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  • 1
    Online Resource
    Online Resource
    Precisely Constructed Metal Sulfides with Localized Single‐Atom Rhodium for Photocatalytic C−H Activation and Direct Methanol Coupling to Ethylene Glycol
    Wiley ; 2023
    In:  Advanced Materials Vol. 35, No. 5 ( 2023-02)
    Details
    In: Advanced Materials, Wiley, Vol. 35, No. 5 ( 2023-02)
    Abstract: Although there are many studies on photocatalytic environmental remediation, hydrogen evolution, and chemical transformations, less success has been achieved for the synthesis of industrially important and largely demanded bulk chemicals using semiconductor photocatalysis, which holds great potential to drive unique chemical reactions that are difficult to implement by the conventional heterogeneous catalysis. The performance of semiconductors used for photochemical synthesis is, however, usually unsatisfactory due to limited efficiencies in light harvesting, charge‐carrier separation, and surface reactions. The precise construction of heterogeneous photocatalysts to facilitate these processes is an attractive but challenging goal. Here, single‐atom rhodium‐doped metal sulfide nanorods composed of alternately stacked wurtzite/zinc‐blende segments are successfully designed and fabricated, which demonstrate record‐breaking efficiencies for visible light‐driven preferential activation of C−H bond in methanol to form ethylene glycol (EG), a key bulk chemical used for the production of polyethylene terephthalate (PET) polymer. The wurtzite/zinc‐blende heterojunctions lined regularly in one dimension accelerate the charge‐carrier separation and migration. Single‐atom rhodium selectively deposited onto the wurtzite segment with photogenerated holes accumulated facilitates methanol adsorption and C−H activation. The present work paves the way to harnessing photocatalysis for bulk chemical synthesis with structure‐defined semiconductors.
    Type of Medium: Online Resource
    ISSN: 0935-9648 , 1521-4095
    URL: Issue
    URL: Article
    DOI: 10.1002/adma.v35.5
    DOI: 10.1002/adma.202205782
    RVK:
    UA 1538
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 1474949-X
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  • 2
    Online Resource
    Online Resource
    A Transformer‐Based microvascular invasion classifier enhances prognostic stratification in HCC following radiofrequency ablation
    Wiley ; 2024
    In:  Liver International
    Details
    In: Liver International, Wiley
    Abstract: We aimed to develop a Transformer‐based deep learning (DL) network for prognostic stratification in hepatocellular carcinoma (HCC) patients undergoing RFA. Methods A Swin Transformer DL network was trained to establish associations between magnetic resonance imaging (MRI) datasets and the ground truth of microvascular invasion (MVI) based on 696 surgical resection (SR) patients with solitary HCC ≤3 cm, and was validated in an external cohort ( n = 180). The multiphase MRI‐based DL risk outputs using an optimal threshold of .5 was employed as a MVI classifier for prognosis stratification in the RFA cohort ( n = 180). Results Over 90% of all enrolled patients exhibited hepatitis B virus infection. Liver cirrhosis was significantly more prevalent in the RFA cohort compared to the SR cohort (72.2% vs. 44.1%, p 〈 .001). The MVI risk outputs exhibited good performance (area under the curve values = .938 and .883) for predicting MVI in the training and validation cohort, respectively. The RFA patients at high risk of MVI classified by the MVI classifier demonstrated significantly lower recurrence‐free survival (RFS) and overall survival rates at 1, 3 and 5 years compared to those classified as low risk ( p 〈 .001). Multivariate cox regression modelling of a‐fetoprotein 〉 20 ng/mL [hazard ratio (HR) = 1.53; 95% confidence interval (95% CI): 1.02–2.33, p = .047], high risk of MVI (HR = 3.76; 95% CI: 2.40–5.88, p 〈 .001) and unfavourable tumour location (HR = 2.15; 95% CI: 1.40–3.29, p = .001) yielded a c‐index of .731 (bootstrapped 95% CI: .667–.778) for evaluating RFS after RFA. Among the three risk factors, MVI was the most powerful predictor for intrahepatic distance recurrence. Conclusions The proposed MVI classifier can serve as a valuable imaging biomarker for prognostic stratification in early‐stage HCC patients undergoing RFA.
