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  • 1
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    Online Resource
    The Phenotypic and Genetic Spectrum of Paroxysmal Kinesigenic Dyskinesia in China
    Wiley ; 2020
    In:  Movement Disorders Vol. 35, No. 8 ( 2020-08), p. 1428-1437
    Details
    In: Movement Disorders, Wiley, Vol. 35, No. 8 ( 2020-08), p. 1428-1437
    Abstract: Paroxysmal kinesigenic dyskinesia is a spectrum of involuntary dyskinetic disorders with high clinical and genetic heterogeneity. Mutations in proline‐rich transmembrane protein 2 have been identified as the major pathogenic factor. Objectives We analyzed 600 paroxysmal kinesigenic dyskinesia patients nationwide who were identified by the China Paroxysmal Dyskinesia Collaborative Group to summarize the clinical phenotypes and genetic features of paroxysmal kinesigenic dyskinesia in China and to provide new thoughts on diagnosis and therapy. Methods The China Paroxysmal Dyskinesia Collaborative Group was composed of departments of neurology from 22 hospitals. Clinical manifestations and proline‐rich transmembrane protein 2 screening results were recorded using unified paroxysmal kinesigenic dyskinesia registration forms. Genotype‐phenotype correlation analyses were conducted in patients with and without proline‐rich transmembrane protein 2 mutations. High‐knee exercises were applied in partial patients as a new diagnostic test to induce attacks. Results Kinesigenic triggers, male predilection, dystonic attacks, aura, complicated forms of paroxysmal kinesigenic dyskinesia, clustering in patients with family history, and dramatic responses to antiepileptic treatment were the prominent features in this multicenter study. Clinical analysis showed that proline‐rich transmembrane protein 2 mutation carriers were prone to present at a younger age and have longer attack duration, bilateral limb involvement, choreic attacks, a complicated form of paroxysmal kinesigenic dyskinesia, family history, and more forms of dyskinesia. The new high‐knee‐exercise test efficiently induced attacks and could assist in diagnosis. Conclusions We propose recommendations regarding diagnostic criteria for paroxysmal kinesigenic dyskinesia based on this large clinical study of paroxysmal kinesigenic dyskinesia. The findings offered some new insights into the diagnosis and treatment of paroxysmal kinesigenic dyskinesia and might help in building standardized paroxysmal kinesigenic dyskinesia clinical evaluations and therapies. © 2020 International Parkinson and Movement Disorder Society
    Type of Medium: Online Resource
    ISSN: 0885-3185 , 1531-8257
    URL: Issue
    URL: Article
    DOI: 10.1002/mds.v35.8
    DOI: 10.1002/mds.28061
    RVK:
    XA 10000
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2041249-6
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  • 2
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    Optimal dose of meropenem for the treatment of neonatal sepsis: Dosing guideline variations and clinical practice deviations
    Wiley ; 2022
    In:  British Journal of Clinical Pharmacology Vol. 88, No. 7 ( 2022-07), p. 3483-3489
    Details
    In: British Journal of Clinical Pharmacology, Wiley, Vol. 88, No. 7 ( 2022-07), p. 3483-3489
    Abstract: Meropenem is increasingly used to treat neonatal sepsis. There are several guidelines recommending different dosing regimens of meropenem in neonates. Furthermore, deviations from these guidelines regularly occur in daily clinical practice. Therefore, the current study aimed to evaluate the variations of meropenem dosing guidelines and compare the difference between guideline and clinical practice in terms of the probability of target attainment. Methods This study is based on a population pharmacokinetic model. After defining the predictive performance of the model, Monte Carlo simulations were used to calculate the probability of target attainment of the currently existing dosing guidelines of meropenem and their use in daily clinical practice. Results Two guidelines and two labels were included in the Monte Carlo simulations. For 70% fT 〉 MIC (fraction of time when the free meropenem concentration exceeded the minimum inhibitory concentration during the dosing interval), the probability of target attainment of four recommended doses ranged from 59% to 88% (MIC = 2 mg·L −1 ) and from 17% to 47% (MIC = 8 mg·L −1 ). At the clinical practice evaluation, only 20% of patients attained target exposure for the MIC of 8 mg·L −1 with 70% fT 〉 MIC , which was much less than those found in the Food and Drug Administration labels (40%). Conclusion This model‐based population pharmacokinetics simulation showed that improper guidelines and/or clinical practice deviations will result in low probability of target attainment for patients infected with resistant bacteria and critically ill patients. It is important to develop and adhere to evidence‐based and clinically pragmatic guidelines.
