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  • 1
    Online Resource
    Online Resource
    Accurate Cancer Diagnosis and Stage Monitoring Enabled by Comprehensive Profiling of Different Types of Exosomal Biomarkers: Surface Proteins and miRNAs
    Wiley ; 2020
    In:  Small Vol. 16, No. 48 ( 2020-12)
    Details
    In: Small, Wiley, Vol. 16, No. 48 ( 2020-12)
    Abstract: Exosomes are recognized as promising biomarkers for early cancer diagnosis and prognosis owing to a large amount of biological information they carried. But the key is that single type of exosomal biomarker analysis is not sufficient enough for accurate cancer diagnosis and stage monitoring due to the insufficient information and high false positive signal. To address the challenge, here simultaneous in situ detection of different types of exosomal biomarkers (surface proteins: CD81, ephrin type‐A receptor 2, and carbohydrate antigen 19‐9; miRNAs: miR‐451a, miR‐21, and miR‐10b) is conducted with a 3D microfluidic chip, which works in conjunction with quantum dot (QD) labeling and vesicle fusion technology. After exosomes are efficiently captured by the microfluidic chip, the quantification of multiple exosomal proteins is achieved by using three kinds of QDs with the same excitation and different emission wavelengths, and virus‐mimicking fusogenic vesicles encapsulating three exquisitely engineered molecular beacons are introduced for ultrasensitive detection of multiple exosomal miRNAs without requiring RNA extraction. Through comprehensive profiling different types of exosomal biomarkers, the false positive rate is substantially avoided and the accuracy of cancer diagnosis and stage monitoring is improved to ≈100%, which are critical to cancer effective treatment and favorable prognosis.
    Type of Medium: Online Resource
    ISSN: 1613-6810 , 1613-6829
    URL: Issue
    URL: Article
    DOI: 10.1002/smll.v16.48
    DOI: 10.1002/smll.202004492
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2168935-0
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  • 2
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    Cerebral 18 F‐fluorodeoxyglucose metabolism alteration of reward‐ and motivation‐related regions in groups of different BMI classifications
    Wiley ; 2022
    In:  Obesity Vol. 30, No. 11 ( 2022-11), p. 2213-2221
    Details
    In: Obesity, Wiley, Vol. 30, No. 11 ( 2022-11), p. 2213-2221
    Abstract: This study explored the relationship between BMI and regional cerebral glucose metabolism and explicitly detected regions with significant differences in cerebral metabolism using positron emission tomography (PET)/magnetic resonance imaging in the resting state. Methods Corresponding PET images acquired from 220 participants were sorted into four groups according to Asian BMI standards: underweight, normal weight, overweight, and obesity. Pearson correlation coefficient analysis was performed to assess the association between BMI and standard uptake value. The regional cerebral glucose metabolism was measured in the fasted state. The PET images were analyzed using statistical parameter maps. One‐way ANOVA was used to explore differences in the standard uptake value as an indicator of regional cerebral glucose metabolism. Results This study found that lower cerebral glucose metabolism in reward‐ and motivation‐related regions was accompanied by more severe obesity and that regional cerebral glucose metabolism activities were negatively correlated with BMI. In addition, more severe obesity was accompanied by a larger range of areas with significant differences independent of current dietary status. Conclusions These findings suggest that the reward and motivation circuits may be a factor regulating energy balance and influencing the degree of obesity.
    Type of Medium: Online Resource
    ISSN: 1930-7381 , 1930-739X
    URL: Issue
    URL: Article
    DOI: 10.1002/oby.v30.11
    DOI: 10.1002/oby.23553
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2027211-X
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  • 3
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    Online Resource
    Preferential Formation of Homochiral Helical Sandwich-Shaped Architectures through the Metal-Mediated Assembly of Tris(imidazoline) Ligands with a Set of d3-d10 Transition-Metal Ions
    Wiley ; 2008
    In:  Chemistry - A European Journal Vol. 14, No. 36 ( 2008-11-14), p. 11601-11609
    Details
    In: Chemistry - A European Journal, Wiley, Vol. 14, No. 36 ( 2008-11-14), p. 11601-11609
    Type of Medium: Online Resource
    ISSN: 0947-6539
    URL: Article
    DOI: 10.1002/chem.200801154
    RVK:
    VA 1120 ; VA 3507
    Language: English
    Publisher: Wiley
    Publication Date: 2008
    detail.hit.zdb_id: 1478547-X
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  • 4
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    Synthesis, Characterization, and Thermal Analysis of Two Energetic Ionic Salts Based on 3,4‐Diamino‐1,2,4‐triazole (DATr)
    Wiley ; 2013
    In:  Zeitschrift für anorganische und allgemeine Chemie Vol. 639, No. 12-13 ( 2013-10), p. 2354-2358
    Details
    In: Zeitschrift für anorganische und allgemeine Chemie, Wiley, Vol. 639, No. 12-13 ( 2013-10), p. 2354-2358
    Abstract: Two energetic ionic salts DATr · NTO ( 2 ) and DATr · TNR ( 3 ) of 3,4‐diamino‐1,2,4‐triazole (DATr) ( 1 ) were synthesized by reaction of 3,4‐diamino‐1,2,4‐triazole with either 3‐nitro‐1,2,4‐triazole‐5‐one (NTO) or 2,4,6‐trinitro‐resorcinol (TNR) in aqueous solution. Their structures were characterized by FT IR spectroscopy (FT‐IR) and X‐ray single‐crystal diffraction analysis. Their molecular structure and crystal structure were determined. They belong to the monoclinic crystal system, space group P 2 1 / c . The crystal density is 1.693 g · cm –3 and 1.738 g · cm –3 , respectively. The thermal decomposition characteristics of the title compounds were investigated using differential scanning calorimetry (DSC) and thermogravimetry/differential thermogravimetry (TG/DTG) technologies. Furthermore, the sensitivity properties were determined by standard methods.