    Type of Medium: Online Resource
    ISSN: 1478-3223 , 1478-3231
    URL: Article
    DOI: 10.1111/liv.15846
    Language: English
    Publisher: Wiley
    Publication Date: 2024
    detail.hit.zdb_id: 2124684-1
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  • 3
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    Online Resource
    Tungstate‐mediated In‐situ Passivation of Grain Boundary Grooves in Perovskite Solar Cells
    Wiley ; 2023
    In:  Angewandte Chemie Vol. 135, No. 24 ( 2023-06-12)
    Details
    In: Angewandte Chemie, Wiley, Vol. 135, No. 24 ( 2023-06-12)
    Abstract: Possessed with advantageous optoelectronic properties, perovskites have boosted the rapid development of solution‐processed solar cells. The performance of perovskite solar cells (PSCs) is significantly weakened by the carrier loss at grain boundary grooves (GBGs); however, it receives limited attention and there lacks effective approach to solve this issue. Herein, for the first time, we constructed the tungstate/perovskite heterointerface via a “two step” in situ reaction approach that provides effective defect passivation and ensures efficient carrier dynamics at the GBGs. The exposed perovskite at grain boundaries is converted to wide‐band‐gap PbWO 4 via an in‐situ reaction between Pb 2+ and tungstate ions, which passivate defects due to the strong ionic bonding. Moreover, recombination loss is further suppressed via the heterointerface energetics modification based on an additional transformation from PbWO 4 to CaWO 4 . PSCs based on this groove modification strategy showed good universality in both normal and inverted structure, with an improved efficiency of 23.25 % in the n‐i‐p device and 23.33 % in the p‐i‐n device. Stable power output of the modified device could maintain 91.7 % after around 1100 h, and the device efficiency could retain 92.5 % after aging in air for around 2110 h, and 93.1 % after aging at 85 °C in N 2 for 972 h.
    Type of Medium: Online Resource
    ISSN: 0044-8249 , 1521-3757
    URL: Issue
    URL: Article
    DOI: 10.1002/ange.v135.24
    DOI: 10.1002/ange.202303176
    RVK:
    VA 2100
    RVK:
    VN 5020
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 505868-5
    detail.hit.zdb_id: 506609-8
    detail.hit.zdb_id: 514305-6
    detail.hit.zdb_id: 505872-7
    detail.hit.zdb_id: 1479266-7
    detail.hit.zdb_id: 505867-3
    detail.hit.zdb_id: 506259-7
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  • 4
    Online Resource
    Online Resource
    Tungstate‐mediated In‐situ Passivation of Grain Boundary Grooves in Perovskite Solar Cells
    Wiley ; 2023
    In:  Angewandte Chemie International Edition Vol. 62, No. 24 ( 2023-06-12)
    Details
    In: Angewandte Chemie International Edition, Wiley, Vol. 62, No. 24 ( 2023-06-12)
    Abstract: Possessed with advantageous optoelectronic properties, perovskites have boosted the rapid development of solution‐processed solar cells. The performance of perovskite solar cells (PSCs) is significantly weakened by the carrier loss at grain boundary grooves (GBGs); however, it receives limited attention and there lacks effective approach to solve this issue. Herein, for the first time, we constructed the tungstate/perovskite heterointerface via a “two step” in situ reaction approach that provides effective defect passivation and ensures efficient carrier dynamics at the GBGs. The exposed perovskite at grain boundaries is converted to wide‐band‐gap PbWO 4 via an in‐situ reaction between Pb 2+ and tungstate ions, which passivate defects due to the strong ionic bonding. Moreover, recombination loss is further suppressed via the heterointerface energetics modification based on an additional transformation from PbWO 4 to CaWO 4 . PSCs based on this groove modification strategy showed good universality in both normal and inverted structure, with an improved efficiency of 23.25 % in the n‐i‐p device and 23.33 % in the p‐i‐n device. Stable power output of the modified device could maintain 91.7 % after around 1100 h, and the device efficiency could retain 92.5 % after aging in air for around 2110 h, and 93.1 % after aging at 85 °C in N 2 for 972 h.
