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  • 1
    Online Resource
    Online Resource
    Clinical guideline for the diagnosis and treatment of cutaneous warts (2022)
    Wiley ; 2022
    In:  Journal of Evidence-Based Medicine Vol. 15, No. 3 ( 2022-09), p. 284-301
    Details
    In: Journal of Evidence-Based Medicine, Wiley, Vol. 15, No. 3 ( 2022-09), p. 284-301
    Abstract: Cutaneous warts caused by human papillomavirus are benign proliferative lesions that occur at any ages in human lives. Updated, comprehensive and systematic evidence‐based guidelines to guide clinical practice are urgently needed. Methods We collaborated with multidisciplinary experts to formulate this guideline based on evidences of already published literature, focusing on 13 clinical questions elected by a panel of experts. We adopted Grading of Recommendations Assessment, Development and Evaluation (GRADE) system to form classification of recommendations as well as the improved Delphi method to retain respective recommendations with a consensus degree of over 80%. Results Our guideline covered aspects of the diagnosis and treatment of cutaneous warts such as diagnostic gold standard, transmission routes, laboratory tests, treatment principle, clinical cure criterion, definitions, and treatments of common warts, flat warts, plantar warts, condyloma acuminatum, and epidermodysplasia verruciformis. Recommendations about special population such as children and pregnant women are also listed. In total, 49 recommendations have been obtained. Conclusions It is a comprehensive and systematic evidence‐based guideline and we hope this guideline could systematically and effectively guide the clinical practice of cutaneous warts and improve the overall levels of medical services.
    Type of Medium: Online Resource
    ISSN: 1756-5383 , 1756-5391
    URL: Issue
    URL: Article
    DOI: 10.1111/jebm.v15.3
    DOI: 10.1111/jebm.12494
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2474496-7
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  • 2
    Online Resource
    Online Resource
    Photoconversion‐Tunable Fluorophore Vesicles for Wavelength‐Dependent Photoinduced Cancer Therapy
    Wiley ; 2017
    In:  Advanced Materials Vol. 29, No. 19 ( 2017-05)
    Details
    In: Advanced Materials, Wiley, Vol. 29, No. 19 ( 2017-05)
    Abstract: Photoconversion tunability of fluorophore dye is of great interest in cancer nanomedicine such as fluorescence imaging, photodynamic therapy (PDT), and photothermal therapy (PTT). Herein, this paper reports wavelength‐dependent photoconversional polymeric vesicles of boron dipyrromethene (Bodipy) fluorophore for either PDT under 660 nm irradiation or PTT under 785 nm irradiation. After being assembled within polymeric vesicles at a high drug loading, Bodipy molecules aggregate in the conformations of both J ‐type and H ‐type, thereby causing red‐shifted absorption into near‐infrared region, ultralow radiative transition, and ideal resistance to photobleaching. Such vesicles further possess enhanced blood circulation, preferable tumor accumulation, as well as superior cell uptake as compared to free Bodipy. In particular, the vesicles mainly generate abundant intracellular singlet oxygen for PDT treatment under 660 nm irradiation, while they primarily produce a potent hyperthermia for PTT with tumor ablation through singlet oxygen‐synergized photothermal necrosis under 785 nm irradiation. This approach provides a facile and general strategy to tune photoconversion characteristics of fluorophore dyes for wavelength‐dependent photoinduced cancer therapy.
