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  • Wiley  (23)
  • 1
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    Online Resource
    Biomimetic Nanocarriers Guide Extracellular ATP Homeostasis to Remodel Energy Metabolism for Activating Innate and Adaptive Immunity System
    Wiley ; 2022
    In:  Advanced Science Vol. 9, No. 17 ( 2022-06)
    Details
    In: Advanced Science, Wiley, Vol. 9, No. 17 ( 2022-06)
    Abstract: Metabolic interventions via targeting intratumoral dysregulated metabolism pathways have shown promise in reinvigorating antitumor immunity. However, approved small molecule immunomodulators often suffer from ineffective response rates and severe off‐target toxicity. ATP occupies a crucial role in energy metabolism of components that form the tumor microenvironment (TME) and influences cancer immunosurveillance. Here, a nanocarrier‐assisted immunometabolic therapy strategy that targets the ATP‐adenosine axis for metabolic reprogramming of TME is reported. An ecto‐enzyme (CD39) antagonist POM1 and AMP‐activated protein kinase (AMPK) agonist metformin are both encapsulated into cancer cell‐derived exosomes and used as nanocarriers for tumor targeting delivery. This method increases the level of pro‐inflammatory extracellular ATP (eATP) while preventing the accumulation of immunosuppressive adenosine and alleviating hypoxia. Elevated eATP triggers the activation of P2X7‐NLRP3‐inflammasome to drive macrophage pyroptosis, potentiates the maturation and antigen capacity of dendritic cells (DCs) to enhance the cytotoxic function of T cells and natural killer (NK) cells. As a result, synergistic antitumor immune responses are initiated to suppress tumor progress, inhibit tumor distant metastases, provide long‐term immune memory that offers protection against tumor recurrence and overcome anti‐PD1 resistance. Overall, this study provides an innovative strategy to advance eATP‐driven antitumor immunity in cancer therapy.
    Type of Medium: Online Resource
    ISSN: 2198-3844 , 2198-3844
    URL: Issue
    URL: Article
    DOI: 10.1002/advs.v9.17
    DOI: 10.1002/advs.202105376
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2808093-2
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  • 2
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    INSL‐3 protein expression in normal and cryptorchid testes of Ziwuling black goats
    Wiley ; 2021
    In:  Reproduction in Domestic Animals Vol. 56, No. 5 ( 2021-05), p. 725-735
    Details
    In: Reproduction in Domestic Animals, Wiley, Vol. 56, No. 5 ( 2021-05), p. 725-735
    Abstract: Ziwuling black goats are typically found in loess plateaus regions and the Ziwuling Nature Reserve. Cryptorchidism is a common disease in this inbred goat, and its pathogenesis has been linked with the expression of insulin‐like factor 3 (INSL‐3). Therefore, this study aimed to investigate anatomical alterations caused by cryptorchism and the expression and distribution of INSL‐3 in normal and cryptorchid testicular tissues. The testicular tissues of 6‐month‐old Ziwuling black goats were collected for microscopic analyses using histochemical, immunohistochemical, immunofluorescence and biometrical methods, as well as Western blotting to compare the expression and distribution of INSL‐3. A lower expression of INSL‐3 was observed in cryptorchid compared with normal testicular tissues ( p   〈  .01). Cryptorchidism caused a significant reduction in layers of spermatogenic epithelium and tubule areas in Ziwuling black goat ( p   〈  .01). The interstitial to seminiferous tubule area ratio was larger in cryptorchid than in normal group. Periodic Acid‐Schiff (PAS) staining revealed pronounced positive bands in the interstitial tissue, while positive Alcian blue (AB) staining was not clear, and AB‐PAS staining revealed a positive red band in the basement membrane of cryptorchid group. Immunofluorescence revealed a strong signal of INSL‐3 expression in Sertoli and peritubular myoid cells, and moderate signal in Leydig and spermatogenic cells in the normal group. However, in cryptorchid testicular tissues, the signal of INSL‐3 expression was strong in primary spermatocytes, occasional in Sertoli cells, limited in Leydig cells and absent in peritubular myoid cells. Furthermore, immunohistochemistry showed that INSL‐3 expression was higher in normal testes compared with cryptorchid testicular tissues ( p   〈  .05), especially in primary spermatocytes and Sertoli cells. Collectively, our results indicate that cryptorchidism is closely related to the disorder of acid glycoprotein metabolism and the reduction in release of INSL‐3 from Leydig cells. Moreover, Sertoli and peritubular myoid cells are crucial for INSL signalling and could underpin further research on the mechanism of cryptorchidism in animal.
