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  • 1
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    Impaired robust interhemispheric function integration of depressive brain from REST‐meta‐MDD database in China
    Wiley ; 2022
    In:  Bipolar Disorders Vol. 24, No. 4 ( 2022-06), p. 400-411
    Details
    In: Bipolar Disorders, Wiley, Vol. 24, No. 4 ( 2022-06), p. 400-411
    Abstract: Recently, functional homotopy (FH) architecture, defined as robust functional connectivity (FC) between homotopic regions, has been frequently reported to be altered in MDD patients (MDDs) but with divergent locations. Methods In this study, we obtained resting‐state functional magnetic resonance imaging (R‐fMRI) data from 1004 MDDs (mean age, 33.88 years; age range, 18–60 years) and 898 matched healthy controls (HCs) from an aggregated dataset from 20 centers in China. We focused on interhemispheric function integration in MDDs and its correlation with clinical characteristics using voxel‐mirrored homotopic connectivity (VMHC) devised to inquire about FH patterns. Results As compared with HCs, MDDs showed decreased VMHC in visual, motor, somatosensory, limbic, angular gyrus, and cerebellum, particularly in posterior cingulate gyrus/precuneus (PCC/PCu) (false discovery rate [FDR] q  〈  0.002, z = −7.07). Further analysis observed that the reduction in SMG and insula was more prominent with age, of which SMG reflected such age‐related change in males instead of females. Besides, the reduction in MTG was found to be a male‐special abnormal pattern in MDDs. VMHC alterations were markedly related to episode type and illness severity. The higher Hamilton Depression Rating Scale score, the more apparent VMHC reduction in the primary visual cortex. First‐episode MDDs revealed stronger VMHC reduction in PCu relative to recurrent MDDs. Conclusions We confirmed a significant VMHC reduction in MDDs in broad areas, especially in PCC/PCu. This reduction was affected by gender, age, episode type, and illness severity. These findings suggest that the depressive brain tends to disconnect information exchange across hemispheres.
    Type of Medium: Online Resource
    ISSN: 1398-5647 , 1399-5618
    URL: Issue
    URL: Article
    DOI: 10.1111/bdi.v24.4
    DOI: 10.1111/bdi.13139
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2001157-X
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  • 2
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    Malignant melanotic Xp11 neoplasms exhibit a clinicopathologic spectrum and gene expression profiling akin to alveolar soft part sarcoma: a proposal for reclassification
    Wiley ; 2020
    In:  The Journal of Pathology Vol. 251, No. 4 ( 2020-08), p. 365-377
    Details
    In: The Journal of Pathology, Wiley, Vol. 251, No. 4 ( 2020-08), p. 365-377
    Abstract: The classification of the distinct group of mesenchymal neoplasms, first described as ‘Xp11 translocation perivascular epithelioid cell tumor (PEComa)’ and for which the term ‘melanotic Xp11 neoplasm’ or ‘Xp11 neoplasm with melanocytic differentiation’ has recently been proposed, remains challenging and controversial. We collected 27 melanotic Xp11 neoplasms, the largest series to date, for a comprehensive evaluation. Fourteen of the cases, together with eight alveolar soft part sarcomas (ASPS), nine conventional PEComas and a control group of seven normal tissues were submitted to RNA sequencing. Follow‐up available in 22 patients showed 5‐year overall survival and 5‐year disease‐free survival of 47.6 and 35.7%, respectively, which were similar to ASPS and significantly worse than conventional PEComa. Univariate analysis of location (occurring in the kidney versus not kidney), infiltrative growth pattern, nuclear pleomorphism, mitotic activity ≥2/50 high‐power fields (HPF), necrosis and lymphovascular invasion were found to be associated with overall survival and/or disease‐free survival. Multivariate analysis identified that location was the only factor found to independently correlate with disease‐free survival. More importantly, RNA sequencing‐based clustering analysis segregated melanotic Xp11 neoplasm and ASPS from other tumors, including conventional PEComa and Xp11 translocation renal cell carcinoma, and formed a compact cluster representative of the largely similar expression signature. Here we clearly define the true biologic nature of melanotic Xp11 neoplasms which are distinctive malignant mesenchymal tumors, rather than simply PEComa variants with occasionally unpredictable behavior. Meanwhile, melanotic Xp11 neoplasm and ASPS more likely represent phenotypic variants of the same entity, which is distinct from conventional PEComa and Xp11 translocation renal cell carcinoma. Based on these important findings, melanotic Xp11 neoplasm might be reclassified into a distinctive entity together with ASPS, independent from PEComa, in future revisions of the current WHO categories of tumors of soft tissue and bone for the improved reclassification. © 2020 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
