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  • 1
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    Online Resource
    TaTIP41 and TaTAP46 positively regulate drought tolerance in wheat by inhibiting PP2A activity
    Wiley ; 2023
    In:  Journal of Integrative Plant Biology Vol. 65, No. 9 ( 2023-09), p. 2056-2070
    Details
    In: Journal of Integrative Plant Biology, Wiley, Vol. 65, No. 9 ( 2023-09), p. 2056-2070
    Abstract: Drought is a major environmental stress limiting global wheat ( Triticum aestivum ) production. Exploring drought tolerance genes is important for improving drought adaptation in this crop. Here, we cloned and characterized TaTIP41 , a novel drought tolerance gene in wheat. TaTIP41 is a putative conserved component of target of rapamycin (TOR) signaling, and the TaTIP41 homoeologs were expressed in response to drought stress and abscisic acid (ABA). The overexpression of TaTIP41 enhanced drought tolerance and the ABA response, including ABA‐induced stomatal closure, while its downregulation using RNA interference (RNAi) had the opposite effect. Furthermore, TaTIP41 physically interacted with TaTAP46, another conserved component of TOR signaling. Like TaTIP41, TaTAP46 positively regulated drought tolerance. Furthermore, TaTIP41 and TaTAP46 interacted with type‐2A protein phosphatase (PP2A) catalytic subunits, such as TaPP2A‐2, and inhibited their enzymatic activities. Silencing TaPP2A‐2 improved drought tolerance in wheat. Together, our findings provide new insights into the roles of TaTIP41 and TaTAP46 in the drought tolerance and ABA response in wheat, and their potential application in improving wheat environmental adaptability.
    Type of Medium: Online Resource
    ISSN: 1672-9072 , 1744-7909
    URL: Issue
    URL: Article
    DOI: 10.1111/jipb.v65.9
    DOI: 10.1111/jipb.13542
    Language: English
    Publisher: Wiley
    Publication Date: 2023
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    detail.hit.zdb_id: 2185698-9
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  • 2
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    Intraparticle Double‐Scattering‐Decoded Sonogenetics for Augmenting Immune Checkpoint Blockade and CAR‐T Therapy
    Wiley ; 2022
    In:  Advanced Science Vol. 9, No. 32 ( 2022-11)
    Details
    In: Advanced Science, Wiley, Vol. 9, No. 32 ( 2022-11)
    Abstract: Genetically arming new chimeric antigen receptors (CARs) on T cells is a prevalent method to fulfill CAR‐T immunotherapy. However, this approach fails to completely address the poor infiltration, complex immunosuppressive tumor microenvironment (ITM), and insufficient immune cells, which are recognized as the three dominant hurdles to discouraging the trafficking and persistence of CAR‐T and immune checkpoint blockade (ICB) immunotherapies against solid tumors. To address the three hurdles, a sonoimmunity‐engineered nanoplatform is designed in which a rattle‐type‐structured carrier enables intraparticle‐double‐scattering to generate massive reactive oxygen species (ROS) during the sonodynamic process. Abundant ROS accumulation can directly kill tumor cells, release antigens, and activate systematic immune responses for expanding effector T or CAR‐T cells, while alleviating ITM via immunosuppressive macrophage polarization and reduction in pro‐tumorigenic cytokine secretion. Furthermore, the co‐loaded phosphodiesterase‐5 inhibitors release nitric oxide (NO) to impel vascular normalization and open the infiltration barrier (IB) for allowing more T cells to enter into the tumor. Systematic experiments demonstrate the feasibility of such intraparticle‐double‐scattering‐decoded sonogenetics in the sonoimmunity‐engineered nanoplatforms for expanding effector T or CAR‐T cells, thereby promoting their infiltration into tumors and alleviating ITM. These compelling actions lead to excellent CAR‐T and ICB immunotherapies against solid tumors with repressed tumor metastasis.
