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  • 1
    Online Resource
    Online Resource
    High levels of soluble CD25 in COVID‐19 severity suggest a divergence between anti‐viral and pro‐inflammatory T‐cell responses
    Wiley ; 2021
    In:  Clinical & Translational Immunology Vol. 10, No. 2 ( 2021-01)
    Details
    In: Clinical & Translational Immunology, Wiley, Vol. 10, No. 2 ( 2021-01)
    Abstract: We aimed to gain an understanding of the paradox of the immunity in COVID‐19 patients with T cells showing both functional defects and hyperactivation and enhanced proliferation. Methods A total of 280 hospitalised patients with COVID‐19 were evaluated for cytokine profiles and clinical features including viral shedding. A mouse model of acute infection by lymphocytic choriomeningitis virus (LCMV) was applied to dissect the relationship between immunological, virological and pathological features. The results from the mouse model were validated by published data set of single‐cell RNA sequencing (scRNA‐seq) of immune cells in bronchoalveolar lavage fluid (BALF) of COVID‐19 patients. Results The levels of soluble CD25 (sCD25), IL‐6, IL‐8, IL‐10 and TNF‐α were higher in severe COVID‐19 patients than non‐severe cases, but only sCD25 was identified as an independent risk factor for disease severity by multivariable binary logistic regression analysis and showed a positive association with the duration of viral shedding. In agreement with the clinical observation, LCMV‐infected mice with high levels of sCD25 demonstrated insufficient anti‐viral response and delayed viral clearance. The elevation of sCD25 in mice was mainly contributed by the expansion of CD25 + CD8 + T cells that also expressed the highest level of PD‐1 with pro‐inflammatory potential. The counterpart human CD25 + PD‐1 + T cells were expanded in BALF of COVID‐19 patients with severe disease compared to those with modest disease. Conclusion These results suggest that high levels of sCD25 in COVID‐19 patients probably result from insufficient anti‐viral immunity and indicate an expansion of pro‐inflammatory T cells that contribute to disease severity.
    Type of Medium: Online Resource
    ISSN: 2050-0068 , 2050-0068
    URL: Issue
    URL: Article
    DOI: 10.1002/cti2.v10.2
    DOI: 10.1002/cti2.1251
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2694482-0
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  • 2
    Online Resource
    Online Resource
    Highly Efficient Hydrogen Evolution from a Mesoporous Hybrid of Nickel Phosphide Nanoparticles Anchored on Cobalt Phosphosulfide/Phosphide Nanosheet Arrays
    Wiley ; 2019
    In:  Small Vol. 15, No. 6 ( 2019-02)
    Details
    In: Small, Wiley, Vol. 15, No. 6 ( 2019-02)
    Abstract: Facile design of low‐cost and high‐efficiency catalysts with earth‐abundant and cheap materials is desirable to replace platinum (Pt) for the hydrogen evolution reaction (HER) in water splitting, but the development of such HER catalysts with Pt‐like activity using simple strategies remains challenging. A mesoporous hybrid catalyst of nickel phosphides nanoparticles and cobalt phosphosulfide/phosphide (CoS|Ni|P) nanosheet arrays for HER is reported here, which is developed by a facile three‐step approach consisting of electrodeposition, thermal sulfurization, and phosphorization. This hybrid catalyst is highly robust and stable in acid for HER, and is distinguished by very low overpotentials of 41, 88, and 150 mV to achieve 10, 100, and 1000 mA cm −2 , respectively, as well as a small Tafel slope (45.2 mV dec −1 ), and a large exchange current density (964 µA cm −2 ). It is among the most efficient earth‐abundant catalysts reported thus far for HER. More importantly, this electrocatalyst has electrochemical durability over 20 h under a wide range of current densities (up to 1 A cm −2 ) in acidic conditions, as well as very high turnover frequencies of 0.40 and 1.26 H 2 s −1 at overpotentials of 75 and 100 mV, respectively, showing that it has great potential for practical applications in large‐scale water electrolysis.
