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  • 1
    Online Resource
    Online Resource
    Hierarchical Bimetallic Hydroxides Built by Porous Nanowire‐Lapped Bundles with Ultrahigh Areal Capacity for Stable Hybrid Solid‐State Supercapacitors
    Wiley ; 2019
    In:  Advanced Materials Interfaces Vol. 6, No. 24 ( 2019-12)
    Details
    In: Advanced Materials Interfaces, Wiley, Vol. 6, No. 24 ( 2019-12)
    Abstract: Exploring advanced electrode materials with superb energy/power densities and long lifetime as well as low cost is the recent focus of hybrid solid‐state supercapacitor (HSSC). This study reports a novel hierarchical bimetallic hydroxide (Ni 1 Co 1 ‐OH) built by nanowire‐lapped bonfire‐like bundles through a facile and scalable method, and provides thorough insights into possible formation mechanism and structural merits of the interesting hierarchical architecture. Benefiting from multistep redox reactions, high accessible surface area and fast kinetics contributed by the unique structure, Ni 1 Co 1 ‐OH using 2 m KOH electrolyte can achieve highly improved gravimetric capacity/capacitance of 876.8 C g −1 /1753.6 F g −1 at active mass loading of 3 mg cm −2 at 1 A g −1 , and especially deliver a record‐high areal capacity of 7.6 C cm −2 at 1 A g −1 under a commercial loading of 15 mg cm −2 . 1.5 V Ni 1 Co 1 ‐OH based HSSC with the poly(vinyl alcohol)/KOH gel electrolyte verifies the intriguing performance including high energy/power densities of 27.9 Wh kg −1 /13812.9 W kg −1 , a long life over 10 000 cycles, and a low self‐discharge rate with a voltage decline of 20% after 24 h. The findings identify the scalable production of high‐performance bimetal compounds, which will boost the development of highly demanding HSSC devices.
    Type of Medium: Online Resource
    ISSN: 2196-7350 , 2196-7350
    URL: Issue
    URL: Article
    DOI: 10.1002/admi.v6.24
    DOI: 10.1002/admi.201900959
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 2750376-8
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  • 2
    Online Resource
    Online Resource
    Genetic diagnosis of common fetal renal abnormalities detected on prenatal ultrasound
    Wiley ; 2022
    In:  Prenatal Diagnosis Vol. 42, No. 7 ( 2022-06), p. 894-900
    Details
    In: Prenatal Diagnosis, Wiley, Vol. 42, No. 7 ( 2022-06), p. 894-900
    Abstract: What's already known about this topic? Fetal renal abnormalities are some of the common and most easily detectable anomalies on ultrasound. The disease has a wide range of prenatal phenotypes with distinct prognoses and etiologies. Studies have shown that fetal renal abnormalities may be related to certain genetic disorders or syndromes. However, one of the major challenges to the use of genetic information in the clinical setting remains the lack of strict genotype‐phenotype correlation. What does this study add? This study first explored the correlations between phenotypes of fetal renal abnormalities detected on prenatal ultrasound and genetic aetiologies detected by CMA and WES. Our results suggest that hyperechogenic kidney should be confirmed with genetic testing. Renal abnormalities presenting together with reduced AF are likely to be related to monogenic variants. Genetic abnormalities in cases with obstructive renal dysplasia and duplex kidney were rarely observed.
    Type of Medium: Online Resource
    ISSN: 0197-3851 , 1097-0223
    URL: Issue
    URL: Article
    DOI: 10.1002/pd.v42.7
    DOI: 10.1002/pd.6154
    RVK:
    XA 10000
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 1491217-X
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  • 3
    Online Resource
    Online Resource
    RPS15A promotes gastric cancer progression via activation of the Akt/IKK‐β/NF‐κB signalling pathway
    Wiley ; 2019
    In:  Journal of Cellular and Molecular Medicine Vol. 23, No. 3 ( 2019-03), p. 2207-2218
    Details
    In: Journal of Cellular and Molecular Medicine, Wiley, Vol. 23, No. 3 ( 2019-03), p. 2207-2218
    Abstract: This study aimed to investigate the clinical significance, potential biological function and underlying mechanism of RPS15A in gastric cancer (GC) progression. RPS15A expression was detected in 40 pairs of GC tissues and matched normal gastric mucosae (MNGM) using qRT‐PCR analysis. Immunohistochemistry assay was conducted using a tissue microarray including 186 primary GC samples to characterize the clinical significance of RPS15A. A series of in vitro and in vivo assays were performed to elucidate the biological function of RPS15A in GC development and underlying molecular mechanisms. The expression of RPS15A was significantly up‐regulated in GC samples compared to MNGM, and its expression was closely related to TNM stage, tumour size, differentiation, lymph node metastasis and poor patient survival. Ectopic expression of RPS15A markedly enhanced the proliferation and metastasis of GC cells both in vitro and in vivo. RPS15A overexpression also promoted the epithelial‐mesenchymal transition (EMT) phenotype formation of GC cells. Investigations of underlying mechanisms found that RPS15A activated the NF‐κB signalling pathway by inducing the nuclear translocation and phosphorylation of the p65 NF‐κB subunit, transactivation of NF‐κB reporter and up‐regulating target genes of this pathway. In addition, RPS15A overexpression activated, while RPS15A knockdown inhibited the Akt/IKK‐β signalling axis in GC cells. And both Akt inhibitor LY294002 and IKK inhibitor Bay117082 neutralized the p65 and p‐p65 nuclear translocation induced by RPS15A overexpression. Collectively, our findings suggest that RPS15A activates the NF‐κB pathway through Akt/IKK‐β signalling axis, and consequently promotes EMT and GC metastasis. This newly identified RPS15A/Akt/IKK‐β/NF‐κB signalling pathway may be a potential therapeutic target to prevent GC progression.
