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  • 1
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    Online Resource
    Serum vascular endothelial growth factor B is elevated in women with polycystic ovary syndrome and can be decreased with metformin treatment
    Wiley ; 2016
    In:  Clinical Endocrinology Vol. 84, No. 3 ( 2016-03), p. 386-393
    Details
    In: Clinical Endocrinology, Wiley, Vol. 84, No. 3 ( 2016-03), p. 386-393
    Abstract: To determine serum vascular endothelial growth factor B (VEGF‐B) levels in polycystic ovary syndrome, their association with insulin resistance and β‐cell dysfunction, and the effect of metformin on serum VEGF‐B levels. Design A cross‐sectional, interventional study. Patients We recruited 103 women with polycystic ovary syndrome and 96 age‐matched healthy controls. Serum VEGF‐B levels were determined in all participants, and 44 polycystic ovary syndrome patients randomly received metformin. Measurements We measured VEGF‐B levels in healthy controls and women with polycystic ovary syndrome before and after metformin treatment. Results Women with polycystic ovary syndrome had higher serum VEGF‐B levels, which decreased with metformin treatment. In the lean and overweight/obese groups, patients with polycystic ovary syndrome had higher plasma VEGF‐B levels than did healthy controls ( P 〈 0·05). VEGF‐B levels were correlated with body mass index, body fat percentage, M values, homeostasis model assessment of insulin resistance and β‐cell function indices. A multiple linear regression analysis showed that VEGF‐B level was associated with M values after adjusting for age, body mass index, serum sex hormones and serum lipids in women with polycystic ovary syndrome. Conclusions Serum VEGF‐B is significantly higher in women with polycystic ovary syndrome and is closely and positively related to insulin resistance. Metformin treatment reduces VEGF‐B levels and ameliorates insulin resistance.
    Type of Medium: Online Resource
    ISSN: 0300-0664 , 1365-2265
    URL: Issue
    URL: Article
    DOI: 10.1111/cen.2016.84.issue-3
    DOI: 10.1111/cen.12950
    RVK:
    XA 10000
    Language: English
    Publisher: Wiley
    Publication Date: 2016
    detail.hit.zdb_id: 2004597-9
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  • 2
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    Sonodynamic Therapy of NRP2 Monoclonal Antibody‐Guided MOFs@COF Targeted Disruption of Mitochondrial and Endoplasmic Reticulum Homeostasis to Induce Autophagy‐Dependent Ferroptosis
    Wiley ; 2023
    In:  Advanced Science
    Details
    In: Advanced Science, Wiley
    Abstract: The lethality and chemotherapy resistance of pancreatic cancer necessitates the urgent development of innovative strategies to improve patient outcomes. To address this issue, we designed a novel drug delivery system named GDMCN2,which uses iron‐based metal organic framework (Fe‐MOF) nanocages encased in a covalent organic framework (COF) and modified with the pancreatic cancer‐specific antibody, NRP2. After being targeted into tumor cells, GDMCN2 gradually release the sonosensitizer sinoporphyrin sodium (DVDMS) and chemotherapeutic gemcitabine (GEM) and simultaneously generated reactive oxygen species (ROS) under ultrasound (US) irradiation. This system can overcome gemcitabine resistance in pancreatic cancer and reduce its toxicity to non‐targeted cells and tissues. In a mechanistic cascade, the release of ROS activates the mitochondrial transition pore (MPTP), leading to the release of Ca 2+ and induction of endoplasmic reticulum (ER) stress. Therefore, microtubule‐associated protein 1A/1B‐light chain 3 (LC3) is activated, promoting lysosomal autophagy. This process also induces autophagy‐dependent ferroptosis, aided by the upregulation of Nuclear Receptor Coactivator 4 (NCOA4). This mechanism increases the sensitivity of pancreatic cancer cells to chemotherapeutic drugs and increases mitochondrial and DNA damage. The findings demonstrate the potential of GDMCN2 nanocages as a new avenue for the development of cancer therapeutics.