    Type of Medium: Online Resource
    ISSN: 1613-6810 , 1613-6829
    URL: Issue
    URL: Article
    DOI: 10.1002/smll.v15.6
    DOI: 10.1002/smll.201804272
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 2168761-4
    detail.hit.zdb_id: 2168935-0
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  • 3
    Online Resource
    Online Resource
    Gendered effects on inflammation reaction and outcome of COVID‐19 patients in Wuhan
    Wiley ; 2020
    In:  Journal of Medical Virology Vol. 92, No. 11 ( 2020-11), p. 2684-2692
    Details
    In: Journal of Medical Virology, Wiley, Vol. 92, No. 11 ( 2020-11), p. 2684-2692
    Abstract: Gender is a risk factor for mortality of COVID‐19 adjusted by age, comorbidity, and smoking history. Excess inflammation reaction is related to severity of COVID‐19. Male patients with COVID‐19 develop greater inflammation reaction than females do. Gender‐specific inflammation reaction contributes to sex bias in outcome of COVID‐19.
    Type of Medium: Online Resource
    ISSN: 0146-6615 , 1096-9071
    URL: Issue
    URL: Article
    DOI: 10.1002/jmv.v92.11
    DOI: 10.1002/jmv.26137
    RVK:
    XA 10000
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 752392-0
    detail.hit.zdb_id: 1475090-9
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  • 4
    Online Resource
    Online Resource
    Analysis of the 2OG‐Fe (II) oxygenase family reveals new insights associated with flowering regulation in Saccharum spontaneum
    Wiley ; 2024
    In:  Crop Science Vol. 64, No. 1 ( 2024-01), p. 260-277
    Details
    In: Crop Science, Wiley, Vol. 64, No. 1 ( 2024-01), p. 260-277
    Abstract: Transcriptome sequencing reveals flowering‐related genes and pathways in Saccharum spontaneum . 122 2OG‐Fe (II) oxygenase genes are identified and compared with Oryza sativa and Arabidopsis . 2OG‐Fe (II) oxygenase genes are involved in flavonoid biosynthesis and flowering promotion in S. spontaneum . qPCR validates the expression patterns of key 2OG‐Fe (II) oxygenase genes in inflorescences of S. spontaneum .
    Type of Medium: Online Resource
    ISSN: 0011-183X , 1435-0653
    URL: Issue
    URL: Article
    DOI: 10.1002/csc2.v64.1
    DOI: 10.1002/csc2.21136
    Language: English
    Publisher: Wiley
    Publication Date: 2024
    detail.hit.zdb_id: 2375444-8
    detail.hit.zdb_id: 1480918-7
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  • 5
    Online Resource
    Online Resource
    Clinical heterogeneity and intrafamilial variability of Joubert syndrome in two siblings with CPLANE1 variants
    Wiley ; 2021
    In:  Molecular Genetics & Genomic Medicine Vol. 9, No. 6 ( 2021-06)
    Details
    In: Molecular Genetics & Genomic Medicine, Wiley, Vol. 9, No. 6 ( 2021-06)
    Abstract: Joubert syndrome (JBTS) is a rare genetic disorder that is characterized by midbrain‐hindbrain malformations. Multiple variants in genes that affect ciliary function contribute to the genetic and clinical heterogeneity of JBTS and its subtypes. However, the correlation between genotype and phenotype has not been elucidated due to the limited number of patients available. Methods In this study, we observed different clinical features in two siblings from the same family. The older sibling was classified as a pure JBTS patient, whereas her younger sibling displayed oral‐facial‐digital defects and was therefore classified as an oral‐facial‐digital syndrome type VI (OFD VI) patient. Next, we performed human genetic tests to identify the potential pathogenic variants in the two siblings. Results Genetic sequencing indicated that both siblings harbored compound heterozygous variants of a missense variant (c.1067C 〉 T, p.S356F) and a frameshift variant (c.8377_8378del, p.E2793Lfs*24) in CPLANE1 (NM_023073.3). Conclusion This study reports that two novel CPLANE1 variants are associated with the occurrence of JBTS and OFD VI. These results help elucidate the intrafamilial phenotypic variability associated with CPLANE1 variants.
