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  • 1
    Online Resource
    Online Resource
    Both epilepsy and anti‐seizure medications affect bone metabolism in children with self‐limited epilepsy with centrotemporal spikes
    Wiley ; 2023
    In:  Epilepsia
    Details
    In: Epilepsia, Wiley
    Abstract: Bone metabolism can be influenced by a range of factors. We selected children with self‐limited epilepsy with centrotemporal spikes (SeLECTS) and lifestyles similar to those of healthy children to control for the confounding factors that may influence bone metabolism. We aimed to identify the specific effects of epilepsy and/or anti‐seizure medications (ASMs) on bone metabolism. Methods Patients with SeLECTS were divided into an untreated group and a monotherapy group, and the third group was a healthy control group. We determined the levels of various biochemical markers of bone metabolism, including procollagen type I nitrogenous propeptide (PINP), alkaline phosphatase (ALP), osteocalcin (OC), collagen type I cross‐linked C‐telopeptide (CTX), calcium, magnesium, phosphorus, parathyroid hormone (PTH), and vitamin D 3 (VD 3 ). Results A total of 1487 patients (from 19 centers) were diagnosed with SeLECTS; 1032 were analyzed, including 117 patients who did not receive any ASMs (untreated group), 643 patients who received only one ASM (monotherapy group), and 272 children in the healthy control group. Except for VD 3 , other bone metabolism of the three groups were different ( p   〈  .001). Bone metabolism was significantly lower in the untreated group than the healthy control group (p   〈  .05). There were significant differences between the monotherapy and healthy control group in the level of many markers. However, when comparing the monotherapy and untreated groups, the results were different; oxcarbazepine, levetiracetam, and topiramate had no significant effect on bone metabolism. Phosphorus and magnesium were significantly lower in the valproic acid group than the untreated group (adjusted p   〈  .05, Cliff's delta .282–.768). CTX was significantly higher in the lamotrigine group than in the untreated group (adjusted p  = .012, Cliff's delta = .316). Significance Epilepsy can affect many aspects of bone metabolism. After controlling epilepsy and other confounders that affect bone metabolism, we found that the effects of ASMs on bone metabolism differed. Oxcarbazepine, levetiracetam, and topiramate did not affect bone metabolism, and lamotrigine corrected some of the abnormal markers of bone metabolism in patients with epilepsy.
    Type of Medium: Online Resource
    ISSN: 0013-9580 , 1528-1167
    URL: Article
    DOI: 10.1111/epi.17733
    RVK:
    XA 10000
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2002194-X
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  • 2
    Online Resource
    Online Resource
    Complications and Prevention Strategies of Oblique Lateral Interbody Fusion Technique
    Wiley ; 2018
    In:  Orthopaedic Surgery Vol. 10, No. 2 ( 2018-05), p. 98-106
    Details
    In: Orthopaedic Surgery, Wiley, Vol. 10, No. 2 ( 2018-05), p. 98-106
    Abstract: To analyze the early complications and causes of oblique lateral interbody fusion, and put forward preventive measures. Methods There were 235 patients (79 males and 156 females) analyzed in our study from October 2014 to May 2017. The average age was 61.9 ± 0.21 years (from 32 to 83 years). Ninety‐one cases were treated with oblique lateral interbody fusion (OLIF) alone (OLIF alone group) and 144 with OLIF combined with posterior pedicle screw fixation through the intermuscular space approach (OLIF combined group). In addition, 137/144 cases in the combined group were primarily treated by posterior pedicle screw fixation, while the treatments were postponed in 7 cases. There were 190 cases of single fusion segments, 11 of 2 segments, 21 of 3 segments, and 13 of 4 segments. Intraoperative and postoperative complications were observed. Results Average follow‐up time was 15.6 ± 7.5 months (ranged from 6 to 36 months). Five cases were lost to follow‐up (2 cases from the OLIF alone group and 3 cases from the OLIF combined group). There were 7 cases of vascular injury, 22 cases of endplate damage, 2 cases of vertebral body fracture, 11 cases of nerve injury, 18 cases of cage sedimentation or cage transverse shifting, 