    Type of Medium: Online Resource
    ISSN: 2198-3844 , 2198-3844
    URL: Article
    DOI: 10.1002/advs.202303872
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2808093-2
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  • 3
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    Elevated serum thioredoxin‐interacting protein in women with polycystic ovary syndrome is associated with insulin resistance
    Wiley ; 2014
    In:  Clinical Endocrinology Vol. 80, No. 4 ( 2014-04), p. 538-544
    Details
    In: Clinical Endocrinology, Wiley, Vol. 80, No. 4 ( 2014-04), p. 538-544
    Abstract: Women with polycystic ovary syndrome ( PCOS ) mostly have profound insulin resistance ( IR ) and β‐cell dysfunction. Although thioredoxin‐interacting protein ( TXNIP ) is a major regulator in IR and insulin secretion, no data on the plasma TXNIP level in patients with PCOS are available. This study aimed to determine the plasma TXNIP level and discuss the relationship between TXNIP and β‐cell dysfunction/ IR in patients with PCOS . Patients Eighty‐three women with PCOS and 52 controls. Measurements Insulin sensitivity was expressed by M value obtained from euglycaemic–hyperinsulinaemic clamp. Homoeostatic model assessment for β‐cell function ( HOMA ‐β), △Ins 30 /△Glu 30 and AUC ins/glu were considered as the indices of fasting state, early‐phase and total insulin secretion during oral glucose tolerance test, respectively. To evaluate β‐cell function adjusted for insulin sensitivity, disposition index ( DI ) was used: basal DI ( DI 0 ), early‐phase DI ( DI 30 ) and total DI ( DI 120 ). Plasma TXNIP levels were measured by enzyme‐linked immunosorbent assay. Design Case‐control study. Results Patients with PCOS had higher serum TXNIP , whereas lower M value, DI 0 , DI 30 and DI 120 than controls ( P  〈   0·05); their TXNIP correlated positively with weight , waist‐to‐hip ratio ( WHR ), body mass index ( BMI ), Ins 0 , Ins 120 and HOMA ‐β and correlated negatively with M value and DI 120 ( P  〈   0·05). Multiple stepwise regression analysis indicated that TXNIP remained associated with M value in PCOS subjects, after adjusting weight , BMI , WHR , HOMA ‐β, Ins 0 , Ins 120 and DI 120 . However, no relationship between TXNIP and impaired β‐cell function was found. Conclusion Serum TXNIP is elevated in women with PCOS and may be a contributing factor for IR .
    Type of Medium: Online Resource
    ISSN: 0300-0664 , 1365-2265
    URL: Issue
    URL: Article
    DOI: 10.1111/cen.2014.80.issue-4
    DOI: 10.1111/cen.12192
    RVK:
    XA 10000
    Language: English
    Publisher: Wiley
    Publication Date: 2014
    detail.hit.zdb_id: 2004597-9
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  • 4
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    Reduction system “vitamin C/glycerol” promoted copper(II)‐catalyzed N ‐arylation
    Wiley ; 2022
    In:  Applied Organometallic Chemistry Vol. 36, No. 5 ( 2022-05)
    Details
    In: Applied Organometallic Chemistry, Wiley, Vol. 36, No. 5 ( 2022-05)
    Abstract: The common access to forming CN bond is the copper‐catalyzed Ullmann‐type reaction. The relatively expensive and easily oxidized copper(I) is usually used in the reaction. Our group discovered that the “vitamin C/glycerol” reduction system could convert cheap and stable CuO to active low valence state copper species, as measured via X‐ray photoelectron spectroscopy (XPS), to promote the CN coupling reaction. In particular, 2‐phenylindole, pyrrolo[1,2‐ a ]quinoxaline, 1,2,4‐triazole and 4‐amino‐7 H ‐pyrrolo[2,3‐ d ] pyrimidine derivative were obtained in the presence of CuO and reduction system “vitamin C/glycerol.” This method provided a simple and cost‐effective approach to the preparation of N ‐arylation products.
