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  • 1
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    Portal vein thrombosis compromises the performance of MELD and MELD‐Na scores in patients with cirrhosis
    Wiley ; 2023
    In:  Journal of Gastroenterology and Hepatology Vol. 38, No. 1 ( 2023-01), p. 129-137
    Details
    In: Journal of Gastroenterology and Hepatology, Wiley, Vol. 38, No. 1 ( 2023-01), p. 129-137
    Abstract: The accuracy of model for end‐stage liver disease (MELD) and MELD with sodium (MELD‐Na) scores in reflecting the clinical outcomes of patients with cirrhosis and portal vein thrombosis (PVT) remains unclear. This study aimed to evaluate the performance of scores in predicting 90‐day mortality in patients with cirrhosis and PVT. Methods Post hoc analysis was performed in two prospective cohorts (NCT02457637 and NCT03641872). The correlation between the MELD/MELD‐Na score and 90‐day liver transplantation (LT)‐free mortality was investigated in patients with cirrhosis with and without PVT. Results In this study, 2826 patients with cirrhosis were included, and 255 (9.02%) had PVT. The cumulative incidence of 90‐day LT‐free mortality did not significantly differ between patients with and without PVT (log‐rank P  = 0.0854). MELD [area under the receiver operating curve (AUROC), 0.649 vs. 0.842; P  = 0.0036] and MELD‐Na scores (AUROC, 0.691 vs. 0.851; P  = 0.0108) were compared in patients with and without PVT, regarding the prediction of 90‐day LT‐free mortality. In MELD  〈  15 and MELD‐Na  〈  20 subgroups, patients with PVT had a higher 90‐day LT‐free mortality than those without PVT (7.91% vs. 2.64%, log‐rank P  = 0.0011; 7.14% vs. 3.43%, log‐rank P  = 0.0223), whereas in MELD ≥ 15 and MELD‐Na ≥ 20 subgroups, no significant difference was observed between patients with and without PVT. Conclusions The performance of MELD and MELD‐Na scores in predicting 90‐day LT‐free mortality of patients with cirrhosis was compromised by PVT. MELD  〈  15 or MELD‐Na  〈  20 may underestimate the 90‐day LT‐free mortality in patients with PVT.
    Type of Medium: Online Resource
    ISSN: 0815-9319 , 1440-1746
    URL: Issue
    URL: Article
    DOI: 10.1111/jgh.v38.1
    DOI: 10.1111/jgh.16053
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2006782-3
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  • 2
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    Antiphospholipid Antibodies in Critically Ill Patients With COVID‐19
    Wiley ; 2020
    In:  Arthritis & Rheumatology Vol. 72, No. 12 ( 2020-12), p. 1998-2004
    Details
    In: Arthritis & Rheumatology, Wiley, Vol. 72, No. 12 ( 2020-12), p. 1998-2004
    Abstract: Coagulopathy is one of the characteristics observed in critically ill patients with coronavirus disease 2019 (COVID‐19). Antiphospholipid antibodies (aPLs) contribute to coagulopathy, though their role in COVID‐19 remains unclear. This study was undertaken to determine the prevalence and characteristics of aPLs in patients with COVID‐19. Methods Sera collected from 66 COVID‐19 patients who were critically ill and 13 COVID‐19 patients who were not critically ill were tested by chemiluminescence immunoassay for anticardiolipin antibodies (aCLs), anti–β 2 ‐glycoprotein I (anti‐β 2 GPI) (IgG, IgM, and IgA), and IgG anti‐β 2 GPI–domain 1 (anti‐β 2 GPI–D1) and IgM and IgG anti–phosphatidylserine/prothrombin (anti‐PS/PT) antibodies were detected in the serum by enzyme‐linked immunosorbent assay. Results Of the 66 COVID‐19 patients in critical condition, aPLs were detected in 31 (47% ). Antiphospholipid antibodies were not present among COVID‐19 patients who were not in critical condition. The IgA anti‐β 2 GPI antibody was the most commonly observed aPL in patients with COVID‐19 and was present in 28.8% (19 of 66) of the critically ill patients, followed by IgA aCLs (17 of 66, or 25.8%) and IgG anti‐β 2 GPI (12 of 66, or 18.2%). For multiple aPLs, IgA anti‐β 2 GPI + IgA aCLs was the most common antibody profile observed (15 of 66, or 22.7%), followed by IgA anti‐β 2 GPI + IgA aCL + IgG anti‐β 2 GPI (10 of 66, or 15.2%). Antiphospholipid antibodies emerge ~35–39 days after disease onset. A dynamic analysis of aPLs revealed 4 patterns based on the persistence or transient appearance of the aPLs. Patients with multiple aPLs had a significantly higher incidence of cerebral infarction compared to patients who were negative for aPLs ( P = 0.023). Conclusion Antiphospholipid antibodies were common in critically ill patients with COVID‐19. Repeated testing demonstrating medium to high titers of aPLs and the number of aPL types a patient is positive for may help in identifying patients who are at risk of developing cerebral infarction. Antiphospholipid antibodies may be transient and disappear within a few weeks, but in genetically predisposed patients, COVID‐19 may trigger the development of an autoimmune condition similar to the antiphospholipid syndrome (APS), referred to as “COVID‐19–induced APS‐like syndrome.” Long‐term follow‐up of COVID‐19 patients who are positive for aPLs would be of great importance in understanding the pathogenesis of this novel coronavirus.