    Type of Medium: Online Resource
    ISSN: 0022-3417 , 1096-9896
    URL: Issue
    URL: Article
    DOI: 10.1002/path.v251.4
    DOI: 10.1002/path.5470
    RVK:
    XA 10000
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 1475280-3
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  • 3
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    Wintering home range and habitat use of the whooper swans ( Cygnus cygnus ) in Sanmenxia Wetland, China
    Wiley ; 2019
    In:  Ecological Research Vol. 34, No. 5 ( 2019-09), p. 637-643
    Details
    In: Ecological Research, Wiley, Vol. 34, No. 5 ( 2019-09), p. 637-643
    Abstract: Home range and habitat use are the central components of avian ecology, and studies on these aspects will be helpful for the conservation and management of avian populations. Sixty‐seven swans were global positioning system tagged at Sanmenxia Wetland of Henan Province to obtain detailed location data in winter from 2015 to 2016. The home range size of swans was the largest in the middle wintering period and followed by the early period and late period, and sizes were significantly different among the three wintering periods. There were significant differences in habitat use among the different wintering periods. In the early period, the swans mainly used the aquatic grasses and emergent plants zones, and they mainly relied on artificial supplementation because of a lack of natural feeding habitats in the middle period. In the late period, the swans mainly used the newly emerged terrestrial grasses zone. Except for the deep water, the use of other water levels was significantly different among the different wintering periods. In the early wintering period, the swans tended to prefer the low and high water level areas; in the middle period, they were mainly in the intermediate and high water level areas and they used all the water level areas except the deep water level in the late wintering period. It was concluded that some plants are preferred by the swans, such as reeds, cattails and barnyard grass, and that water depth should be suitable for the swans, with the water levels varying over a gradient.
    Type of Medium: Online Resource
    ISSN: 0912-3814 , 1440-1703
    URL: Issue
    URL: Article
    DOI: 10.1111/ere.v34.5
    DOI: 10.1111/1440-1703.12031
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 2023900-2
    SSG: 12
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  • 4
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    Synthesis, structures, photoluminescence and magnetic properties of three dinuclear lanthanide(III) complexes derived from 4‐fluorophenylselenoacetic acid
    Wiley ; 2021
    In:  Zeitschrift für anorganische und allgemeine Chemie Vol. 647, No. 11 ( 2021-06-11), p. 1213-1220
    Details
    In: Zeitschrift für anorganische und allgemeine Chemie, Wiley, Vol. 647, No. 11 ( 2021-06-11), p. 1213-1220
    Abstract: Three novel dinuclear lanthanide(III) complexes [Ln 2 L 6 (phen) 2 ] (Ln=Eu III ( 1 ), Tb III ( 2 ), Dy III ( 3 )), derived from 4‐fluorophenylselenoacetic acid and 1,10‐phenanthroline, have been synthesized and characterized by elemental analysis, IR, TGA, powder X‐ray diffraction and single‐crystal X‐ray diffraction analysis. Single crystal X‐ray diffraction reveal they are isostructural and crystallize in the monoclinic crystal system, space group P2(1)/c . The investigations on luminescent properties of Eu(III) complex 1 and Tb(III) complex 2 exhibit the characteristic emissions of Eu III ( 5 D 0 → 7 F 0‐4 ) and Tb III ( 5 D 4 → 7 F 6‐3 ), and the corresponding luminescent lifetimes are 1.52 and 1.10 ms, respectively. Temperature‐dependent photoluminescence studies show the emission intensities and lifetimes for both complexes decrease upon increasing temperature, which indicates complexes 1 and 2 have the potential for sensing temperature. The magnetic studies reveal that Dy(III) complex 3 exhibits weak antiferromagnetic interactions and slow magnetic relaxation behavior.
