In:
International Journal of Cancer, Wiley, Vol. 143, No. 6 ( 2018-09-15), p. 1456-1469
Abstract:
What's new? Compared to other ovarian cancer histotypes, ovarian clear cell carcinoma (OCCC) is highly resistant to conventional chemotherapeutic agents. While mechanisms remain unclear, OCCC chemoresistance likely is linked to elevated expression of iASPP, an inhibitory member of the otherwise apoptosis‐stimulating ASPP protein family. Here, expression of both iASPP and polo‐like kinase 1 (PLK1) was correlated with OCCC chemoresistance, while high iASPP expression alone was associated with poor survival in OCCC patients. Sensitivity to cisplatin increased in vitro and in vivo following iASPP knockdown. Further in vitro studies demonstrated a critical role for iASPP and PLK1 in the maintenance of autophagy.
Type of Medium:
Online Resource
ISSN:
0020-7136
,
1097-0215
Language:
English
Publisher:
Wiley
Publication Date:
2018
detail.hit.zdb_id:
218257-9
detail.hit.zdb_id:
1474822-8
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