    Type of Medium: Online Resource
    ISSN: 1582-1838 , 1582-4934
    URL: Issue
    URL: Article
    DOI: 10.1111/jcmm.2019.23.issue-3
    DOI: 10.1111/jcmm.14141
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 2076114-4
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  • 4
    Online Resource
    Online Resource
    The CC–NB–LRR protein BSR1 from Brachypodium confers resistance to Barley stripe mosaic virus in gramineous plants by recognising TGB1 movement protein
    Wiley ; 2022
    In:  New Phytologist Vol. 236, No. 6 ( 2022-12), p. 2233-2248
    Details
    In: New Phytologist, Wiley, Vol. 236, No. 6 ( 2022-12), p. 2233-2248
    Abstract: Although some nucleotide binding, leucine‐rich repeat immune receptor (NLR) proteins conferring resistance to specific viruses have been identified in dicot plants, NLR proteins involved in viral resistance have not been described in monocots. We have used map‐based cloning to isolate the CC‐NB‐LRR (CNL) Barley stripe mosaic virus (BSMV) resistance gene barley stripe resistance 1 ( BSR1 ) from Brachypodium distachyon Bd3‐1 inbred line. Stable BSR1 transgenic Brachypodium line Bd21‐3, barley (Golden Promise) and wheat (Kenong 199) plants developed resistance against BSMV ND18 strain. Allelic variation analyses indicated that BSR1 is present in several Brachypodium accessions collected from countries in the Middle East. Protein domain swaps revealed that the intact LRR domain and the C‐terminus of BSR1 are required for resistance. BSR1 interacts with the BSMV ND18 TGB1 protein in planta and shows temperature‐sensitive antiviral resistance. The R 390 and T 392 residues of TGB1 ND (ND18 strain) and the G 196 and K 197 residues within the BSR1 P‐loop motif are key amino acids required for immune activation. BSR1 is the first cloned virus resistance gene encoding a typical CNL protein in monocots, highlighting the utility of the Brachypodium model for isolation and analysis of agronomically important genes for crop improvement.
    Type of Medium: Online Resource
    ISSN: 0028-646X , 1469-8137
    URL: Issue
    URL: Article
    DOI: 10.1111/nph.v236.6
    DOI: 10.1111/nph.18457
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 208885-X
    detail.hit.zdb_id: 1472194-6
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  • 5
    Online Resource
    Online Resource
    Mixed planting enhances soil multi‐nutrient cycling by homogenizing microbial communities across soil vertical scale
    Wiley ; 2023
    In:  Land Degradation & Development Vol. 34, No. 5 ( 2023-03), p. 1477-1490
    Details
    In: Land Degradation & Development, Wiley, Vol. 34, No. 5 ( 2023-03), p. 1477-1490
    Abstract: Soil multi‐nutrient cycling (SMC) driven by microbial communities determines the primary productivity of forests. While functional microbes and microbial community composition are thought to contribute to SMC, the importance of different microbial communities in SMC enhancement in forest ecosystems are largely unknown. Here, we aimed to decode the underlying mechanisms of bacterial and fungal communities in the surface (0–20 cm) and subsurface soils (20–40 cm) that drive SMC in two afforestation models: pure plantation (Chinese fir) and mixed plantation (different tree varieties). Mixed planting significantly enhanced the SMC along the soil vertical spatial scale, implying that mixed planting effectively alleviated soil degradation caused by pure planting. This was attributed to the homogenization effect of mixed planting on bacterial and fungal community assemblies across the soil vertical scales. Specifically, fungal communities mainly contributed to SMC in the surface soil in mixed plantations, and bacterial communities were the primary drivers of SMC in the subsurface soil. Furthermore, multiple regression and structural equation modeling confirmed that specific key fungal taxa preferentially mediate the transformation of available phosphorus and soil organic carbon, and contribute 77.0% of SMC variation in the surface soil, while bacterial taxa mainly drive the transformation of ammonium nitrogen and soil organic carbon, and account for 60.0% of SMC variation in the subsurface soil. This study highlights the different patterns of bacterial and fungal community assembly, and their function in SMC along the soil vertical spatial scale, and advances the understanding of the roles of soil microbial communities in degraded forest soil remediation.
