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  • 1
    Online Resource
    Online Resource
    Reversibly immortalized human umbilical cord–derived mesenchymal stem cells (UC‐MSCs) are responsive to BMP9‐induced osteogenic and adipogenic differentiation
    Wiley ; 2018
    In:  Journal of Cellular Biochemistry Vol. 119, No. 11 ( 2018-11), p. 8872-8886
    Details
    In: Journal of Cellular Biochemistry, Wiley, Vol. 119, No. 11 ( 2018-11), p. 8872-8886
    Abstract: Human mesenchymal stem cells (MSCs) are a heterogeneous subset of nonhematopoietic multipotent stromal stem cells and can differentiate into mesodermal lineage, such as adipocytes, osteocytes, and chondrocytes, as well as ectodermal and endodermal lineages. Human umbilical cord (UC) is one of the most promising sources of MSCs. However, the molecular and cellular characteristics of UC‐derived MSCs (UC‐MSCs) require extensive investigations, which are hampered by the limited lifespan and the diminished potency over passages. Here, we used the piggyBac transposon–based simian virus 40 T antigen (SV40T) immortalization system and effectively immortalized UC‐MSCs, yielding the iUC‐MSCs. A vast majority of the immortalized lines are positive for MSC markers but not for hematopoietic markers. The immortalization phenotype of the iUC‐MSCs can be effectively reversed by flippase recombinase–induced the removal of SV40T antigen. While possessing long‐term proliferation capability, the iUC‐MSCs are not tumorigenic in vivo. Upon bone morphogenetic protein 9 (BMP9) stimulation, the iUC‐MSC cells effectively differentiate into osteogenic, chondrogenic, and adipogenic lineages both in vitro and in vivo, which is indistinguishable from that of primary UC‐MSCs, indicating that the immortalized UC‐MSCs possess the characteristics similar to that of their primary counterparts and retain trilineage differentiation potential upon BMP9 stimulation. Therefore, the engineered iUC‐MSCs should be a valuable alternative cell source for studying UC‐MSC biology and their potential utilities in immunotherapies and regenerative medicine.
    Type of Medium: Online Resource
    ISSN: 0730-2312 , 1097-4644
    URL: Issue
    URL: Article
    DOI: 10.1002/jcb.v119.11
    DOI: 10.1002/jcb.27140
    Language: English
    Publisher: Wiley
    Publication Date: 2018
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    SSG: 12
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  • 2
    Online Resource
    Online Resource
    Hemodynamics and stroke risk in intracranial atherosclerotic disease
    Wiley ; 2019
    In:  Annals of Neurology Vol. 85, No. 5 ( 2019-05), p. 752-764
    Details
    In: Annals of Neurology, Wiley, Vol. 85, No. 5 ( 2019-05), p. 752-764
    Abstract: To investigate whether hemodynamic features of symptomatic intracranial atherosclerotic stenosis (sICAS) might correlate with the risk of stroke relapse, using a computational fluid dynamics (CFD) model. Methods In a cohort study, we recruited patients with acute ischemic stroke attributed to 50 to 99% ICAS confirmed by computed tomographic angiography (CTA). With CTA‐based CFD models, translesional pressure ratio (PR = pressure poststenotic /pressure prestenotic ) and translesional wall shear stress ratio (WSSR = WSS stenotic − throat /WSS prestenotic ) were obtained in each sICAS lesion. Translesional PR ≤ median was defined as low PR and WSSR ≥4th quartile as high WSSR. All patients received standard medical treatment. The primary outcome was recurrent ischemic stroke in the same territory (SIT) within 1 year. Results Overall, 245 patients (median age = 61 years, 63.7% males) were analyzed. Median translesional PR was 0.94 (interquartile range [IQR] = 0.87–0.97); median translesional WSSR was 13.3 (IQR = 7.0–26.7). SIT occurred in 20 (8.2%) patients, mostly with multiple infarcts in the border zone and/or cortical regions. In multivariate Cox regression, low PR (adjusted hazard ratio [HR]  = 3.16, p  = 0.026) and high WSSR (adjusted HR = 3.05, p  = 0.014) were independently associated with SIT. Patients with both low PR and high WSSR had significantly higher risk of SIT than those with normal PR and WSSR (risk = 17.5% vs 3.0%, adjusted HR = 7.52, p  = 0.004). Interpretation This work represents a step forward in utilizing computational flow simulation techniques in studying intracranial atherosclerotic disease. It reveals a hemodynamic pattern of sICAS that is more prone to stroke relapse, and supports hypoperfusion and artery‐to‐artery embolism as common mechanisms of ischemic stroke in such patients. Ann Neurol 2019;85:752–764
    Type of Medium: Online Resource
    ISSN: 0364-5134 , 1531-8249
    URL: Issue
    URL: Article
    DOI: 10.1002/ana.v85.5
    DOI: 10.1002/ana.25456
    Language: English
    Publisher: Wiley
    Publication Date: 2019
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  • 3
    Online Resource
    Online Resource
    Catalytic Degradation of Polyethylene Terephthalate Using a Phase‐Transitional Zirconium‐Based Metal–Organic Framework
    Wiley ; 2022
    In:  Angewandte Chemie Vol. 134, No. 24 ( 2022-06-13)
    Details
    In: Angewandte Chemie, Wiley, Vol. 134, No. 24 ( 2022-06-13)
    Abstract: Polyethylene terephthalate (PET) is utilized as one of the most popular consumer plastics worldwide, but difficulties associated with recycling PET have generated a severe environmental crisis with most PET ending its lifecycle in landfills. We report that zirconium‐based metal–organic framework (Zr‐MOF) UiO‐66 deconstructs waste PET into the building blocks terephthalic acid (TA) and mono‐methyl terephthalate (MMT) within 24 hours at 260 °C (total yield of 98 % under 1 atm H 2 and 81 % under 1 atm Ar). Extensive structural characterization studies reveal that during the degradation process, UiO‐66 undergoes an intriguing transformation into MIL‐140A, which is another Zr‐MOF that shows good catalytic activity toward PET degradation under similar reaction conditions. These results illustrate the diversity of applications for Zr‐MOFs and establish MOFs as a new class of polymer degradation catalysts with the potential to address long‐standing challenges associated with plastic waste.