3 cases of iliac crest pain, 1 case of right psoas major hematoma, 2 cases of incomplete ileus, 1 case of acute heart failure, 1 case of cerebral infarction, 3 case of left lower abdominal pain, 9 cases of transient psoas weakness, 3 cases of transient quadriceps weakness, and 8 cases of reoperation. The complication incidence was 32.34%. Thirty‐three cases occurred in the OLIF alone group, with a rate of 36.26%, and 43 cases in the group of OLIF combined posterior pedicle screw fixation, with a rate of 29.86%. Fifty‐seven cases occurred in single‐segment fusion, with a rate of 30.0% (57/190), 4 cases occurred in two‐segment fusion, with a rate of 36.36% (4/11), 9 cases occurred in three‐segment fusion, with a rate of 42.86% (9/21), and 6 cases occurred in four‐segment fusion, with a rate of 46.15% (6/13). Conclusion In summary, OLIF is a relatively safe and very effective technique for minimally invasive lumbar fusion. Nonetheless, it should be noted that OLIF carries the risk of complications, especially in the early stage of development.
    Type of Medium: Online Resource
    ISSN: 1757-7853 , 1757-7861
    URL: Issue
    URL: Article
    DOI: 10.1111/os.2018.10.issue-2
    DOI: 10.1111/os.12380
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2483883-4
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  • 3
    Online Resource
    Online Resource
    Ulinastatin inhibits the metastasis of nasopharyngeal carcinoma by involving uPA/uPAR signaling
    Wiley ; 2023
    In:  Drug Development Research
    Details
    In: Drug Development Research, Wiley
    Abstract: Distant metastasis is the primary reason for treatment failure in patients with nasopharyngeal carcinoma (NPC). In this study, we investigated the effect of ulinastatin (UTI) on NPC metastasis and its underlying mechanism. Highly‐metastatic NPC cell lines S18 and 58F were treated with UTI and the effect on cell proliferation, migration, and invasion were determined by MTS and Transwell assays. S18 cells with luciferase‐expressing (S18–1C3) were injected into the left hind footpad of nude mice to establish a model of spontaneous metastasis from the footpad to popliteal lymph node (LN). The luciferase messenger RNA (mRNA) was measured by quantitative polymerase chain reaction (qPCR), and the metastasis inhibition rate was calculated. Key molecular members of the UTI‐related uPA, uPAR, and JAT/STAT3 signaling pathways were detected by qPCR and immunoblotting. UTI suppressed the migration and infiltration of S18 and 5‐8F cells and suppressed the metastasis of S18 cells in vivo without affecting cell proliferation. uPAR expression decreased from 24 to 48 h after UTI treatment. The antimetastatic effect of UTI is partly due to the suppression of uPA and uPAR. UTI partially suppresses NPC metastasis by downregulating the expression of uPA and uPAR.
    Type of Medium: Online Resource
    ISSN: 0272-4391 , 1098-2299
    URL: Article
    DOI: 10.1002/ddr.22098
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 1500191-X
    SSG: 15,3
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  • 4
    Online Resource
    Online Resource
    Aqueous synthesis of highly luminescent surface Mn 2+ ‐doped CdTe quantum dots as a potential multimodal agent
    Wiley ; 2014
    In:  Luminescence Vol. 29, No. 8 ( 2014-12), p. 1059-1065
    Details
    In: Luminescence, Wiley, Vol. 29, No. 8 ( 2014-12), p. 1059-1065
    Abstract: Mn 2+ ‐doped CdTe quantum dots (QDs) were synthesized directly via a facile surface doping strategy in aqueous solution. The best optical property emerged when the added amount of Mn 2+ was 5% compared to Cd 2+ in the CdTe nanoparticles and the reaction temperature was 60 °C. The fluorescence and magnetic properties of the QDs were studied. The as‐prepared Mn 2+ ‐doped CdTe QDs have high quantum yield (48.13%) and a narrow distribution with an average diameter of 3.7 nm. The utility of biological imaging was also studied. Depending on the high quantum yield, cells in culture were illuminated and made more distinct from each other compared to results obtained with normal QDs. They also have a prominent longitudinal relaxivity value ( r 1  = 4.2 mM −1 s −1 ), which could indicate that the Mn 2+ ‐doped CdTe QDs can be used as a potential multimodal agent for fluorescence and magnetic resonance imaging. Copyright © 2014 John Wiley & Sons, Ltd.
