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  • 1
    Online Resource
    Online Resource
    Studying Complex Evolution of Hyperelastic Materials under External Field Stimuli using Artificial Neural Networks with Spatiotemporal Features in a Small‐Scale Dataset
    Wiley ; 2022
    In:  Advanced Materials Vol. 34, No. 26 ( 2022-07)
    Details
    In: Advanced Materials, Wiley, Vol. 34, No. 26 ( 2022-07)
    Abstract: Deep‐learning (DL) methods, in consideration of their excellence in dealing with highly complex structure–performance relationships for materials, are expected to become a new design paradigm for breakthroughs in material performance. However, in most cases, it is impractical to collect massive‐scale experimental data or open‐source theoretical databases to support training DL models with sufficient prediction accuracy. In a dataset consisting of 483 porous silicone rubber observations generated via ink‐writing additive manufacturing, this work demonstrates that constructing low‐dimensional, accurate descriptors is the prerequisite for obtaining high‐precision DL models based on small experimental datasets. On this basis, a unique convolutional bidirectional long short‐term memory model with spatiotemporal features extraction capability is designed, whose hierarchical learning mechanism further reduces the requirement for the amount of data by taking full advantage of data information. The proposed approach can be expected as a powerful tool for innovative material design on small experimental datasets, which can also be used to explore the evolutionary mechanisms of the structures and properties of materials under complex working conditions.
    Type of Medium: Online Resource
    ISSN: 0935-9648 , 1521-4095
    URL: Issue
    URL: Article
    DOI: 10.1002/adma.v34.26
    DOI: 10.1002/adma.202200908
    RVK:
    UA 1538
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 1474949-X
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  • 2
    Online Resource
    Online Resource
    Distinctive regulation and function of PI 3K/Akt and MAPKs in doxorubicin-induced apoptosis of human lung adenocarcinoma cells
    Wiley ; 2004
    In:  Journal of Cellular Biochemistry Vol. 91, No. 3 ( 2004-02-15), p. 621-632
    Details
    In: Journal of Cellular Biochemistry, Wiley, Vol. 91, No. 3 ( 2004-02-15), p. 621-632
    Type of Medium: Online Resource
    ISSN: 0730-2312 , 1097-4644
    URL: Issue
    URL: Journal
    URL: Article
    DOI: 10.1002/jcb.v91:3
    DOI: 10.1002/(ISSN)1097-4644
    DOI: 10.1002/jcb.10751
    Language: English
    Publisher: Wiley
    Publication Date: 2004
    detail.hit.zdb_id: 1479976-5
    SSG: 12
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  • 3
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    Online Resource
    Mineral trioxide aggregate enhances the osteogenic capacity of periodontal ligament stem cells via NF‐κB and MAPK signaling pathways
    Wiley ; 2018
    In:  Journal of Cellular Physiology Vol. 233, No. 3 ( 2018-03), p. 2386-2397
    Details
    In: Journal of Cellular Physiology, Wiley, Vol. 233, No. 3 ( 2018-03), p. 2386-2397
    Abstract: Mineral trioxide aggregate (MTA), as a bioactive material, has a widespread application in clinical practice. To date, the effects of MTA on the proliferation and differentiation of human periodontal ligament stem cells (hPDLSCs) remain unclear. hPDLSCs were isolated from human periodontal ligament tissues and cultured with MTA conditioned media. Cell counting kit‐8 (CCK‐8) assay was performed to assess the proliferation capacity of MTA‐treated hPDLSCs. Immunofluorescence assay, alkaline phosphatase (ALP) activity, alizarin red staining, real‐time RT‐PCR, and western blot analyses were used to investigate the odonto/osteogenic capacity of hPDLSCs as well as the involvement of NF‐κB and MAPK pathways. ALP activity assay revealed that 2 mg/ml was the optimal concentration for the induction of hPDLSCs by MTA. The protein expression of DSP, RUNX2, OCN, OSX, OPN, DMP1, ALP, and COL‐I in MTA‐treated hPDLSCs was significantly higher than those in control group ( p  〈  0.01). When hPDLSCs were treated with the inhibitors of NF‐κB and MAPK pathways (U0126, SP600125, SB203580, and BMS345541), the effects of MTA on the differentiation of hPDLSCs were suppressed. Mechanistically, P65 was detected to transfer from cytoplasm to nuclei, as indicated by western blot and immunofluorescence assay. Moreover, MAPK‐related proteins and its downstream transcription factors were also upregulated in MTA‐treated hPDLSCs. Together, mineral trioxide aggregate can promote the odonto/osteogenic capacity of hPDLSCs via activating the NF‐κB and MAPK pathways.