    Type of Medium: Online Resource
    ISSN: 1085-3278 , 1099-145X
    URL: Issue
    URL: Article
    DOI: 10.1002/ldr.v34.5
    DOI: 10.1002/ldr.4547
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2021787-0
    detail.hit.zdb_id: 1319202-4
    SSG: 14
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  • 6
    Online Resource
    Online Resource
    The RxLR effector Avh241 from Phytophthora sojae requires plasma membrane localization to induce plant cell death
    Wiley ; 2012
    In:  New Phytologist Vol. 196, No. 1 ( 2012-10), p. 247-260
    Details
    In: New Phytologist, Wiley, Vol. 196, No. 1 ( 2012-10), p. 247-260
    Type of Medium: Online Resource
    ISSN: 0028-646X , 1469-8137
    URL: Issue
    URL: Article
    DOI: 10.1111/nph.2012.196.issue-1
    DOI: 10.1111/j.1469-8137.2012.04241.x
    Language: English
    Publisher: Wiley
    Publication Date: 2012
    detail.hit.zdb_id: 208885-X
    detail.hit.zdb_id: 1472194-6
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  • 7
    Online Resource
    Online Resource
    Fast‐Response Fluorogenic Probe for Visualizing Hypochlorite in Living Cells and in Zebrafish
    Wiley ; 2019
    In:  ChemBioChem Vol. 20, No. 6 ( 2019-03-15), p. 831-837
    Details
    In: ChemBioChem, Wiley, Vol. 20, No. 6 ( 2019-03-15), p. 831-837
    Abstract: A fast‐response fluorogenic probe—compound D1 —for monitoring hypochlorite (ClO − ), based on specific ClO − cleavage of a C=N bond and producing results observable to the naked eye, has been developed. The response of the probe to ClO − increases linearly, and the fluorescence intensity was heightened by a factor of about 25. D1 responses to ClO − , with high selectivity and sensitivity, were observable by naked eye within 10 s. D1 can not only detect levels of hypochlorite in vitro, such as in urine, but is also capable of monitoring hypochlorite content under extremely cold conditions, as low as −78 °C. Meanwhile, its good biocompatibility permitted the use of D1 to detect intracellular ClO − by confocal microscopy. Moreover, D1 was successfully applied to monitor exogenous and endogenous ClO − in zebrafish through fluorescence imaging.
    Type of Medium: Online Resource
    ISSN: 1439-4227 , 1439-7633
    URL: Issue
    URL: Article
    DOI: 10.1002/cbic.v20.6
    DOI: 10.1002/cbic.201800659
    RVK:
    VA 2918
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 2020469-3
    SSG: 12
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  • 8
    Online Resource
    Online Resource
    Vesicular Antibodies: Shedding Light on Antibody Therapeutics with Cell Membrane Nanotechnology
    Wiley ; 2023
    In:  Advanced Materials Vol. 35, No. 12 ( 2023-03)
    Details
    In: Advanced Materials, Wiley, Vol. 35, No. 12 ( 2023-03)
    Abstract: The high stability of antibodies and their ability to precisely bind to antigens and endogenous immune receptors, as well as their susceptibility to protein engineering, enable antibody‐based therapeutics to be widely applied in cancer, inflammation, infection, and other disorders. Nevertheless, the application of traditional antibody‐based therapeutics has certain limitations, such as high price, limited permeability, and protein engineering complexity. Recent breakthroughs in cell membrane nanotechnology have deepened the understanding of the critical role of membrane protein receptors in disease treatment, enabling vesicular‐antibody‐based therapeutics. Here, the concept of vesicular antibodies that are obtained by modifying target antibodies onto cell membranes for biomedical applications is proposed. Given that an antibody is basically a protein, as an extension of this concept, vesicles or membrane‐coated nanoparticles that use surface antibodies and protein receptors on cell membranes for biomedical applications as vesicular antibodies are defined. Furthermore, several engineering strategies for vesicular antibodies are summarized and how vesicular antibodies can be used in a variety of situations is highlighted. In addition, current challenges and future prospects of vesicular antibodies are also discussed. It is anticipated this perspective will provide new insights on the development of next‐generation antibodies for enhanced therapeutics.