    Type of Medium: Online Resource
    ISSN: 0306-5251 , 1365-2125
    URL: Issue
    URL: Article
    DOI: 10.1111/bcp.v88.7
    DOI: 10.1111/bcp.15308
    RVK:
    XA 33650
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 1498142-7
    SSG: 15,3
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  • 3
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    Impaired robust interhemispheric function integration of depressive brain from REST‐meta‐MDD database in China
    Wiley ; 2022
    In:  Bipolar Disorders Vol. 24, No. 4 ( 2022-06), p. 400-411
    Details
    In: Bipolar Disorders, Wiley, Vol. 24, No. 4 ( 2022-06), p. 400-411
    Abstract: Recently, functional homotopy (FH) architecture, defined as robust functional connectivity (FC) between homotopic regions, has been frequently reported to be altered in MDD patients (MDDs) but with divergent locations. Methods In this study, we obtained resting‐state functional magnetic resonance imaging (R‐fMRI) data from 1004 MDDs (mean age, 33.88 years; age range, 18–60 years) and 898 matched healthy controls (HCs) from an aggregated dataset from 20 centers in China. We focused on interhemispheric function integration in MDDs and its correlation with clinical characteristics using voxel‐mirrored homotopic connectivity (VMHC) devised to inquire about FH patterns. Results As compared with HCs, MDDs showed decreased VMHC in visual, motor, somatosensory, limbic, angular gyrus, and cerebellum, particularly in posterior cingulate gyrus/precuneus (PCC/PCu) (false discovery rate [FDR] q  〈  0.002, z = −7.07). Further analysis observed that the reduction in SMG and insula was more prominent with age, of which SMG reflected such age‐related change in males instead of females. Besides, the reduction in MTG was found to be a male‐special abnormal pattern in MDDs. VMHC alterations were markedly related to episode type and illness severity. The higher Hamilton Depression Rating Scale score, the more apparent VMHC reduction in the primary visual cortex. First‐episode MDDs revealed stronger VMHC reduction in PCu relative to recurrent MDDs. Conclusions We confirmed a significant VMHC reduction in MDDs in broad areas, especially in PCC/PCu. This reduction was affected by gender, age, episode type, and illness severity. These findings suggest that the depressive brain tends to disconnect information exchange across hemispheres.
    Type of Medium: Online Resource
    ISSN: 1398-5647 , 1399-5618
    URL: Issue
    URL: Article
    DOI: 10.1111/bdi.v24.4
    DOI: 10.1111/bdi.13139
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2001157-X
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  • 4
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    mi R ‐27 impairs the adipogenic lineage commitment via targeting lysyl oxidase
    Wiley ; 2015
    In:  Obesity Vol. 23, No. 12 ( 2015-12), p. 2445-2453
    Details
    In: Obesity, Wiley, Vol. 23, No. 12 ( 2015-12), p. 2445-2453
    Abstract: The recruitment and commitment of mesenchymal stem cells and their terminal differentiation into adipocytes are the main pathways for increasing adipocyte cell numbers during obesity. Our previous studies have shown that lysyl oxidase (Lox) is upregulated and functions as an essential factor during bone morphogenetic protein 4 (BMP4) ‐induced C3H10T1/2 cell adipocytic lineage commitment. However, the mechanism of Lox regulation during adipogenic lineage commitment has remained largely unestablished. Methods Samples of adipose tissue from humans with different BMI and C57BL/6 mice with a high‐fat diet were used to compare microRNA‐27 (miR‐27) expression level associated with obesity. Taqman assays were used for miR‐27 expression detection and Oil Red O staining for adipogenesis analysis. Results A negative correlation was identified between Lox expression level and miR‐27 expression in both BMP4‐treated C3H10T1/2 cells and human subcutaneous adipose tissues. A Lox 3′ UTR luciferase reporter assay showed that miR‐27 directly targeted Lox . Furthermore, overexpression of miR‐27 impaired BMP4‐induced upregulation of Lox and adipocytic commitment, which could be rescued by overexpression of mature Lox. Conversely, miR‐27 inhibition by specific inhibitors increased Lox expression and adipocytic commitment. Conclusions Taken together, these results suggest a novel role for miR‐27 in repressing adipogenic lineage commitment by targeting Lox .