    Type of Medium: Online Resource
    ISSN: 0935-9648 , 1521-4095
    URL: Issue
    URL: Article
    DOI: 10.1002/adma.v29.19
    DOI: 10.1002/adma.201606690
    RVK:
    UA 1538
    Language: English
    Publisher: Wiley
    Publication Date: 2017
    detail.hit.zdb_id: 1474949-X
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  • 3
    Online Resource
    Online Resource
    Potassium Doping to Enhance Green Photoemission of Light‐Emitting Diodes Based on CsPbBr 3 Perovskite Nanocrystals
    Wiley ; 2020
    In:  Advanced Optical Materials Vol. 8, No. 18 ( 2020-09)
    Details
    In: Advanced Optical Materials, Wiley, Vol. 8, No. 18 ( 2020-09)
    Abstract: Metal halide perovskite nanocrystals (PeNCs) are emerging as one of the most promising materials for optoelectrical devices such as light‐emitting diode (LED) owing to their tunable band gaps, high color purity, and tolerance to defects. Nevertheless, the materials have not yet demonstrated their full potential in practical applications due to the poor stability of PeNCs and their unsatisfactory performance in devices. In this research, LED devices based on CsPbBr 3 NCs are successfully demonstrated as an active light‐emitting layer with enhanced efficiency via potassium doping. The study of the effect of potassium dopant on physicochemical properties of inorganic CsPbBr 3 PeNCs shows that potassium cations (K + ) remain in the crystal structure of perovskite compound as interstitial defects, which results in better coverage of surface ligands on the PeNCs and improved energy band alignment with adjacent electron injection layer (2,2′,2′‐(1,3,5‐benzinetriyl)‐tris(1‐phenyl‐1‐ H ‐benzimidazole)) and hole injection layer (poly(3,4‐ethylenedioxythiophene) polystyrene sulfonate) in an LED. As a consequence, the green LED with the K‐doped CsPbBr 3 PeNCs shows luminance up to 5759 cd m ‐2 and external quantum efficiency (EQE) of 5.6%, which is superior to the pristine device without K‐doping (luminance: 4579 cd m ‐2 , EQE: 4.8%).
    Type of Medium: Online Resource
    ISSN: 2195-1071 , 2195-1071
    URL: Issue
    URL: Article
    DOI: 10.1002/adom.v8.18
    DOI: 10.1002/adom.202000742
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2708158-8
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  • 4
    Online Resource
    Online Resource
    Melatonin antagonizes hypoxia‐mediated glioblastoma cell migration and invasion via inhibition of HIF ‐1α
    Wiley ; 2013
    In:  Journal of Pineal Research Vol. 55, No. 2 ( 2013-09), p. 121-130
    Details
    In: Journal of Pineal Research, Wiley, Vol. 55, No. 2 ( 2013-09), p. 121-130
    Abstract: Hypoxia is a crucial factor in tumor aggressiveness and resistance to therapy, especially in glioblastoma. Our previous results have shown that melatonin exerts antimigratory and anti‐invasive action in glioblastoma cells under normoxia. However, the effect of melatonin on migration and invasion of glioblastoma cells under hypoxic condition remains poorly understood. Here, we show that melatonin strongly reduced hypoxia‐mediated invasion and migration of U 251 and U 87 glioblastoma cells. In addition, we found that melatonin significantly blocked HIF ‐1α protein expression and suppressed the expression of downstream target genes, matrix metalloproteinase 2 ( MMP ‐2) and vascular endothelial growth factor ( VEGF ). Furthermore, melatonin destabilized hypoxia‐induced HIF ‐1α protein via its antioxidant activity against ROS produced by glioblastoma cells in response to hypoxia. Along with this, HIF ‐1α silencing by small interfering RNA markedly inhibited glioblastoma cell migration and invasion, and this appeared to be associated with MMP ‐2 and VEGF under hypoxia. Taken together, our findings suggest that melatonin suppresses hypoxia‐induced glioblastoma cell migration and invasion via inhibition of HIF ‐1α. Considering the fact that overexpression of the HIF ‐1α protein is often detected in glioblastoma multiforme, melatonin may prove to be a potent therapeutic agent for this tumor.