    Type of Medium: Online Resource
    ISSN: 1433-7851 , 1521-3773
    URL: Issue
    URL: Article
    DOI: 10.1002/anie.v62.24
    DOI: 10.1002/anie.202303176
    RVK:
    VA 2100
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2011836-3
    detail.hit.zdb_id: 123227-7
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  • 5
    Online Resource
    Online Resource
    Activation of CREB‐mediated autophagy by thioperamide ameliorates β‐amyloid pathology and cognition in Alzheimer’s disease
    Wiley ; 2021
    In:  Aging Cell Vol. 20, No. 3 ( 2021-03)
    Details
    In: Aging Cell, Wiley, Vol. 20, No. 3 ( 2021-03)
    Abstract: Alzheimer's disease (AD) is an age‐related neurodegenerative disease, and the imbalance between production and clearance of β‐amyloid (Aβ) is involved in its pathogenesis. Autophagy is an intracellular degradation pathway whereby leads to removal of aggregated proteins, up‐regulation of which may be a plausible therapeutic strategy for the treatment of AD. Histamine H3 receptor (H3R) is a presynaptic autoreceptor regulating histamine release via negative feedback way. Our previous study showed that thioperamide, as an antagonist of H3R, enhances autophagy and protects against ischemic injury. However, the effect of thioperamide on autophagic function and Aβ pathology in AD remains unknown. In this study, we found that thioperamide promoted cognitive function, ameliorated neuronal loss, and Aβ pathology in APP/PS1 transgenic (Tg) mice. Interestingly, thioperamide up‐regulated autophagic level and lysosomal function both in APP/PS1 Tg mice and in primary neurons under Aβ‐induced injury. The neuroprotection by thioperamide against AD was reversed by 3‐MA, inhibitor of autophagy, and siRNA of Atg7 , key autophagic‐related gene. Furthermore, inhibition of activity of CREB, H3R downstream signaling, by H89 reversed the effect of thioperamide on promoted cell viability, activated autophagic flux, and increased autophagic‐lysosomal proteins expression, including Atg7, TFEB, and LAMP1, suggesting a CREB‐dependent autophagic activation by thioperamide in AD. Taken together, these results suggested that H3R antagonist thioperamide improved cognitive impairment in APP/PS1 Tg mice via modulation of the CREB‐mediated autophagy and lysosomal pathway, which contributed to Aβ clearance. This study uncovered a novel mechanism involving autophagic regulating behind the therapeutic effect of thioperamide in AD.
