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  • 1
    Online Resource
    Online Resource
    Mapping of Spatiotemporal Auricular Electrophysiological Signals Reveals Human Biometric Clusters
    Wiley ; 2022
    In:  Advanced Healthcare Materials Vol. 11, No. 23 ( 2022-12)
    Details
    In: Advanced Healthcare Materials, Wiley, Vol. 11, No. 23 ( 2022-12)
    Abstract: Underneath the ear skin there are rich vascular network and sensory nerve branches. Hence, the 3D mapping of auricular electrophysiological signals can provide new biomedical perspectives. However, it is still extremely challenging for current sensing techniques to cover the entire ultra‐curved auricle. Here, a 3D graphene‐based ear‐conformable sensing device with embedded and distributed 3D electrodes for full‐auricle physiological monitoring is reported. As a proof‐of‐concept, spatiotemporal auricular electrical skin resistance (AESR) mapping is demonstrated for the first time, and human subject‐specific AESR distributions are observed. From the data of more than 30 ears (both right and left ears), the auricular region‐specific AESR changes after cycling exercise are observed in 98% of the tests and are clustered into four groups via machine learning‐based data analyses. Correlations of AESR with heart rate and blood pressure are also studied. This 3D electronic platform and AESR‐based biometrical findings show promising biomedical applications.
    Type of Medium: Online Resource
    ISSN: 2192-2640 , 2192-2659
    URL: Issue
    URL: Article
    DOI: 10.1002/adhm.v11.23
    DOI: 10.1002/adhm.202201404
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2645585-7
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  • 2
    Online Resource
    Online Resource
    ChemInform Abstract: Hydroxyl May Not Be Indispensable for Raltegravir: Design, Synthesis and SAR Studies of Raltegravir Derivatives as HIV-1 Inhibitors.
    Wiley ; 2012
    In:  ChemInform Vol. 43, No. 33 ( 2012-08-14), p. no-no
    Details
    In: ChemInform, Wiley, Vol. 43, No. 33 ( 2012-08-14), p. no-no
    Type of Medium: Online Resource
    ISSN: 0931-7597
    URL: Article
    DOI: 10.1002/chin.201233177
    Language: English
    Publisher: Wiley
    Publication Date: 2012
    detail.hit.zdb_id: 2110203-X
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  • 3
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    Online Resource
    PEGylated polylysine derived copolymers with reduction‐responsive side chains for anticancer drug delivery
    Wiley ; 2019
    In:  Polymer International Vol. 68, No. 10 ( 2019-10), p. 1817-1825
    Details
    In: Polymer International, Wiley, Vol. 68, No. 10 ( 2019-10), p. 1817-1825
    Abstract: Reduction‐responsive drug delivery systems have recently gained intense attention in intracellular delivery of anticancer drugs. In this study, we developed a PEGylated polypeptide, poly(ethylene glycol)‐ block ‐poly(ϵ‐propargyloxycarbonyl‐ l ‐lysine) (PEG 113 ‐ b ‐PPAL), as a novel clickable substrate for conjugation of reduction‐responsive side chains for antineoplastic drug delivery. PEG 113 ‐ b ‐PPAL was synthesized through ring‐opening polymerization of alkyne‐containing N ‐carboxyanhydride monomers. A designed disulfide‐containing side chain was introduced onto the PEGylated polypeptide by click reaction. The obtained copolymer PEG 113 ‐ b ‐P(Lys‐DSA) formed micelles by self‐assembly, which exhibited reduction‐responsive behavior under the stimulus of 10 mmol L –1 glutathione (GSH) in water. A small molecule intermediate, compound 2 , was used as a model to investigate the thiol reduction mechanism of PEG 113 ‐ b ‐P(Lys‐DSA) copolymers. The anticancer drug doxorubicin (DOX) was then loaded into the micelles with a drug loading content of 6.73 wt% and a loading efficiency of 40.3%. Both the blank and the drug‐loaded micelles (DOX‐loaded polylysine derived polymeric micelles (LMs/DOX)) adopted a spherical morphology, with average diameters of 48.0 ± 13.1 and 63.8 ± 20.0 nm, respectively. The in vitro drug release results indicated that DOX could be released faster from the micelles by the trigger of GSH in phosphate buffered saline. Confocal laser scanning microscopy and flow cytometer analysis further proved the intracellular delivery of DOX by LMs/DOX and their GSH‐sensitive release behavior. A 3‐(4,5‐dimethyl‐thiazol‐2‐yl)‐2,5‐diphenyl tetrazolium bromide assay showed that the polymers exhibited negligible cytotoxicity towards normal L929 cells or cancer MCF‐7 cells with a treated concentration up to 1.0 mg mL –1 . In conclusion, our synthesized biocompatible and biodegradable PEGylated polypeptides hold great promise for intracellular antineoplastic drug delivery. © 2019 Society of Chemical Industry
    Type of Medium: Online Resource
    ISSN: 0959-8103 , 1097-0126
    URL: Issue
    URL: Article
    DOI: 10.1002/pi.v68.10
    DOI: 10.1002/pi.5892
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 2004753-8
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  • 4