    Type of Medium: Online Resource
    ISSN: 2324-9269 , 2324-9269
    URL: Issue
    URL: Article
    DOI: 10.1002/mgg3.v9.6
    DOI: 10.1002/mgg3.1682
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2734884-2
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  • 6
    Online Resource
    Online Resource
    [8]‐Gingerol exerts anti‐myocardial ischemic effects in rats via modulation of the MAPK signaling pathway and L‐type Ca 2+ channels
    Wiley ; 2021
    In:  Pharmacology Research & Perspectives Vol. 9, No. 5 ( 2021-10)
    Details
    In: Pharmacology Research & Perspectives, Wiley, Vol. 9, No. 5 ( 2021-10)
    Abstract: Myocardial ischemia (MI) remains the leading cause of mortality worldwide. Therefore, it is urgent to seek the treatment to protect the heart. [8]‐Gingerol (8‐Gin), one of the most active ingredients in ginger, has antioxidant, cardiotonic, and cardiovascular protective properties. The present study elucidated the cardioprotection effects and underlying mechanisms of 8‐Gin in isoproterenol (ISO)‐induced MI. ISO (85 mg/kg/d) was subcutaneously injected for 2 consecutive days to induce acute MI model in rats. Electrocardiography, oxidative stress levels, calcium concentrations, and apoptosis degree were observed. The effects of 8‐Gin on L‐type Ca 2+ current (I Ca‐L ), contraction, and Ca 2+ transients were monitored in rat myocytes via patch‐clamp and IonOptix detection systems. 8‐Gin decreased J‐point elevation and heart rate and improved pathological heart damage. Moreover, 8‐Gin reduced the levels of CK, LDH, and MDA, ROS production, and calcium concentrations in myocardial tissue, while increased the activities of SOD, CAT, and GSH. In addition, 8‐Gin down‐regulated Caspase‐3 and Bax expressions, while up‐regulated Bcl‐2 expression. 8‐Gin produced a marked decrease in the expression of p38, JNK, and ERK1/2 proteins. 8‐Gin inhibited I Ca‐L , cell contraction, and Ca 2+ transients in isolated rat myocytes. The results indicate that 8‐Gin could exert anti‐myocardial ischemic effects, which may be associated with oxidative stress reduction, cardiomyocytes apoptosis inhibition through MAPK signaling pathway, and Ca 2+ homeostasis regulation via I Ca‐L modulation.
    Type of Medium: Online Resource
    ISSN: 2052-1707 , 2052-1707
    URL: Issue
    URL: Article
    DOI: 10.1002/prp2.v9.5
    DOI: 10.1002/prp2.852
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2740389-0
    SSG: 15,3
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  • 7
    Online Resource
    Online Resource
    Passenger Flow Path Prediction Based on Urban Rail Transit AFC Data: An Example of Chengdu, China
    Wiley ; 2023
    In:  Journal of Advanced Transportation Vol. 2023 ( 2023-11-10), p. 1-19
    Details
    In: Journal of Advanced Transportation, Wiley, Vol. 2023 ( 2023-11-10), p. 1-19
    Abstract: The development of the automatic fare collection (AFC) systems provides significant support for predicting passenger flow on urban rail transit. This paper extracts passenger travel patterns using AFC data on urban rail transit in Chengdu, China, over a one-month period. Passengers are divided into two categories based on their travel habits and data mining models, and multinomial logit (MNL) models are separately used to predict their destinations. Furthermore, a two-way search algorithm is developed to search the optimal paths between origin-destination (OD) pairs by considering interchange constraints. Start a path search through the origin point and destination point, respectively, until the shortest path is found. The maximum effectiveness of a path is measured by travel time, interchange time, and the number of interchanges between the OD pairs. Finally, the validity of the proposed passenger flow path prediction method is verified by using the AFC data of Chengdu metropolitan rail transit from April 2018.
    Type of Medium: Online Resource
    ISSN: 2042-3195 , 0197-6729
    URL: Article
    DOI: 10.1155/2023/5596285
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2553327-7
    detail.hit.zdb_id: 244227-9
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  • 8
    Online Resource
    Online Resource
    Accounting for BEV Users’ Risk Attitudes and Charging Inertia in En Route Charging Choice Behavior
    Wiley ; 2024
    In:  Journal of Advanced Transportation Vol. 2024 ( 2024-5-2), p. 1-17
    Details
    In: Journal of Advanced Transportation, Wiley, Vol. 2024 ( 2024-5-2), p. 1-17
    Abstract: This paper innovatively explores BEV (battery electric vehicle) users’ risk attitudes and charging inertia, examining their effects on en route charging and charging route choice behavior. An attitudinal survey was conducted to explore the two latent variables of risk attitudes and charging inertia in relation to socioeconomic and travel-related characteristics. ICLV (Integrated choice and latent variable) models are adopted to estimate the latent variables and the charging choice behavior simultaneously. Specifically, uncertainty in energy consumption is first considered in the ICLV model, which is represented by the available range (AR) uncertainty. Multinomial logit (MNL) models directly incorporating socioeconomic attributes are employed as a reference for comparison with ICLV models. Results illustrate that risk attitudes and charging inertia both play significant roles in modeling en route charging choice behavior. Risk-averse users and users having charging inertia value AR uncertainty more. Battery range, charging frequency, and income emerge as the most crucial factors influencing users’ intention to charge en route. The results show significant heterogeneity of BEV users in attitudes and charging choice behavior, underscoring the importance of accounting for the heterogeneity in en route charging demand estimation and deployment optimization of public charging stations, particularly for medium-to long-distance trips.