    Type of Medium: Online Resource
    ISSN: 0044-2313 , 1521-3749
    URL: Issue
    URL: Article
    DOI: 10.1002/zaac.v647.11
    DOI: 10.1002/zaac.202000438
    RVK:
    VA 8102
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 201094-X
    detail.hit.zdb_id: 1481139-X
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  • 5
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    Additional cytogenetic abnormalities in patients with newly diagnosed acute promyelocytic leukemia predict inferior event‐free survival
    Wiley ; 2023
    In:  Cancer Medicine Vol. 12, No. 17 ( 2023-09), p. 17766-17775
    Details
    In: Cancer Medicine, Wiley, Vol. 12, No. 17 ( 2023-09), p. 17766-17775
    Abstract: The innovative combination of all‐trans retinoic acid (ATRA) and arsenic trioxide (ATO) has established a new chapter of curative approach in acute promyelocytic leukemia (APL). The disease characteristics and prognostic influence of additional cytogenetic abnormalities (ACA) in APL with modern therapeutic strategy need to be elucidated. Methods In the present study, we retrospectively investigated disease features and prognostic power of ACA in 171 APL patients treated with ATRA‐ATO‐containing regimens. Results Patients with ACA had markedly decreased hemoglobin levels than that without ACA ( p  = 0.021). Risk stratification in the ACA group was significantly worse than that in the non‐ACA group ( p  = 0.032). With a median follow‐up period of 62.0 months, worse event‐free survival (EFS) was demonstrated in patients harboring ACA. Multivariate analysis showed that ACA was an independent adverse factor for EFS ( p  = 0.033). By further subgroup analysis, in CD34 and CD56 negative APL, patients harboring ACA had inferior EFS ( p  = 0.017; p  = 0.037). Conclusions To sum up, ACA remains the independent prognostic value for EFS, we should build risk‐adapted therapeutic strategies in the long‐term management of APL when such abnormalities are detected.
    Type of Medium: Online Resource
    ISSN: 2045-7634 , 2045-7634
    URL: Issue
    URL: Article
    DOI: 10.1002/cam4.v12.17
    DOI: 10.1002/cam4.6398
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2659751-2
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  • 6
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    An N ‐Trifluoromethylation/Cyclization Strategy for Accessing Diverse N ‐Trifluoromethyl Azoles from Nitriles and 1,3‐Dipoles
    Wiley ; 2022
    In:  Angewandte Chemie Vol. 134, No. 1 ( 2022-01-03)
    Details
    In: Angewandte Chemie, Wiley, Vol. 134, No. 1 ( 2022-01-03)
    Abstract: N‐Trifluoromethyl azoles are valuable targets in medicinal chemistry, but their synthesis is challenging. Classical preparation of N‐CF 3 azoles relies on the functional group interconversions but suffers from tedious N‐pre‐functionalization and unfriendly agents. Introduction of the CF 3 onto the nitrogen of heterocycles provides a direct route to such motifs, but the N‐trifluoromethylation remains underdeveloped. Reported here is an alternative and scalable cyclization strategy based on NCF 3 ‐containing synthons for constructing N‐CF 3 azoles. The approach involves the N‐trifluoromethylation of nitriles followed by a [3+2] cyclization between resulting N‐CF 3 nitrilium derivatives and 1,3‐dipoles. PhICF 3 Cl was an effective CF 3 source for the transformation. As a result, a generic platform is established to divergently synthesize N‐trifluoromethylated tetrazoles, imidazoles, and 1,2,3‐triazoles by using sodium azide, activated methylene isocyanides, and diazo compounds as dipoles.