    Type of Medium: Online Resource
    ISSN: 1474-9718 , 1474-9726
    URL: Issue
    URL: Article
    DOI: 10.1111/acel.v20.3
    DOI: 10.1111/acel.13333
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2099130-7
    SSG: 12
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  • 6
    Online Resource
    Online Resource
    Multiscale Hierarchical Architecture‐Based Bioactive Scaffolds for Versatile Tissue Engineering (Adv. Healthcare Mater. 13/2022)
    Wiley ; 2022
    In:  Advanced Healthcare Materials Vol. 11, No. 13 ( 2022-07)
    Details
    In: Advanced Healthcare Materials, Wiley, Vol. 11, No. 13 ( 2022-07)
    Type of Medium: Online Resource
    ISSN: 2192-2640 , 2192-2659
    URL: Issue
    URL: Article
    DOI: 10.1002/adhm.v11.13
    DOI: 10.1002/adhm.202270080
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2645585-7
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  • 7
    Online Resource
    Online Resource
    PARK7 enhances antioxidative‐stress processes of BMSCs via the ERK1/2 pathway
    Wiley ; 2021
    In:  Journal of Cellular Biochemistry Vol. 122, No. 2 ( 2021-02), p. 222-234
    Details
    In: Journal of Cellular Biochemistry, Wiley, Vol. 122, No. 2 ( 2021-02), p. 222-234
    Abstract: Oxidative stresss in the microenvironment surrounding lesions induces apoptosis of transplanted bone‐marrow‐derived mesenchymal stem cells (BMSCs). Hence, there is an urgent need for improving antioxidative‐stress processes of transplanted BMSCs to further promote their survival. The present study reports the role and mechanism of Parkinson's disease protein 7 (PARK7) in enhancing antioxidative activity in BMSCs. We used a PARK7 lentivirus to transfect BMSCs to up‐ or downregulate PARK7, and then used H 2 O 2 to simulate oxidative stress in BMSCs in vitro. Overexpression of PARK7 effectively reduced reactive oxygen species and malondialdehyde, protected mitochondrial membrane potential, and resisted oxidative‐stress‐induced apoptosis of BMSCs, but the expression of PARK7 was downregulated, these results were reversed. At the same time, we also found that overexpression of PARK7 increased extracellular‐regulated protein kinase 1/2 (ERK1/2) phosphorylation and nuclear translocation, as well as upregulated Elk1 phosphorylation and superoxide dismutase (SOD) expression. In contrast, when U0126 was used to block the ERK1/2 pathway, ERK1/2 and Elk1 phosphorylation levels were downregulated, ERK1/2 nuclear translocation and SOD content were significantly reduced, and PARK7‐overexperssion‐induced antioxidative activity was completely blocked. Collectively, our results suggest that PARK7 overexpression increased antioxidative‐stress processes and survival of BMSCs subjected to H 2 O 2 via activating the ERK1/2 signaling pathway. Our findings may guide the development of a PARK7‐specific strategy for improving the transplantation efficacy of BMSCs.
    Type of Medium: Online Resource
    ISSN: 0730-2312 , 1097-4644
    URL: Issue
    URL: Article
    DOI: 10.1002/jcb.v122.2
    DOI: 10.1002/jcb.29845
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 1479976-5
    SSG: 12
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  • 8
    Online Resource
    Online Resource
    Multiscale Hierarchical Architecture‐Based Bioactive Scaffolds for Versatile Tissue Engineering
    Wiley ; 2022
    In:  Advanced Healthcare Materials Vol. 11, No. 13 ( 2022-07)
    Details
    In: Advanced Healthcare Materials, Wiley, Vol. 11, No. 13 ( 2022-07)
    Abstract: Artificial construction from tendon to bone remains a formidable challenge in tissue engineering owing to their structural complexity. In this work, bioinspired calcium silicate nanowires and alginate composite hydrogels are utilized as building blocks to construct multiscale hierarchical bioactive scaffolds for versatile tissue engineering from tendon to bone. By integrating 3D printing technology and mechanical stretch post‐treatment in a confined condition, the obtained composite hydrogels possess bioinspired reinforcement architectures from nano‐ to submicron‐ to microscale with significantly enhanced mechanical properties. The biochemical and topographical cues of the composite hydrogel scaffolds provide much more efficient microenvironment to the rabbit bone mesenchymal stem cells and rabbit tendon stem cells, leading to ordered alignment and improved differentiation. The composite hydrogels markedly promote in vivo tissue regeneration from bone to tendon, especially fibrocartilage transitional tissue. Therefore, such calcium silicate nanowires/alginate composite hydrogels with multiscale hierarchical structures have potential application for tissue regeneration from tendon to bone. This work provides an innovative strategy to construct multiscale hierarchical architecture‐based scaffolds for tendon/bone engineering.