    Type of Medium: Online Resource
    ISSN: 0021-9541 , 1097-4652
    URL: Issue
    URL: Article
    DOI: 10.1002/jcp.v233.3
    DOI: 10.1002/jcp.26110
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 1478143-8
    SSG: 12
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  • 4
    Online Resource
    Online Resource
    3D‐Printed Coaxial Fibers for Integrated Wearable Sensor Skin
    Wiley ; 2019
    In:  Advanced Materials Technologies Vol. 4, No. 10 ( 2019-10)
    Details
    In: Advanced Materials Technologies, Wiley, Vol. 4, No. 10 ( 2019-10)
    Abstract: Coaxial 3D printing technology, with its advantages of scalability and controllability, is applied in research to develop integrated wearable sensors composed of pressure sensor arrays and strain sensors. In order to improve the performance of the pressure sensor array, microstructures molded from sandpaper are introduced into the contact interface of the extruded fibers, resulting in a sensitivity (defined as the ratio of capacitance change to the change of applied pressure) of 0.562 kPa −1 , a response/relaxation time of 230 ms, and a high durability. The printed strain sensor has a sensitivity (defined as the ratio of resistance change to the change of applied strain) of 11.8 and a good stability for 10 000 cycles. The high‐performance pressure sensor array and strain sensors give the integrated device the ability to detect various mechanical stimuli such as pressing, bending, twisting, and shear forces, showing potential application in the field of electronic skin.
    Type of Medium: Online Resource
    ISSN: 2365-709X , 2365-709X
    URL: Issue
    URL: Article
    DOI: 10.1002/admt.v4.10
    DOI: 10.1002/admt.201900504
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 2850995-X
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  • 5
    Online Resource
    Online Resource
    Reticular Chemistry‐Enabled Sonodynamic Activity of Covalent Organic Frameworks for Nanodynamic Cancer Therapy
    Wiley ; 2023
    In:  Angewandte Chemie Vol. 135, No. 20 ( 2023-05-08)
    Details
    In: Angewandte Chemie, Wiley, Vol. 135, No. 20 ( 2023-05-08)
    Abstract: The development of covalent organic framework (COF) sonosensitizers with intrinsic sonodynamic effects is highly desirable. However, such COFs are generally constructed using small‐molecule photosensitizers. Herein, we report that the reticular chemistry‐based synthesis of COFs from two inert monomers yields a COF‐based sonosensitizer (TPE‐NN) with inherent sonodynamic activity. Subsequently, a nanoscale COF TPE‐NN is fabricated and embedded with copper (Cu)‐coordinated sites to obtain TPE‐NN‐Cu. Results show that Cu coordination can enhance the sonodynamic effect of TPE‐NN, whereas ultrasound (US) irradiation for sonodynamic therapy can augment the chemodynamic efficacy of TPE‐NN‐Cu. Consequently, TPE‐NN‐Cu upon US irradiation shows high‐performance anticancer effects based on mutually reinforced sono‐/chemo‐nanodynamic therapy. This study reveals the backbone‐originated sonodynamic activity of COFs and proposes a paradigm of intrinsic COF sonosensitizers for nanodynamic therapy.
    Type of Medium: Online Resource
    ISSN: 0044-8249 , 1521-3757
    URL: Issue
    URL: Article
    DOI: 10.1002/ange.v135.20
    DOI: 10.1002/ange.202302146
    RVK:
    VA 2100
    RVK:
    VN 5020
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 505868-5
    detail.hit.zdb_id: 506609-8
    detail.hit.zdb_id: 514305-6
    detail.hit.zdb_id: 505872-7
    detail.hit.zdb_id: 1479266-7
    detail.hit.zdb_id: 505867-3
    detail.hit.zdb_id: 506259-7
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  • 6
    Online Resource
    Online Resource
    Persistent Endoplasmic Reticulum Stress Stimulated by Peptide Assemblies for Sensitizing Cancer Chemotherapy
    Wiley ; 2023
    In:  Advanced Healthcare Materials Vol. 12, No. 5 ( 2023-02)
    Details
    In: Advanced Healthcare Materials, Wiley, Vol. 12, No. 5 ( 2023-02)
    Abstract: Pharmacological targeting of endoplasmic reticulum (ER) stress represents one of important methods for disease therapy, which, however, is significantly suppressed by the ER homeostatic processe. Herein, a proof‐of‐concept strategy is reported for persistent stimulation of ER stress via preventing ER stress adaptation by utilizing multifunctional peptide assemblies. The strategy is established via creation of peptide assemblies with ER‐targeting and chaperone glucose‐regulated protein 78 (GRP78)‐inhibiting functions. The peptides assemblies form well‐defined nanofibers that are retrieved by ER organelles in human cervical cancer cell. The underlying mechanism studies unravel that the ER‐accumulated peptide assemblies simultaneously stimulate ER stress and inhibit GRP78 refolding activity and thereby promoting endogenous protein aggregation. Combining the internalized peptide assemblies with the induced protein aggregates leads to the persistent stimulation of ER stress. The persistent ER stress induced by the peptide assemblies bestows their application in sensitizing cancer chemotherapy. Both in vitro and in vivo results confirm the enhanced cytotoxicity of drug toyocamycin against HeLa cells by peptide assemblies, thus efficiently inhibiting in vivo tumor growth. The strategy reported here discloses the fundamental keys for efficient promotion of ER stress, thus providing the guidance for development of ER‐targeting‐assisted cancer chemotherapy in the future.