    Type of Medium: Online Resource
    ISSN: 0044-2313 , 1521-3749
    URL: Issue
    URL: Article
    DOI: 10.1002/zaac.v639.12/13
    DOI: 10.1002/zaac.201300247
    RVK:
    VA 8102
    Language: German
    Publisher: Wiley
    Publication Date: 2013
    detail.hit.zdb_id: 201094-X
    detail.hit.zdb_id: 1481139-X
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  • 5
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    Online Resource
    Prediction model of ocular metastasis from primary liver cancer: Machine learning‐based development and interpretation study
    Wiley ; 2023
    In:  Cancer Medicine
    Details
    In: Cancer Medicine, Wiley
    Abstract: Ocular metastasis (OM) is a rare metastatic site of primary liver cancer (PLC). The purpose of this study was to establish a clinical predictive model of OM in PLC patients based on machine learning (ML). Methods We retrospectively collected the clinical data of 1540 PLC patients and divided it into a training set and an internal test set in a 7:3 proportion. PLC patients were divided into OM and non‐ocular metastasis (NOM) groups, and univariate logistic regression analysis was performed between the two groups. The variables with univariate logistic analysis p   〈  0.05 were selected for the ML model. We constructed six ML models, which were internally verified by 10‐fold cross‐validation. The prediction performance of each ML model was evaluated by receiver operating characteristic curves (ROCs). We also constructed a web calculator based on the optimal performance ML model to personalize the risk probability for OM. Results Six variables were selected for the ML model. The extreme gradient boost (XGB) ML model achieved the optimal differential diagnosis ability, with an area under the curve (AUC) = 0.993, accuracy = 0.992, sensitivity = 0.998, and specificity = 0.984. Based on these results, an online web calculator was constructed by using the XGB ML model to help clinicians diagnose and treat the risk probability of OM in PLC patients. Finally, the Shapley additive explanations (SHAP) library was used to obtain the six most important risk factors for OM in PLC patients: CA125, ALP, AFP, TG, CA199, and CEA. Conclusion We used the XGB model to establish a risk prediction model of OM in PLC patients. The predictive model can help identify PLC patients with a high risk of OM, provide early and personalized diagnosis and treatment, reduce the poor prognosis of OM patients, and improve the quality of life of PLC patients.
    Type of Medium: Online Resource
    ISSN: 2045-7634 , 2045-7634
    URL: Article
    DOI: 10.1002/cam4.6540
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2659751-2
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  • 6
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    Online Resource
    Electroacupuncture modulates abnormal brain connectivity after ischemia reperfusion injury in rats: A graph theory‐based approach
    Wiley ; 2024
    In:  Brain and Behavior Vol. 14, No. 5 ( 2024-05)
    Details
    In: Brain and Behavior, Wiley, Vol. 14, No. 5 ( 2024-05)
    Abstract: Electroacupuncture (EA) has been shown to facilitate brain plasticity‐related functional recovery following ischemic stroke. The functional magnetic resonance imaging technique can be used to determine the range and mode of brain activation. After stroke, EA has been shown to alter brain connectivity, whereas EA's effect on brain network topology properties remains unclear. An evaluation of EA's effects on global and nodal topological properties in rats with ischemia reperfusion was conducted in this study. Methods and results There were three groups of adult male Sprague‐Dawley rats: sham‐operated group (sham group), middle cerebral artery occlusion/reperfusion (MCAO/R) group, and MCAO/R plus EA (MCAO/R + EA) group. The differences in global and nodal topological properties, including shortest path length, global efficiency, local efficiency, small‐worldness index, betweenness centrality (BC), and degree centrality (DC) were estimated. Graphical network analyses revealed that, as compared with the sham group, the MCAO/R group demonstrated a decrease in BC value in the right ventral hippocampus and increased BC in the right substantia nigra, accompanied by increased DC in the left nucleus accumbens shell (AcbSh). The BC was increased in the right hippocampus ventral and decreased in the right substantia nigra after EA intervention, and MCAO/R + EA resulted in a decreased DC in left AcbSh compared to MCAO/R. Conclusion The results of this study provide a potential basis for EA to promote cognitive and motor function recovery after ischemic stroke.