    Type of Medium: Online Resource
    ISSN: 1930-7381 , 1930-739X
    URL: Issue
    URL: Article
    DOI: 10.1002/oby.v23.12
    DOI: 10.1002/oby.21319
    Language: English
    Publisher: Wiley
    Publication Date: 2015
    detail.hit.zdb_id: 2027211-X
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  • 5
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    A Lox/CHOP‐10 crosstalk governs osteogenic and adipogenic cell fate by MSCs
    Wiley ; 2018
    In:  Journal of Cellular and Molecular Medicine Vol. 22, No. 10 ( 2018-10), p. 5097-5108
    Details
    In: Journal of Cellular and Molecular Medicine, Wiley, Vol. 22, No. 10 ( 2018-10), p. 5097-5108
    Abstract: Accelerated marrow adipogenesis has been associated with ageing and osteoporosis and is thought to be because of an imbalance between adipogenic and osteogenic differentiation of mesenchymal stem cell (MSCs). We have previously found that lysyl oxidase (Lox) inhibition disrupts BMP4‐induced adipocytic lineage commitment and differentiation of MSCs. In this study, we found that lox inhibition dramatically up‐regulates BMP4‐induced expression of CCAAT/enhancer binding protein (C/EBP) homologous protein 10 (CHOP‐10), which then promotes BMP4‐induced osteogenesis of MSCs both in vitro and in vivo. Specifically, Lox inhibition or CHOP‐10 up‐regulation activated Wnt/β‐catenin signalling to enhance BMP4‐induced osteogenesis, with pro‐adipogenic p38 MAPK and Smad signalling suppressed. Together, we demonstrate that Lox/CHOP‐10 crosstalk regulates BMP4‐induced osteogenic and adipogenic fate determination of MSCs, presenting a promising therapeutic target for osteoporosis and other bone diseases.
    Type of Medium: Online Resource
    ISSN: 1582-1838 , 1582-4934
    URL: Issue
    URL: Article
    DOI: 10.1111/jcmm.2018.22.issue-10
    DOI: 10.1111/jcmm.13798
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2076114-4
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  • 6
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    Clinical outcomes of EGFR +/ MET amp + vs. EGFR +/ MET amp ‐ untreated patients with advanced non‐small cell lung cancer
    Wiley ; 2022
    In:  Thoracic Cancer Vol. 13, No. 11 ( 2022-06), p. 1619-1630
    Details
    In: Thoracic Cancer, Wiley, Vol. 13, No. 11 ( 2022-06), p. 1619-1630
    Abstract: MET dysregulation has been implicated in the development of primary and secondary resistance to EGFR tyrosine kinase inhibitor (TKI) therapy. However, the clinicopathological characteristics and outcomes of patients harboring EGFR ‐sensitive mutations and de novo MET amplifications still need to be explored. Methods A total of 54 patients from our hospital with non‐small cell lung cancer harboring EGFR ‐sensitive mutations and/or de novo MET amplifications were included in this study. Survival rates were estimated by the Kaplan–Meier method with log‐rank statistics. Lung cancer organoids (LCOs) were generated from patient‐derived malignant pleural effusion to perform drug sensitivity assays. Results Fifty‐four patients with the appropriate clinicopathological characteristics were enrolled. MET FISH was performed in 40 patients who were stratified accordingly into two groups: EGFR +/ MET amp‐ ( n  = 22) and EGFR +/ MET amp + ( n  = 18). Survival rates for EGFR +/ MET amp‐ and EGFR +/ MET amp + patients respectively, were as follows: the median progression‐free survival (PFS) was 12.1 and 1.9 months ( p 〈 0.001); the median post‐progression overall survival (pOS) was 25.6 and 11.6 months ( p  = 0.023); the median overall survival (OS) was 33.2 and 12.7 months ( p  = 0.013). Drug testing conducted in LCOs derived from malignant pleural effusion from EGFR +/ MET amp + patients showed that dual targeted therapy was more effective than TKI monotherapy. Conclusion EGFR +/ MET amp + patients treated with first‐line TKI monotherapy had poor clinical outcomes. Dual targeted therapy showed potent anticancer activity in the LCO drug testing assay, suggesting that it is a promising first‐line treatment for EGFR +/ MET amp + patients. Randomized controlled trials are needed to further validate these results.