    Type of Medium: Online Resource
    ISSN: 0936-6768 , 1439-0531
    URL: Issue
    URL: Article
    DOI: 10.1111/rda.v56.5
    DOI: 10.1111/rda.13911
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2020494-2
    SSG: 12
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  • 3
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    A Nonconjugated Zwitterionic Polymer: Cathode Interfacial Layer Comparable with PFN for Narrow‐Bandgap Polymer Solar Cells
    Wiley ; 2018
    In:  Macromolecular Rapid Communications Vol. 39, No. 14 ( 2018-07)
    Details
    In: Macromolecular Rapid Communications, Wiley, Vol. 39, No. 14 ( 2018-07)
    Abstract: A nonconjugated, alcohol‐soluble zwitterionic polymer, poly(sulfobetaine methacrylate) (denoted by PSBMA), is employed as cathode interfacial layer (CIL) in polymer solar cells (PSCs) based on PTB7‐Th:PC 71 BM. Compared with the control device without CIL, PSCs with PSBMA CILs show significant enhancement on the resulting performance, and the highest power conversion efficiency (PCE) of 8.27% is achieved. Under parallel conditions, PSCs with PSBMA as CIL show comparable performance than those with widely used poly[(9,9‐bis(30‐( N , N ‐dimethylamino)propyl)‐2,7‐fluorene)‐ alt ‐2,7‐(9,9‐ioctylfluorene)] as CIL. The polar groups of PSBMA not only provide a solvent orthogonal solubility in the process of preparation of the devices but also lead to interfacial dipole to the electrode, which promises a better energy level alignment. In addition, PSBMA‐based devices show better abilities of hole blocking. These results indicate that the zwitterionic polymer PSBMA should be a promising CIL in PSC‐based narrow‐bandgap polymers.
    Type of Medium: Online Resource
    ISSN: 1022-1336 , 1521-3927
    URL: Issue
    URL: Article
    DOI: 10.1002/marc.v39.14
    DOI: 10.1002/marc.201700828
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 1475027-2
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  • 4
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    Trifluoromethylphenylacetic Acid as In Situ Accelerant of Ostwald Ripening for Stable and Efficient Perovskite Solar Cells
    Wiley ; 2021
    In:  Solar RRL Vol. 5, No. 5 ( 2021-05)
    Details
    In: Solar RRL, Wiley, Vol. 5, No. 5 ( 2021-05)
    Abstract: Perovskite thin film quality, including large grain size and low defect, is one of the fundamental factors to improve the performance and stability of perovskite solar cells (PSCs). Herein, trifluoromethylphenylacetic acid (TFPA) as the accelerant of Ostwald ripening is introduced and an in situ crystal growth control (ICGC) strategy is developed to obtain high‐quality thin films. With adding a proper amount of TFPA into the FAI/MAX (X is Br and Cl) precursor in the two‐step method, the larger grain size and reduced defect density perovskite are achieved due to Ostwald ripening. The ICGC process makes the average particle size from 476 to 625 nm. The defect density is reduced by a factor of 3.18. The high‐quality thin film endows the champion PSC (SnO 2 /perovskite/spiro‐OMeTAD) with a power conversion efficiency (PCE) of champion PSC higher than 22.19%. Furthermore, TFPA is insoluble in the water and thus TFPA‐modified film is resistive to moisture. The device can be stored in an argon glove box for 2000 h without efficiency change and when exposed to 65–75% relative humidity for more than 1500 h, it retains more than 85% of the initial PCE.
