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  • 1
    In: Basin Research, Wiley, Vol. 29, No. 3 ( 2017-06), p. 340-362
    Abstract: The Qiongdongnan Basin is one of the largest Cenozoic rifted basins on the northern passive margin of the South China Sea. It is well known that since the Late Miocene, approximately 10 Ma after the end of the syn‐rift phase, this basin has exhibited rapid thermal subsidence. However, detailed analysis reveals a two‐stage anomalous subsidence feature of the syn‐rift subsidence deficit and the well‐known rapid post‐rift subsidence after 10.5 Ma. Heat‐flow data show that heat flow in the central depression zone is 70–105 mW m −2 , considerably higher than the heat flow ( 〈 70 mW m −2 ) on the northern shelf. In particular, there is a NE‐trending high heat‐flow zone of 〉 85 mW m −2 in the eastern basin. We used a numerical model of coupled geothermal processes, lithosphere thinning and depositional processes to analyse the origin of the anomalous subsidence pattern. Numerical analysis of different cases shows that the stretching factor β s based on syn‐rift sequences is less than the observed crustal stretching factor β c , and if the lithosphere is thinned with β c during the syn‐rift phase (before 21 Ma), the present basement depth can be predicted fairly accurately. Further analysis does not support crustal thinning after 21 Ma, which indicates that the syn‐rift subsidence is in deficit compared with the predicted subsidence with the crustal stretching factor β c . The observed high heat flow in the central depression zone is caused by the heating of magmatic injection equivalently at approximately 3–5 Ma, which affected the eastern basin more than the western basin, and the Neogene magmatism might be fed by the deep thermal anomaly. Our results suggest that the causes of the syn‐rift subsidence deficit and rapid post‐rift subsidence might be related. The syn‐rift subsidence deficit might be caused by the dynamic support of the influx of warmer asthenosphere material and a small‐scale thermal upwelling beneath the study area, which might have been persisting for about 10 Ma during the early post‐rift phase, and the post‐rift rapid subsidence might be the result of losing the dynamic support with the decaying or moving away of the deep thermal source, and the rapid cooling of the asthenosphere. We concluded that the excess post‐rift subsidence occurs to compensate for the syn‐rift subsidence deficit, and the deep thermal anomaly might have affected the eastern Qiongdongnan Basin since the Late Oligocene.
    Type of Medium: Online Resource
    ISSN: 0950-091X , 1365-2117
    URL: Issue
    RVK:
    Language: English
    Publisher: Wiley
    Publication Date: 2017
    detail.hit.zdb_id: 2019914-4
    SSG: 16,13
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  • 2
    Online Resource
    Online Resource
    Wiley ; 2021
    In:  Brain and Behavior Vol. 11, No. 5 ( 2021-05)
    In: Brain and Behavior, Wiley, Vol. 11, No. 5 ( 2021-05)
    Abstract: To evaluate if the hyperdense middle cerebral artery sign (HMCAS) is an imaging biomarker for hemorrhagic transformation (HT) and the functional outcome of patients with large cerebral infarctions without thrombolytic therapy. Materials and Methods The clinical and imaging data of 312 patients with large cerebral infarction without thrombolytic therapy were retrospectively analyzed. They were divided into patients who presented with HMCAS ( n  = 121) and those who did not (non‐HMCAS[ n  = 168] patients), and the clinical data of the 2 groups were compared. This was a retrospective study. Results Of the 289 patients, 83(28.7%) developed HT. The incidence of atrial fibrillation, high homocysteine and admission NIHSS score at the time of admission was significantly higher in the HMCAS patients than in non‐HMCAS patients ( p   〈  .05). The ASPECTS was significantly lower in HMCAS patients ( t  = −5.835, p  〈  .001). The incidence of PH‐2 and 3‐month mRS score was also statistically significant higher in HMCAS patients (χ 2  = 3.971, p  = .046; χ 2  = 5.653, p  〈  .001, respectively). A sub‐analysis showed HMCAS patients with HT were significantly older than non‐HMCAS patients with HT ( t  = 2.473, p  = .015). The incidence of atrial fibrillation and the 3‐month mortality rate were higher in HMCAS patients with HT than in non‐HMCAS patients with HT (χ 2  = 3.944, p  = .047; χ 2  = 6.043, p  = .014, respectively). Multiple logistic regression analysis showed HT was independently associated with HMCAS (adjusted OR/95% CI/ p  = 2.762/1.571–4.854/ p  〈  .001) and admission NIHSS score (adjusted OR/95% CI/ p  = 1.081/1.026–1.139/0.003). And HMCAS with HT was independently associated with length of HMCAS (adjusted OR/95% CI/ p  = 1.216/1.076–1.374/0.002). Conclusions HMCAS in patients with a large cerebral infarction without thrombolytic therapy is an independent biomarker of HT. Length of HMCAS is also a marker of HT with lower ASPECTS in HMCAS patients.
