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  • 1
    Online Resource
    Online Resource
    MXene‐Based Current Collectors for Advanced Rechargeable Batteries
    Wiley ; 2023
    In:  Advanced Materials
    Details
    In: Advanced Materials, Wiley
    Abstract: As an indispensable component of rechargeable batteries, the current collector plays a crucial role in supporting the electrode materials and collecting the accumulated electrical energy. However, some key issues, like uneven resources, high weight percentage, electrolytic corrosion, and high‐voltage instability, cannot meet the growing needs for rechargeable batteries. In recent years, MXene‐based current collectors have achieved considerable achievements due to its unique structure, large surface area and high conductivity. The related research has increased significantly. Nonetheless, a comprehensive review of this area is seldom. Herein the applications and progress of MXene in current collector are systematically summarized and discussed. Meanwhile, some challenges and future directions are presented. This article is protected by copyright. All rights reserved
    Type of Medium: Online Resource
    ISSN: 0935-9648 , 1521-4095
    URL: Article
    DOI: 10.1002/adma.202306015
    RVK:
    UA 1538
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 1474949-X
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  • 2
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    New regimens as first‐line eradication therapy for Helicobacter pylori infection in patients allergic to penicillin: A randomized controlled trial
    Wiley ; 2023
    In:  Helicobacter Vol. 28, No. 2 ( 2023-04)
    Details
    In: Helicobacter, Wiley, Vol. 28, No. 2 ( 2023-04)
    Abstract: Helicobacter pylori eradication in penicillin‐allergic patients is challenging. The effective regimen is lacking in areas with high antibiotic resistance and tetracycline unavailable. Minocycline, cefuroxime, and full‐dose metronidazole are promising drugs. Aims To compare the eradication rate, safety, and compliance among three new bismuth quadruple therapies for first‐line H. pylori eradication in penicillin‐allergic patients. Methods This randomized trial was conducted on 450 naive patients with H. pylori infection and penicillin allergy. The 14‐day minocycline‐metronidazole‐containing (minocycline 100 mg twice daily and metronidazole 400 mg four times/day), minocycline‐cefuroxime‐containing (minocycline 100 mg twice daily and cefuroxime 500 mg twice daily), and cefuroxime‐metronidazole‐containing (cefuroxime 500 mg twice daily and metronidazole 400 mg four times/day) bismuth quadruple therapies were randomly assigned to the participants. Safety and compliance were assessed within 3 days after eradication. Urea breath test was performed 4–8 weeks after eradication to evaluate outcome. Results The differences of eradication rates in either intention‐to‐treat (84.0%, 82.7%, and 23 82.0%, p  = .896) or per‐protocol (91.7%, 90.9%, and 88.2%, p  = .599) analysis among minocycline‐metronidazole, minocycline‐cefuroxime, and cefuroxime‐metronidazole‐containing bismuth quadruple therapies were statistically insignificant. The incidence of adverse events (35.1%, 22.6%, and 28.9%) and compliance (90.5%, 91.8%, and 91.9%) were similar. Taste distortion, nausea, and anorexia were more common in metronidazole‐containing regimens, and dizziness was more common in minocycline‐containing regimens. The allergy was rare (~3%). Conclusions The efficacies of three bismuth quadruple therapies containing minocycline, cefuroxime, and full‐dose metronidazole (pairwise) for first‐line H. pylori eradication in penicillin‐allergic patients were similarly satisfactory with relatively good safety and compliance. The study was registered in the Chinese Clinical Trials Registration (ChiCTR1900023702).