    Type of Medium: Online Resource
    ISSN: 0742-3098 , 1600-079X
    URL: Issue
    URL: Article
    DOI: 10.1111/jpi.2013.55.issue-2
    DOI: 10.1111/jpi.12052
    Language: English
    Publisher: Wiley
    Publication Date: 2013
    detail.hit.zdb_id: 2027992-9
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  • 5
    Online Resource
    Online Resource
    Loss of m6A demethylase ALKBH5 promotes post‐ischemic angiogenesis via post‐transcriptional stabilization of WNT5A
    Wiley ; 2021
    In:  Clinical and Translational Medicine Vol. 11, No. 5 ( 2021-05)
    Details
    In: Clinical and Translational Medicine, Wiley, Vol. 11, No. 5 ( 2021-05)
    Abstract: Post‐ischemic angiogenesis is critical for blood flow recovery and ischemic tissue repair. N6‐methyladenosine (m6A) plays essential roles in numerous biological processes. However, the impact and connected mechanism of m6A on post‐ischemic angiogenesis are not fully understood. Methods AlkB homolog 5 (ALKBH5) was screened out among several methyltransferases and demethylases involved in dynamic m6A regulation. Cardiac microvascular endothelial cells (CMECs) angiogenesis and WNT family member 5A (WNT5A) stability were analyzed upon ALKBH5 overexpression with adenovirus or knockdown with small interfering RNAs in vitro. The blood flow recovery, capillary, and small artery densities were evaluated in adeno‐associated virus (AAV)‐ALKBH5 overexpression or ALKBH5 knockout (KO) mice in a hind‐limb ischemia model. The same experiments were conducted to explore the translational value of transient silencing of ALKBH5 with adenovirus. Results ALKBH5 was significantly upregulated in hypoxic CMECs and led to a global decrease of m6A level. ALKBH5 overexpression further reduced m6A level in normoxic and hypoxic CMECs, impaired proliferation, migration, and tube formation only in hypoxic CMECs. Conversely, ALKBH5 knockdown preserved m6A levels and promoted angiogenic phenotypes in hypoxic but not in normoxic CMECs. Mechanistically, ALKBH5 regulated WNT5A expression through post‐transcriptional mRNA modulation in an m6A‐dependent manner, which decreased its stability and subsequently impeded angiogenesis in hypoxic CMECs. Furthermore, ALKBH5 overexpression hindered blood flow recovery and reduced CD31 and alpha‐smooth muscle actin expression in hind‐limb ischemia mice. As expected, ALKBH5‐KO mice exhibited improved blood flow recovery, increased capillary, and small artery densities after hind‐limb ischemia, and similar beneficial effects were observed in mice with transient adenoviral ALKBH5 gene silencing. Conclusion We demonstrate that ALKBH5 is a negative regulator of post‐ischemic angiogenesis via post‐transcriptional modulation and destabilization of WNT5A mRNA in an m6A‐dependent manner. Targeting ALKBH5 may be a potential therapeutic option for ischemic diseases, including peripheral artery disease.
    Type of Medium: Online Resource
    ISSN: 2001-1326 , 2001-1326
    URL: Issue
    URL: Article
    DOI: 10.1002/ctm2.v11.5
    DOI: 10.1002/ctm2.402
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2697013-2
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  • 6
    Online Resource
    Online Resource
    ZDHHC16 modulates FGF/ERK dependent proliferation of neural stem/progenitor cells in the zebrafish telencephalon
    Wiley ; 2016
    In:  Developmental Neurobiology Vol. 76, No. 9 ( 2016-09), p. 1014-1028
    Details
    In: Developmental Neurobiology, Wiley, Vol. 76, No. 9 ( 2016-09), p. 1014-1028
    Abstract: In vertebrates, neural stem/progenitor cells (NSPCs) maintenance is critical for nervous system development and homeostasis. However, the molecular mechanisms underlying the maintenance of NSPCs have not been fully elucidated. Here, we demonstrated that zebrafish ZDHHC16, a DHHC encoding protein, which was related to protein palmitoylation after translation, was expressed in the developing forebrain, and especially in the telencephalon. Loss‐ and gain‐of‐function studies showed that ZDHHC16 played a crucial role in the regualtion of NSPCs proliferation during zebrafish telencephalic development, via a mechanism dependent on its palmitoyltransferase activity. Further analyses showed that the inhibition of ZDHHC16 led to inactivation of the FGF/ERK signaling pathway during telencephalic NSPCs proliferation and maintenance. Taken together, our results suggest that ZDHHC16 activity is essential for early NSPCs proliferation where it acts to activate the FGF/ERK network, allowing for the initiation of proliferation –regulated gene expression programs. © 2016 Wiley Periodicals, Inc. Develop Neurobiol 76: 1014–1028, 2016