    Type of Medium: Online Resource
    ISSN: 2326-5191 , 2326-5205
    URL: Issue
    URL: Article
    DOI: 10.1002/art.v72.12
    DOI: 10.1002/art.41425
    RVK:
    XA 10000
    RVK:
    XA 30325
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2754614-7
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  • 3
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    Role of Drugs Used for Chronic Disease Management on Susceptibility and Severity of COVID‐19: A Large Case‐Control Study
    Wiley ; 2020
    In:  Clinical Pharmacology & Therapeutics Vol. 108, No. 6 ( 2020-12), p. 1185-1194
    Details
    In: Clinical Pharmacology & Therapeutics, Wiley, Vol. 108, No. 6 ( 2020-12), p. 1185-1194
    Abstract: This study aimed to investigate whether specific medications used in the treatment chronic diseases affected either the development and/ or severity of coronavirus disease 2019 (COVID‐19) in a cohort of 610 COVID‐19 cases and 48,667 population‐based controls from Zhejiang, China. Using a cohort of 578 COVID‐19 cases and 48,667 population‐based controls from Zhejiang, China, we tested the role of usage of cardiovascular, antidiabetic, and other medications on risk and severity of COVID‐19. Analyses were adjusted for age, sex, and body mass index and for presence of relevant comorbidities. Individuals with hypertension taking calcium channel blockers had significantly increased risk (odds ratio (OR) = 1.73, 95% confidence interval (CI) 1.2–2.3) of manifesting symptoms of COVID‐19, whereas those taking angiotensin receptor blockers and diuretics had significantly lower disease risk (OR = 0.22, 95% CI 0.15–0.30 and OR = 0.30, 95% CI 0.19–0.58, respectively). Among those with type 2 diabetes, dipeptidyl peptidase‐4 inhibitors (OR = 6.02, 95% CI 2.3–15.5) and insulin (OR = 2.71, 95% CI 1.6–5.5) were more and glucosidase inhibitors were less prevalent (OR = 0.11, 95% CI 0.1–0.3) among with patients with COVID‐19. Drugs used in the treatment of hypertension and diabetes influence the risk of development of COVID‐19, but, not its severity.
    Type of Medium: Online Resource
    ISSN: 0009-9236 , 1532-6535
    URL: Article
    DOI: 10.1002/cpt.2047
    RVK:
    XA 36900
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2040184-X
    SSG: 15,3
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  • 4
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    In vivo photoacoustic/ultrasonic dual‐modality endoscopy with a miniaturized full field‐of‐view catheter
    Wiley ; 2018
    In:  Journal of Biophotonics Vol. 11, No. 10 ( 2018-10)
    Details
    In: Journal of Biophotonics, Wiley, Vol. 11, No. 10 ( 2018-10)
    Abstract: Endoscopy is an essential clinical tool for the diagnosis of gastrointestinal (GI) tract cancer. A photoacoustic system that elegantly combines optical and ultrasound endoscopy advantages by providing high‐sensitivity functional information and large imaging depth is a potentially powerful tool for GI tract imaging. Recently, several photoacoustic endoscopic imaging systems have been proposed and developed. However, the relatively large size and rigid length of the catheter make it difficult to translate them into wide clinical applications; while the existing system of a relatively small catheter, capable of in vivo animal imaging, is unable to acquire full (360°) field‐of‐view cross‐section images. In this study, we developed a photoacoustic/ultrasonic dual‐modality endoscopic system and a corresponding miniaturized, encapsulated imaging catheter, which provides a full 360° field‐of‐view. The diameter of the catheter is 2.5 mm, which is compatible with the 2.8‐mm instrumental channel of a conventional clinical optical endoscope. Using this system, we demonstrate in vivo 3‐dimensional endoscopic photoacoustic/ultrasonic imaging of the colorectum of a healthy Sprague Dawley rat, by depicting vasculature and morphology of the GI tract. The significantly improved imaging field of view, reduced catheter size, high‐quality imaging results suggest that the developed photoacoustic/ultrasonic dual‐modality endoscopy has a great potential to be translated into a broad range of clinical applications in gastroenterology.