    Type of Medium: Online Resource
    ISSN: 1759-7706 , 1759-7714
    URL: Issue
    URL: Article
    DOI: 10.1111/tca.v13.11
    DOI: 10.1111/1759-7714.14429
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2559245-2
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  • 7
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    Genomic and immune characteristics of HER2 ‐mutated non‐small‐cell lung cancer and response to immune checkpoint inhibitor‐based therapy
    Wiley ; 2023
    In:  Molecular Oncology Vol. 17, No. 8 ( 2023-08), p. 1581-1594
    Details
    In: Molecular Oncology, Wiley, Vol. 17, No. 8 ( 2023-08), p. 1581-1594
    Abstract: The efficacy of immunotherapy in advanced HER2 ‐mutated non‐small‐cell lung cancer (NSCLC) remains incomprehensively studied. A total of 107 NSCLC patients with de novo HER2 mutations were retrospectively studied at Guangdong Lung Cancer Institute [GLCI cohort, exon 20 insertions (ex20ins): 71.0%] to compare clinical/molecular features and immune checkpoint inhibitor (ICI)‐based therapy efficacy between patients with ex20ins and non‐ex20ins. Two external cohorts (TCGA, n  = 21; META‐ICI, n  = 30) were used for validation. In the GLCI cohort, 68.2% of patients displayed programmed death‐ligand 1 (PD‐L1) expression 〈  1%. Compared with ex20ins patients, non‐ex20ins patients had more concurrent mutations in the GLCI cohort ( P   〈  0.01) and a higher tumour mutation burden in the TCGA cohort ( P  = 0.03). Under ICI‐based therapy, advanced NSCLC patients with non‐ex20ins had potentially superior progression‐free survival [median: 13.0 vs . 3.6 months, adjusted hazard ratio (HR): 0.31, 95% confidence interval (CI): 0.11–0.83] and overall survival (median: 27.5 vs. 8.1 months, adjusted HR: 0.39, 95% CI: 0.13–1.18) to ex20ins patients, consistent with findings in the META‐ICI cohort. ICI‐based therapy may serve as an option for advanced HER2 ‐mutated NSCLC, with potentially better efficacy in non‐ex20ins patients. Further investigations are warranted in clinical practice.
    Type of Medium: Online Resource
    ISSN: 1574-7891 , 1878-0261
    URL: Issue
    URL: Article
    DOI: 10.1002/mol2.v17.8
    DOI: 10.1002/1878-0261.13439
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2322586-5
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  • 8
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    Influence of PD‐L1 expression on the efficacy of EGFR ‐TKIs in EGFR ‐mutant non‐small cell lung cancer
    Wiley ; 2023
    In:  Thoracic Cancer Vol. 14, No. 24 ( 2023-08), p. 2327-2337
    Details
    In: Thoracic Cancer, Wiley, Vol. 14, No. 24 ( 2023-08), p. 2327-2337
    Abstract: Evidence on the influence of programmed death‐ligand 1 (PD‐L1) expression on the efficacy of epidermal growth factor receptor tyrosine kinase inhibitors ( EGFR ‐TKIs) in EGFR ‐mutant non‐small cell lung cancer (NSCLC) patients is at variance. Methods A single‐center retrospective study was conducted to evaluate the influence of PD‐L1 expression on the efficacy of EGFR ‐TKIs for NSCLC patients with EGFR mutation. Clinical information was retrieved from electronic medical records. The patients were divided into three subgroups according to PD‐L1 expression level: PD‐L1  〈  1% (negative), PD‐L1 1%–49% and PD‐L1 ≥ 50%. The clinicopathological features, overall response rate (ORR), progression‐free survival (PFS) and comutation information were collected and compared between the three subgroups. Results A total of 117 patients were included. For PD‐L1  〈  1%, PD‐L1 1%–49% and PD‐L1 ≥ 50% group, there were 39 (33.3%), 51 (43.5%) and 27 (23.0%) patients respectively, and the ORR was 43.2%, 64.0%, and 51.9%, respectively ( p  = 0.162), and