    Type of Medium: Online Resource
    ISSN: 1932-8451 , 1932-846X
    URL: Issue
    URL: Article
    DOI: 10.1002/dneu.v76.9
    DOI: 10.1002/dneu.22372
    Language: English
    Publisher: Wiley
    Publication Date: 2016
    detail.hit.zdb_id: 2266191-8
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  • 7
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    Cyanine‐Anchored Silica Nanochannels for Light‐Driven Synergistic Thermo‐Chemotherapy
    Wiley ; 2017
    In:  Small Vol. 13, No. 6 ( 2017-02)
    Details
    In: Small, Wiley, Vol. 13, No. 6 ( 2017-02)
    Abstract: Smart nanoparticles are increasingly important in a variety of applications such as cancer therapy. However, it is still a major challenge to develop light‐responsive nanoparticles that can maximize the potency of synergistic thermo‐chemotherapy under light irradiation. Here, spatially confined cyanine‐anchored silica nanochannels loaded with chemotherapeutic doxorubicin (CS‐DOX‐NCs) for light‐driven synergistic cancer therapy are introduced. CS‐DOX‐NCs possess a J ‐type aggregation conformation of cyanine dye within the nanochannels and encapsulate doxorubicin through the π–π interaction with cyanine dye. Under near‐infrared light irradiation, CS‐DOX‐NCs produce the enhanced photothermal conversion efficiency through the maximized nonradiative transition of J ‐type Cypate aggregates, trigger the light‐driven drug release through the destabilization of temperature‐sensitive π–π interaction, and generate the effective intracellular translocation of doxorubicin from the lysosomes to cytoplasma through reactive oxygen species‐mediated lysosomal disruption, thereby causing the potent in vivo hyperthermia and intracellular trafficking of drug into cytoplasma at tumors. Moreover, CS‐DOX‐NCs possess good resistance to photobleaching and preferable tumor accumulation, facilitating severe photoinduced cell damage, and subsequent synergy between photothermal and chemotherapeutic therapy with tumor ablation. These findings provide new insights of light‐driven nanoparticles for synergistic cancer therapy.
    Type of Medium: Online Resource
    ISSN: 1613-6810 , 1613-6829
    URL: Issue
    URL: Article
    DOI: 10.1002/smll.v13.6
    DOI: 10.1002/smll.201602747
    Language: English
    Publisher: Wiley
    Publication Date: 2017
    detail.hit.zdb_id: 2168935-0
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  • 8
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    Online Resource
    The development of a geospatial data Grid by integrating OGC Web services with Globus‐based Grid technology
    Wiley ; 2008
    In:  Concurrency and Computation: Practice and Experience Vol. 20, No. 14 ( 2008-09-25), p. 1617-1635
    Details
    In: Concurrency and Computation: Practice and Experience, Wiley, Vol. 20, No. 14 ( 2008-09-25), p. 1617-1635
    Abstract: Geospatial science is the science and art of acquiring, archiving, manipulating, analyzing, communicating, modeling with, and utilizing spatially explicit data for understanding physical, chemical, biological, and social systems on the Earth's surface or near the surface. In order to share distributed geospatial resources and facilitate the interoperability, the Open Geospatial Consortium (OGC), an industry–government–academia consortium, has developed a set of widely accepted Web‐based interoperability standards and protocols. Grid is the technology enabling resource sharing and coordinated problem solving in dynamic, multi‐institutional virtual organizations. Geospatial Grid is an extension and application of Grid technology in the geospatial discipline. This paper discusses problems associated with directly using Globus‐based Grid technology in the geospatial disciplines, the needs for geospatial Grids, and the features of geospatial Grids. Then, the paper presents a research project that develops and deploys a geospatial Grid through integrating Web‐based geospatial interoperability standards and technology developed by OGC with Globus‐based Grid technology. The geospatial Grid technology developed by this project makes the interoperable, personalized, on‐demand data access and services a reality at large geospatial data archives. Such a technology can significantly reduce problems associated with archiving, manipulating, analyzing, and utilizing large volumes of geospatial data at distributed locations. Copyright © 2008 John Wiley & Sons, Ltd.