    Type of Medium: Online Resource
    ISSN: 1864-063X , 1864-0648
    URL: Issue
    URL: Article
    DOI: 10.1002/jbio.2018.11.issue-10
    DOI: 10.1002/jbio.201800034
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2403788-6
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  • 5
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    A‐π‐D‐π‐A type Small Molecules Using Ethynylene Linkages for Organic Solar Cells with High Open‐circuit Voltages
    Wiley ; 2016
    In:  Chinese Journal of Chemistry Vol. 34, No. 4 ( 2016-04), p. 353-358
    Details
    In: Chinese Journal of Chemistry, Wiley, Vol. 34, No. 4 ( 2016-04), p. 353-358
    Abstract: Introducing ethynylene linkages in a conjugated molecule can deepen the HOMO level, decrease the steric constraints and better delocalize the π electrons and so on, which are beneficial for organic solar cells. Furthermore, the typical method of introducing acetylene linkages by Sonogashira reactions can avoid the usage of toxic stannyl intermediates and potentially dangerous lithiation reactions. In this study, two simple small molecules BEDPP and NEDPP are designed and synthesized, in which two diketopyrrolopyrrole units are symmetrically connected to benzene and naphthalene cores, respectively, via acetylene linkages. And the BHJ (Bulk Heterojunction) solar cells based on BEDPP and NEDPP without using solvent additive and without any post‐treatment for the active layers provide us power conversion efficiencies of 1.48% and 2.31% with remarkably high open circuit voltages up to 0.90 and 0.98 V, respectively.
    Type of Medium: Online Resource
    ISSN: 1001-604X , 1614-7065
    URL: Issue
    URL: Article
    DOI: 10.1002/cjoc.v34.4
    DOI: 10.1002/cjoc.201500825
    Language: English
    Publisher: Wiley
    Publication Date: 2016
    detail.hit.zdb_id: 2144352-X
    SSG: 6,25
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  • 6
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    Incidence and risk factors of anti‐tuberculosis drug induced liver injury (DILI): Large cohort study involving 4652 Chinese adult tuberculosis patients
    Wiley ; 2021
    In:  Liver International Vol. 41, No. 7 ( 2021-07), p. 1565-1575
    Details
    In: Liver International, Wiley, Vol. 41, No. 7 ( 2021-07), p. 1565-1575
    Abstract: Anti‐tuberculosis drugs remain as an important cause of drug‐induced liver injury (DILI) worldwide. Adverse drug reactions reduce the effectiveness of treatment. We aimed to determine the incidence and risk factors associated with anti‐tuberculosis DILI (ATDILI). Methods Using established criteria and causality assessment methods, risk factors for ATDILI were identified in a contemporary cohort and validated in another cohort prospectively. Independent determinants of ATDILI were identified using Cox regression analysis. Results In the derivation cohort (n = 3155), 170 (5.4%) developed ATDILI of which 27 (15.9%) developed jaundice; 9(5.3%) developed acute liver failure (ALF) and 3 died. Among HBsAg positive patients, 11/27 (40.7%) of ATDILI developed after 3 months of starting treatment. In addition, of 218 (6.9%) who developed raised alanine transferase (ALT) levels ≥3 times upper limit normal, 193 (88.5%) resolved and 25 (11.4%) progressed to DILI. Age (HR = 1.014, 95% CI: 1.005‐1.023), baseline ALT (HR = 1.014, 95% CI: 1.003‐1.024), haemoglobin (HR = 1.011, 95% CI: 1.002‐1.020) and HBsAg positivity (HR = 1.516, 95% CI: 1.004‐2.290) were independent risk factors for DILI. In the second cohort (n = 1497) of which 85 (5.7%) developed ATDILI. Age (HR = 1.029, 95% CI: 1.003‐1.056), baseline AST (HR = 1.036, 95% CI: 1.010‐1.062), previous TB treatment (HR = 3.894, 95% CI: 1.304‐11.625) and active drinking (HR = 3.624, 95% CI: 1.147‐11.454) were risk factors for developing jaundice. Conclusion Elevation of ALT of ≥3 × ULN during anti‐TB treatment resolves in the vast majority without developing serious consequences. In two cohorts involving 4652 patients, incidence of ALF and death because of ATDILI are low. Age, baseline ALT, haemoglobin and HBsAg positivity are risk factors for the development of DILI and these inform monitoring and management of these patients.