    Type of Medium: Online Resource
    ISSN: 2162-3279 , 2162-3279
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2623587-0
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  • 3
    In: The FASEB Journal, Wiley, Vol. 32, No. 2 ( 2018-02), p. 1007-1016
    Type of Medium: Online Resource
    ISSN: 0892-6638 , 1530-6860
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 1468876-1
    SSG: 12
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  • 4
    In: Rapid Communications in Mass Spectrometry, Wiley, Vol. 37, No. 20 ( 2023-10-30)
    Type of Medium: Online Resource
    ISSN: 0951-4198 , 1097-0231
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2002158-6
    detail.hit.zdb_id: 58731-X
    SSG: 11
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  • 5
    In: Mycoses, Wiley, Vol. 64, No. 5 ( 2021-05), p. 495-502
    Abstract: Pneumocystis jirovecii pneumonia (PJP) is an opportunistic infection among solid organ transplantation. The occurrence of PJP is dangerous and fatal if there is no early identification and sufficient treatment. Objective The aim of this study was to evaluate the risk factors and provide appropriate strategies of prophylaxis and treatment for PJP after kidney transplantation in our centre. Patients/Methods From January 2009 to December 2018, a total of 167 kidney transplantation recipients with pneumonia were enrolled, including 47 PJP patients as PJP group and 120 non‐PJP patients as control group. The clinical characteristics of the two groups were analysed retrospectively. Results Multivariate analysis showed that high total dosage of ATG [OR, 2.03; 95% CI, 1.12–3.68] and cytomegalovirus (CMV) infection were independent risk factors for PJP. Trimethoprim‐sulfamethoxazole (TMP‐SMX) (1.44 g q6h)–based treatment was used for 2 weeks, and its dosage and course were adjusted according to the therapeutic effect and side effects. Forty‐five cases were recovered after 3 months of follow‐up, and two patients died of respiratory failure. TMP‐SMX (0.48 g/day) prophylaxis was used for 3–6 months and prolonged to 7–8 months after treatment for acute rejection, which reduced the incidence of PJP compared with those without prophylaxis. Conclusion Our study suggests that the high total dosage of ATG and CMV infection indicate the increased risk of PJP. The strategies of prophylaxis and treatment for PJP after kidney transplantation in our centre were effective.
    Type of Medium: Online Resource
    ISSN: 0933-7407 , 1439-0507
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2020780-3
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  • 6
    In: Clinical and Experimental Pharmacology and Physiology, Wiley, Vol. 39, No. 12 ( 2012-12), p. 1026-1033
    Type of Medium: Online Resource
    ISSN: 0305-1870
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2012
    detail.hit.zdb_id: 2020033-X
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  • 7
    In: Molecular Nutrition & Food Research, Wiley, Vol. 61, No. 5 ( 2017-05)
    Abstract: Diabetic cardiomyopathy is one of the most important cardiac complications associated with diabetes. However, the mechanisms underlying diabetic cardiomyopathy remain unclear. The PARP1, SIRT1, and mTOR pathways have been implicated in cardiac diseases, and they are also associated with diabetes. 1,25(OH) 2 D 3 was recently recognized as a potential PARP1inhibitor in a macrophage cell line. The aim of our study was to investigate whether 1,25(OH) 2 D 3 can improve diabetic cardiomyopathy through a vitamin D receptor (VDR)‐dependent mechanism associated with the PARP1/SIRT1/mTOR pathway. Methods and results 1,25(OH) 2 D 3 ‐treated diabetic rats displayed improved left ventricular wall thickness and end‐diastolic/systolic diameter, end‐diastolic/systolic volume, left ventricular ejection fraction, fractional shortening, atrial natriuretic peptide, and brain natriuretic peptide gene expression, and interstitial fibrosis compared with untreated diabetic rats, while silencing the VDR gene in DM rats blocked the above results. 1,25(OH) 2 D 3 treatment also decreased PARP1 and increased SIRT1 expression levels and repressed the phosphorylation of mTOR. Treating neonatal cardiomyocytes with 1,25(OH) 2 D 3 and a PARP1 inhibitor decreased PARP1 and increased SIRT1 protein expression. Conclusion The present study demonstrates that 1,25(OH) 2 D 3 treatment has the potential to improve diabetic cardiomyopathy in rats and suggests that VD‐VDR signaling induces this protective effect against diabetic cardiomyopathy might partly through the PARP1/SIRT1/mTOR pathway.