    Type of Medium: Online Resource
    ISSN: 0044-8249 , 1521-3757
    URL: Issue
    URL: Article
    DOI: 10.1002/ange.v134.24
    DOI: 10.1002/ange.202117528
    RVK:
    VA 2100
    RVK:
    VN 5020
    Language: English
    Publisher: Wiley
    Publication Date: 2022
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  • 4
    Online Resource
    Online Resource
    Catalytic Degradation of Polyethylene Terephthalate Using a Phase‐Transitional Zirconium‐Based Metal–Organic Framework
    Wiley ; 2022
    In:  Angewandte Chemie International Edition Vol. 61, No. 24 ( 2022-06-13)
    Details
    In: Angewandte Chemie International Edition, Wiley, Vol. 61, No. 24 ( 2022-06-13)
    Abstract: Polyethylene terephthalate (PET) is utilized as one of the most popular consumer plastics worldwide, but difficulties associated with recycling PET have generated a severe environmental crisis with most PET ending its lifecycle in landfills. We report that zirconium‐based metal–organic framework (Zr‐MOF) UiO‐66 deconstructs waste PET into the building blocks terephthalic acid (TA) and mono‐methyl terephthalate (MMT) within 24 hours at 260 °C (total yield of 98 % under 1 atm H 2 and 81 % under 1 atm Ar). Extensive structural characterization studies reveal that during the degradation process, UiO‐66 undergoes an intriguing transformation into MIL‐140A, which is another Zr‐MOF that shows good catalytic activity toward PET degradation under similar reaction conditions. These results illustrate the diversity of applications for Zr‐MOFs and establish MOFs as a new class of polymer degradation catalysts with the potential to address long‐standing challenges associated with plastic waste.
    Type of Medium: Online Resource
    ISSN: 1433-7851 , 1521-3773
    URL: Issue
    URL: Article
    DOI: 10.1002/anie.v61.24
    DOI: 10.1002/anie.202117528
    RVK:
    VA 2100
    Language: English
    Publisher: Wiley
    Publication Date: 2022
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    detail.hit.zdb_id: 123227-7
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  • 5
    Online Resource
    Online Resource
    Retrospective audit: Utility of PET scan in routine preoperative rectal cancer staging
    Wiley ; 2023
    In:  ANZ Journal of Surgery Vol. 93, No. 3 ( 2023-03), p. 617-621
    Details
    In: ANZ Journal of Surgery, Wiley, Vol. 93, No. 3 ( 2023-03), p. 617-621
    Abstract: Accurate staging for rectal cancer is pertinent with recent introduction of rectum‐sparing approaches for patients showing complete clinical response on restaging. Positron emission tomography(PET) is used in detection of recurrence or metastasis, but its value in routine preoperative rectal cancer staging remains unclear. Studies report that preoperative PET altered the stage in 39% and changed the management in 17–27% of patients. Our study aims to look at the utility of PET in routine preoperative staging of rectal cancer within 2 two colorectal units, and to determine if PET did result in a change in management. Methods Patients in Nepean Hospital (NSW) and Peter MacCallum Cancer Centre (VIC) who were diagnosed with rectal cancer between 1 January 2017 and 31 December 2021 were included in this retrospective study. All patients who did not have a PET scan were excluded. PET scan results were then compared with MRI and CT results. Results Three hundred and fifty‐seven patients were included in the study. 30.3% of the patients had Stage 3 rectal cancer. 71.7% received neoadjuvant therapy. PET scan provided additional information in 55.5% of patients when compared with CT and MRI alone; 18.2% of the PET findings resulted in an altered management for the patient. Conclusion PET scan can be a valuable tool in accurate staging, especially for ambiguous or equivocal lesions on CT. Our study demonstrated that additional information from PET scan resulted in an altered management plan in 18.2% of the patients. PET/MRI as a newer modality may be more accurate with reduced radiation exposure.
    Type of Medium: Online Resource
    ISSN: 1445-1433 , 1445-2197
    URL: Issue
    URL: Article
    DOI: 10.1111/ans.v93.3
    DOI: 10.1111/ans.18058
    Language: English
    Publisher: Wiley
    Publication Date: 2023
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    detail.hit.zdb_id: 2095927-8
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