    Type of Medium: Online Resource
    ISSN: 2192-2640 , 2192-2659
    URL: Issue
    URL: Article
    DOI: 10.1002/adhm.v12.5
    DOI: 10.1002/adhm.202202039
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2645585-7
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  • 7
    Online Resource
    Online Resource
    MicroRNA hsa ‐ let ‐7 b suppresses the odonto/osteogenic differentiation capacity of stem cells from apical papilla by targeting MMP1
    Wiley ; 2018
    In:  Journal of Cellular Biochemistry Vol. 119, No. 8 ( 2018-08), p. 6545-6554
    Details
    In: Journal of Cellular Biochemistry, Wiley, Vol. 119, No. 8 ( 2018-08), p. 6545-6554
    Abstract: MicroRNA let‐7 family acts as the key regulator of the differentiation of mesenchymal stem cells (MSCs). However, the influence of let‐7b on biological characteristics of stem cells from apical papilla (SCAPs) is still controversial. In this study, the expression of hsa‐let‐7b was obviously downregulated during the osteogenic differentiation of SCAPs. SCAPs were then infected with hsa‐let‐7b or hsa‐let‐7b inhibitor lentiviruses. The proliferation ability was determined by CCK‐8 and flow cytometry. The odonto/osteogenic differentiation capacity was analyzed by alkaline phosphatase (ALP) activity, alizarin red staining, Western blot assay, and real‐time RT‐PCR. Bioinformatics analysis was used to screen out the target of hsa‐let‐7b and the target relationship was confirmed by dual luciferase reporter assay. Hsa‐let‐7b was of no influence on the proliferation of SCAPs. Interferential expression of hsa‐let‐7b increased the ALP activity as well as the formation of calcified nodules of SCAPs. Moreover, the mRNA levels of osteoblastic markers ( ALP , RUNX2 , OSX , OPN , and OCN ) were upregulated while the protein levels of DSPP, ALP, RUNX2, OSX, OPN, and OCN also increased considerably. Conversely, overexpression of hsa‐let‐7b inhibited the odonto/osteogenic differentiation capacity of SCAPs. Bioinformatics analysis revealed a putative binding site of hsa‐let‐7b in the matrix metalloproteinase 1 ( MMP 1) 3′‐untranslated region (3′‐UTR). Dual luciferase reporter assay confirmed that hsa‐let‐7b targets MMP 1. The odonto/osteogenic differentiation ability of SCAPs ascended after repression of hsa‐let‐7b , which was then reversed after co‐transfection with si MMP 1. Together, hsa‐let‐7b can suppress the odonto/osteogenic differentiation capacity of SCAPs by targeting MMP 1.
    Type of Medium: Online Resource
    ISSN: 0730-2312 , 1097-4644
    URL: Issue
    URL: Article
    DOI: 10.1002/jcb.v119.8
    DOI: 10.1002/jcb.26737
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 1479976-5
    SSG: 12
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  • 8
    Online Resource
    Online Resource
    Reticular Chemistry‐Enabled Sonodynamic Activity of Covalent Organic Frameworks for Nanodynamic Cancer Therapy
    Wiley ; 2023
    In:  Angewandte Chemie International Edition Vol. 62, No. 20 ( 2023-05-08)
    Details
    In: Angewandte Chemie International Edition, Wiley, Vol. 62, No. 20 ( 2023-05-08)
    Abstract: The development of covalent organic framework (COF) sonosensitizers with intrinsic sonodynamic effects is highly desirable. However, such COFs are generally constructed using small‐molecule photosensitizers. Herein, we report that the reticular chemistry‐based synthesis of COFs from two inert monomers yields a COF‐based sonosensitizer (TPE‐NN) with inherent sonodynamic activity. Subsequently, a nanoscale COF TPE‐NN is fabricated and embedded with copper (Cu)‐coordinated sites to obtain TPE‐NN‐Cu. Results show that Cu coordination can enhance the sonodynamic effect of TPE‐NN, whereas ultrasound (US) irradiation for sonodynamic therapy can augment the chemodynamic efficacy of TPE‐NN‐Cu. Consequently, TPE‐NN‐Cu upon US irradiation shows high‐performance anticancer effects based on mutually reinforced sono‐/chemo‐nanodynamic therapy. This study reveals the backbone‐originated sonodynamic activity of COFs and proposes a paradigm of intrinsic COF sonosensitizers for nanodynamic therapy.