    Type of Medium: Online Resource
    ISSN: 0268-2605 , 1099-0739
    URL: Issue
    URL: Article
    DOI: 10.1002/aoc.v36.5
    DOI: 10.1002/aoc.6618
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 1480791-9
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  • 5
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    Efficient All‐Perovskite Tandem Solar Cells with Low‐Optical‐Loss Carbazolyl Interconnecting Layers
    Wiley ; 2023
    In:  Angewandte Chemie Vol. 135, No. 51 ( 2023-12-18)
    Details
    In: Angewandte Chemie, Wiley, Vol. 135, No. 51 ( 2023-12-18)
    Abstract: Combining wide‐band gap (WBG) and narrow‐band gap (NBG) perovskites with interconnecting layers (ICLs) to construct monolithic all‐perovskite tandem solar cell is an effective way to achieve high power conversion efficiency (PCE). However, optical losses from ICLs need to be further reduced to leverage the full potential of all‐perovskite tandem solar cells. Here, metal oxide nanocrystal layers anchored with carbazolyl hole‐selective‐molecules (CHs), which exhibit much lower optical loss, is employed to replace poly(3,4‐ethylenedioxythiophene) polystyrenesulfonate (PEDOT : PSS) as the hole transporting layers (HTLs) in lead‐tin (Pb‐Sn) perovskite sub‐cells and ICLs in all‐perovskite tandem solar cells. Optically transparent indium tin oxide nanocrystals (ITO NCs) layers are employed to enhance anchoring of CHs, while a mixture of two CHs is adopted to tune the surface energy‐levels of ITO NCs. The optimized mixed Pb‐Sn NBG perovskite solar cells demonstrate a high PCE of 23.2 %, with a high short‐circuit current density ( J sc ) of 33.5 mA cm −2 . A high PCE of 28.1 % is further obtained in all‐perovskite tandem solar cells, with the highest J sc of 16.7 mA cm −2 to date. Encapsulated tandem solar cells maintain 90 % of their reference point after 500 h of operation at the maximum power point (MPP) under 1‐Sun illumination.
    Type of Medium: Online Resource
    ISSN: 0044-8249 , 1521-3757
    URL: Issue
    URL: Article
    DOI: 10.1002/ange.v135.51
    DOI: 10.1002/ange.202313374
    RVK:
    VA 2100
    RVK:
    VN 5020
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 505868-5
    detail.hit.zdb_id: 506609-8
    detail.hit.zdb_id: 514305-6
    detail.hit.zdb_id: 505872-7
    detail.hit.zdb_id: 1479266-7
    detail.hit.zdb_id: 505867-3
    detail.hit.zdb_id: 506259-7
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  • 6
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    CeO 2 Nanoparticles to Promote Wound Healing: A Systematic Review
    Wiley ; 2023
    In:  Advanced Healthcare Materials
    Details
    In: Advanced Healthcare Materials, Wiley
    Abstract: Cerium (Ce) is a hot topic in the field of materials research due to its electronic layer structure and the unique antioxidant abilities of its oxide (CeO 2 ). Cerium oxide nanoparticles (CeO 2 NPs) demonstrate their potential as an antioxidant and antibacterial agent. Current research focuses on whether they can be used to promote wound healing and in what manner. This article provides a systematic review of the various forms of CeO 2 NPs that are used in wound‐healing materials over the past decade, as well as the effectiveness demonstrated by in vivo and in vitro experiments, with a focus on the relationship between concentration and effectiveness. CeO 2 NPs are expected to become effective ingredients in dressings that require antibacterial, antioxidant, and wound healing promoting properties. This article serves as a reference for further research and clinical applications of nano‐sized CeO 2 in wound healing.