    Type of Medium: Online Resource
    ISSN: 1083-4389 , 1523-5378
    URL: Issue
    URL: Article
    DOI: 10.1111/hel.v28.2
    DOI: 10.1111/hel.12956
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2020336-6
    SSG: 12
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  • 3
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    Zero‐fluoroscopy transseptal puncture guided by right atrial electroanatomical mapping combined with intracardiac echocardiography: A single‐center experience
    Wiley ; 2020
    In:  Clinical Cardiology Vol. 43, No. 9 ( 2020-09), p. 1009-1016
    Details
    In: Clinical Cardiology, Wiley, Vol. 43, No. 9 ( 2020-09), p. 1009-1016
    Abstract: Right atrial electroanatomical mapping may be combined with SoundStar 3D diagnostic ultrasound catheter (EAM‐ICE) as a zero‐fluoroscopy procedure for radiofrequency catheter ablation (RFCA). We aimed to evaluate the efficiency and safety of zero‐fluoroscopy transseptal puncture guided by EAM‐ICE and fluoroscopy combined with intracardiac echocardiography (F‐ICE) in patients with paroxysmal atrial fibrillation (PAF). Hypothesis Zero‐fluoroscopy transseptal puncture is an effective and safe procedure. Methods This study had a prospective design. A total of 57 patients with PAF were enrolled and assigned to two groups. Twenty‐seven patients were enrolled in the EAM‐ICE group, and 30 patients were enrolled in the F‐ICE group. Results There were no statistically significant differences in baseline patient characteristics between groups. Transseptal puncture was successful in all patients (57/57, 100%). Total procedure time and duration of transseptal puncture were lower in the F‐ICE group (199.4 ± 26.0 minutes vs 150.7 ± 22.1 minutes, P = 0.000; 118.4 ± 19.7 vs 70.5 ± 13.5 minutes, P = 0.000). There was no use of fluoroscopy in the EAM‐ICE group (0 mGy vs 70.5 ± 13.5 mGy); the duration of fluoroscopy in the EAM‐ICE group was negligible (0 minutes vs 5.4 ± 1.9 minutes). No procedural complication occurred in either group. Conclusions EAM‐ICE guided zero‐fluoroscopy transseptal puncture is an effective and safe procedure.
    Type of Medium: Online Resource
    ISSN: 0160-9289 , 1932-8737
    URL: Issue
    URL: Article
    DOI: 10.1002/clc.v43.9
    DOI: 10.1002/clc.23401
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2048223-1
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  • 4
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    Building Functional Liquid‐Based Interfaces: From Mechanism to Application
    Wiley ; 2024
    In:  Angewandte Chemie International Edition
    Details
    In: Angewandte Chemie International Edition, Wiley
    Abstract: Functional liquid‐based interfaces, with their inhomogeneous regions that emphasize the functionalized liquids, have attracted much interest as a versatile platform for a broad spectrum of applications, from chemical manufacturing to practical uses. These interfaces leverage the physicochemical characteristics of liquids, alongside dynamic behaviors induced by macroscopic wettability and microscopic molecular exchange balance, to allow for tailored properties within their functional structures. In this Minireview, we provide a foundational overview of these functional interfaces, based on the structural investigations and molecular mechanisms of interaction forces that directly modulate functionalities. Then, we discuss design strategies that have been employed in recent applications, and the crucial aspects that require focus. Finally, we highlight the current challenges in functional liquid‐based interfaces and provide a perspective on future research directions.
    Type of Medium: Online Resource
    ISSN: 1433-7851 , 1521-3773
    URL: Article
    DOI: 10.1002/anie.202403919
    RVK:
    VA 2100
    Language: English
    Publisher: Wiley
    Publication Date: 2024
    detail.hit.zdb_id: 2011836-3
    detail.hit.zdb_id: 123227-7
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  • 5
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    Programmed Size‐Changeable Nanotheranostic Agents for Enhanced Imaging‐Guided Chemo/Photodynamic Combination Therapy and Fast Elimination
    Wiley ; 2021
    In:  Advanced Materials Vol. 33, No. 21 ( 2021-05)
    Details
    In: Advanced Materials, Wiley, Vol. 33, No. 21 ( 2021-05)
    Abstract: An ideal nanotheranostic agent should be able to achieve efficient tumor accumulation, retention, and fast elimination after its theranostic functions exhausts. However, there is an irreconcilable contradiction on optimum sizes for effective tumor retention and fast elimination. Herein, a programmed size‐changeable nanotheranostic agent based on polyprodrug‐modified iron oxide nanoparticles (IONPs) and aggregation‐induced emission photosensitizer is developed for enhanced magnetic resonance imaging (MRI)‐guided chemo/photodynamic combination therapy. The nano‐sized theranostic agents with an initial diameter of about 90 nm can accumulate in tumor tissue through passive targeting. In the acidic tumor microenvironment, large aggregates of IONPs are formed, realizing enhanced tumor retention and MR signal enhancement. Under the guidance of MRI, light irradiation is applied to the tumor site for triggering the generation of reactive oxygen species and drug release. Moreover, after chemo/photodynamic combination therapy, the large‐sized aggregates are re‐dispersed into small‐sized IONPs for fast elimination, reducing the risk of toxicity caused by long‐term retention. Therefore, this study provides a promising size‐changeable strategy for the development of nanotheranostic agents.