    Type of Medium: Online Resource
    ISSN: 1613-4125 , 1613-4133
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2017
    detail.hit.zdb_id: 2160372-8
    SSG: 12
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  • 8
    Online Resource
    Online Resource
    Wiley ; 2023
    In:  Annals of Clinical and Translational Neurology Vol. 10, No. 8 ( 2023-08), p. 1365-1373
    In: Annals of Clinical and Translational Neurology, Wiley, Vol. 10, No. 8 ( 2023-08), p. 1365-1373
    Abstract: To assess seizure semiology and disease evolution in a large number of hypothalamic hamartoma (HH) patients. Methods Seizure semiology and associated medical records for 78 patients with HH‐related epilepsy were retrospectively reviewed. Potential predictors of seizure types were assessed through univariate and binary logistic regression analyses. Results 57 (73.1%) patients presented with gelastic seizures at the onset of epilepsy, of whole 39 (68.4%) experienced additional seizure types with a mean latency interval of 4.59 years. Automatism, version, and sGTCs were increasingly common with disease evolution. The intraventricular size of HH was significantly negatively correlated with the disease evolution interval ( r  = −0.445, p  = 0.009). A significantly higher rate of patients with automatism in the DF‐II group relative to the DF‐III group was found in both χ 2 ( X  = 6.07, p  = 0.014) and logistic regression analyses ( B  = 3.196, p  = 0.020). Interpretation Gelastic seizures are the most common initial seizure type in HH patients, but variable semiologies occur with disease evolution. The intraventricular HH lesion size is an important determinant of epilepsy evolution. DF‐II HH lesions contribute to a higher chance of automatism evolution. The present study furthers our understanding of the dynamic organization of the seizure network affected by HH.
    Type of Medium: Online Resource
    ISSN: 2328-9503 , 2328-9503
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2740696-9
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  • 9
    Online Resource
    Online Resource
    Wiley ; 2016
    In:  Chemistry – An Asian Journal Vol. 11, No. 17 ( 2016-09-06), p. 2352-2371
    In: Chemistry – An Asian Journal, Wiley, Vol. 11, No. 17 ( 2016-09-06), p. 2352-2371
    Abstract: One of the most important applications for photocatalysis is engineered water treatment that photodegrades organic pollutants in wastewater at low cost. To overcome the low efficiency of batch degradation methods, continuous‐flow photocatalytic reactors have been proposed and have become the most promising method for mass water treatment. However, most commercial semiconductor photocatalysts are granular nanoparticles with low activity and a narrow active light wavelength band; this creates difficulties for direct use in continuous‐flow photocatalytic reactors. Therefore, a high‐performance photodegradation photocatalyst with proper morphology or structure is key for continuous photocatalytic degradation. Moreover, a well‐designed photocatalytic device is another important component for continuous‐flow photocatalysis and determines the efficiency of photocatalysis in practical water treatment. This review describes the basic design principles and synthesis of photocatalysts with excellent performance and special morphologies suitable for a filtering photocatalysis process. Certain promising continuous photodegradation reactors are also categorized and summarized. Additionally, selected scientific and technical problems that must be urgently solved are suggested.
    Type of Medium: Online Resource
    ISSN: 1861-4728 , 1861-471X
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2016
    detail.hit.zdb_id: 2233006-9
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  • 10
    In: Advanced Materials Technologies, Wiley, Vol. 8, No. 10 ( 2023-05)
    Abstract: Aqueous zinc‐ion battery (AZIB) based on Zn//MnO 2 is considered as one of the most promising energy storage devices. However, the poor Zn 2+ storage kinetics and structural integrity of MnO 2 affect its electrochemical performance. In this work, the vertically aligned multilayer graphene sheets (VGS) are in situ formed on the graphite paper via laser activation, and then MnO 2 nanoflakes are coated on the VGS by electrochemical deposition, leading to the layered MnO 2 @graphene with hierarchical structure. The MnO 2 nanoflakes coated on the VGS not only have improved charges transfer and structural integrity owing to the conductive skeleton, but also expose more accessible area to the electrolyte. In addition, the inner layer of graphite paper maintains its original structure, which can serve as current collector and endow the composite materials with good flexibility. In light of this rational design, the coin‐type AZIB assembled with layered MnO 2 @graphene as cathode shows a maximum capacity of 363.6 mAh g −1 . Furthermore, a flexible quasisolid‐state AZIB is fabricated, which also exhibits superior electrochemical performance and flexibility (97.0% capacity retention after 1000 bending cycles). This work provides a feasible and effective strategy to develop flexible MnO 2 @graphene as cathode for high‐performance rechargeable Zn//MnO 2 AZIB by rational design of the structure.
    Type of Medium: Online Resource
    ISSN: 2365-709X , 2365-709X
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2850995-X
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