    Type of Medium: Online Resource
    ISSN: 2192-2640 , 2192-2659
    URL: Article
    DOI: 10.1002/adhm.202302858
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2645585-7
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  • 7
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    Improving Liposome Delivery with Macroporous Granular Hydrogels Synthesized through Freezing‐Facilitated Secondary Crosslinking of Macromonomers
    Wiley ; 2023
    In:  Advanced Materials Interfaces
    Details
    In: Advanced Materials Interfaces, Wiley
    Abstract: The integration of liposomes into hydrogels through direct soaking presents advantages such as facile formulation, enhanced drug stability, and controlled release kinetics. However, the feasibility of this approach is impeded by the difficulty of developing matching porous structures within hydrogels and achieving appropriate affinity with liposomes. To address these challenges, an alternative method is proposed for synthesizing macroporous hydrogels using thiolated hyaluronic acid and hyperbranched polyethylene glycol macromonomers in combination with a freezing‐induced secondary crosslinking process. This approach allows the locking of macropores formed by ice crystals during freezing and enables easy modification of the hydrogels with cholesterol groups to promote liposome association. Furthermore, these macroporous hydrogels can be crushed into granular hydrogels, which offer numerous benefits such as high loading capacity, injectability, self‐healing properties, and convenience in storage, dosing, and administration. Therefore, a liposome‐in‐hydrogel system can be formulated without any gelation or pre‐treatment, providing valuable insights for the further development of liposome‐based formulations for medical and cosmetic applications.
    Type of Medium: Online Resource
    ISSN: 2196-7350 , 2196-7350
    URL: Article
    DOI: 10.1002/admi.202300262
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2750376-8
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  • 8
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    Transcriptome analysis reveals candidate genes related to steroid alkaloid biosynthesis in Fritillaria anhuiensis
    Wiley ; 2022
    In:  Physiologia Plantarum Vol. 174, No. 4 ( 2022-07)
    Details
    In: Physiologia Plantarum, Wiley, Vol. 174, No. 4 ( 2022-07)
    Abstract: Fritillaria anhuiensis ( F. anhuiensis ), a traditional medicinal herb of the Liliaceae family, has various pharmacological effects, including anti‐tussive, anti‐asthmatic, and expectorant activities. Peimine, a steroidal alkaloid, is a major active constituent of F. anhuiensis . Although steroidal alkaloids of F. anhuiensis have been explored chemically and pharmacologically, the molecular basis of their biosynthesis remains unknown due to a lack of genomic and transcriptomic information. In this study, peimine was detected in bulbs, stems, and leaves of F. anhuiensis , with the highest content in the bulbs. We analyzed the transcriptomes of the bulbs, stems, and leaves of F. anhuiensis using an Illumina HiSeq 4000 platform. A total of 92,829 unigenes with a mean length of 804 base pairs (bp) and an N50 value of 1354 bp were assembled from a total of 30.56 Gb high‐quality reads. Based on the Kyoto Encyclopedia of Genes and Genomes annotation, 83 unigenes were found to be related to the steroid biosynthesis pathway, while 155 unigenes were related to the terpenoid backbone biosynthesis pathway. Numerous transcription factors are involved in the regulation of alkaloid biosynthesis. A putative steroidal alkaloid biosynthesis pathway in F. anhuiensis was constructed, providing a novel understanding of peimine biosynthesis. We performed extensive bioinformatics and phylogenetic analyses to investigate the functional characteristics and evolutionary history of cycloartenol synthase. This study is the first to report transcriptome data from F. anhuiensis and extends our knowledge of the molecular mechanisms of steroid alkaloid biosynthesis.