    Type of Medium: Online Resource
    ISSN: 0935-9648 , 1521-4095
    URL: Issue
    URL: Article
    DOI: 10.1002/adma.v33.21
    DOI: 10.1002/adma.202100398
    RVK:
    UA 1538
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 1474949-X
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  • 6
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    YAP/TEAD3 signal mediates cardiac lineage commitment of human‐induced pluripotent stem cells
    Wiley ; 2020
    In:  Journal of Cellular Physiology Vol. 235, No. 3 ( 2020-03), p. 2753-2760
    Details
    In: Journal of Cellular Physiology, Wiley, Vol. 235, No. 3 ( 2020-03), p. 2753-2760
    Abstract: Cardiomyocytes differentiated from human‐induced pluripotent stem cells (hiPSCs) hold great potential for therapy of heart diseases. However, the underlying mechanisms of its cardiac differentiation have not been fully elucidated. Hippo‐YAP signal pathway plays important roles in cell differentiation, tissue homeostasis, and organ size. Here, we identify the role of Hippo‐YAP signal pathway in determining cardiac differentiation fate of hiPSCs. We found that cardiac differentiation of hiPSCs were significantly inhibited after treatment with verteporfin (a selective and potent YAP inhibitor). During hiPSCs differentiation from mesoderm cells (MESs) into cardiomyocytes, verteporfin treatment caused the cells retained in the earlier cardiovascular progenitor cells (CVPCs) stage. Interestingly, during hiPSCs differentiation from CVPC into cardiomyocytes, verteporfin treatment induced cells dedifferentiation into the earlier CVPC stage. Mechanistically, we found that YAP interacted with transcriptional enhanced associate domain transcription factor 3 (TEAD3) to regulate cardiac differentiation of hiPSCs during the CVPC stage. Consistently, RNAi‐based silencing of TEAD3 mimicked the phenotype as the cells treated with verteporfin. Collectively, our study suggests that YAP‐TEAD3 signaling is important for cardiomyocyte differentiation of hiPSCs. Our findings provide new insight into the function of Hippo‐YAP signal in cardiovascular lineage commitment.
    Type of Medium: Online Resource
    ISSN: 0021-9541 , 1097-4652
    URL: Issue
    URL: Article
    DOI: 10.1002/jcp.v235.3
    DOI: 10.1002/jcp.29179
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 1478143-8
    SSG: 12
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  • 7
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    Machine learning algorithms utilizing blood parameters enable early detection of immunethrombotic dysregulation in COVID‐19
    Wiley ; 2021
    In:  Clinical and Translational Medicine Vol. 11, No. 9 ( 2021-09)
    Details
    In: Clinical and Translational Medicine, Wiley, Vol. 11, No. 9 ( 2021-09)
    Type of Medium: Online Resource
    ISSN: 2001-1326 , 2001-1326
    URL: Issue
    URL: Article
    DOI: 10.1002/ctm2.v11.9
    DOI: 10.1002/ctm2.523
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2697013-2
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  • 8
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    A time‐dependent density functional study on optical response in all‐inorganic lead‐halide perovskite nanostructures
    Wiley ; 2020
    In:  International Journal of Quantum Chemistry Vol. 120, No. 13 ( 2020-07)
    Details
    In: International Journal of Quantum Chemistry, Wiley, Vol. 120, No. 13 ( 2020-07)
    Abstract: Recently, all‐inorganic perovskite nanostructures have become a hot research topic due to their unique optical response and novel properties. Here, we theoretically study the optical response in Cs 2 PbX 4 and CsPb 2 X 5 (X = Cl, Br, and I) nanostructures. First, to study the ground state, we calculate the band structures of the periodic system using the HSE06 method, which shows that all those periodic perovskites possess the direct band gaps, with distribution from 2.225 to 3.536 eV. Their valence band maximum are mainly contributed from both halogen and lead atoms, while the conduction band minimum are mainly contributed from lead atoms. Then, we study the excited state using the time‐dependent density functional theory method and find that, with the increase of halogen atom radius, the photogenerated carrier concentrations in perovskite nanostructures become larger, while the surface plasmon resonance becomes localized rather than long‐range. Moreover, through the analysis of photocurrent and local field enhancement, Cs 2 PbX 4 and CsPb 2 X 5 nanostructures exhibit nearly 40 μA photocurrent along the direction of optical polarization. Besides, by regulating the different anions, we predict that field enhancement in Cs 2 PbI 4 and CsPb 2 I 5 share a much stronger distribution at both the center and border parts of Pb‐I planes due to localized plasmon resonance, while other perovskites are distributed at the edge parts of Pb‐I planes, caused by long‐range plasmon resonance. Our research shows that all‐inorganic perovskite nanostructures are great candidate materials for developing optoelectronic devices working in high‐frequency and high‐energy regions and improving their application in sensitive detection and sensors.