    Type of Medium: Online Resource
    ISSN: 2367-198X , 2367-198X
    URL: Issue
    URL: Article
    DOI: 10.1002/solr.v5.5
    DOI: 10.1002/solr.202100040
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2882014-9
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  • 5
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    Electrochemical Hydrogen Evolution Reaction Efficiently Catalyzed by Ru 2 P Nanoparticles
    Wiley ; 2018
    In:  ChemSusChem Vol. 11, No. 16 ( 2018-08-22), p. 2724-2729
    Details
    In: ChemSusChem, Wiley, Vol. 11, No. 16 ( 2018-08-22), p. 2724-2729
    Abstract: Developing alternatives to Pt catalysts is a prerequisite to cost‐effectively produce hydrogen. Herein, we demonstrate Ru 2 P nanoparticles (without any doping and modifications) as a highly efficient Pt‐like catalyst for the hydrogen evolution reaction (HER) in different pH electrolytes. On transferring the hexagonal close‐packed crystal structure of Ru to the orthorhombic structure of Ru 2 P, a greatly improved catalytic activity and stability toward HER is found owing to Ru−P coordination. The electronic state change originates from the P−Ru bonding structures, which accounts for the HER activity improvement compared with Ru nanoparticles. Specifically, Ru 2 P nanoparticles can drive 10 mA cm −2 at a very low overpotential of 55 mV, only 8 mV more than Pt/C in an acidic solution; and an extremely low overpotential of approximately 50 mV is needed in alkaline solution, about 20 mV less than the Pt/C catalyst. The Volmer–Tafel mechanism is indicated on Ru 2 P nanoparticles with the typical Tafel slope of 30 mV dec −1 of Pt metal indicating a Pt‐like catalytic ability. Ru 2 P is more active in the Ru‐P family as H atoms prefer to adsorb on Ru atoms rather than on the P element according to theoretical calculations. Considering the low price of Ru (20 % of Pt), anti‐corrosion ability in the electrolyte, and the safe and reliable fabrication approach, the powder Ru 2 P nanoparticles make an excellent HER catalyst with great promise for large‐scale water electrolysis applications.
    Type of Medium: Online Resource
    ISSN: 1864-5631 , 1864-564X
    URL: Issue
    URL: Article
    DOI: 10.1002/cssc.v11.16
    DOI: 10.1002/cssc.201801103
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2411405-4
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  • 6
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    Perovskite Bifunctional Diode with High Photovoltaic and Electroluminescent Performance by Holistic Defect Passivation
    Wiley ; 2022
    In:  Small Vol. 18, No. 7 ( 2022-02)
    Details
    In: Small, Wiley, Vol. 18, No. 7 ( 2022-02)
    Abstract: Integration of photovoltaic (PV) and electroluminescent (EL) functions and/or units in one device is attractive for new generation optoelectronic devices but it is challenging to achieve highly comprehensive efficiency. Herein, perovskite solar cells (PSCs) are fabricated, assisted by 3‐sulfopropyl methacrylate potassium salt (SPM) additive to tackle this issue. SPMs not only induce large grain size during the film formation but also produce a secondary phase of 2D K 2 PbI 4 to passivate the grain boundaries (GBs). In addition, its sulfonic acid group and potassium ion can coordinate to lead ion and fill the interstitial defects, respectively. Thus, SPM reduces the defective states and suppresses nonradiative recombination loss. As a result, planar PSC delivers a power conversion efficiency of ≈22%, with a maximum open‐circuit voltage ( V oc ) of 1.20 V. The V oc is 94% of the radiative V oc limit (1.28 V), higher than the control device ( V oc of 1.12 V). In addition, the reciprocity between PV and EL is also correlated to quantify the energy losses and understand the device physics. When operated as a light‐emitting diode, the maximum EL external quantum efficiency (EQE EL ) is up to 12.2% (EQE EL of 10.7% under an injection current of short‐circuit photocurrent), thus leading to high‐performance PV/EL dual functions.