    Type of Medium: Online Resource
    ISSN: 1478-3223 , 1478-3231
    URL: Issue
    URL: Article
    DOI: 10.1111/liv.v41.7
    DOI: 10.1111/liv.14896
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2124684-1
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  • 7
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    Characteristics of systemic inflammation in hepatitis B‐precipitated ACLF : Differentiate it from No‐ ACLF
    Wiley ; 2018
    In:  Liver International Vol. 38, No. 2 ( 2018-02), p. 248-257
    Details
    In: Liver International, Wiley, Vol. 38, No. 2 ( 2018-02), p. 248-257
    Abstract: Patients with severe exacerbation of chronic hepatitis B ( SE ‐ CHB ) are at risk of developing acute‐on‐chronic liver failure ( ACLF ). Systemic inflammation ( SI ) is a major driver of ACLF . The aim of this study was to identify characteristics of SI in hepatitis B‐precipitated‐ ACLF ( HB ‐ ACLF ), which may be distinct from No‐ ACLF patients with SE ‐ CHB . Methods Two cohorts of patients with SE ‐ CHB were enrolled in two tertiary hospitals. The associations between circulating leucocyte counts/subsets and ACLF progression and prognoses were analysed in Cohort A. Cytokine measurements, leucocyte phenotyping and whole blood transcriptomic analyses were performed using peripheral blood samples obtained from patients in Cohort B. Results Circulating leucocyte counts were higher in the HB ‐ ACLF patients than in the No‐ ACLF patients ( P   〈  .001). Peripheral neutrophilic leucocytosis and monocytosis were associated with lymphopenia. The neutrophil‐to‐lymphocyte ratio ( NLR ) and monocyte‐to‐lymphocyte ratio ( MLR ) were correlated with risk of death in patients with SE ‐ CHB . NLR independently predicted progression to ACLF in patients without ACLF at enrolment and short‐term mortality in ACLF patients. Plasma IL ‐6, IL ‐10, G‐ CSF and GM ‐ CSF levels were higher in ACLF patients ( P   〈  .05). Blood transcriptome analyses showed that genes associated with cell migration and mobility and responses to wounding and bacteria were expressed at higher levels while genes involved in lymphocyte‐mediated immunity were expressed at lower levels in HB ‐ ACLF patients than in No‐ ACLF patients. Conclusions Systemic inflammation in HB ‐ ACLF was characterized by an excessive innate immune response, which was associated with disease progression and mortality.
    Type of Medium: Online Resource
    ISSN: 1478-3223 , 1478-3231
    URL: Issue
    URL: Article
    DOI: 10.1111/liv.2018.38.issue-2
    DOI: 10.1111/liv.13504
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2124684-1
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  • 8
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    Clinical characteristics and risk factors of mild‐to‐moderate COVID‐19 patients with false‐negative SARS‐CoV‐2 nucleic acid
    Wiley ; 2021
    In:  Journal of Medical Virology Vol. 93, No. 1 ( 2021-01), p. 448-455
    Details
    In: Journal of Medical Virology, Wiley, Vol. 93, No. 1 ( 2021-01), p. 448-455
    Abstract: The clinical and imaging features of mild‐to‐moderate COVID‐19 patients with nucleic acid false negative have certain characteristics. These patients have less clear history of epidemiological exposure, lighter clinical symptoms, lower lung damage severity score, and laboratory test results are better than those with nucleic acid positive.