    Type of Medium: Online Resource
    ISSN: 0031-9317 , 1399-3054
    URL: Issue
    URL: Article
    DOI: 10.1111/ppl.v174.4
    DOI: 10.1111/ppl.13755
    RVK:
    WA 15000
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 208872-1
    detail.hit.zdb_id: 2020837-6
    SSG: 12
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  • 9
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    Full‐length transcriptome analysis provides insights into flavonoid biosynthesis in Ranunculus japonicus
    Wiley ; 2023
    In:  Physiologia Plantarum Vol. 175, No. 4 ( 2023-07)
    Details
    In: Physiologia Plantarum, Wiley, Vol. 175, No. 4 ( 2023-07)
    Abstract: Ranunculus japonicus Thunb. is a traditional Chinese herb. Plants in the genus Ranunculus are generally rich in flavonoids, which have antibacterial, anti‐infective, and other pharmacological effects. However, owing to the lack of reference genomes, little is known about the flavonoid biosynthetic pathway in R. japonicus . In this study, PacBio isoform sequencing (PacBio iso‐seq) and DNA nanoball sequencing (DNB‐seq) were combined to build a full‐length transcriptome database for three different tissues of R. japonicus . A total of 395,402 full‐length transcripts were obtained, of which 308,474 were successfully annotated. A Kyoto Encyclopedia of Genes and Genomes analysis identified 29 differentially expressed genes encoding nine key enzymes for flavonoid biosynthesis. Correlation analysis indicated that flavanone 3‐hydroxylase and flavonol synthase genes might have key roles in the accumulation of flavonoid substances in the different tissues of R. japonicus . The structures of chalcone synthase and chalcone isomerase enzymes were spatially modeled. Reverse‐transcription quantitative PCR was used to verify gene expression levels of key enzymes associated with flavonoid biosynthesis. In addition, 22 MYB transcription factors involved in flavonoid biosynthesis and phenylpropanoid biosynthesis were discovered. The reliable transcriptomic data from this study provide genetic information about R. japonicus as well as insights into the molecular mechanism of flavonoid biosynthesis. The results also provide a basis for developing the medicinal value R. japonicus .
    Type of Medium: Online Resource
    ISSN: 0031-9317 , 1399-3054
    URL: Issue
    URL: Article
    DOI: 10.1111/ppl.v175.4
    DOI: 10.1111/ppl.13965
    RVK:
    WA 15000
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 208872-1
    detail.hit.zdb_id: 2020837-6
    SSG: 12
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  • 10
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    Pressure‐Induced Wide‐Range Reversible Emission Shift of Triphenylamine‐Substituted Anthracene via Hybridized Local and Charge Transfer (HLCT) Excited State
    Wiley ; 2018
    In:  Advanced Optical Materials Vol. 6, No. 3 ( 2018-02)
    Details
    In: Advanced Optical Materials, Wiley, Vol. 6, No. 3 ( 2018-02)
    Abstract: 4‐(Anthracen‐9‐yl)‐N,N‐diphenylaniline (TPA‐AN) is a typical molecule belonging to a donor–acceptor system. Here, the ordered crystal and the powder of TPA‐AN are used for high‐pressure Raman and fluorescence experiments, and their spectroscopic features under the shearing force of grinding and the hydrostatic pressure applied by a diamond anvil cell (DAC) are compared. The mechanochromism of TPA‐AN is discussed in detail based on the analysis of its single‐crystal structure and pressure‐driven spectral changes. During the DAC compression process, the TPA‐AN crystal shows an obvious emission band shift (from 476 to 600 nm) along with a new intramolecular charge transfer state that is separated from the hybridized local and charge transfer excited state and extremely sensitive to external force. Once the pressure is relieved, the Raman and fluorescence spectra both entirely self‐recover without a secondary force. To the authors' knowledge, TPA‐AN crystal is one of the largest emission shift organic mechanochromic fluorescent materials among reported publications. The reversible mechanochromic property of TPA‐AN for a wide‐range emission shift implies a great application potential as smart stimuli‐responsive layer in the fields of sensing, organic light‐emitting diode displays, and data storage.
    Type of Medium: Online Resource
    ISSN: 2195-1071 , 2195-1071
    URL: Issue
    URL: Article
    DOI: 10.1002/adom.v6.3
    DOI: 10.1002/adom.201700647
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2708158-8
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