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  • Wiley  (20)
  • 1
    Online Resource
    Online Resource
    Response: D‐dimer Triage for COVID‐19
    Wiley ; 2020
    In:  Academic Emergency Medicine Vol. 27, No. 9 ( 2020-09), p. 931-931
    Details
    In: Academic Emergency Medicine, Wiley, Vol. 27, No. 9 ( 2020-09), p. 931-931
    Type of Medium: Online Resource
    ISSN: 1069-6563 , 1553-2712
    URL: Issue
    URL: Article
    DOI: 10.1111/acem.v27.9
    DOI: 10.1111/acem.14084
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2029751-8
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  • 2
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    D‐dimer Triage for COVID‐19
    Wiley ; 2020
    In:  Academic Emergency Medicine Vol. 27, No. 7 ( 2020-07), p. 612-613
    Details
    In: Academic Emergency Medicine, Wiley, Vol. 27, No. 7 ( 2020-07), p. 612-613
    Type of Medium: Online Resource
    ISSN: 1069-6563 , 1553-2712
    URL: Issue
    URL: Article
    DOI: 10.1111/acem.v27.7
    DOI: 10.1111/acem.14037
    Language: English
    Publisher: Wiley
    Publication Date: 2020
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  • 3
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    Comparison of prediction value of four bleeding risk scores for pulmonary embolism with anticoagulation: A real‐world study in Chinese patients
    Wiley ; 2019
    In:  The Clinical Respiratory Journal Vol. 13, No. 3 ( 2019-03), p. 139-147
    Details
    In: The Clinical Respiratory Journal, Wiley, Vol. 13, No. 3 ( 2019-03), p. 139-147
    Abstract: Major bleeding (MB) and clinically relevant bleeding (CRB) are the most common seen complications associated with anticoagulation treatment for pulmonary embolism (PE) patients. A bleeding risk score (BRS) may help to accurately determine the risk of bleeding and make better decisions for patients in clinical practice. Methods Patients diagnosed as acute PE and who met the inclusion criteria in Beijing Chao‐Yang Hospital from January 2009 to September 2013 were consecutively enrolled. Baseline data were collected. Four BRS (Kuijer score, RIETE score, Kearon score and Nieuwenhuis score) were assessed and compared using the area under the receiver operating characteristic curve (AUC). Results A total number of 563 patients were included in the study. Of which, 16 had MB and 89 had CRB within three months of anticoagulation treatment. Three months' cumulative incidence for MB and CRB events was 0.03 (95% CI 0.01‐0.05) and 0.17 (95% CI 0.12‐0.21), respectively. In our study population, the AUCs for Kuijer, RIETE, Kearon and Nieuwenhuis scores were 0.57 (95% CI 0.44~0.68), 0.56 (95% CI 0.45‐0.71), 0.75 (95% CI 0.60~0.89) and 0.59 (95% CI 0.41~0.74), respectively. In addition, the AUCs of four BRS for CRB were all poor, with values less than 0.65. Conclusions Only the Kearon score appeared to have more accuracy in predicting the risk of MB. Further large prospective studies are needed to externally validate a BRS for CRB.
    Type of Medium: Online Resource
    ISSN: 1752-6981 , 1752-699X
    URL: Issue
    URL: Article
    DOI: 10.1111/crj.2019.13.issue-3
    DOI: 10.1111/crj.12993
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 2442214-9
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  • 4
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    Successful thrombolytic therapy of post‐operative massive pulmonary embolism after ultralong cardiopulmonary resuscitation: a case report and review of literature
    Wiley ; 2017
    In:  The Clinical Respiratory Journal Vol. 11, No. 3 ( 2017-05), p. 383-390
    Details
    In: The Clinical Respiratory Journal, Wiley, Vol. 11, No. 3 ( 2017-05), p. 383-390
    Abstract: Cardiac arrest caused by massive pulmonary embolism (PE) is highly refractory to conventional resuscitation. Thrombolytic therapy has been considered to be an effective way to massive PE. Methods We reported a case of successful thrombolytic therapy of post‐operative massive PE after 90‐min cardiopulmonary resuscitation (CPR) and reviewed the relevant literature. Results We presented the case of a 48‐year‐old woman with surgery of varicosis of great saphenous vein who suffered from a massive PE with circulatory arrest refractory to 90 min of aggressive CPR. Thrombolysis was given only as a single dose of 50 mg of recombinant tissue plasminogen activator. Rapid haemodynamic and clinical improvement followed the bolus dose. The patient was discharged later without neurological or other sequelae. An extensive literature search of the PubMed database only identified 11 cases of massive PE with cardiac arrest during the perioperative period with a survival rate was 88.9%. The time period of CPR before thrombolysis or anti‐coagulation was 15–90 min. Conclusions Thrombolytic therapy is useful to achieve the return of spontaneous circulation in the resuscitation of patients with cardiac arrest secondary to massive PE during the perioperative period, even in the prolong resuscitation.