    Type of Medium: Online Resource
    ISSN: 2162-3279 , 2162-3279
    URL: Issue
    URL: Article
    DOI: 10.1002/brb3.v14.5
    DOI: 10.1002/brb3.3504
    Language: English
    Publisher: Wiley
    Publication Date: 2024
    detail.hit.zdb_id: 2623587-0
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  • 7
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    FLOURY ENDOSPERM24 , a heat shock protein 101 ( HSP101 ), is required for starch biosynthesis and endosperm development in rice
    Wiley ; 2024
    In:  New Phytologist Vol. 242, No. 6 ( 2024-06), p. 2635-2651
    Details
    In: New Phytologist, Wiley, Vol. 242, No. 6 ( 2024-06), p. 2635-2651
    Abstract: Endosperm is the main storage organ in cereal grain and determines grain yield and quality. The molecular mechanisms of heat shock proteins in regulating starch biosynthesis and endosperm development remain obscure. Here, we report a rice floury endosperm mutant flo24 that develops abnormal starch grains in the central starchy endosperm cells. Map‐based cloning and complementation test showed that FLO24 encodes a heat shock protein HSP101, which is localized in plastids. The mutated protein FLO24 T296I dramatically lost its ability to hydrolyze ATP and to rescue the thermotolerance defects of the yeast hsp104 mutant. The flo24 mutant develops more severe floury endosperm when grown under high‐temperature conditions than normal conditions. And the FLO24 protein was dramatically induced at high temperature. FLO24 physically interacts with several key enzymes required for starch biosynthesis, including AGPL1, AGPL3 and PHO1. Combined biochemical and genetic evidence suggests that FLO24 acts cooperatively with HSP70cp‐2 to regulate starch biosynthesis and endosperm development in rice. Our results reveal that FLO24 acts as an important regulator of endosperm development, which might function in maintaining the activities of enzymes involved in starch biosynthesis in rice.
    Type of Medium: Online Resource
    ISSN: 0028-646X , 1469-8137
    URL: Issue
    URL: Article
    DOI: 10.1111/nph.v242.6
    DOI: 10.1111/nph.19761
    Language: English
    Publisher: Wiley
    Publication Date: 2024
    detail.hit.zdb_id: 208885-X
    detail.hit.zdb_id: 1472194-6
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  • 8
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    Morphological alterations of contralesional hemisphere relate to functional outcomes after stroke
    Wiley ; 2023
    In:  European Journal of Neuroscience Vol. 58, No. 5 ( 2023-09), p. 3347-3361
    Details
    In: European Journal of Neuroscience, Wiley, Vol. 58, No. 5 ( 2023-09), p. 3347-3361
    Abstract: The present study aimed to investigate poststroke morphological alterations contralesionally and correlations with functional outcomes. Structural magnetic resonance images were obtained from 27 poststroke patients (24 males, 50.21 ± 10.97 years) and 20 healthy controls (13 males, 46.63 ± 12.18 years). Voxel‐based and surface‐based morphometry analysis were conducted to detect alterations of contralesional grey matter volume (GMV), cortical thickness (CT), gyrification index (GI), sulcus depth (SD), and fractal dimension (FD) in poststroke patients. Partial correlation analysis was used to explore the relationship between regions with significant structural differences and scores of clinical assessments, including Modified Barthel Index (MBI), Berg Balance Scale (BBS), Fugl–Meyer Assessment of Upper Extremity (FMA‐UE), Mini‐Mental State Examination (MMSE), and Montreal Cognitive Assessment (MoCA). Correction for multiplicity was conducted within each parameter and for all tests. GMV significantly decreased in the contralesional motor‐related, occipital and temporal cortex, limbic system, and cerebellum lobe ( P   〈  0.01, family‐wise error [FWE] correction). Lower CT was found in the contralesional precentral and lingual gyrus ( P   〈  0.01, FWE correction), while lower GI found in the contralesional superior temporal gyrus and insula ( P   〈  0.01, FWE correction). There were significant correlations between GMV of contralesional lingual gyrus and MBI ( P  = 0.031, r  = 0.441), and BBS ( P  = 0.047, r  = 0.409) scores, and GMV of contralesional hippocampus and FMA‐UE scores ( P  = 0.048, r  = 0.408). In conclusion, stroke patients exhibited wide grey matter loss and cortical morphological changes in the contralesional hemisphere, which correlated with sensorimotor functions and the ability of daily living.
