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  • 1
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    Online Resource
    Epileptic seizures worsen the gait and motor abnormalities in adult patients with Dravet syndrome (with a case report and literature review)
    Wiley ; 2023
    In:  Epilepsia Open
    Details
    In: Epilepsia Open, Wiley
    Abstract: Dravet syndrome (DS), previously known as severe myoclonic epilepsy in infancy (SMEI), is considered the most serious “epileptic encephalopathy.” Here, we present a man with a de novo SCN1A mutation who was diagnosed with DS at the age of 29. In addition to pharmaco‐resistant seizures and cognitive delay, he also developed moderate to severe motor and gait problems, such as crouching gait and Pisa syndrome. Moreover, it deteriorated significantly following an epileptic seizure. The patient presented with severe flexion of the head and trunk in the sagittal plane and fulfilled the diagnostic criteria for camptocormia and antecollis. After a week, it spontaneously alleviated partially. We applied levodopa to the patient and had a good response. Functional Gait Assessment (FGA) was assessed at three different times: 4 days after the seizure, 1 week after the seizure, and after taking levodopa for 2 years. The results were 4, 12, and 19 points, respectively. We postulated that: (1) gait and motor deficits are somehow influenced by recurrent epileptic episodes;(2) the nigrostriatal dopamine system is involved. To our knowledge, we were the ones who first reported this phenomenon.
    Type of Medium: Online Resource
    ISSN: 2470-9239 , 2470-9239
    URL: Article
    DOI: 10.1002/epi4.12780
    Language: English
    Publisher: Wiley
    Publication Date: 2023
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  • 2
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    Online Resource
    Tuning the Selectivity of Catalytic Carbon Dioxide Hydrogenation over Iridium/Cerium Oxide Catalysts with a Strong Metal–Support Interaction
    Wiley ; 2017
    In:  Angewandte Chemie Vol. 129, No. 36 ( 2017-08-28), p. 10901-10905
    Details
    In: Angewandte Chemie, Wiley, Vol. 129, No. 36 ( 2017-08-28), p. 10901-10905
    Abstract: A one‐step ligand‐free method based on an adsorption–precipitation process was developed to fabricate iridium/cerium oxide (Ir/CeO 2 ) nanocatalysts. Ir species demonstrated a strong metal–support interaction (SMSI) with the CeO 2 substrate. The chemical state of Ir could be finely tuned by altering the loading of the metal. In the carbon dioxide (CO 2 ) hydrogenation reaction it was shown that the chemical state of Ir species—induced by a SMSI—has a major impact on the reaction selectivity. Direct evidence is provided indicating that a single‐site catalyst is not a prerequisite for inhibition of methanation and sole production of carbon monoxide (CO) in CO 2 hydrogenation. Instead, modulation of the chemical state of metal species by a strong metal–support interaction is more important for regulation of the observed selectivity (metallic Ir particles select for methane while partially oxidized Ir species select for CO production). The study provides insight into heterogeneous catalysts at nano, sub‐nano, and atomic scales.