    Type of Medium: Online Resource
    ISSN: 1752-6981 , 1752-699X
    URL: Issue
    URL: Article
    DOI: 10.1111/crj.2017.11.issue-3
    DOI: 10.1111/crj.12332
    Language: English
    Publisher: Wiley
    Publication Date: 2017
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  • 5
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    Circulating biomarkers in chronic thromboembolic pulmonary hypertension
    Wiley ; 2019
    In:  Pulmonary Circulation Vol. 9, No. 2 ( 2019-04), p. 1-13
    Details
    In: Pulmonary Circulation, Wiley, Vol. 9, No. 2 ( 2019-04), p. 1-13
    Abstract: Chronic thromboembolic pulmonary hypertension (CTEPH) is a serious condition characterized with chronic organized thrombi that obstruct the pulmonary vessels, leading to pulmonary hypertension (PH) and ultimately right heart failure. Although CTEPH is the only form of PH that can be cured with surgical intervention, not all patients with CTEPH will be deemed operable. Some CTEPH patients still have a poor prognosis. Therefore, the determination of diagnostic and prognostic biomarkers of CTEPH is of great importance for the early intervention to improve prognosis of patients with CTEPH. Several markers related to multiple mechanisms of CTEPH have been recently identified as circulating diagnostic and prognostic biomarkers in these patients. However, the existing literature review of biomarkers of CTEPH is relatively sparse. In this article, we review recent advances in circulating biomarkers of CTEPH and describe future applications of these biomarkers in the management of CTEPH.
    Type of Medium: Online Resource
    ISSN: 2045-8940 , 2045-8940
    URL: Article
    DOI: 10.1177/2045894019844480
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 2638089-4
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  • 6
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    CMR‐based heart deformation analysis for quantification of hemodynamics and right ventricular dysfunction in patients with CTEPH
    Wiley ; 2020
    In:  The Clinical Respiratory Journal Vol. 14, No. 3 ( 2020-03), p. 277-284
    Details
    In: The Clinical Respiratory Journal, Wiley, Vol. 14, No. 3 ( 2020-03), p. 277-284
    Abstract: Quantification of hemodynamics and right ventricular (RV) function is crucial for pulmonary hypertension (PH). Cardiovascular magnetic resonance–based heart deformation analysis (CMR‐HDA) has been used to assess the ventricular strain. Objective This study was to determine the correlation of right ventricular longitudinal strain (RVLS) assessed with CMR‐HDA with RV function as well as hemodynamics in patients with chronic thromboembolic pulmonary hypertension (CTEPH). Methods Thirty‐six CTEPH patients were prospectively included in this research. Each patients underwent CMR and right heart catheterization (RHC). RVLS and RV ejection fraction (RVEF) was quantified from cine images acquired with a retrospectively gated turbo FLASH gradient‐echo sequence. The late gadolinium enhancement (LGE) images were acquired using a 2D inversion recovery phase‐sensitive fast gradient‐echo sequence. Hemodynamics were determined with RHC. Results Right ventricular longitudinal strain measured with CMR‐HDA was −13.99 ± 4.94%. Bland–Altman plots showed statistical agreement with RVLS with low intra‐ and interobserver variability. RVLS correlated with serum N‐terminal‐pro‐B‐type natriuretic peptide ( r  = 0.615, P   〈  .001). RVLS inversely correlated with RVEF ( r  = −0.699, P   〈  .001), and it was positively correlated with both RVESV ( r  = 0.664, P   〈  .001) and myocardial the volume of LGE ( r  = 0.447, P  = .008). Receiver‐operating characteristic (ROC) indicated that RVLS values of 〉 −14.20% could be used to predict RVEF 〈 40% with a 100% sensitivity and a 96.7% specificity. Hemodynamically, RVLS was positively correlated with mean pulmonary artery pressure ( r  = 0.598, P   〈  .001) and pulmonary vascular resistance ( r  = 0.685, P   〈  .001). Conclusion Right ventricular longitudinal strain assessed by CMR‐HDA is a readily available and reproducible parameters of RV function. RVLS 〉 −14.20% suggests the presence of RV dysfunction.