    Type of Medium: Online Resource
    ISSN: 0146-6615 , 1096-9071
    URL: Issue
    URL: Article
    DOI: 10.1002/jmv.v93.1
    DOI: 10.1002/jmv.26242
    RVK:
    XA 10000
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 752392-0
    detail.hit.zdb_id: 1475090-9
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  • 9
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    Unraveling the mysteries of endostatin
    Wiley ; 2009
    In:  IUBMB Life Vol. 61, No. 6 ( 2009-06), p. 613-626
    Details
    In: IUBMB Life, Wiley, Vol. 61, No. 6 ( 2009-06), p. 613-626
    Abstract: Endostatin, a 20‐kDa C‐terminal proteolytic fragment of collagen XVIII, is a specific endogenous angiogenesis inhibitor discovered more than a decade. The structure, stability, and mechanism of actions of endostatin have been extensively investigated during the past 12 years, among which controversial reports remain unclarified. The mysteries include the following: 1) Why controversial efficacies were observed with endostatin regarding tumor inhibition? Particularly, why does an N‐terminal modified endostatin show good clinical responses in China, whereas the clinical trials of the wild type endostatin were terminated at the early stage of phase II in the USA? 2) What is the contribution of zinc‐binding to the stability and biological functions of endostatin? 3) Why does insoluble endostatin shrink tumors? 4) How to ensure that endostatin is correctly refolded? 5) How does endostatin exert its biological functions? Recent progress regarding the biophysical properties, biological functions, signaling pathways, and clinical trials of endostatin are reviewed here. Surprising findings show that the integrity of the N‐terminal sequence, the capability of zinc‐binding, and the correct folding are three essential elements for assurance of structural stability and biological functions of endostatin. This review provides clues to understand the mysteries of endostatin and its derivatives. © 2009 IUBMB IUBMB Life, 61(6): 613–626, 2009
    Type of Medium: Online Resource
    ISSN: 1521-6543 , 1521-6551
    URL: Issue
    URL: Article
    DOI: 10.1002/iub.v61:6
    DOI: 10.1002/iub.215
    Language: English
    Publisher: Wiley
    Publication Date: 2009
    detail.hit.zdb_id: 2009952-6
    detail.hit.zdb_id: 2485214-4
    SSG: 12
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  • 10
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    Serum glucose, lactate dehydrogenase and hypertension are mediators of the effect of body mass index on severity of COVID‐19
    Wiley ; 2021
    In:  Endocrinology, Diabetes & Metabolism Vol. 4, No. 2 ( 2021-04)
    Details
    In: Endocrinology, Diabetes & Metabolism, Wiley, Vol. 4, No. 2 ( 2021-04)
    Abstract: COVID‐19 has a broad clinical spectrum. We investigated the role of serum markers measured on admission on severity as assessed at discharge and investigated those which relate to the effect of BMI on severity. Methods Clinical and laboratory data from 610 COVID‐19 cases hospitalized in the province of Zheijang, China were investigated as risk factors for severe COVID‐19 (assessed by respiratory distress) compared to mild or common forms using logistic regression methods. Biochemical markers were correlated with severity using spearman correlations, and a ROC analysis was used to determine the individual contribution of each of the biochemical markers on severity. We carried out formal mediation analyses to investigate the extent of the effect of body mass index (BMI) on COVID‐19 severity mediated by hypertension, glycemia, Lactose Dehydrogenase (LDH) at the time of hospitalization and C‐Reactive Protein levels (CRP), in units of standard deviations. Results The individual markers measured on admission contributing most strongly to prediction of COVID‐19 severity as assessed at discharge were LDH, CRP and glucose. The proportion of the effect of BMI on severity of COVID‐19 mediated by CRP, glycemia or hypertension, we find that glucose mediated 79% (p  〈  .0001), LDH mediated 78% (p  〈  .0001), hypertension mediated 66% (p  〈  .0001); however, only 44% (p  〈  .005) was mediated by systemic inflammation (CRP). Conclusion Our data indicate that a larger proportion of the effect of BMI on severity of COVID‐19 is mediated by glycemia and LDH levels whereas less than half of it is mediated by systemic inflammation.
    Type of Medium: Online Resource
    ISSN: 2398-9238 , 2398-9238
    URL: Issue
    URL: Article
    DOI: 10.1002/edm2.v4.2
    DOI: 10.1002/edm2.215
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2934368-9
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