    Type of Medium: Online Resource
    ISSN: 0044-8249 , 1521-3757
    URL: Issue
    URL: Article
    DOI: 10.1002/ange.v129.36
    DOI: 10.1002/ange.201705002
    RVK:
    VA 2100
    RVK:
    VN 5020
    Language: English
    Publisher: Wiley
    Publication Date: 2017
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    detail.hit.zdb_id: 506609-8
    detail.hit.zdb_id: 514305-6
    detail.hit.zdb_id: 505872-7
    detail.hit.zdb_id: 1479266-7
    detail.hit.zdb_id: 505867-3
    detail.hit.zdb_id: 506259-7
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  • 3
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    Online Resource
    Effects of dietary protein level on small intestinal morphology, occludin protein, and bacterial diversity in weaned piglets
    Wiley ; 2022
    In:  Food Science & Nutrition Vol. 10, No. 7 ( 2022-07), p. 2168-2201
    Details
    In: Food Science & Nutrition, Wiley, Vol. 10, No. 7 ( 2022-07), p. 2168-2201
    Abstract: Due to the physiological characteristics of piglets, the morphological structure and function of the small intestinal mucosa change after weaning, which easily leads to diarrhea in piglets. The aim of this study was to investigate effects of crude protein (CP) levels on small intestinal morphology, occludin protein expression, and intestinal bacteria diversity in weaned piglets. Ninety‐six weaned piglets (25 days of age) were randomly divided into four groups and fed diets containing 18%, 20%, 22%, and 24% protein. At 6, 24, 48, 72, and 96 h, changes in mucosal morphological structure, occludin mRNA, and protein expression and in the localization of occludin in jejunal and ileal tissues were evaluated. At 6, 24, and 72 h, changes in bacterial diversity and number of the ileal and colonic contents were analyzed. Results showed that structures of the jejunum and the ileum of piglets in the 20% CP group were intact. The expression of occludin mRNA and protein in the small intestine of piglets in the 20% CP group were significantly higher than those in the other groups. As the CP level increased, the number of pathogens, such as Clostridium difficile and Escherichia coli , in the intestine increased, while the number of beneficial bacteria, such as Lactobacillus, Bifidobacterium , and Roseburia , decreased. It is concluded that maintaining the CP level at 20% is beneficial to maintaining the small intestinal mucosal barrier and its absorption function, reducing the occurrence of diarrhea, and facilitating the growth and development of piglets.
    Type of Medium: Online Resource
    ISSN: 2048-7177 , 2048-7177
    URL: Issue
    URL: Article
    DOI: 10.1002/fsn3.v10.7
    DOI: 10.1002/fsn3.2828
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2703010-6
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  • 4
    Online Resource
    Online Resource
    Tuning the Selectivity of Catalytic Carbon Dioxide Hydrogenation over Iridium/Cerium Oxide Catalysts with a Strong Metal–Support Interaction
    Wiley ; 2017
    In:  Angewandte Chemie International Edition Vol. 56, No. 36 ( 2017-08-28), p. 10761-10765
    Details
    In: Angewandte Chemie International Edition, Wiley, Vol. 56, No. 36 ( 2017-08-28), p. 10761-10765
    Abstract: A one‐step ligand‐free method based on an adsorption–precipitation process was developed to fabricate iridium/cerium oxide (Ir/CeO 2 ) nanocatalysts. Ir species demonstrated a strong metal–support interaction (SMSI) with the CeO 2 substrate. The chemical state of Ir could be finely tuned by altering the loading of the metal. In the carbon dioxide (CO 2 ) hydrogenation reaction it was shown that the chemical state of Ir species—induced by a SMSI—has a major impact on the reaction selectivity. Direct evidence is provided indicating that a single‐site catalyst is not a prerequisite for inhibition of methanation and sole production of carbon monoxide (CO) in CO 2 hydrogenation. Instead, modulation of the chemical state of metal species by a strong metal–support interaction is more important for regulation of the observed selectivity (metallic Ir particles select for methane while partially oxidized Ir species select for CO production). The study provides insight into heterogeneous catalysts at nano, sub‐nano, and atomic scales.