    Type of Medium: Online Resource
    ISSN: 1522-7235 , 1522-7243
    URL: Issue
    URL: Article
    DOI: 10.1002/bio.v29.8
    DOI: 10.1002/bio.2660
    Language: English
    Publisher: Wiley
    Publication Date: 2014
    detail.hit.zdb_id: 2001819-8
    SSG: 12
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  • 5
    Online Resource
    Online Resource
    Solar‐Driven Nitrogen Fixation Catalyzed by Stable Radical‐Containing MOFs: Improved Efficiency Induced by a Structural Transformation
    Wiley ; 2020
    In:  Angewandte Chemie Vol. 132, No. 46 ( 2020-11-09), p. 20847-20852
    Details
    In: Angewandte Chemie, Wiley, Vol. 132, No. 46 ( 2020-11-09), p. 20847-20852
    Abstract: Herein we present a new viologen‐based radical‐containing metal–organic framework (RMOF) Gd‐IHEP‐7, which upon heating in air undergoes a single‐crystal‐to‐single‐crystal transformation to generate Gd‐IHEP‐8. Both RMOFs exhibit excellent air and water stability as a result of favorable radical‐radical interactions, and their long‐lifetime radicals result in wide spectral absorption in the range 200–2500 nm. Gd‐IHEP‐7 and Gd‐IHEP‐8 show excellent activity toward solar‐driven nitrogen fixation, with ammonia production rates of 128 and 220 μmol h −1  g −1 , respectively. Experiments and theoretical calculations indicate that both RMOFs have similar nitrogen fixation pathways. The enhanced catalytic efficiency of Gd‐IHEP‐8 versus Gd‐IHEP‐7 is attributed to intermediates stabilized by enhanced hydrogen bonding.
    Type of Medium: Online Resource
    ISSN: 0044-8249 , 1521-3757
    URL: Issue
    URL: Article
    DOI: 10.1002/ange.v132.46
    DOI: 10.1002/ange.202009630
    RVK:
    VA 2100
    RVK:
    VN 5020
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 505868-5
    detail.hit.zdb_id: 506609-8
    detail.hit.zdb_id: 514305-6
    detail.hit.zdb_id: 505872-7
    detail.hit.zdb_id: 1479266-7
    detail.hit.zdb_id: 505867-3
    detail.hit.zdb_id: 506259-7
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  • 6
    Online Resource
    Online Resource
    Transparent, flame‐retarded, self‐healable, mechanically strong polyurethane elastomers: Enabled by the synthesis of phosphorus/nitrogen‐containing oxime chain‐extender
    Wiley ; 2022
    In:  Journal of Applied Polymer Science Vol. 139, No. 6 ( 2022-02-10)
    Details
    In: Journal of Applied Polymer Science, Wiley, Vol. 139, No. 6 ( 2022-02-10)
    Abstract: Polyurethane (PU) elastomer has been widely used due to its excellent mechanics, acid and alkali resistance, abrasion resistance, and other properties. However, obtaining simultaneous mechanically strong, flame‐retarded, transparent, and efficient self‐heal ability of PU elastomer is of great challenge due to the structural design. Here, a phosphorus/nitrogen‐containing Oxime chain extender (PSK‐2) was introduced into the synthesis of PU elastomers to obtain a transparent, flame‐retarded, self‐healable, mechanically strong PU elastomers. The PU elastomers exhibited high tensile strength of ~23.3 MPa, breaking strain of ~1693%, good flame retardancy with high LOI of ~29.2%, and UL‐94 V1 rating with the addition of 4.67 mmol (mass fraction 1.37 wt%) PSK2. Furthermore, the PUPSK2 elastomer material also had good healing ability up to 60% at room temperature and good transparency of 83.7% at 350–800 nm visible.
