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  • Wiley  (19)
  • 1
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    Online Resource
    Compliant and Robust Tissue‐Like Hydrogels via Ferric Ion‐Induced of Hierarchical Structure
    Wiley ; 2023
    In:  Advanced Functional Materials Vol. 33, No. 12 ( 2023-03)
    Details
    In: Advanced Functional Materials, Wiley, Vol. 33, No. 12 ( 2023-03)
    Abstract: It is a challenge to synthesize materials that possess biological tissue‐like properties: strain‐stiffening, robust yet compliant, sensitive, and water‐rich. Herein, a ferric ion‐induced salting out and coordination cross‐linking strategy is presented to create a hierarchical hydrogel network, including dipole–dipole interactions connected curved chains, acrylonitrile (AN)‐rich clusters, and homogeneous iron‐ligand interactions. The design allows the network to deform stress‐free under small strain by unfolding the curved segments with the elastic deformation of the AN‐rich clusters, and sequentially breaking the dipole–dipole interactions and iron‐ligand interactions from weak to strong ones under large strain. As a result, the hydrogel exhibits tissue‐like mechanical properties: low elastic modulus (0.06 MPa), high strength (1.4 MPa), high toughness (5.1 MJ m −3 ), intense strain‐stiffening capability (27.5 folds of stiffness enhancement), excellent self‐recovery ability and fatigue resistance. Moreover, the hydrogel exhibits high water content (≈84%), good biocompatibility and multi‐sensory capabilities to strain, pressure and hazardous chemicals stimuli. Therefore, this work offers a novel strategy to prepare hydrogel that can mimic the diverse functions of tissues, thereby expanding advanced applications of hydrogel in soft robotics, wearable devices, and biomedical engineering.
    Type of Medium: Online Resource
    ISSN: 1616-301X , 1616-3028
    URL: Issue
    URL: Article
    DOI: 10.1002/adfm.v33.12
    DOI: 10.1002/adfm.202210224
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2029061-5
    detail.hit.zdb_id: 2039420-2
    SSG: 11
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  • 2
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    Online Resource
    Thermal etching process of microscale pits on the GaAs(001) surface
    Wiley ; 2012
    In:  physica status solidi (RRL) – Rapid Research Letters Vol. 6, No. 1 ( 2012-01), p. 25-27
    Details
    In: physica status solidi (RRL) – Rapid Research Letters, Wiley, Vol. 6, No. 1 ( 2012-01), p. 25-27
    Abstract: When a GaAs(001) substrate is heated up to 650 °C in a scanning electron microscope (SEM) vacuum chamber with vacuum range from 10 –4 Torr to 10 –5 Torr, real‐time SEM observation reveals microscale pits on GaAs substrate surface. The annealing process of GaAs substrate in vacuum causes excess evaporation of arsenic and accumulation of gallium as liquid droplets on the surface. As the function of electrochemical drills, the gallium droplets etch away GaAs beneath the surface to make microscale holes on GaAs substrate. With small amount of oxygen in the chamber acting as etching catalyst, gallium droplets etch GaAs much faster than in ultra‐high vacuum (UHV) MBE chamber. This process provides an easy technique to fabricate microscale pits on GaAs(001) surface. magnified image Top view of microscale pits, (a) 8000× magnification view of pit; (b) 15000× magnification view of pit. (© 2012 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
    Type of Medium: Online Resource
    ISSN: 1862-6254 , 1862-6270
    URL: Issue
    URL: Article
    DOI: 10.1002/pssr.v6.1
    DOI: 10.1002/pssr.201105482
    Language: English
    Publisher: Wiley
    Publication Date: 2012
    detail.hit.zdb_id: 2259465-6
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  • 3
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    Online Resource
    Boosting Trapping in Dark Mode and Emission in Bright Mode using a Quad‐Nanohole
    Wiley ; 2023
    In:  Advanced Optical Materials Vol. 11, No. 12 ( 2023-06)
    Details
    In: Advanced Optical Materials, Wiley, Vol. 11, No. 12 ( 2023-06)
    Abstract: Single‐emitter luminescence is attractive for various applications, including single‐molecular biology, super‐resolution optical imaging, and single‐photon sources. Optical trapping as a particle positioning method is promising for enhancing luminescence by a precise matching of the nanoemitter to the sub‐wavelength mode volume of the photonic structure. Simultaneously satisfying the requirement of both luminescence and trapping enhancement, however, is challenging. Here, stable optical trapping and the in situ excitation of highly bright photoluminescence of a single up‐conversion nanoparticle (UCNP) are demonstrated. A quad‐nanohole structure with two bright‐field modes for enhanced excitation and emission of the UCNP, as well as a dark‐field mode for enhanced optical trapping is designed. It is experimentally demonstrated that the photoluminescence of the UCNP optically trapped in the quad‐nanohole is enhanced by a factor of 87 (as compared to a UCNP trapped in the single nanohole), and this enhancement factor surpasses that from a bowtie nanohole—one of the “gold standards” for local field enhancement. This work provides a route to assemble super‐bright single‐emitter luminescence by optical trapping.