    Type of Medium: Online Resource
    ISSN: 1613-6810 , 1613-6829
    URL: Issue
    URL: Article
    DOI: 10.1002/smll.v18.7
    DOI: 10.1002/smll.202105196
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2168935-0
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  • 7
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    PEDOT:PSS‐Metal Oxide Composite Electrode with Regulated Wettability and Work Function for High‐Performance Inverted Perovskite Solar Cells
    Wiley ; 2020
    In:  Advanced Optical Materials Vol. 8, No. 17 ( 2020-09)
    Details
    In: Advanced Optical Materials, Wiley, Vol. 8, No. 17 ( 2020-09)
    Abstract: Poly(3,4‐ethylenedioxythiophene):polystyrenesulfonate (PEDOT:PSS) can be roll‐to‐roll deposited on the substrate facilely in the electronics, but its acidity and mismatched energy level limit the performance and stability. Herein, different metal salts are incorporated into PEDOT:PSS solution to prepare PEDOT:PSS‐A x O y (metal oxide) composite hole transport layer and it is found that the performance of inverted perovskite solar cells (PSCs) can be greatly enhanced. PSC using PEDOT:PSS‐MoO x has achieved much higher power conversion efficiency (PCE) (19.64%) than that of pristine PEDOT:PSS (12.19%). Two key factors are important for the performance enhancement. First, the increased surface free energy of PEDOT:PSS‐A x O y is beneficial for the formation of large crystal size and pinhole‐free film, leading to reduced nonradiative recombination. Second, the work function of PEDOT:PSS can be tuned to match the energy level of photoactive layer with small amount incorporation, which greatly enhances the photovoltage by a factor of 1.1. Besides, the devices based on PEDOT:PSS‐A x O y exhibit improved long‐term stability. Unencapsulated PSCs with PEDOT:PSS‐MoO x retain over 90% and 80% of their initial PCEs in N 2 for 45 d and in ambient air for 20 d, respectively. The modified PEDOT:PSS solutions overcome the intrinsic imperfection and can be potentially employed for large‐scale production in the electronic devices.
    Type of Medium: Online Resource
    ISSN: 2195-1071 , 2195-1071
    URL: Issue
    URL: Article
    DOI: 10.1002/adom.v8.17
    DOI: 10.1002/adom.202000216
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2708158-8
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  • 8
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    Resonance‐Mediated Dynamic Modulation of Perovskite Crystallization for Efficient and Stable Solar Cells
    Wiley ; 2022
    In:  Advanced Materials Vol. 34, No. 6 ( 2022-02)
    Details
    In: Advanced Materials, Wiley, Vol. 34, No. 6 ( 2022-02)
    Abstract: Manipulating perovskite crystallization to prepare high‐quality perovskite films is the key to achieving highly efficient and stable perovskite solar cells (PSCs). Here, a dynamic strategy is proposed to modulate perovskite crystallization using a resonance hole‐transporting material (HTM) capable of fast self‐adaptive tautomerization between multiple electronic states with neutral and charged resonance forms for mediating perovskite crystal growth and defect passivation in situ. This approach, based on resonance variation with self‐adaptive molecular interactions between the HTM and the perovskite, produces high‐quality perovskite films with smooth surface, oriented crystallization, and low charge recombination, leading to high‐performance inverted PSCs with power conversion efficiencies approaching 22% for small‐area devices (0.09 cm 2 ) and up to 19.5% for large‐area devices (1.02 cm 2 ). Also, remarkably high stability of the PSCs is observed, retaining over 90%, 88%, or 83% of the initial efficiencies in air with relative humidity of 40–50%, under continuous one‐sun illumination, or at 75 °C annealing for 1000 h without encapsulation.