    Type of Medium: Online Resource
    ISSN: 2198-3844 , 2198-3844
    URL: Issue
    URL: Article
    DOI: 10.1002/advs.v9.32
    DOI: 10.1002/advs.202203106
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2808093-2
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  • 3
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    The interaction of CaM7 and CNGC14 regulates root hair growth in Arabidopsis
    Wiley ; 2020
    In:  Journal of Integrative Plant Biology Vol. 62, No. 7 ( 2020-07), p. 887-896
    Details
    In: Journal of Integrative Plant Biology, Wiley, Vol. 62, No. 7 ( 2020-07), p. 887-896
    Abstract: Oscillations in cytosolic free calcium determine the polarity of tip‐growing root hairs. The Ca 2+ channel cyclic nucleotide gated channel 14 (CNGC14) contributes to the dynamic changes in Ca 2+ concentration gradient at the root hair tip. However, the mechanisms that regulate CNGC14 are unknown. In this study, we detected a direct interaction between calmodulin 7 (CaM7) and CNGC14 through yeast two‐hybrid and bimolecular fluorescence complementation assays. We demonstrated that the third EF‐hand domain of CaM7 specifically interacts with the cytosolic C‐terminal domain of CNGC14. A two‐electrode voltage clamp assay showed that CaM7 completely inhibits CNGC14‐mediated Ca 2+ influx, suggesting that CaM7 negatively regulates CNGC14‐mediated calcium signaling. Furthermore, CaM7 overexpressing lines phenocopy the short root hair phenotype of a cngc14 mutant and this phenotype is insensitive to changes in external Ca 2+ concentrations. We, thus, identified CaM7‐CNGC14 as a novel interacting module that regulates polar growth in root hairs by controlling the tip‐focused Ca 2+ signal.
    Type of Medium: Online Resource
    ISSN: 1672-9072 , 1744-7909
    URL: Issue
    URL: Article
    DOI: 10.1111/jipb.v62.7
    DOI: 10.1111/jipb.12890
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2130095-1
    detail.hit.zdb_id: 2185698-9
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  • 4
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    Effect of glycine betaine on chilling injury in relation to energy metabolism in papaya fruit during cold storage
    Wiley ; 2019
    In:  Food Science & Nutrition Vol. 7, No. 3 ( 2019-03), p. 1123-1130
    Details
    In: Food Science & Nutrition, Wiley, Vol. 7, No. 3 ( 2019-03), p. 1123-1130
    Abstract: “Zhongbai” papaya fruit were treated with 15 mmol/L glycine betaine ( GB ) and then refrigerated at 6°C for 40 days to study the influence of GB on chilling injury (CI) and possible mechanism associated with energy metabolism. The results exhibited that GB treatment remarkably reduced the CI severity as indicated by lower CI index during storage. GB treatment lowered electrolyte leakage and malondialdehyde content, which accounted for maintenance of membrane integrity and reduced lipid peroxidation. Moreover, GB treatment improved the energy status as revealed by increased adenosine triphosphate (ATP) level, energy charge, and activities of energy metabolism‐related enzymes including mitochondrial membrane H + ‐adenosine triphosphatase (H + ‐ ATP ase) and Ca 2+ ‐adenosine triphosphatase (Ca 2+ ‐ ATP ase), succinate dehydrogenase ( SDH ), and cytochrome C oxidase ( CCO ). The results indicate that enhanced chilling tolerance in papaya fruit by GB treatment during cold storage might be ascribed to improved energy status in association with increased activities of energy metabolism‐related enzymes.
    Type of Medium: Online Resource
    ISSN: 2048-7177 , 2048-7177
    URL: Issue
    URL: Article
    DOI: 10.1002/fsn3.2019.7.issue-3
    DOI: 10.1002/fsn3.957
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 2703010-6
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  • 5
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    Diagnostic value of nerve conduction study in NOTCH2NLC ‐related neuronal intranuclear inclusion disease
    Wiley ; 2023
    In:  Journal of the Peripheral Nervous System Vol. 28, No. 4 ( 2023-12), p. 629-641
    Details
    In: Journal of the Peripheral Nervous System, Wiley, Vol. 28, No. 4 ( 2023-12), p. 629-641
    Abstract: Neuronal intranuclear inclusion disease (NIID) is a rare progressive neurodegenerative disorder mainly caused by abnormally expanded GGC repeats within the NOTCH2NLC gene. Most patients with NIID show polyneuropathy. Here, we aim to investigate diagnostic electrophysiological markers of NIID. Methods In this retrospective dual‐center study, we reviewed 96 patients with NOTCH2NLC ‐related NIID, 94 patients with genetically confirmed Charcot–Marie‐Tooth (CMT) disease, and 62 control participants without history of peripheral neuropathy, who underwent nerve conduction studies between 2018 and 2022. Results Peripheral nerve symptoms were presented by 53.1% of patients with NIID, whereas 97.9% of them showed peripheral neuropathy according to electrophysiological examinations. Patients with NIID were characterized by slight demyelinating sensorimotor polyneuropathy; some patients also showed mild axonal lesions. Motor nerve conduction velocity (MCV) of the median nerve usually exceeded 35 m/s, and were found to be negatively correlated with the GGC repeat sizes. Regarding the electrophysiological differences between muscle weakness type ( n  = 27) and non‐muscle weakness type ( n  = 69) of NIID, nerve conduction abnormalities were more severe in the muscle weakness type involving both demyelination and axonal impairment. Notably, specific DWI subcortical lace sign was presented in only 33.3% of muscle weakness type, thus it was difficult to differentiate them from CMT. Combining age of onset, distal motor latency, and compound muscle action potential of the median nerve showed the optimal diagnostic performance to distinguish NIID from major CMT (AUC = 0.989, sensitivity = 92.6%, specificity = 97.4%). Interpretation Peripheral polyneuropathy is common in NIID. Our study suggest that nerve conduction study is useful to discriminate NIID.