    Type of Medium: Online Resource
    ISSN: 2192-2640 , 2192-2659
    URL: Issue
    URL: Article
    DOI: 10.1002/adhm.v11.13
    DOI: 10.1002/adhm.202102837
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2645585-7
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  • 9
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    Online Resource
    Mechanical properties and oxidation corrosion resistance of phosphate ceramic coating enhanced by SiO 2 ‐BNNSs material
    Wiley ; 2024
    In:  International Journal of Applied Ceramic Technology
    Details
    In: International Journal of Applied Ceramic Technology, Wiley
    Abstract: A method of preparing SiO 2 ‐BNNSs hybrid material by surface modification of boron nitride nanosheets (BNNSs) with SiO 2 was proposed to improve the dispersion of BNNSs in the coatings. Then, phosphate ceramic coatings with BNNSs and SiO 2 ‐BNNSs were prepared on stainless steel (304) by spraying. Characterization of BNNSs and SiO 2 ‐BNNSs by X‐ray diffraction, Fourier transform‐infrared, Raman, and scanning electron microscopy proved the success of hybridization. The surface morphology and mechanical properties were conducted to characterize the protective performance of the coating. Simultaneously, the phase composition and electrochemical properties of the coatings after high‐temperature oxidation were studied. The results showed that ceramic coatings had low surface energy with a contact angle of 102.41° when .4 wt.% SiO 2 ‐BNNSs was added. Compared with BNNSs coating, the mechanical properties of SiO 2 ‐BNNSs coating were significantly enhanced, the hardness of .4 wt.%SiO 2 ‐BNNSs coating was as high as 170 HV, and the interface bonding strength was 12.24 MPa. For the oxidation corrosion resistance, .4 wt.% SiO 2 ‐BNNSs coating under oxidation at 400°C for 50 h had the minimum corrosion current density and maximum impedance, which were .864 μA/cm 2 and 177 kΩ/cm 2 , respectively, this indicated that SiO 2 ‐BNNSs coating could still maintain excellent oxidation corrosion resistance under high‐temperature conditions for a long time.
    Type of Medium: Online Resource
    ISSN: 1546-542X , 1744-7402
    URL: Article
    DOI: 10.1111/ijac.14679
    Language: English
    Publisher: Wiley
    Publication Date: 2024
    detail.hit.zdb_id: 2167226-X
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  • 10
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    Online Resource
    On‐Chip Polarization‐ and Frequency‐Division Demultiplexing for Multidimensional Terahertz Communication
    Wiley ; 2022
    In:  Laser & Photonics Reviews Vol. 16, No. 10 ( 2022-10)
    Details
    In: Laser & Photonics Reviews, Wiley, Vol. 16, No. 10 ( 2022-10)
    Abstract: Integrated terahertz (THz) technology is of great significance for driving high‐speed communication, sensing, and imaging with its advantages of miniaturization, low cost, and high efficiency. Recent research has focused on highly‐efficient transmitters and ultrafast detectors, as well as exploring new devices for coupling, transmission, and polarization control. However, multidimensional on‐chip multiplexing and demultiplexing techniques in the THz region still remains unexplored, due to the lack of multifunctional integrated components and systems. Here, a novel silicon‐based integrated multidimensional THz (de)multiplexer for high‐capacity communication is proposed and demonstrated based on ring resonators and polarization beam splitter‐rotators, which simultaneously enable the manipulation of THz polarization and frequency. Furthermore, a THz communication system operating in the 380 GHz band is experimentally demonstrated. By using on‐chip polarization‐ and frequency‐division multiplexing techniques, an aggregate data rate of 8 Gbit s −1 is successfully achieved with quadrature phase‐shift keying modulation scheme. This work provides a spectrally efficient way for accelerating the development of on‐chip THz technologies and the application in future large‐volume communications.
    Type of Medium: Online Resource
    ISSN: 1863-8880 , 1863-8899
    URL: Issue
    URL: Article
    DOI: 10.1002/lpor.v16.10
    DOI: 10.1002/lpor.202200136
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2266512-2
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