    Type of Medium: Online Resource
    ISSN: 1433-7851 , 1521-3773
    URL: Issue
    URL: Article
    DOI: 10.1002/anie.v56.36
    DOI: 10.1002/anie.201705002
    RVK:
    VA 2100
    Language: English
    Publisher: Wiley
    Publication Date: 2017
    detail.hit.zdb_id: 2011836-3
    detail.hit.zdb_id: 123227-7
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  • 5
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    Online Resource
    Interactions of glial cells with neuronal synapses, from astrocytes to microglia and oligodendrocyte lineage cells
    Wiley ; 2023
    In:  Glia Vol. 71, No. 6 ( 2023-06), p. 1383-1401
    Details
    In: Glia, Wiley, Vol. 71, No. 6 ( 2023-06), p. 1383-1401
    Abstract: The mammalian brain is a complex organ comprising neurons, glia, and more than 1 × 10 14 synapses. Neurons are a heterogeneous group of electrically active cells, which form the framework of the complex circuitry of the brain. However, glial cells, which are primarily divided into astrocytes, microglia, oligodendrocytes (OLs), and oligodendrocyte precursor cells (OPCs), constitute approximately half of all neural cells in the mammalian central nervous system (CNS) and mainly provide nutrition and tropic support to neurons in the brain. In the last two decades, the concept of “tripartite synapses” has drawn great attention, which emphasizes that astrocytes are an integral part of the synapse and regulate neuronal activity in a feedback manner after receiving neuronal signals. Since then, synaptic modulation by glial cells has been extensively studied and substantially revised. In this review, we summarize the latest significant findings on how glial cells, in particular, microglia and OL lineage cells, impact and remodel the structure and function of synapses in the brain. Our review highlights the cellular and molecular aspects of neuron‐glia crosstalk and provides additional information on how aberrant synaptic communication between neurons and glia may contribute to neural pathologies.
    Type of Medium: Online Resource
    ISSN: 0894-1491 , 1098-1136
    URL: Issue
    URL: Article
    DOI: 10.1002/glia.v71.6
    DOI: 10.1002/glia.24343
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 1474828-9
    SSG: 12
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  • 6
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    Regulatory T cells and T helper 17 cells in viral infection
    Wiley ; 2020
    In:  Scandinavian Journal of Immunology Vol. 91, No. 5 ( 2020-05)
    Details
    In: Scandinavian Journal of Immunology, Wiley, Vol. 91, No. 5 ( 2020-05)
    Abstract: CD4 + T cells are the central element of the adaptive immune responses and protect the body from a variety of pathogens. Starting from naive cells, CD4 + T cells can differentiate into various effector cell subsets with specialized functions including T helper (Th) 1, Th2, Th17, regulatory T (Treg) and T follicular helper (Tfh) cells. Among them, Tregs and Th17 cells show a strong plasticity allowing the functional adaptation to various physiological and pathological environments during immune responses. Although they are derived from the same precursor cells and their differentiation pathways are interrelated, the terminally differentiated cells have totally opposite functions. Studies have shown that Tregs and Th17 cells have rather complex interplays in viral infection: Th17 cells may contribute to immune activation and disease progression while Tregs may inhibit this process and play a key role in the maintenance of immune homoeostasis, possibly at the cost of compromised viral control. In this review, we take respiratory syncytial virus (RSV), hepatitis B virus (HBV)/hepatitis C virus (HCV) and human immunodeficiency virus (HIV) infections as examples to discuss these interplays and their impacts on disease progression in viral infection.
    Type of Medium: Online Resource
    ISSN: 0300-9475 , 1365-3083
    URL: Issue
    URL: Article
    DOI: 10.1111/sji.v91.5
    DOI: 10.1111/sji.12873
    RVK:
    XA 10000
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2020954-X
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  • 7
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    Influencing factors and necessity of post‐vaccination serologic testing follow‐up for HBsAg‐positive mothers and their infants: A 5‐year prospective study in Zhejiang Province, China (2016–2020)
    Wiley ; 2021
    In:  Journal of Viral Hepatitis Vol. 28, No. 10 ( 2021-10), p. 1413-1421
    Details
    In: Journal of Viral Hepatitis, Wiley, Vol. 28, No. 10 ( 2021-10), p. 1413-1421
    Abstract: In 2016, China officially proposed for the first time that infants born to HBsAg‐positive mothers should be tested for HBsAg and anti‐HBs 1–2 months after their third dose of HepB, also known as the post‐vaccination serological testing programme. This study aimed to systematically evaluate the implementation and influencing factors of PVST to further reduce HBV infection risk in infants and improve the protective effect of HepB to the greatest extent. A prospective observational study was conducted to investigate the interruption of MTCT of hepatitis B. Univariate and multivariate analyses were applied to explore factors associated with the PVST follow‐up rate among HBsAg‐positive mothers and their infants. Additionally, bivariate analysis was performed on HBsAg and anti‐HBs results in infants born to HBsAg‐positive mothers. Here, the participation rate of PVST was 67.08% among 2120 pairs of positive mothers and infants. The HBsAg‐positive rate among participants was 0.77%, whereas the anti‐HBs positive rate was 96.84%, and both negative rates were 2.39%. Among infants with double negative results (34), only 15 completed three doses of HepB and PVST again, and 14 (93.33%) of which the antibody test results turned positive. Older mothers with high educational levels who reside in the local area were the most likely to PVST follow‐up. The PVST programme is necessary to evaluate the HepB response status of newborns after vaccination. Moreover, revaccination for susceptible infants can effectively improve the MTCT‐blocking rate of hepatitis B. Therefore, the scope of PVST projects in Zhejiang and China should be expanded.