    Type of Medium: Online Resource
    ISSN: 2042-3195 , 0197-6729
    URL: Article
    DOI: 10.1155/2024/9926334
    Language: English
    Publisher: Wiley
    Publication Date: 2024
    detail.hit.zdb_id: 2553327-7
    detail.hit.zdb_id: 244227-9
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  • 9
    Online Resource
    Online Resource
    Comparison of breast density measured on MR images acquired using fat‐suppressed versus nonfat‐suppressed sequences
    Wiley ; 2011
    In:  Medical Physics Vol. 38, No. 11 ( 2011-11), p. 5961-5968
    Details
    In: Medical Physics, Wiley, Vol. 38, No. 11 ( 2011-11), p. 5961-5968
    Abstract: To investigate the difference of MR percent breast density measured from fat‐suppressed versus nonfat‐suppressed imaging sequences. Methods: Breast magnetic resonance imaging (MRI) with and without fat suppression was acquired from 38 subjects. Breasts were divided into subgroups of different morphological patterns (“central” and “intermingled” types). Breast volume, fibroglandular tissue volume, and percent density were measured. The results were compared using nonparametric statistical tests and regarded as significant at p  〈  0.05. Results: Breast volume, fibroglandular volume, and percent density between fat‐suppressed and nonfat‐suppressed sequences were highly correlated. Breast volumes measured on these two sequences were almost identical. Fibroglandular tissue volume and percent density, however, had small ( 〈 5%) yet significant differences between the two sequences—they were both higher on the fat‐suppressed sequence. Intraobserver variability was within 4% for both sequences and different morphological types. The fibroglandular tissue volume measured on downsampled images showed a small ( 〈 5%) yet significant difference. Conclusions: The measurement of breast density made on MRI acquired using fat‐suppressed and nonfat‐suppressed T1W images was about 5% difference, only slightly higher than the intraobserver variability of 3%–4%. When the density data from multiple centers were to be combined, evaluating the degree of difference is needed to take this difference into account.
    Type of Medium: Online Resource
    ISSN: 0094-2405 , 2473-4209
    URL: Article
    DOI: 10.1118/1.3646756
    Language: English
    Publisher: Wiley
    Publication Date: 2011
    detail.hit.zdb_id: 188780-4
    detail.hit.zdb_id: 1466421-5
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  • 10
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    Online Resource
    Design of Nanoparticle-Based Carriers for Targeted Drug Delivery
    Wiley ; 2016
    In:  Journal of Nanomaterials Vol. 2016 ( 2016), p. 1-15
    Details
    In: Journal of Nanomaterials, Wiley, Vol. 2016 ( 2016), p. 1-15
    Abstract: Nanoparticles have shown promise as both drug delivery vehicles and direct antitumor systems, but they must be properly designed in order to maximize efficacy. Computational modeling is often used both to design new nanoparticles and to better understand existing ones. Modeled processes include the release of drugs at the tumor site and the physical interaction between the nanoparticle and cancer cells. In this paper, we provide an overview of three different targeted drug delivery methods (passive targeting, active targeting, and physical targeting) and compare methods of action, advantages, limitations, and the current stages of research. For the most commonly used nanoparticle carriers, fabrication methods are also reviewed. This is followed by a review of computational simulations and models on nanoparticle-based drug delivery.
    Type of Medium: Online Resource
    ISSN: 1687-4110 , 1687-4129
    URL: Article
    DOI: 10.1155/2016/1087250
    Language: English
    Publisher: Wiley
    Publication Date: 2016
    detail.hit.zdb_id: 2229480-6
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