    Type of Medium: Online Resource
    ISSN: 1752-6981 , 1752-699X
    URL: Issue
    URL: Article
    DOI: 10.1111/crj.v14.3
    DOI: 10.1111/crj.13128
    Language: English
    Publisher: Wiley
    Publication Date: 2020
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  • 7
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    Current status of diagnosis and treatment of pulmonary hypertension in Chinese tertiary hospitals: A nationwide survey
    Wiley ; 2023
    In:  Pulmonary Circulation Vol. 13, No. 2 ( 2023-04)
    Details
    In: Pulmonary Circulation, Wiley, Vol. 13, No. 2 ( 2023-04)
    Abstract: We intended to evaluate the diagnosis and treatment status of pulmonary hypertension (PH) in China and provide the basis for the design of the Chinese PH centers system. A questionnaire survey was conducted by sampling from Chinese Class A tertiary hospitals that have carried out the clinical work of PH, including the composition of PH clinical team, the current application of examinations related to PH diagnosis, the availability of PAH‐specific medicine and the implementation of PH‐related intervention and surgery. A total of 44 valid questionnaires from 20 provinces were collected in this survey. In the vast majority of centers (83.33%, n  = 35), pulmonary artery catheterization was routinely performed under X‐ray guidance. In 19.05% ( n  = 8) of centers, pressure measurements were determined at the right time (the end of normal expiration). Only 73.81% ( n  = 31) centers have carried out acute vasoreactivity testing. Prostacyclin analogues and prostaglandin receptor agonists were just prescribed in 45.45% ( n  = 20) of the centers. 19 centers (43.18%) were capable of performing balloon pulmonary angioplasty (BPA) and pulmonary endarterectomy (PEA), while 25% ( n  = 11) were able to perform BPA, PEA, and lung transplantation. There was no significant difference in the diagnosis and treatment of PH between economic regions. The majority of Chinese tertiary hospitals were well equipped with the corresponding personnel, examinations and medicines related to PH, but the standardization and specialization of the management of PH need to be strengthened.
    Type of Medium: Online Resource
    ISSN: 2045-8940 , 2045-8940
    URL: Issue
    URL: Article
    DOI: 10.1002/pul2.v13.2
    DOI: 10.1002/pul2.12241
    Language: English
    Publisher: Wiley
    Publication Date: 2023
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  • 8
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    Safety and efficacy of balloon pulmonary angioplasty for technically operable chronic thromboembolic pulmonary hypertension
    Wiley ; 2024
    In:  Pulmonary Circulation Vol. 14, No. 1 ( 2024-01)
    Details
    In: Pulmonary Circulation, Wiley, Vol. 14, No. 1 ( 2024-01)
    Abstract: Balloon pulmonary angioplasty (BPA) has been proven effective for addressing technically inoperable chronic thromboembolic pulmonary hypertension (CTEPH). However, the effectiveness of BPA in technically operable CTEPH patients who, for various reasons, did not undergo the procedure remains an area requiring exploration. This study sought to assess the safety and efficacy of BPA in such cases. We collected and reviewed data from CTEPH patients who underwent BPA in a consecutive manner. Following multidisciplinary team (MDT) decisions, patients were classified into two groups: technically inoperable (group A) and operable (group B). Group B comprised patients deemed technically suitable for pulmonary endarterectomy (PEA) but who did not undergo the procedure for various reasons. All patients underwent a comprehensive diagnostic work‐up, including right heart categorization at baseline and the last intervention. This study compared changes in hemodynamic parameters, functional capacity, and quality of life between the two groups. In total, 161 patients underwent 414 procedures at our center, with Group A comprising 112 patients who underwent 282 BPA sessions and group B comprising 49 patients who underwent 132 BPA sessions. Significantly, both groups exhibited improvements in hemodynamics, functional capacity, and quality of life. The occurrence rate of complications, including hemoptysis and lung injury, was similar [12 (63.2%) vs. 7 (36.8%), p = 0.68]. BPA demonstrated favorable outcomes in patients with proximal CTEPH who did not undergo pulmonary endarterectomy. However, the clinical impact of BPA in technically operable CTEPH was found to be less significant than in inoperable cases.