    Type of Medium: Online Resource
    ISSN: 1352-0504 , 1365-2893
    URL: Issue
    URL: Article
    DOI: 10.1111/jvh.v28.10
    DOI: 10.1111/jvh.13581
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2007924-2
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  • 8
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    Frataxin‐Mediated PINK1–Parkin‐Dependent Mitophagy in Hepatic Steatosis: The Protective Effects of Quercetin
    Wiley ; 2018
    In:  Molecular Nutrition & Food Research Vol. 62, No. 16 ( 2018-08)
    Details
    In: Molecular Nutrition & Food Research, Wiley, Vol. 62, No. 16 ( 2018-08)
    Abstract: Naturally occurring quercetin has been found to induce mitophagy and prevent nonalcoholic fatty liver disease (NAFLD). However, it still remains elusive whether frataxin upregulation by quercetin contributes to the beneficial effect through mitophagy or not. Methods and results Adult male C57BL/J mice were fed a high‐fat diet (HFD, 60% of energy from fat) with quercetin (100 mg kg −1 body weight) or not for 10 weeks. Quercetin alleviated HFD‐induced histopathological changes, disorders of lipid metabolism, and mitochondrial damage. Moreover, quercetin blocked mitophagy suppression by HFD based on the increased LC3II, PTEN‐induced putative kinase 1 (PINK1) and Beclin1 expressions, as well as decreased p62 levels. Quercetin also improved the Parkin translocation to mitochondria confirmed by immunofluorescence. Specifically, frataxin was lowered in the liver of HFD‐fed mice or HepG2 cell incubated with oleate/palmitate but restored by quercetin, and quercetin's regulation of frataxin may depend on p53. Furthermore, lentivirus‐mediated stable knockdown of frataxin in HepG2 inhibited PINK1–Parkin‐associated mitophagy and resulted in lipid accumulation. Frataxin was further decreased by free fatty acids in knockdown cells concomitantly with depressed PINK1–Parkin‐associated mitophagy, which was partially normalized by quercetin. Conclusion Quercetin alleviated hepatic steatosis by enhancing frataxin‐mediated PINK1/Parkin‐dependent mitophagy, highlighting a promising preventive strategy and mechanism for NAFLD by quercetin.
