In:
Journal of Surgical Oncology, Wiley, Vol. 117, No. 3 ( 2018-03), p. 409-416
Abstract:
The Sendai consensus guidelines (SCG) and Fukuoka consensus guidelines (FCG) have been examined for their roles in predicting advanced neoplasia (AN) in pancreatic cystic neoplasm (PCN) patients with mixed results. We aim to evaluate the utilities of both guidelines in a Chinese cohort with preoperatively diagnosed mucinous PCNs. Methods One hundred ninety‐seven patients who underwent resections from 2008 to 2015 in Zhong Shan Hospital, Fudan University for suspected PCNs were retrospectively reviewed. Receiver operating characteristic (ROC) curves were calculated and compared to measure diagnostic value. Results Fifty‐five patients were diagnosed with AN pathologically. The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of the SCG high‐risk (SCG HR ) criteria were 87.3%, 28.2%, 32.0%, 85.1%, and 44.7%, respectively, and for the FCG high‐risk (FCG HR ) criteria, they were 40.0%, 95.8%, 78.6%, 80.5%, and 80.2%, respectively. ROC curve comparison analyses showed that the FCG HR were superior to the SCG HR ( P = 0.02). The performance of the FCG HR was enhanced with CA19‐9 incorporated ( P = 0.004). Conclusions The FCG were superior to the SCG in this retrospective analysis, which could be further improved by the incorporation of CA19‐9. However, the practical safety remains uncertain because of missed invasive carcinoma cases.
Type of Medium:
Online Resource
ISSN:
0022-4790
,
1096-9098
Language:
English
Publisher:
Wiley
Publication Date:
2018
detail.hit.zdb_id:
1475314-5
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