the median progression‐free survival (mPFS) was 22.0 months (95% CI: 14.0–29.9 months), 15.4 months (95% CI: 8.9–21.8 months) and 13.0 months (95% CI: 10.6–15.3 months), respectively (log‐rank, p  = 0.01). The mPFS was negatively correlated with PD‐L1 expression level (r = −0.264, p  = 0.041) and PD‐L1 expression was an independent risk factor for worse PFS of EGFR ‐TKIs in multivariate Cox regression. Patients with concurrent TP53 mutation had shorter PFS ( p  = 0.039) and the patients harboring both mutant TP53 and positive PD‐L1 had the shortest PFS ( p  = 0.006). Conclusions The efficacy of EGFR ‐TKIs was influenced by the baseline PD‐L1 expression. Higher PD‐L1 expression was associated with shorter PFS. The combined indicators of TP53 and PD‐L1 identified subgroups showing divergent benefits from EGFR ‐TKIs.
    Type of Medium: Online Resource
    ISSN: 1759-7706 , 1759-7714
    URL: Issue
    URL: Article
    DOI: 10.1111/tca.v14.24
    DOI: 10.1111/1759-7714.15021
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2559245-2
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  • 9
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    Soft–Rigid Heterostructures with Functional Cation Vacancies for Fast‐Charging and High‐Capacity Sodium Storage
    Wiley ; 2023
    In:  Advanced Materials Vol. 35, No. 40 ( 2023-10)
    Details
    In: Advanced Materials, Wiley, Vol. 35, No. 40 ( 2023-10)
    Abstract: Optimizing charge transfer and alleviating volume expansion in electrode materials are critical to maximize electrochemical performance for energy‐storage systems. Herein, an atomically thin soft–rigid Co 9 S 8 @MoS 2 core–shell heterostructure with dual cation vacancies at the atomic interface is constructed as a promising anode for high‐performance sodium‐ion batteries. The dual cation vacancies involving V Co and V Mo in the heterostructure and the soft MoS 2 shell afford ionic pathways for rapid charge transfer, as well as the rigid Co 9 S 8 core acting as the dominant active component and resisting structural deformation during charge–discharge. Electrochemical testing and theoretical calculations demonstrate both excellent Na + ‐transfer kinetics and pseudocapacitive behavior. Consequently, the soft–rigid heterostructure delivers extraordinary sodium‐storage performance (389.7 mA h g −1 after 500 cycles at 5.0 A g −1 ), superior to those of the single‐phase counterparts: the assembled Na 3 V 2 (PO 4 ) 3 ||d‐Co 9 S 8 @MoS 2 /S‐Gr full cell achieves an energy density of 235.5 Wh kg −1 at 0.5 C. This finding opens up a unique strategy of soft–rigid heterostructure and broadens the horizons of material design in energy storage and conversion.
    Type of Medium: Online Resource
    ISSN: 0935-9648 , 1521-4095
    URL: Issue
    URL: Article
    DOI: 10.1002/adma.v35.40
    DOI: 10.1002/adma.202305149
    RVK:
    UA 1538
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 1474949-X
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  • 10
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    A multi–Chinese blood center study testing serologic-negative donor samples for hepatitis C virus and human immunodeficiency virus with nucleic acid testing
    Wiley ; 2007
    In:  Transfusion Vol. 47, No. 11 ( 2007-11), p. 2011-2016
    Details
    In: Transfusion, Wiley, Vol. 47, No. 11 ( 2007-11), p. 2011-2016
    Type of Medium: Online Resource
    ISSN: 0041-1132 , 1537-2995
    URL: Issue
    URL: Article
    DOI: 10.1111/trf.2007.47.issue-11
    DOI: 10.1111/j.1537-2995.2007.01424.x
    Language: English
    Publisher: Wiley
    Publication Date: 2007
    detail.hit.zdb_id: 2018415-3
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