    Type of Medium: Online Resource
    ISSN: 0935-9648 , 1521-4095
    URL: Issue
    URL: Article
    DOI: 10.1002/adma.v34.6
    DOI: 10.1002/adma.202107111
    RVK:
    UA 1538
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 1474949-X
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  • 9
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    Comparison of MMP ‐2 and TIMP ‐2 expressions in yak testes at different ages
    Wiley ; 2023
    In:  Reproduction in Domestic Animals Vol. 58, No. 6 ( 2023-06), p. 746-753
    Details
    In: Reproduction in Domestic Animals, Wiley, Vol. 58, No. 6 ( 2023-06), p. 746-753
    Abstract: This study aimed to investigate the distribution and expression of matrix metalloproteinase‐2 (MMP‐2) and tissue inhibitor of matrix metalloproteinase‐2 (TIMP‐2) in yak testes. The testes of healthy yaks at different ages: newborn [3 days], young [1 year] , adult [4 years], and old [9 years] were collected for microscopic analyses using hematoxylin and eosin staining, immunohistochemistry and immunofluorescence, as well as western blot to compare the expression of MMP‐2 and TIMP‐2. Furthermore, the levels of MMP‐2 mRNA and TIMP‐2 mRNA was detected by real‐time quantitative polymerase chain reaction (qPCR). The results of immunohistochemistry and immunofluorescence demonstrated that MMP‐2 and TIMP‐2 were mainly located in gonocytes of newborn, Sertoli cells of young, spermatozoa of adult and Leydig cells of old. The protein levels of MMP‐2 and TIMP‐2 exhibited a downward from newborn to adult, but increased again in old yaks. The analysis of qPCR showed that MMP‐2 was higher in young compared with newborn or adult(** p   〈  .01), but a lower expression was detected in adult compared with old yak testicular tissues (* p   〈  .05). Compared with adults, TIMP‐2 was significantly higher in newborn and young yaks (** p   〈  .01), and slightly higher in old yaks (* p   〈  .05). Hence, The location of MMP‐2 and TIMP‐2 in gonocytes were associated with the development of newborn yak testes. The expression of MMP‐2 and TIMP‐2 in Sertoli cells at young and adult yaks suggested that they provided a clue for the regulation of spermatogenesis. The positive labeling of MMP‐2 and TIMP‐2 in Leydig cells in old yaks suggested that both may be involved in the interstitial metabolism of the testes during this period. This study revealed the possible role of MMP‐2 and TIMP‐2 in testicular functionality of yaks at different ages.
    Type of Medium: Online Resource
    ISSN: 0936-6768 , 1439-0531
    URL: Issue
    URL: Article
    DOI: 10.1111/rda.v58.6
    DOI: 10.1111/rda.14345
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2020494-2
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  • 10
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    Reexamining the Post‐Treatment Effects on Perovskite Solar Cells: Passivation and Chloride Redistribution
    Wiley ; 2023
    In:  Small Methods Vol. 7, No. 3 ( 2023-03)
    Details
    In: Small Methods, Wiley, Vol. 7, No. 3 ( 2023-03)
    Abstract: Post‐treatment is an essential passivation step for the state‐of‐the‐art perovskite solar cells (PSCs) but the additional role is not yet exploited. In this work, perovskite film is fabricated under ambient air with wide humidity window and identify that chloride redistribution induced by post‐treatment plays an important role in high performance. The chlorine/iodine ratio on the perovskite surface increases from 0.037 to 0.439 after cyclohexylmethylammonium iodide (CHMAI) treatment and the PSCs deliver a champion power conversion efficiency (PCE) of 24.42% (certificated 23.60%). The maximum external quantum efficiency of electroluminescence (EQE EL ) reaches to 10.84% with a radiance of 170 W sr −1  m −2 , forming the reciprocity relation between EQE EL and nonradiative open‐circuit voltage loss (86.0 mV). After thermal annealing, 2D component of perovskite will increase while chloride decline, leading to improved photovoltage but reduced fill factor. Hence, it distinguishes that chloride enrichment can improve charge transport/recombination simultaneously and 2D passivation can suppress the nonradiative recombination. Moreover, CHMAI can leverage their roles in charge transport/recombination for better performance than phenylethylammonium iodide (Cl/I = 0.114, PCE = 23.32%), due to the stronger binding energy of Cl − . This work provides the insight that the chloride fixation can improve the photovoltaic performance.
    Type of Medium: Online Resource
    ISSN: 2366-9608 , 2366-9608
    URL: Issue
    URL: Article
    DOI: 10.1002/smtd.v7.3
    DOI: 10.1002/smtd.202201467
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2884448-8
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