    Type of Medium: Online Resource
    ISSN: 1085-9489 , 1529-8027
    URL: Issue
    URL: Article
    DOI: 10.1111/jns.v28.4
    DOI: 10.1111/jns.12599
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 1364009-4
    detail.hit.zdb_id: 2030613-1
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  • 6
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    Three GLI2 mutations combined potentially underlie non‐syndromic cleft lip with or without cleft palate in a Chinese pedigree
    Wiley ; 2019
    In:  Molecular Genetics & Genomic Medicine Vol. 7, No. 9 ( 2019-09)
    Details
    In: Molecular Genetics & Genomic Medicine, Wiley, Vol. 7, No. 9 ( 2019-09)
    Abstract: Nonsyndromic cleft lip with or without cleft palate (NSCL/P) is the most common craniofacial birth defect. Its etiology is complex and it has a lifelong influence on affected individuals. Despite many studies, the pathogenic gene alleles are not completely clear. Here, we recruited a Chinese NSCL/P family and explored the candidate causative variants in this pedigree. Methods We performed whole‐exome sequencing on two patients and two unaffected subjects of this family. Variants were screened based on bioinformatics analysis to identify the potential etiological alleles. Species conservation analysis, mutation function prediction, and homology protein modeling were also performed to preliminarily evaluate the influence of the mutations. Results We identified three rare mutations that are located on a single chromatid (c.2684C  〉  T_p.Ala895Val, c.4350G  〉  T_p.Gln1450His, and c.4622C  〉  A_p.Ser1541Tyr) in GLI2 as candidate causative variants. All of these three mutations were predicted to be deleterious, and they affect amino acids that are conserved in many species. The mutation c.2684C  〉  T was predicted to affect the structure of the GLI2 protein. Conclusion Our results further demonstrate that GLI2 variants play a role in the pathogenesis of NSCL/P, and the three rare missense mutations combined are probably the potential disease‐causing variants in this family.
    Type of Medium: Online Resource
    ISSN: 2324-9269 , 2324-9269
    URL: Issue
    URL: Article
    DOI: 10.1002/mgg3.v7.9
    DOI: 10.1002/mgg3.714
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 2734884-2
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  • 7
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    Prolonged corrected QT interval in predicting atrial fibrillation: A systematic review and meta‐analysis
    Wiley ; 2018
    In:  Pacing and Clinical Electrophysiology Vol. 41, No. 3 ( 2018-03), p. 321-327
    Details
    In: Pacing and Clinical Electrophysiology, Wiley, Vol. 41, No. 3 ( 2018-03), p. 321-327
    Abstract: Corrected QT interval (QTc) on the electrocardiogram is a marker of ventricular repolarization. Recent studies have examined its value in predicting the occurrence of atrial fibrillation (AF). Methods and results We conducted a meta‐analysis to determine whether alterations in QTc interval are associated with an increased risk of incident AF. The PUBMED and EMBASE databases were searched for all studies that evaluated the incident AF associated with prolonged QTc interval published before December 2016. Sensitivity and subgroup analysis were subsequently performed. A total of six studies including eight data sets for prolonged QTc interval were eligible. Subjects with prolonged QTc interval as a categorical variable had a significantly higher risk of AF during follow‐up (hazard ratio [HR]: 1.16; 95% confidence interval [CI] , 1.09–1.24, I 2  = 90%) based on Bazett formula. In continuous variable analysis, we found a statistically significant risk for AF (HR, 1.17; 95% CI, 1.09–1.25; I 2  = 0) every 10‐ms prolongation in QTc. AF type, QTc cut‐off value, geographical location, follow‐up duration, and study population may be the possible reasons for the significant heterogeneity among the studies. Conclusions Prolonged QTc interval is associated with an increased risk of AF. And the potential mechanisms underlying this cause‐and‐effect relationship need further investigation.