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    Online Resource
    Perioperative Alanyl‐Glutamine–Supplemented Parenteral Nutrition in Chronic Radiation Enteritis Patients With Surgical Intestinal Obstruction : A Prospective, Randomized, Controlled Study
    Wiley ; 2016
    In:  Nutrition in Clinical Practice Vol. 31, No. 2 ( 2016-04), p. 250-256
    Details
    In: Nutrition in Clinical Practice, Wiley, Vol. 31, No. 2 ( 2016-04), p. 250-256
    Abstract: Background: A prospective, randomized, controlled study was performed to evaluate the effects of perioperative alanyl‐glutamine–supplemented parenteral nutrition (PN) support on the immunologic function, intestinal permeability, and nutrition status of surgical patients with chronic radiation enteritis (CRE)–induced intestinal obstruction. Methods: Patients who received 0.4 g/kg/d alanyl‐glutamine and isonitrogenous PN were assigned to an alanyl‐glutamine–supplemented PN (Gln‐PN) group and a control group, respectively. Serum levels of alanine aminotransferase and glutamine, body fat mass (FM), immunologic function, and intestinal permeability were measured before and after surgery. Results: Serum glutamine levels of the Gln‐PN group significantly exceeded that of the control group ( P 〈 .001; Gln‐PN, baseline 460.7 ± 42.5 vs 523.3 ± 48.6 µmol/L on postoperative day 14 [POD14], P 〈 .001; control, baseline 451.9 ± 44.0 vs 453.8 ± 42.3 µmol/L on POD14, P = .708). Lactulose/mannitol ratios of both groups decreased over time (Gln‐PN, baseline 0.129 ± 0.0403 vs 0.024 ± 0.0107 on POD1 4; control, baseline 0.125 ± 0.0378 vs 0.044 ± 0.0126 on POD14, P 〈 .001 in both groups). CD4/CD8‐positive T‐lymphocyte ratios significantly rose in both groups, with significant intergroup difference ( P 〈 .001; Gln‐PN, baseline 1.36 ± 0.32 vs 1.82 ± 0.30 on POD14, P 〈 .001; control, baseline 1.37 ± 0.25 vs 1.63 ± 0.31 on POD14, P 〈 .001). In the Gln‐PN group, FM increased from 3.68 ± 1.68 kg at baseline to 5.22 ± 1.42 kg on POD14 ( P 〈 .001). FM of control group increased from 3.84 ± 1.57 kg at baseline to 5.40 ± 1.54 kg on POD14 ( P 〈 .001). However, there were no significant intergroup differences ( P = .614). Conclusion: Gln‐PN significantly boosted the immune state and decreased the intestinal permeability of CRE patients. However, Gln‐PN was not superior to standard PN in improving the nutrition state and intestinal motility of surgical patients with CRE‐induced intestinal obstruction.
    Type of Medium: Online Resource
    ISSN: 0884-5336 , 1941-2452
    URL: Article
    DOI: 10.1177/0884533615591601
    Language: English
    Publisher: Wiley
    Publication Date: 2016
    detail.hit.zdb_id: 2170063-1
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  • 5
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    Online Resource
    Intestinal Conditioning After Cardiac Arrest: The Use of Normothermic Extracorporeal Membrane Oxygenation in the Non‐Heart‐Beating Animal Model
    Wiley ; 2016
    In:  Artificial Organs Vol. 40, No. 8 ( 2016-08), p. 738-745
    Details
    In: Artificial Organs, Wiley, Vol. 40, No. 8 ( 2016-08), p. 738-745
    Abstract: The effect of normothermic extracorporeal membrane oxygenation (NECMO) on small bowel preservation in a clinically relevant large animal model of expected donation after cardiac death (eDCD) was evaluated. Thirty domestic crossbred donor pigs were divided into five groups. The first group served as the live donation (LD) group, the second group served as the donation after cardiac death (DCD) group, and the remaining were further assigned into three subgroups: E1 group (1 h NECMO support), E3 group (3 h NECMO support), and E5 group (5 h NECMO support). Pathology, electron microscopy, energy metabolism, cell apoptosis, and tight junction (TJ) protein expression level of intestinal mucosa and the level of plasma d ‐lactic acid were evaluated in normal, cardiac death and at the end of extracorporeal support, respectively. The mean arterial pressure and PaO 2 were maintained over 60 and 267 mm Hg during NECMO support, respectively. One hour of extracorporeal support could improve the energy status in intestines of the DCD group. Although the histologic damage and apoptosis of the E1 group had no significant difference with those of the LD and DCD groups ( P   〉  0.05), the levels of intestinal mucosa TJ protein decreased ( P   〈  0.05), and plasma d ‐lactic acid increased progressively ( P   〈  0.05). With the extension of extracorporeal support, the degree of intestinal mucosa damage and intestinal permeability gradually increased, as well as the content of adenosine triphosphate in intestinal mucosa. The normothermic extracorporeal support for 1 h in DCD is beneficial for improving the energy status and viability of the bowel. However, the integrity of intestinal mucosa was destroyed gradually as extracorporeal support time went by. And the activation of intestinal epithelial apoptosis and hyperoxia might be the factors that lead to intestinal mucosa injury.