    Type of Medium: Online Resource
    ISSN: 0953-816X , 1460-9568
    URL: Issue
    URL: Article
    DOI: 10.1111/ejn.v58.5
    DOI: 10.1111/ejn.16097
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2005178-5
    SSG: 12
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  • 9
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    Intra and inter: Alterations in functional brain resting‐state networks after peripheral nerve injury
    Wiley ; 2020
    In:  Brain and Behavior Vol. 10, No. 9 ( 2020-09)
    Details
    In: Brain and Behavior, Wiley, Vol. 10, No. 9 ( 2020-09)
    Abstract: Numerous treatments suggest that brain plasticity changes after peripheral nerve injury (PNI), and most studies examining functional magnetic resonance imaging focused on abnormal changes in specific brain regions. However, it is the large‐scale interaction of neuronal networks instead of isolated brain regions contributed to the functional recovery after PNI. In the present study, we examined the intra‐ and internetworks alterations between the related functional resting‐state networks (RSNs) in a sciatic nerve injury rat model. Methods Ninety‐six female rats were divided into a control and model group. Unilateral sciatic nerve transection and direct anastomosis were performed in the latter group. We used an independent component analysis (ICA) algorithm to observe the changes in RSNs and assessed functional connectivity between different networks using the functional networks connectivity (FNC) toolbox. Results Six RSNs related to PNI were identified, including the basal ganglia network (BGN), sensorimotor network (SMN), salience network (SN), interoceptive network (IN), cerebellar network (CN), and default mode network (DMN). The model group showed significant changes in whole‐brain FC changes within these resting‐state networks (RSNs), but four of these RSNs exhibited a conspicuous decrease. The interalterations performed that significantly decreased FNC existed between the BGN and SMN, BGN and IN, and BGN and DMN ( p   〈  .05, corrected). A significant increase in FNC existed between DMN and CN and between CN and SN ( p   〈  .05, corrected). Conclusion The results showed the large‐scale functional reorganization at the network level after PNI. This evidence reveals new implications to the pathophysiological mechanisms in brain plasticity of PNI.
    Type of Medium: Online Resource
    ISSN: 2162-3279 , 2162-3279
    URL: Issue
    URL: Article
    DOI: 10.1002/brb3.v10.9
    DOI: 10.1002/brb3.1747
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2623587-0
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  • 10
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    52.4: Toward Longer Lifetime‐‐Elongating the Operation Lifetime of Organic Lighting Emitting Diode by Implementing Novel Driving Method
    Wiley ; 2019
    In:  SID Symposium Digest of Technical Papers Vol. 50, No. S1 ( 2019-09), p. 576-579
    Details
    In: SID Symposium Digest of Technical Papers, Wiley, Vol. 50, No. S1 ( 2019-09), p. 576-579
    Abstract: A novel driving method, different from direct current and alternating current methods, was implemented to alleviate the luminance degradation of OLED device. The current density‐voltage‐luminance characteristics measurement results shown that red, green and blue OLED devices have current efficiency of 50 cd/A, 133.4 cd/A and 5.9 cd/A at the CIE coordinate of (0.685, 0.315), (0.252, 0.718) and (0.142, 0.043), with the electroluminescence emission peaks of 622 nm, 532 nm and 457nm, respectively. Driven by the new driving method, the LT97 of red, green and blue OLED devices were about 1.35, 1.3 and 2 times longer than that of driven by direct current method, at the initial luminance of 9320 cd/m 2 , 20000 cd/m 2 and 1758 cd/m 2 , respectively. If using this new driving method on our 12.3 inch automotive panel, the estimated LT80 of green and blue sub‐pixel were up to over 10,000 hours while that of the red sub‐pixel is nearly 9,000 hours, which means this new driving method is a promising solution to trade off long‐term stability and high efficiency of full color OLED display.
    Type of Medium: Online Resource
    ISSN: 0097-966X , 2168-0159
    URL: Issue
    URL: Article
    DOI: 10.1002/sdtp.2019.50.issue-s1
    DOI: 10.1002/sdtp.13573
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 2526337-7
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