    Type of Medium: Online Resource
    ISSN: 0044-8249 , 1521-3757
    URL: Issue
    URL: Article
    DOI: 10.1002/ange.v134.1
    DOI: 10.1002/ange.202110749
    RVK:
    VA 2100
    RVK:
    VN 5020
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 505868-5
    detail.hit.zdb_id: 506609-8
    detail.hit.zdb_id: 514305-6
    detail.hit.zdb_id: 505872-7
    detail.hit.zdb_id: 1479266-7
    detail.hit.zdb_id: 505867-3
    detail.hit.zdb_id: 506259-7
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  • 7
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    An N ‐Trifluoromethylation/Cyclization Strategy for Accessing Diverse N ‐Trifluoromethyl Azoles from Nitriles and 1,3‐Dipoles
    Wiley ; 2022
    In:  Angewandte Chemie International Edition Vol. 61, No. 1 ( 2022-01-03)
    Details
    In: Angewandte Chemie International Edition, Wiley, Vol. 61, No. 1 ( 2022-01-03)
    Abstract: N‐Trifluoromethyl azoles are valuable targets in medicinal chemistry, but their synthesis is challenging. Classical preparation of N‐CF 3 azoles relies on the functional group interconversions but suffers from tedious N‐pre‐functionalization and unfriendly agents. Introduction of the CF 3 onto the nitrogen of heterocycles provides a direct route to such motifs, but the N‐trifluoromethylation remains underdeveloped. Reported here is an alternative and scalable cyclization strategy based on NCF 3 ‐containing synthons for constructing N‐CF 3 azoles. The approach involves the N‐trifluoromethylation of nitriles followed by a [3+2] cyclization between resulting N‐CF 3 nitrilium derivatives and 1,3‐dipoles. PhICF 3 Cl was an effective CF 3 source for the transformation. As a result, a generic platform is established to divergently synthesize N‐trifluoromethylated tetrazoles, imidazoles, and 1,2,3‐triazoles by using sodium azide, activated methylene isocyanides, and diazo compounds as dipoles.
    Type of Medium: Online Resource
    ISSN: 1433-7851 , 1521-3773
    URL: Issue
    URL: Article
    DOI: 10.1002/anie.v61.1
    DOI: 10.1002/anie.202110749
    RVK:
    VA 2100
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2011836-3
    detail.hit.zdb_id: 123227-7
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  • 8
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    Prediction of postpartum hemorrhage in pregnant women with immune thrombocytopenia: Development and validation of the MONITOR model in a nationwide multicenter study
    Wiley ; 2021
    In:  American Journal of Hematology Vol. 96, No. 5 ( 2021-05), p. 561-570
    Details
    In: American Journal of Hematology, Wiley, Vol. 96, No. 5 ( 2021-05), p. 561-570
    Abstract: Globally, postpartum hemorrhage (PPH) is the leading cause of maternal death. Women with immune thrombocytopenia (ITP) are at increased risk of developing PPH. Early identification of PPH helps to prevent adverse outcomes, but is underused because clinicians do not have a tool to predict PPH for women with ITP. We therefore conducted a nationwide multicenter retrospective study to develop and validate a prediction model of PPH in patients with ITP. We included 432 pregnant women (677 pregnancies) with primary ITP from 18 academic tertiary centers in China from January 2008 to August 2018. A total of 157 (23.2%) pregnancies experienced PPH. The derivation cohort included 450 pregnancies. For the validation cohort, we included 117 pregnancies in the temporal validation cohort and 110 pregnancies in the geographical validation cohort. We assessed 25 clinical parameters as candidate predictors and used multivariable logistic regression to develop our prediction model. The final model included seven variables and was named MONITOR ( m aternal complication, WH O bleeding score, a n tepartum platelet transfusion, placental abnormal i ties, pla t elet count, previ o us uterine surgery, and p r imiparity). We established an easy‐to‐use risk heatmap and risk score of PPH based on the seven risk factors. We externally validated this model using both a temporal validation cohort and a geographical validation cohort. The MONITOR model had an AUC of 0.868 (95% CI 0.828–0.909) in internal validation, 0.869 (95% CI 0.802–0.937) in the temporal validation, and 0.811 (95% CI 0.713–0.908) in the geographical validation. Calibration plots demonstrated good agreement between MONITOR‐predicted probability and actual observation in both internal validation and external validation. Therefore, we developed and validated a very accurate prediction model for PPH. We hope that the model will contribute to more precise clinical care, decreased adverse outcomes, and better health care resource allocation.