    Type of Medium: Online Resource
    ISSN: 2195-1071 , 2195-1071
    URL: Issue
    URL: Article
    DOI: 10.1002/adom.v11.12
    DOI: 10.1002/adom.202202924
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2708158-8
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  • 4
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    Heritability of tea drinking and its relationship with cigarette smoking in the Chinese male adult twins
    Wiley ; 2022
    In:  Addiction Biology Vol. 27, No. 2 ( 2022-03)
    Details
    In: Addiction Biology, Wiley, Vol. 27, No. 2 ( 2022-03)
    Abstract: The aims of this study are to estimate the contributions of genetic factors to the variation of tea drinking and cigarette smoking, to examine the roles of genetic factors in their correlation and further to investigate underlying causation between them. We included 11 625 male twin pairs from the Chinese National Twin Registry (CNTR). Bivariate genetic modelling was fitted to explore the genetic influences on tea drinking, cigarette smoking and their correlation. Inference about Causation through Examination of FAmiliaL CONfounding (ICE FALCON) was further used to explore the causal relationship between them. We found that genetic factors explained 17% and 23% of the variation in tea drinking and cigarette smoking, respectively. A low phenotypic association between them was reported ( r ph  = 0.21, 95% confidence interval [CI]: [0.19, 0.24] ), which was partly attributed to common genetic factors ( r A  = 0.45, 95% CI [0.19, 1.00]). In the ICE FALCON analysis with current smoking as the exposure, tea drinking was associated with his own (βself = 0.39, 95% CI [0.23, 0.55] ) and his co‐twin's smoking status (βco‐twin = 0.25, 95% CI [0.10, 0.41]). Their association attenuated with borderline significance conditioning on his own smoking status ( p  = 0.045), indicating a suggestive causal effect of smoking status on tea drinking. On the contrary, when we used tea drinking as the predictor, we found familial confounding between them only. In conclusion, both tea drinking and cigarette smoking were influenced by genetic factors, and their correlation was partly explained by common genetic factors. In addition, our finding suggests that familial confounders account for the relationship between tea drinking and cigarette smoking. And current smoking might have a causal effect on weekly tea drinking, but not vice versa.
    Type of Medium: Online Resource
    ISSN: 1355-6215 , 1369-1600
    URL: Issue
    URL: Article
    DOI: 10.1111/adb.v27.2
    DOI: 10.1111/adb.13129
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 1495537-4
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  • 5
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    Online Resource
    Education, income, and obesity: A nationwide Chinese twin study
    Wiley ; 2022
    In:  Obesity Vol. 30, No. 4 ( 2022-04), p. 931-942
    Details
    In: Obesity, Wiley, Vol. 30, No. 4 ( 2022-04), p. 931-942
    Abstract: This study aimed to examine the association of socioeconomic status with obesity. Methods A total of 39,262 twin individuals were included from the Chinese National Twin Registry (CNTR). Generalized estimating equation models for unmatched twin individual analyses and conditional logistic regression for the co‐twin matched design were used. Inference about Causation through Examination of FAmiliaL CONfounding (ICE FALCON) was used to explore the evidence of a causal relationship. Results In general estimating equation models, high education level and income were associated with lower risk of obesity (odds ratio [OR] = 0.74 [95% CI: 0.65 to 0.84] and 0.86 [95% CI: 0.77 to 0.96]). In conditional logistic regression analysis, the association with education was significant (OR = 0.50 [95% CI: 0.34 to 0.74] ) but the association with income was insignificant (OR = 0.74 [95% CI: 0.48 to 1.15]). From the ICE FALCON analysis, a twin’s obesity was associated with the co‐twin’s education and income. After adjusting for the twin’s own education, the association disappeared ( = −0.10 [95% CI: −0.26 to 0.07] ), whereas the twin’s obesity was still associated with the co‐twin’s income but attenuated toward the null ( = −0.21 [95% CI: −0.36 to −0.06]). Conclusions Socioeconomic status is negatively associated with obesity. Education may have a causal effect on obesity, whereas the association between income and obesity is confounded by familial factors.