    Type of Medium: Online Resource
    ISSN: 0160-564X , 1525-1594
    URL: Issue
    URL: Article
    DOI: 10.1111/aor.2016.40.issue-8
    DOI: 10.1111/aor.12691
    Language: English
    Publisher: Wiley
    Publication Date: 2016
    detail.hit.zdb_id: 2003825-2
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  • 6
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    In Situ Structure Transformation of a Sprayed Gel for pH‐Ultrasensitive Nano‐Catalytic Antibacterial Therapy
    Wiley ; 2023
    In:  Advanced Healthcare Materials Vol. 12, No. 10 ( 2023-04)
    Details
    In: Advanced Healthcare Materials, Wiley, Vol. 12, No. 10 ( 2023-04)
    Abstract: Nano‐catalytic bacterial killing provides new opportunities to address ever‐increasing antibiotic resistance. However, the intrinsic catalytic activity usually depends on a much lower pH conditions (pH = 2–5) than that in the weakly acidic bacterial microenvironments (pH = 6–7) for reactive oxygen species production by Fenton reactions. Herein, a MnSiO 3 ‐based pH‐ultrasensitive “in situ structure transformation” is first reported to significantly promote the adhesion between material and bacteria, and shorten the diffusion distance ( 〈 20 nm) to compensate ultra‐short life ( 〈 200 ns) of ·OH generated by Mn 2+ ‐mediated Fenton‐like reaction, finally enhancing its nano‐catalytic antibacterial performance in weakly acidic conditions. A separated spray bottle is further designed to achieve in situ gelation at the wound site, which demonstrates excellent shape adaptability to complicated and rough surfaces of wounds, allowing for long‐term nano‐catalyst release. As a result, bacterial‐infected wound healing is efficiently promoted. Herein, the in situ sprayed nano‐catalytic antibacterial gel presents a promising paradigm for bacterial infection treatment.
    Type of Medium: Online Resource
    ISSN: 2192-2640 , 2192-2659
    URL: Issue
    URL: Article
    DOI: 10.1002/adhm.v12.10
    DOI: 10.1002/adhm.202202441
    Language: English
    Publisher: Wiley
    Publication Date: 2023
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  • 7
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    Online Resource
    Normothermic extracorporeal membrane oxygenation support: Improving the function of intestinal grafts obtained from cardiac death donors
    Wiley ; 2020
    In:  Artificial Organs Vol. 44, No. 10 ( 2020-10), p. 1098-1106
    Details
    In: Artificial Organs, Wiley, Vol. 44, No. 10 ( 2020-10), p. 1098-1106
    Abstract: Extracorporeal membrane oxygenation (ECMO) could ameliorate the energy status and viability of bowel grafts from cardiac death donors. However, the function of these grafts after transplantation is not clear. The purpose of the study was to evaluate the early function of intestinal grafts after transplantation from expected cardiac death donors supported with normothermic extracorporeal support using a porcine allogeneic orthotopic segmental small bowel transplantation model. Eighteen domestic crossbred donor pigs were assigned to living donation (LD), donation after cardiac death (DCD), and ECMO groups. In the LD group, small bowels were harvested and preserved immediately in cold storage. In the other two groups, the donor pigs received conventional rapid recovery treatment or 1‐hour normothermic extracorporeal support after 10‐minutes expected cardiac arrest. Subsequently, the small bowels were removed and preserved in cold storage. After 5‐6 hours of preservation, small bowel grafts were transplanted into the recipient pigs that underwent enterectomy. The pathology and electron microscopy results, cell apoptosis rate, tight junction protein expression level in the intestinal mucosa, and plasma endotoxin level were evaluated after transplantation. All grafts functioned on the basis of the maltose absorption test results at day 7 after transplantation. There were no significant differences in the morphological changes in the intestinal mucosa among the three groups at day 7 after transplantation. The cell apoptosis rate and plasma endotoxin level in the ECMO group did not differ significantly than those in the LD group, but were evidently lower than those in the DCD group ( P   〈  .001). The intestinal absorptive function improved significantly in the ECMO group in contrast with that in the DCD group ( P   〈  .001). Short‐term ECMO intervention can alleviate ischemia–reperfusion injuries in intestinal grafts and improve intestinal absorptive function in the early stage after transplantation. Reducing caspase‐3 protein expression and cell apoptosis in the intestinal mucosa may be one of the protective mechanisms of ECMO intervention.
    Type of Medium: Online Resource
    ISSN: 0160-564X , 1525-1594
    URL: Issue
    URL: Article
    DOI: 10.1111/aor.v44.10
    DOI: 10.1111/aor.13697
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2003825-2
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