast cancer predisposition genesare not well investigated in Asia. We assessed germline mutations of 40 cancer susceptibility genes in 937 consecutive selected breast cancer patients from 26 centers of China, and discovered 23.8% of participates carried the pathogenic mutation, including 6.8% with mutations in non‐ BRCA1/2 genes, while TP53 and PALB2 had a relatively high mutation rates (1.9% and 1.2%).There was no factors predicted for detrimental mutations in non‐ BRCA1/2 genes when treated as a whole.
    Type of Medium: Online Resource
    ISSN: 0020-7136 , 1097-0215
    URL: Issue
    URL: Article
    DOI: 10.1002/ijc.v144.2
    DOI: 10.1002/ijc.31601
    RVK:
    XA 10000
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 218257-9
    detail.hit.zdb_id: 1474822-8
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 9
    Online Resource
    Online Resource
    Prevalence of pollen‐induced allergic rhinitis with high pollen exposure in grasslands of northern China
    Wiley ; 2018
    In:  Allergy Vol. 73, No. 6 ( 2018-06), p. 1232-1243
    Details
    In: Allergy, Wiley, Vol. 73, No. 6 ( 2018-06), p. 1232-1243
    Abstract: The aim of this study was to investigate the prevalence of epidemiologic and physician‐diagnosed pollen‐induced AR (Pi AR ) in the grasslands of northern China and to study the impact of the intensity and time of pollen exposure on Pi AR prevalence. Methods A multistage, clustered and proportionately stratified random sampling with a field interviewer‐administered survey study was performed together with skin prick tests ( SPT ) and measurements of the daily pollen count. Results A total of 6043 subjects completed the study, with a proportion of 32.4% epidemiologic AR and 18.5% Pi AR . The prevalence was higher in males than females (19.6% vs 17.4%, P  =   .024), but no difference between the two major residential and ethnic groups (Han and Mongolian) was observed. Subjects from urban areas showed higher prevalence of Pi AR than rural areas (23.1% vs 14.0%, P  〈   .001). Most Pi AR patients were sensitized to two or more pollens (79.4%) with artemisia , chenopodium , and humulus scandens being the most common pollen types, which were similarly found as the top three sensitizing pollen allergens by SPT . There were significant regional differences in the prevalence of epidemiologic AR (from 18.6% to 52.9%) and Pi AR (from 10.5% to 31.4%) among the six areas investigated. Pi AR symptoms were positively associated with pollen counts, temperature, and precipitation ( P  〈   .05), but negatively with wind speed and pressure P  〈   .05). Conclusion Pollen‐induced AR (Pi AR ) prevalence in the investigated region is extremely high due to high seasonal pollen exposure, which was influenced by local environmental and climate conditions.
    Type of Medium: Online Resource
    ISSN: 0105-4538 , 1398-9995
    URL: Issue
    URL: Article
    DOI: 10.1111/all.2018.73.issue-6
    DOI: 10.1111/all.13388
    RVK:
    XA 10000
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2003114-2
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 10
    Online Resource
    Online Resource
    Both epilepsy and anti‐seizure medications affect bone metabolism in children with self‐limited epilepsy with centrotemporal spikes
    Wiley ; 2023
    In:  Epilepsia
    Details
    In: Epilepsia, Wiley
    Abstract: Bone metabolism can be influenced by a range of factors. We selected children with self‐limited epilepsy with centrotemporal spikes (SeLECTS) and lifestyles similar to those of healthy children to control for the confounding factors that may influence bone metabolism. We aimed to identify the specific effects of epilepsy and/or anti‐seizure medications (ASMs) on bone metabolism. Methods Patients with SeLECTS were divided into an untreated group and a monotherapy group, and the third group was a healthy control group. We determined the levels of various biochemical markers of bone metabolism, including procollagen type I nitrogenous propeptide (PINP), alkaline phosphatase (ALP), osteocalcin (OC), collagen type I cross‐linked C‐telopeptide (CTX), calcium, magnesium, phosphorus, parathyroid hormone (PTH), and vitamin D 3 (VD 3 ). Results A total of 1487 patients (from 19 centers) were diagnosed with SeLECTS; 1032 were analyzed, including 117 patients who did not receive any ASMs (untreated group), 643 patients who received only one ASM (monotherapy group), and 272 children in the healthy control group. Except for VD 3 , other bone metabolism of the three groups were different ( p   〈  .001). Bone metabolism was significantly lower in the untreated group than the healthy control group (p   〈  .05). There were significant differences between the monotherapy and healthy control group in the level of many markers. However, when comparing the monotherapy and untreated groups, the results were different; oxcarbazepine, levetiracetam, and topiramate had no significant effect on bone metabolism. Phosphorus and magnesium were significantly lower in the valproic acid group than the untreated group (adjusted p   〈  .05, Cliff's delta .282–.768). CTX was significantly higher in the lamotrigine group than in the untreated group (adjusted p  = .012, Cliff's delta = .316). Significance Epilepsy can affect many aspects of bone metabolism. After controlling epilepsy and other confounders that affect bone metabolism, we found that the effects of ASMs on bone metabolism differed. Oxcarbazepine, levetiracetam, and topiramate did not affect bone metabolism, and lamotrigine corrected some of the abnormal markers of bone metabolism in patients with epilepsy.
    Type of Medium: Online Resource
    ISSN: 0013-9580 , 1528-1167
    URL: Article
    DOI: 10.1111/epi.17733
    RVK:
    XA 10000
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2002194-X
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...