    Type of Medium: Online Resource
    ISSN: 1930-7381 , 1930-739X
    URL: Article
    DOI: 10.1002/oby.23390
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2027211-X
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  • 6
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    MiR‐490‐5p inhibits the stemness of hepatocellular carcinoma cells by targeting ECT2
    Wiley ; 2019
    In:  Journal of Cellular Biochemistry Vol. 120, No. 1 ( 2019-01), p. 967-976
    Details
    In: Journal of Cellular Biochemistry, Wiley, Vol. 120, No. 1 ( 2019-01), p. 967-976
    Abstract: To explore the targeting relationship between miR‐490‐5p and ECT2 in hepatocellular carcinoma (HCC) and the influences of miR‐490‐5p and ECT2 on the stemness of HCC cells. The expressions of miR‐490‐5p and ECT2 in HCC tissues and adjacent tissues were identified by quantitative real‐time polymerase chain reaction (qRT‐PCR). The relationships between the expression levels of miR‐490‐5p/ ECT2 and the overall/disease‐free survival (OS/DFS) of patients with HCC were evaluated using correlative curves. In addition, the targeting relationship between miR‐490‐5p and ECT2 was predicted by TargetScan and verified by dual‐luciferase reporter assay. Plasmid transfection was used for overexpression of ECT2 in HepG2 cells, and transfection efficiency was verified by qRT‐PCR. Cell Counting Kit‐8 assay and cell sphere‐formation assay were conducted to detect the proliferation and sphere‐formation ability of HCC cells, respectively. Cell populations with different cell transfections were sorted using flow cytometry. The expression levels of proteins in the stem cell signaling pathway were determined using Western blot analysis. MiR‐490‐5p was remarkably downregulated, yet ECT2 was upregulated in HCC tissues compared with adjacent tissues. MiR‐490‐5p expression was positively correlated with OS and DFS of patients with HCC, which were otherwise negatively correlated with ECT2 expression. ECT2 was validated to be the downstream target of miR‐490‐5p. Overexpression of miR‐490‐5p restrained the sphere formation ability, stemness, and proliferation of HCC cells. MiR‐490‐5p repressed the stemness of HCC cells through inhibiting the expression of ECT2 . MiR‐490‐5p may be an underlying therapeutic target in HCC treatment.
    Type of Medium: Online Resource
    ISSN: 0730-2312 , 1097-4644
    URL: Issue
    URL: Article
    DOI: 10.1002/jcb.v120.1
    DOI: 10.1002/jcb.27459
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 1479976-5
    SSG: 12
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  • 7
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    Cardiovascular disease burden in patients with urological cancers: The new discipline of uro‐cardio‐oncology
    Wiley ; 2024
    In:  Cancer Innovation
    Details
    In: Cancer Innovation, Wiley
    Abstract: Cancer remains a major cause of mortality worldwide, and urological cancers are the most common cancers among men. Several therapeutic agents have been used to treat urological cancer, leading to improved survival for patients. However, this has been accompanied by an increase in the frequency of survivors with cardiovascular complications caused by anticancer medications. Here, we propose the novel discipline of uro‐cardio‐oncology, an evolving subspecialty focused on the complex interactions between cardiovascular disease and urological cancer. In this comprehensive review, we discuss the various cardiovascular toxicities induced by different classes of antineoplastic agents used to treat urological cancers, including androgen deprivation therapy, vascular endothelial growth factor receptor tyrosine kinase inhibitors, immune checkpoint inhibitors, and chemotherapeutics. In addition, we discuss possible mechanisms underlying the cardiovascular toxicity associated with anticancer therapy and outline strategies for the surveillance, diagnosis, and effective management of cardiovascular complications. Finally, we provide an analysis of future perspectives in this emerging specialty, identifying areas in need of further research.
    Type of Medium: Online Resource
    ISSN: 2770-9191 , 2770-9183
    URL: Article
    DOI: 10.1002/cai2.108
    Language: English
    Publisher: Wiley
    Publication Date: 2024
    detail.hit.zdb_id: 3138557-6
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  • 8
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    Association of psychological distress and DNA methylation: A 5‐year longitudinal population‐based twin study
    Wiley ; 2023
    In:  Psychiatry and Clinical Neurosciences
    Details
    In: Psychiatry and Clinical Neurosciences, Wiley
    Abstract: To identify the psychological distress (PD) associated 5'‐cytosine‐phosphate‐guanine‐3' (CpG) sites (CpGs), and investigate the temporal relationship between dynamic changes in DNA methylation (DNAm) and PD. Methods This study included 1,084 twins from the Chinese National Twin Register (CNTR). The CNTR conducted epidemiological investigations and blood withdrawal twice in 2013 and 2018. These included twins were used to perform Epigenome‐Wide Association Studies (EWAS) and to validate the previously reported PD‐associated CpGs selected from previous EWAS in PubMed, EMBASE and the EWAS catalogue. Next, a cross‐lagged study was performed to examine the temporality between changes in DNAm and PD in 308 twins who completed both 2013 and 2018 surveys. Results The EWAS analysis of our study identified 25 CpGs. In the validation analysis, 741 CpGs from 29 previous EWAS studies on PD were selected for validation, and 101 CpGs were validated to be significant at FDR 〈 0.05. The cross‐lagged analysis found a unidirectional path from PD to DNAm at 14 CpGs, while no sites showed significance from DNAm to PD. Conclusions This study identified and validated PD‐related CpG sites in Chinese twin population, and suggested that PD may be the cause of changes in DNAm over time. The findings provide new insights into the molecular mechanisms underlying PD pathophysiology. This article is protected by copyright. All rights reserved.