    Type of Medium: Online Resource
    ISSN: 1613-4125 , 1613-4133
    URL: Issue
    URL: Article
    DOI: 10.1002/mnfr.v62.16
    DOI: 10.1002/mnfr.201800164
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2160372-8
    SSG: 12
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  • 9
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    A General Strategy Assisted with Dual Reductants and Dual Protecting Agents for Preparing Pt‐Based Alloys with High‐Index Facets and Excellent Electrocatalytic Performance
    Wiley ; 2017
    In:  Small Vol. 13, No. 46 ( 2017-12)
    Details
    In: Small, Wiley, Vol. 13, No. 46 ( 2017-12)
    Abstract: Synthesizing noble metallic nanoparticles (NPs) enclosed by high‐index facets (HIFs) is challenged as it involves the tuning of growth kinetics, the selective adsorption of certain chemical species, and the epitaxial growth from HIF enclosed seeds. Herein, a simple and general strategy is reported by using dual reduction agents and dual capping agents to prepare Pt‐based alloy NPs with HIFs, in which both glycine and poly(vinylpyrrolidone) serve as the reductants and capping agents. Due to the facilely tunable growth/nucleation rates and protecting abilities of the reductants and capping agents, Pt concave nanocube (CNC), binary Pt–Ni CNC, ternary Pt–Mn–Cu CNC, and Pt–Mn–Cu ramiform polyhedron alloy NPs terminated by HIFs as well as other NPs with well‐defined morphologies such as Pt–Mn–Cu nanocube and Pt–Mn–Cu nanoflower are obtained with this approach. Owing to the high density of low‐coordinated Pt sites (HIF structure) and the unique electronic effect of Pt–Mn–Cu ternary alloys, the as‐prepared Pt–Mn–Cu NPs show enhanced catalytic activity toward methanol and formic acid electro‐oxidation reactions with excellent stability. This work provides a promising methodology for designing and fabricating Pt‐based alloy NPs as efficient fuel cell catalyst.
    Type of Medium: Online Resource
    ISSN: 1613-6810 , 1613-6829
    URL: Issue
    URL: Article
    DOI: 10.1002/smll.v13.46
    DOI: 10.1002/smll.201702617
    Language: English
    Publisher: Wiley
    Publication Date: 2017
    detail.hit.zdb_id: 2168935-0
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  • 10
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    Blood‐based dynamic genomic signature for obsessive–compulsive disorder
    Wiley ; 2018
    In:  American Journal of Medical Genetics Part B: Neuropsychiatric Genetics Vol. 177, No. 8 ( 2018-12), p. 709-716
    Details
    In: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, Wiley, Vol. 177, No. 8 ( 2018-12), p. 709-716
    Abstract: No biologically based diagnostic criteria are in clinical use today for obsessive–compulsive disorder (OCD), schizophrenia, and major depressive disorder (MDD), which are defined with reference to Diagnostic and Statistical Manual clinical symptoms alone. However, these disorders cannot always be well distinguished on clinical grounds and may also be comorbid. A biological blood‐based dynamic genomic signature that can differentiate among OCD, MDD, and schizophrenia would therefore be of great utility. This study enrolled 77 patients with OCD, 67 controls with no psychiatric illness, 39 patients with MDD, and 40 with schizophrenia. An OCD‐specific gene signature was identified using blood gene expression analysis to construct a predictive model of OCD that can differentiate this disorder from healthy controls, MDD, and schizophrenia using a logistic regression algorithm. To verify that the genes selected were not derived as a result of chance, the algorithm was tested twice. First, the algorithm was used to predict the cohort with true disease/control status and second, the algorithm predicted the cohort with disease/control status randomly reassigned (null set). A six‐gene panel ( COPS7A, FKBP1A, FIBP, TP73‐AS1, SDF4, and GOLGA8A ) discriminated patients with OCD from healthy controls, MDD, and schizophrenia in the training set (with an area under the receiver‐operating‐characteristic curve of 0.938; accuracy, 86%; sensitivity, 88%; and specificity, 85%). Our findings indicate that a blood transcriptomic signature can distinguish OCD from healthy controls, MDD, and schizophrenia. This finding further confirms the feasibility of using dynamic blood‐based genomic signatures in psychiatric disorders and may provide a useful tool for clinical staff engaged in OCD diagnosis and decision making.
    Type of Medium: Online Resource
    ISSN: 1552-4841 , 1552-485X
    URL: Issue
    URL: Article
    DOI: 10.1002/ajmg.v117.8
    DOI: 10.1002/ajmg.b.32675
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2143866-3
    SSG: 12
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