    Type of Medium: Online Resource
    ISSN: 0935-9648 , 1521-4095
    URL: Issue
    URL: Article
    DOI: 10.1002/adma.v35.12
    DOI: 10.1002/adma.202207875
    RVK:
    UA 1538
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 1474949-X
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  • 9
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    Online Resource
    Combination of chemical profiling and network pharmacology analysis to investigate the potential mechanism of Li‐Zhong‐Xiao‐Pi granules in the treatment of gastric precancerous lesions
    Wiley ; 2023
    In:  Biomedical Chromatography Vol. 37, No. 4 ( 2023-04)
    Details
    In: Biomedical Chromatography, Wiley, Vol. 37, No. 4 ( 2023-04)
    Abstract: Li‐Zhong‐Xiao‐Pi granules (LZXP) are effective for treating gastric precancerous lesions (GPL) in traditional Chinese medicine. However, the active compounds of LZXP and their potential therapeutic mechanism in GPL remained unclarified. The purpose of this study is to investigate the chemical composition and potential targets of LZXP. Based on the accurate masses, ion fragments, and literature data, a total of 128 compounds were identified in the LZXP sample using ultra‐performance liquid chromatography and quadrupole time‐of‐flight mass spectrometry (UPLC–Q‐TOF–MS) in both positive and negative ion modes, and 28 of these compounds were exactly determined by comparison with authentic reference standards. Meanwhile, 11 typical components were quantified via UPLC during a 24 min period. The linearity, accuracy, stability and recovery of the method were all proven. Through the network pharmacological analysis, six chemicals (quercetin, 4′‐hydroxywogonin, sinensetin, 5, 7, 8, 3′, 4′‐pentamethoxyflavanone, 8‐gingerdione and quercetin) were identified as the active ingredients, and five LZXP targets (AKT1, CYP1B1, PTGS2, MMP9 and EGFR) were found to be the crucial molecules in the treatment of GPL. This study provides a systematic and applicable method for the rapid screening and identification of the chemical constituents from LZXP, and an effective understanding the mechanism of LZXP in the treatment of GPL.
    Type of Medium: Online Resource
    ISSN: 0269-3879 , 1099-0801
    URL: Issue
    URL: Article
    DOI: 10.1002/bmc.v37.4
    DOI: 10.1002/bmc.5589
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 1479945-5
    SSG: 12
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  • 10
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    Sulfone‐Modified Covalent Organic Frameworks Enabling Efficient Photocatalytic Hydrogen Peroxide Generation via One‐Step Two‐Electron O 2 Reduction
    Wiley ; 2023
    In:  Angewandte Chemie International Edition Vol. 62, No. 26 ( 2023-06-26)
    Details
    In: Angewandte Chemie International Edition, Wiley, Vol. 62, No. 26 ( 2023-06-26)
    Abstract: Photocatalytic oxygen reduction reaction (ORR) offers a promising hydrogen peroxide (H 2 O 2 ) synthetic strategy, especially the one‐step two‐electron (2e − ) ORR route holds great potential in achieving highly efficient and selectivity. However, efficient one‐step 2e − ORR is rarely harvested and the underlying mechanism for regulating the ORR pathways remains greatly obscure. Here, by loading sulfone units into covalent organic frameworks (FS‐COFs), we present an efficient photocatalyst for H 2 O 2 generation via one‐step 2e − ORR from pure water and air. Under visible light irradiation, FS‐COFs exert a superb H 2 O 2 yield of 3904.2 μmol h −1  g −1 , outperforming most reported metal‐free catalysts under similar conditions. Experimental and theoretical investigation reveals that the sulfone units accelerate the separation of photoinduced electron‐hole (e − ‐h + ) pairs, enhance the protonation of COFs, and promote O 2 adsorption in the Yeager‐type, which jointly alters the reaction process from two‐step 2e − ORR to the one‐step one, thereby achieving efficient H 2 O 2 generation with high selectivity.
    Type of Medium: Online Resource
    ISSN: 1433-7851 , 1521-3773
    URL: Issue
    URL: Article
    DOI: 10.1002/anie.v62.26
    DOI: 10.1002/anie.202305355
    RVK:
    VA 2100
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2011836-3
    detail.hit.zdb_id: 123227-7
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