    Type of Medium: Online Resource
    ISSN: 1323-1316 , 1440-1819
    URL: Article
    DOI: 10.1111/pcn.13606
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2010264-1
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  • 9
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    Theoretical studies on structure and performance of [1,2,5]‐oxadiazolo‐[3,4‐ d ]‐pyridazine‐based derivatives
    Wiley ; 2017
    In:  Journal of Physical Organic Chemistry Vol. 30, No. 1 ( 2017-01)
    Details
    In: Journal of Physical Organic Chemistry, Wiley, Vol. 30, No. 1 ( 2017-01)
    Abstract: Based on energetic compound [1,2,5]‐oxadiazolo‐[3,4‐ d ]‐pyridazine, a series of functionalized derivatives were designed and first reported. Afterwards, the relationship between their structure and performance was systematically explored by density functional theory at B3LYP/6‐311 g (d, p) level. Results show that the bond dissociation energies of the weakest bond (N–O bond) vary from 157.530 to 189.411 kJ · mol −1 . The bond dissociation energies of these compounds are superior to that of HMX (N–NO 2, 154.905 kJ · mol −1 ). In addition, H1, H2, H4, I2, I3, C1, C2, and D1 possess high density (1.818–1.997 g · cm −3 ) and good detonation performance (detonation velocities, 8.29–9.46 km · s −1 ; detonation pressures, 30.87–42.12 GPa), which may be potential explosives compared with RDX (8.81 km · s −1 , 34.47 GPa ) and HMX (9.19 km · s −1 , 38.45 GPa). Finally, allowing for the explosive performance and molecular stability, three compounds may be suggested as good potential candidates for high‐energy density materials. Copyright © 2016 John Wiley & Sons, Ltd.
    Type of Medium: Online Resource
    ISSN: 0894-3230 , 1099-1395
    URL: Issue
    URL: Article
    DOI: 10.1002/poc.v30.1
    DOI: 10.1002/poc.3591
    Language: English
    Publisher: Wiley
    Publication Date: 2017
    detail.hit.zdb_id: 1475025-9
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  • 10
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    DNA‐repair status should be assessed in treatment‐emergent neuroendocrine prostate cancer before platinum‐based therapy
    Wiley ; 2022
    In:  The Prostate Vol. 82, No. 4 ( 2022-03), p. 464-474
    Details
    In: The Prostate, Wiley, Vol. 82, No. 4 ( 2022-03), p. 464-474
    Abstract: This study sought to provide contemporary data from a multi‐institution with respect to DNA‐repair genes (DRGs) status and its impact on effects of platinum‐based chemotherapy in treatment‐emergent neuroendocrine prostate cancer (t‐NEPC), for which little data exist. Patients and Methods All patients were retrospectively collected with eligible biopsied tissues for targeted next generation sequencing (NGS). The main outcomes were radiologic progression‐free survival and overall survival according to Response Evaluation Criteria in Solid Tumors, version 1.1. Results Among the 43 NEPC patients, 13/43 (30%) harbored homozygous deletions, deleterious mutations, or both in DRGs. Eleven patients (11/13, 85%) with DRGs aberrations had effective response, including 7 patients with BRCA1/2 defects and 2 with mismatch repair‐deficient caused by MSH2 alterations. While significantly fewer responders (30%) were detected in patients without DRGs aberrations (odds ratio = 12.83, p  = 0.003). Compared with patients without genomic DRGs aberrations, the hazard ratio (HR) for radiologic progression in those with DRGs defects was 0.42 (95% confidence interval [CI]: 0.19–0.93), and the HR for death was 0.65 (95% CI: 0.24–1.72). The most common adverse event of Grade 3 or 4 was anemia, as noted in 7 patients (16%). Conclusion The DRGs status is therapeutically meaningful in t‐NEPC. Given the potential responses to platinum‐based chemotherapy, our findings support the clinical use of NGS in t‐NEPC patients to identify DRGs aberrations.
    Type of Medium: Online Resource
    ISSN: 0270-4137 , 1097-0045
    URL: Issue
    URL: Article
    DOI: 10.1002/pros.v82.4
    DOI: 10.1002/pros.24292
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 1494709-2
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