    Type of Medium: Online Resource
    ISSN: 2045-8940 , 2045-8940
    URL: Issue
    URL: Article
    DOI: 10.1002/pul2.v14.1
    DOI: 10.1002/pul2.12327
    Language: English
    Publisher: Wiley
    Publication Date: 2024
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  • 9
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    Recognition, diagnosis, and operability assessment of chronic thromboembolic pulmonary hypertension (CTEPH): A global cross‐sectional scientific survey (CLARITY)
    Wiley ; 2024
    In:  Pulmonary Circulation Vol. 14, No. 1 ( 2024-01)
    Details
    In: Pulmonary Circulation, Wiley, Vol. 14, No. 1 ( 2024-01)
    Abstract: Early recognition and diagnosis of chronic thromboembolic pulmonary hypertension (CTEPH) is crucial for improving prognosis and reducing the disease burden. Established clinical practice guidelines describe interventions for the diagnosis and evaluation of CTEPH, yet limited insight remains into clinical practice variation and barriers to care. The CTEPH global cross‐sectional scientific survey (CLARITY) was developed to gather insights into the current diagnosis, treatment, and management of CTEPH and to identify unmet medical needs. This paper focuses on the recognition and diagnosis of CTEPH and the referral and evaluation of these patients. The survey was offered to hospital‐based medical specialists through Scientific Societies and other medical organizations, from September 2021 to May 2022. Response data from 353 physicians showed that self‐reported awareness of CTEPH increased over the past 10 years among 96% of respondents. Clinical practices in acute pulmonary embolism (PE) follow‐up and CTEPH diagnosis differed among respondents. While 50% of respondents working in a nonexpert center reported to refer patients to an expert pulmonary hypertension/CTEPH center when CTEPH is suspected, 51% of these physicians did not report referral of patients with a confirmed diagnosis for further evaluation. Up to 50% of respondents involved in the evaluation of referred patients have concluded a different operability status than that indicated by the referring center. This study indicates that early diagnosis and timely treatment of CTEPH is challenged by suboptimal acute PE follow‐up and patient referral practices. Nonadherence to guideline recommendations may be impacted by various barriers to care, which were shown to vary by geographical region.
    Type of Medium: Online Resource
    ISSN: 2045-8940 , 2045-8940
    URL: Issue
    URL: Article
    DOI: 10.1002/pul2.v14.1
    DOI: 10.1002/pul2.12330
    Language: English
    Publisher: Wiley
    Publication Date: 2024
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  • 10
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    Identification of a low frequency missense mutation in MUC6 contributing to pulmonary artery hypertension by whole‐exome sequencing
    Wiley ; 2018
    In:  Pulmonary Circulation Vol. 8, No. 3 ( 2018-07), p. 1-8
    Details
    In: Pulmonary Circulation, Wiley, Vol. 8, No. 3 ( 2018-07), p. 1-8
    Abstract: Pulmonary arterial hypertension (PAH) represents a progressive disease characterized by abnormally high blood pressure in the pulmonary artery. Although mutations in the bone morphogenetic receptor 2 (BMPR2) are found in 80% of heritable, their low penetrance suggests that other unidentified genetic modifiers are required for this disease. In this report, whole‐exome sequencing (WES) and a linkage analysis were performed on genomic DNA isolated from four affected relatives and one non‐affected relative in two PAH families. By focusing on meaningful variants which were presented in the four affected family members, but not presented in the non‐affected individual, 49 SNP and eight indel variants in 39 genes were identified as candidates. Further high‐throughput multiplex genotyping and Sanger sequencing were carried out to confirm the putative causal mutations in 150 individuals (30 idiopathic PAH [IPAH] patients, 30 chronic thromboembolic pulmonary hypertension [CTEPH] patients, and 90 normal controls). A heterozygous and deleterious mutation in the gene MUC6 (p.Pro1716Ser) was confirmed in the IPAH group (20/30, 67%) and CTEPH group (1/30, 3.33%); no variant was detected in the 90 normal controls. MUC6 , which is short for mucin 6, encodes high molecular weight glycoprotein produced by many epithelial tissues and forms an insoluble mucous barrier that protects the lumens. We re‐confirmed this low frequency mutation with the 1000 Genomes database across all species; no population or frequency data of this allele were acquired. We also found that this mutation site was highly conserved in different species and predicted MUC6 has the protection function of the airway and pneumoangiogram based on genomic sequence data. The compound heterozygous MUC6 gene mutation (p.Pro1716Ser) suggests a novel disease mechanism leading to PAH.
    Type of Medium: Online Resource
    ISSN: 2045-8940 , 2045-8940
    URL: Article
    DOI: 10.1177/2045894018794374
    Language: English
    Publisher: Wiley
    Publication Date: 2018
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