    Type of Medium: Online Resource
    ISSN: 0361-8609 , 1096-8652
    URL: Issue
    URL: Article
    DOI: 10.1002/ajh.v96.5
    DOI: 10.1002/ajh.26134
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 1492749-4
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  • 9
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    Micro‐ and nano‐emulsions based on soluble soy polysaccharide and octenyl succinic anhydride modified soluble soy polysaccharide
    Wiley ; 2021
    In:  International Journal of Food Science & Technology Vol. 56, No. 6 ( 2021-06), p. 3034-3043
    Details
    In: International Journal of Food Science & Technology, Wiley, Vol. 56, No. 6 ( 2021-06), p. 3034-3043
    Abstract: In this study, emulsion stabilised by soybean soluble polysaccharide (SSPS) and octenyl succinic anhydride modified SSPS (OSA‐SSPS) with high molecular weight (HM W ) at concentrations (2%, 3%, 4%, 5%, 6%) was prepared. The droplet size of emulsion stabilised by OSA‐SSPS (HM W ) was between 150 and 300 nm with a single distribution peak and increased by 0.1 μm after 4 weeks; that of emulsion stabilised by SSPS was between 1 and 5 μm with two distribution peaks and increased by more than 2 μm after 4 weeks. The viscosity of emulsion with OSA‐SSPS (HM W ) was larger than that with SSPS, and the absolute value of zeta potential of microemulsion with SSPS was lower than 43 mV while that of nanoemulsion with OSA‐SSPS (HM W ) was higher than 46 mV. The stability of nanoemulsion with OSA‐SSPS (HM W ) slightly varied with the increase of storage time and concentration, which provided theoretical guidance for the application of OSA‐SSPS in nanoemulsion.
    Type of Medium: Online Resource
    ISSN: 0950-5423 , 1365-2621
    URL: Issue
    URL: Article
    DOI: 10.1111/ijfs.v56.6
    DOI: 10.1111/ijfs.14947
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2016518-3
    detail.hit.zdb_id: 2401430-8
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  • 10
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    Ferromagnetic Resonance Study of FeNi/Cu/FeNi Sandwiches
    Wiley ; 1994
    In:  physica status solidi (b) Vol. 181, No. 2 ( 1994-02-01), p. K65-K68
    Details
    In: physica status solidi (b), Wiley, Vol. 181, No. 2 ( 1994-02-01), p. K65-K68
    Type of Medium: Online Resource
    ISSN: 0370-1972 , 1521-3951
    URL: Issue
    URL: Journal
    URL: Article
    DOI: 10.1002/pssb.v181:2
    DOI: 10.1002/(ISSN)1521-3951
    DOI: 10.1002/pssb.2221810232
    Language: German
    Publisher: Wiley
    Publication Date: 1994
    detail.hit.zdb_id: 208851-4
    detail.hit.zdb_id: 1481096-7
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