    Type of Medium: Online Resource
    ISSN: 1433-7851 , 1521-3773
    URL: Issue
    URL: Article
    DOI: 10.1002/anie.v62.20
    DOI: 10.1002/anie.202302146
    RVK:
    VA 2100
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2011836-3
    detail.hit.zdb_id: 123227-7
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  • 9
    Online Resource
    Online Resource
    Synthesis of Cinnamides via Amidation Reaction of Cinnamic Acids with Tetraalkylthiuram Disulfides Under Simple Condition
    Wiley ; 2020
    In:  European Journal of Organic Chemistry Vol. 2020, No. 2 ( 2020-01-16), p. 198-208
    Details
    In: European Journal of Organic Chemistry, Wiley, Vol. 2020, No. 2 ( 2020-01-16), p. 198-208
    Abstract: A facile and efficient methodology for the synthesis of cinnamides has been achieved under metal‐ and additive‐free conditions. This method allows the efficient C–N cross‐coupling of diverse cinnamic acids with tetraalkylthiuram disulfides through a simply mixing operation in 1,2‐dichloroethane at 100 °C. The protocol provides a direct approach to cinnamides and is featured with readily available starting materials and broad substrate scope, which shows its practical synthetic value in organic synthesis.
    Type of Medium: Online Resource
    ISSN: 1434-193X , 1099-0690
    URL: Issue
    URL: Article
    DOI: 10.1002/ejoc.v2020.2
    DOI: 10.1002/ejoc.201901630
    RVK:
    VA 4073
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 1475010-7
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  • 10
    Online Resource
    Online Resource
    Parathyroid hormone enhances the osteo/odontogenic differentiation of dental pulp stem cells via ERK and P38 MAPK pathways
    Wiley ; 2020
    In:  Journal of Cellular Physiology Vol. 235, No. 2 ( 2020-02), p. 1209-1221
    Details
    In: Journal of Cellular Physiology, Wiley, Vol. 235, No. 2 ( 2020-02), p. 1209-1221
    Abstract: Parathyroid hormone (PTH) is a main systemic mediator of calcium and phosphate homeostasis in the bone. Dental pulp stem cells (DPSCs) have been extensively studied in the regeneration of bone and tooth tissues. This paper aims to uncover the influences of PTH on the proliferative ability and osteo/odontogenic differentiation of DPSCs, as well as the underlying mechanisms. Materials and Methods The optimal concentration of PTH on DPSCs was determined by alkaline phosphatase (ALP) activity assay, ALP staining and western blot analysis. Proliferative ability and cell cycle distribution of DPSCs were analyzed by Cell counting kit‐8, 5‐ethynyl‐20‐deoxyuridine assay, and flow cytometry. Osteo/odontogenic capacity of DPSCs was evaluated and finally, the involvement of mitogen‐activated protein kinase (MAPK) pathway was assessed. Results Purified DPSCs were obtained by enzymatic digestion, which presented a typical fibroblast‐like morphology. 10 −9  mol/L PTH was concerned as the optimal concentration for DPSCs induction. 10 −9  mol/L PTH treatment did not change the proliferative rate of DPSCs ( p  〉   .05). Relative expressions of DSPP /DSPP, RUNX2 /RUNX2, OSX /OSX, and ALP /ALP were upregulated in PTH‐treated DPSCs relative to control group. Particularly, their mRNA/protein levels at Day 7 were markedly higher relative to those at Day 3 ( p  〈   .05 or p  〈  .01). Mineralized nodules were formed after PTH induction, and calcium content increased by cetylpyridinium chloride quantitative analysis. Mechanistically, the protein levels of p‐ERK and p‐P38 significantly increased after PTH treatment, and the inhibitors targeting MAPK were identified that weakened the effects of PTH on the committed differentiation of DPSCs. Conclusions PTH enhances the osteo/odontogenic differentiation capacity of DPSCs via ERK and P38 signaling pathways.
    Type of Medium: Online Resource
    ISSN: 0021-9541 , 1097-4652
    URL: Issue
    URL: Article
    DOI: 10.1002/jcp.v235.2
    DOI: 10.1002/jcp.29034
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 1478143-8
    SSG: 12
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