    Type of Medium: Online Resource
    ISSN: 0020-7608 , 1097-461X
    URL: Issue
    URL: Article
    DOI: 10.1002/qua.v120.13
    DOI: 10.1002/qua.26232
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 1475014-4
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  • 9
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    A Photo‐Activated Continuous Reactive Oxygen Species Nanoamplifier for Dual‐Dynamic Cascade Cancer Therapy
    Wiley ; 2023
    In:  Advanced Healthcare Materials
    Details
    In: Advanced Healthcare Materials, Wiley
    Abstract: The special redox homeostasis of tumor cells makes reactive oxygen species (ROS)‐based approaches a promising cancer therapeutic strategy. Among these approaches, photodynamic therapy is the most widely studied ROS‐based treatment due to its ability to achieve targeted therapy by local light irradiation. However, achieving efficient and continuous ROS generation without prolonged laser exposure is still challenging. In this work, a photo‐activated continuous ROS nanoamplifier is proposed for photodynamic–chemodynamic cascade therapy. Upon local laser irradiation, the nanoamplifier can continuously amplify cellular oxidative stress through a positive feedback loop of “light‐triggered ROS generation, ROS‐responsive prodrug activation, and Fenton reaction‐mediated ROS cyclic regenerative amplification”, avoiding tissue damage caused by excessive laser exposure. This strategy provides a potential pathway to overcome the limitations of ROS‐based therapeutic approaches.
    Type of Medium: Online Resource
    ISSN: 2192-2640 , 2192-2659
    URL: Article
    DOI: 10.1002/adhm.202301469
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2645585-7
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  • 10
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    Risk stratification by long non‐coding RNAs profiling in COVID‐19 patients
    Wiley ; 2021
    In:  Journal of Cellular and Molecular Medicine Vol. 25, No. 10 ( 2021-05), p. 4753-4764
    Details
    In: Journal of Cellular and Molecular Medicine, Wiley, Vol. 25, No. 10 ( 2021-05), p. 4753-4764
    Abstract: Coronavirus disease 2019 (COVID‐19), caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), has become a global pandemic worldwide. Long non‐coding RNAs (lncRNAs) are a subclass of endogenous, non‐protein‐coding RNA, which lacks an open reading frame and is more than 200 nucleotides in length. However, the functions for lncRNAs in COVID‐19 have not been unravelled. The present study aimed at identifying the related lncRNAs based on RNA sequencing of peripheral blood mononuclear cells from patients with SARS‐CoV‐2 infection as well as health individuals. Overall, 17 severe, 12 non‐severe patients and 10 healthy controls were enrolled in this study. Firstly, we reported some altered lncRNAs between severe, non‐severe COVID‐19 patients and healthy controls. Next, we developed a 7‐lncRNA panel with a good differential ability between severe and non‐severe COVID‐19 patients using least absolute shrinkage and selection operator regression. Finally, we observed that COVID‐19 is a heterogeneous disease among which severe COVID‐19 patients have two subtypes with similar risk score and immune score based on lncRNA panel using iCluster algorithm. As the roles of lncRNAs in COVID‐19 have not yet been fully identified and understood, our analysis should provide valuable resource and information for the future studies.
    Type of Medium: Online Resource
    ISSN: 1582-1838 , 1582-4934
    URL: Issue
    URL: Article
    DOI: 10.1111/jcmm.v25.10
    DOI: 10.1111/jcmm.16444
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2076114-4
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