    Type of Medium: Online Resource
    ISSN: 1532-0626 , 1532-0634
    URL: Issue
    URL: Article
    DOI: 10.1002/cpe.v20:14
    DOI: 10.1002/cpe.1292
    RVK:
    SA 4270
    Language: English
    Publisher: Wiley
    Publication Date: 2008
    detail.hit.zdb_id: 2052606-4
    SSG: 11
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  • 9
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    Role of miR‐223‐3p in pulmonary arterial hypertension via targeting ITGB3 in the ECM pathway
    Wiley ; 2019
    In:  Cell Proliferation Vol. 52, No. 2 ( 2019-03)
    Details
    In: Cell Proliferation, Wiley, Vol. 52, No. 2 ( 2019-03)
    Abstract: To investigate the functions of miR‐223‐3p and ITGB3 in pulmonary arterial hypertension (PAH). Materials and Methods Microarray analysis was used to detect differentially expressed genes and microRNAs. In in vitro models, the expressions of miR‐223‐3p and ITGB3 were detected by qRT‐PCR and Western blot. α‐SMA expression and cell proliferation were analysed by immunofluorescence and MTT assay, respectively. In in vivo models, PAH progressions were determined by measuring the levels of mPAP and RVSP. Lung and myocardial tissues were subjected to HE staining and Masson and Sirius red‐saturated carbazotic acid staining to investigate the pathological features. Results The microarray analysis revealed that ITGB3 was upregulated, while hsa‐miR‐223‐3p was downregulated in PAH. After the induction of hypoxia, miR‐223‐3p was downregulated and ITGB3 was upregulated in PASMCs. Hypoxia induction promoted cell proliferation and inhibited α‐SMA expression in PASMCs. Both the upregulation of miR‐223‐3p and the downregulation of ITGB3 attenuated the aberrant proliferation induced by hypoxia conditions. After approximately 4 weeks, the mPAP and RVSP levels of rats injected with MCT were decreased by the overexpression of miR‐223‐3p or the silencing of ITGB3 . The staining results revealed that both miR‐223‐3p overexpression and ITGB3 knockdown alleviated the pulmonary vascular remodelling and improved the PAH pathological features of rats. Conclusions MiR‐223‐3p alleviated the progression of PAH by suppressing the expression of ITGB3 , a finding which provides novel targets for clinical treatment.
    Type of Medium: Online Resource
    ISSN: 0960-7722 , 1365-2184
    URL: Issue
    URL: Article
    DOI: 10.1111/cpr.2019.52.issue-2
    DOI: 10.1111/cpr.12550
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 2019986-7
    SSG: 12
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  • 10
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    Global burden and attributable risk factors of acute lymphoblastic leukemia in 204 countries and territories in 1990–2019: Estimation based on Global Burden of Disease Study 2019
    Wiley ; 2022
    In:  Hematological Oncology Vol. 40, No. 1 ( 2022-02), p. 93-105
    Details
    In: Hematological Oncology, Wiley, Vol. 40, No. 1 ( 2022-02), p. 93-105
    Abstract: To provide a foundational guideline for policy‐makers to efficiently allocate medical resources in the context of population aging and growth, the latest spatial distribution and temporal trend of acute lymphoblastic leukemia (ALL) along with attributable risk factors by sex and age were mapped. Based on the Global Burden of Disease Study 2019, estimated annual percentage change (EAPC) was calculated according to the relativity between age‐standardized rate and calendar year, to quantify temporal trends in morbidity and mortality of ALL. We used applied Spearman rank correlation to estimate the relationship between the EAPC and potential influence factors. The population attributable fraction of potential risk factors for ALL‐related disability‐adjusted life years were estimated by the comparative risk assessment framework. As a result, we found that new ALL cases increased significantly by 1.29% worldwide, and the age‐standardized incidence rate increased by 1.61% annually. The proportion of elder patients sharply increased, especially within the higher socio‐demographic index (SDI) region. Smoking and high body mass index remained the predominant risk factors for ALL‐related mortality. Notably, the contribution of high body mass index presented an increasing trend. In conclusion, the global burden of ALL has steadily increased, especially in Middle SDI region. Health measures and new drugs should be taken into consideration to improve the management and treatment of elders with ALL due to an increasing proportion in the higher SDI region. For Low SDI areas, attention should be paid to the environmental problems caused by industrial development.
    Type of Medium: Online Resource
    ISSN: 0278-0232 , 1099-1069
    URL: Issue
    URL: Article
    DOI: 10.1002/hon.v40.1
    DOI: 10.1002/hon.2936
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2001443-0
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