    Type of Medium: Online Resource
    ISSN: 0147-8389 , 1540-8159
    URL: Issue
    URL: Article
    DOI: 10.1111/pace.2018.41.issue-3
    DOI: 10.1111/pace.13292
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 424437-0
    detail.hit.zdb_id: 2037547-5
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  • 8
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    Nutrient limitation and enzymolysis of phosphorus in Meiliang Bay, Lake Taihu, during algal blooms
    Wiley ; 2019
    In:  Water Environment Research Vol. 91, No. 5 ( 2019-05), p. 369-376
    Details
    In: Water Environment Research, Wiley, Vol. 91, No. 5 ( 2019-05), p. 369-376
    Abstract: In this study, algal growth potential tests were performed in water samples collected from six sampling sites in Meiliang Bay, Lake Taihu. The potential release of soluble reactive phosphorus ( SRP ) by enzymatic hydrolysis of enzymatically hydrolyzable phosphorus ( EHP ) was simultaneously evaluated. Results show that all studied regions were in highly eutrophic states, with additional nitrogen (N) or phosphorus (P) inputs, inducing negligible further increase in algal growth. EHP in water could be rapidly transformed into SRP , further supporting the proliferation of algal blooms. The shortest EHP mineralization time was calculated as 69 minutes; therefore, limiting specific nutrient inputs alone in extremely eutrophic lakes can have a limited effect on suppressing the proliferation of algal blooms. Methods to establish a suitable environmental fate for excessive nitrogen and phosphorus nutrients may be more effective and provide more significant results. Practitioner points N and P were no longer serving as the limiting factors in Meiliang Bay. Enzymatically hydrolysable phosphorus could be hydrolyzed into soluble reactive phosphorus in a very short period during algal blooms. Both enzymatically hydrolysable phosphorus and soluble reactive phosphorus are required to be curbed in practical eutrophication control.
    Type of Medium: Online Resource
    ISSN: 1061-4303 , 1554-7531
    URL: Issue
    URL: Article
    DOI: 10.1002/wer.2019.91.issue-5
    DOI: 10.1002/wer.1021
    RVK:
    AR 10100
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 1098976-6
    detail.hit.zdb_id: 2051010-X
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  • 9
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    Nondestructive rapid identification of wild Cordyceps sinensis with portable instrument
    Wiley ; 2023
    In:  Phytochemical Analysis
    Details
    In: Phytochemical Analysis, Wiley
    Abstract: The correct discrimination of CS has been improved through model transfer, and three characteristic peaks have been proposed to determine the quality of CS at 1443, 1941, and 2183 nm.
    Type of Medium: Online Resource
    ISSN: 0958-0344 , 1099-1565
    URL: Article
    DOI: 10.1002/pca.3310
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 1073576-8
    detail.hit.zdb_id: 1498615-2
    SSG: 12
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  • 10
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    A novel PTCH 1 mutation underlies nonsyndromic cleft lip and/or palate in a Han Chinese family
    Wiley ; 2018
    In:  Oral Diseases Vol. 24, No. 7 ( 2018-10), p. 1318-1325
    Details
    In: Oral Diseases, Wiley, Vol. 24, No. 7 ( 2018-10), p. 1318-1325
    Abstract: Cleft lip and/or palate ( CL /P) is the most common craniofacial congenital disease, and it has a complex aetiology. This study aimed to identify the causative gene mutation of a Han Chinese family with CL /P. Subjects and Methods Whole exome sequencing was conducted on the proband and her mother, who exhibited the same phenotype. A Mendelian dominant inheritance model, allele frequency, mutation regions, functional prediction and literature review were used to screen and filter the variants. The candidate was validated by Sanger sequencing. Conservation analysis and homology modelling were conducted. Results A heterozygous missense mutation c.1175C 〉 T in the PTCH 1 gene predicting p.Ala392Val was identified. This variant has not been reported and was predicted to be deleterious. Sanger sequencing verified the variant and the dominant inheritance model in the family. The missense alteration affects an amino acid that is evolutionarily conserved in the first extracellular loop of the PTCH 1 protein. The local structure of the mutant protein was significantly altered according to homology modelling. Conclusions Our findings suggest that c.1175C 〉 T in PTCH 1 ( NM_000264 ) may be the causative mutation of this pedigree. Our results add to the evidence that PTCH 1 variants play a role in the pathogenesis of orofacial clefts.
    Type of Medium: Online Resource
    ISSN: 1354-523X , 1601-0825
    URL: Issue
    URL: Article
    DOI: 10.1111/odi.2018.24.issue-7
    DOI: 10.1111/odi.12915
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2008428-6
    detail.hit.zdb_id: 1290529-X
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