    Type of Medium: Online Resource
    ISSN: 0021-8995 , 1097-4628
    URL: Issue
    URL: Article
    DOI: 10.1002/app.v139.6
    DOI: 10.1002/app.51598
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 1491105-X
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  • 7
    Online Resource
    Online Resource
    The novel inhibitory effect of Pangdahai on fatty acid synthase
    Wiley ; 2008
    In:  IUBMB Life Vol. 60, No. 3 ( 2008-03), p. 185-194
    Details
    In: IUBMB Life, Wiley, Vol. 60, No. 3 ( 2008-03), p. 185-194
    Abstract: Recently, animal fatty acid synthase (FASN) is reported as a potential therapeutic target for obesity and cancer. Considerable interest has been developed in searching for novel inhibitors of this enzyme. An extract from Pangdahai has been found to inhibit FASN in both reversible and irreversible manners, with an IC 50 of 3.5 μg/ml and an apparent inactivation rate constant of k obs of 2.2 × 10 −3 /min. The kinetic study showed that the Pangdahai extract inhibited the overall FASN reaction uncompetitively with acetyl‐CoA, but it presented in a mixed manner both with NADPH and with malonyl‐CoA. Its major reacting site on this enzyme, as compared between two IC 50 values, is not in the beta‐ketoacyl reduction domain. A weight reducing experiment in rats showed that the extract significantly reduced the adipose and food intake, but in view of statistics ( P 〈 0.05), a correlation between the reductions in the adipose and in the food consumption and the inhibition of hepatic FASN could not be established. Three known flavonoid compounds were isolated from the extract and the structure–activity relationship was discussed. © 2008 IUBMB IUBMB Life, 60(3): 185–194, 2008
    Type of Medium: Online Resource
    ISSN: 1521-6543 , 1521-6551
    URL: Issue
    URL: Article
    DOI: 10.1002/iub.v60:3
    DOI: 10.1002/iub.28
    Language: English
    Publisher: Wiley
    Publication Date: 2008
    detail.hit.zdb_id: 2009952-6
    detail.hit.zdb_id: 2485214-4
    SSG: 12
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  • 8
    Online Resource
    Online Resource
    The Nanoassembly of an Intrinsically Cytotoxic Near‐Infrared Dye for Multifunctionally Synergistic Theranostics
    Wiley ; 2019
    In:  Small Vol. 15, No. 38 ( 2019-09)
    Details
    In: Small, Wiley, Vol. 15, No. 38 ( 2019-09)
    Abstract: The combination of diagnostic and therapeutic functions in a single theranostic nanoagent generally requires the integration of multi‐ingredients. Herein, a cytotoxic near‐infrared (NIR) dye (IR‐797) and its nanoassembly are reported for multifunctional cancer theranostics. The hydrophobic IR‐797 molecules are self‐assembled into nanoparticles, which are further modified with an amphiphilic polymer (C18PMH‐PEG5000) on the surface. The prepared PEG‐IR‐797 nanoparticles (PEG‐IR‐797 NPs) possess inherent cytotoxicity from the IR‐797 dye and work as a chemotherapeutic drug which induces apoptosis of cancer cells. The IR‐797 NPs are found to have an ultrahigh mass extinction coefficient (444.3 L g −1 cm −1 at 797 nm and 385.9 L g −1 cm −1 at 808 nm) beyond all reported organic nanomaterials ( 〈 40 L g −1 cm −1 ) for superior photothermal therapy (PTT). In addition, IR‐797 shows some aggregation‐induced‐emission (AIE) properties. Combining the merits of good NIR absorption, high photothermal energy conversion efficiency, and AIE, makes the PEG‐IR‐797 NPs useful for multimodal NIR AIE fluorescence, photoacoustic, and thermal imaging‐guided therapy. The research exhibits the possibility of using a single ingredient and entity to perform multimodal NIR fluorescence, photoacoustic, and thermal imaging‐guided chemo‐/photothermal combination therapy, which may trigger wide interest from the fields of nanomedicine and medicinal chemistry to explore multifunctional theranostic organic molecules.
    Type of Medium: Online Resource
    ISSN: 1613-6810 , 1613-6829
    URL: Issue
    URL: Article
    DOI: 10.1002/smll.v15.38
    DOI: 10.1002/smll.201903121
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 2168935-0
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  • 9
    Online Resource
    Online Resource
    Telomere Length and Development of Systemic Lupus Erythematosus: A Mendelian Randomization Study
    Wiley ; 2022
    In:  Arthritis & Rheumatology Vol. 74, No. 12 ( 2022-12), p. 1984-1990
    Details
    In: Arthritis & Rheumatology, Wiley, Vol. 74, No. 12 ( 2022-12), p. 1984-1990
    Abstract: Previous observational studies demonstrated that a subset of patients with systemic lupus erythematosus (SLE) have markedly short telomere length in leukocytes. This study was undertaken to test whether leukocyte telomere length is causally associated with risk of SLE. Methods A 2‐sample Mendelian randomization (MR) analysis was conducted to estimate causality of telomere length on SLE in European populations. A replication 2‐sample MR study using Asian genetic data was also conducted. A reverse MR analysis was then performed to test the effects of SLE on telomere length. The autoantibodies targeting telomere‐associated protein (telomeric repeat–binding factor 1 [TERF1] autoantibodies) were detected in patients with SLE, healthy controls, and patients with rheumatoid arthritis. Results The results of the inverse variance–weighted method (odds ratio [OR] 2.96 [95% confidence interval (95% CI) 1.58–5.55] , P   〈  0.001) showed strong evidence for a causal relationship between longer telomere length and risk of SLE in people with European ancestry. The outcomes of MR‐Egger regression analysis (OR 29.46 [95% CI 3.02–287.60], P  = 0.033) and MR pleiotropy residual sum and outlier analysis (OR 3.62 [95% CI 2.03–6.46], P  = 0.002) also showed that longer telomere length was significantly associated with increased risk of SLE in a European population. Sensitivity analyses using different methods and summary data sets showed that the results were still broadly consistent. A replication MR study using Asian genetic data yielded similar findings. However, the reverse MR analysis showed that genetically predicted SLE was not causally associated with telomere length. In addition, we found that TERF1 autoantibodies were present in 2 of 40 SLE patients (5.0%). Conclusion In contrast with previous observational studies, MR analyses show that longer telomere length is significantly associated with increased risk of SLE.
    Type of Medium: Online Resource
    ISSN: 2326-5191 , 2326-5205
    URL: Issue
    URL: Article
    DOI: 10.1002/art.v74.12
    DOI: 10.1002/art.42304
    RVK:
    XA 10000
    RVK:
    XA 30325
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2754614-7
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  • 10
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    Online Resource
    XRCC5/6 polymorphisms and their interactions with smoking, alcohol consumption, and sleep satisfaction in breast cancer risk: A Chinese multi‐center study
    Wiley ; 2021
    In:  Cancer Medicine Vol. 10, No. 8 ( 2021-04), p. 2752-2762
    Details
    In: Cancer Medicine, Wiley, Vol. 10, No. 8 ( 2021-04), p. 2752-2762
    Abstract: X‐ray repair cross‐complementary 5 ( XRCC5 ) and 6 ( XRCC6 ) are critical for DNA repair. Few studies have assessed their association with breast cancer risk, and related gene‐environment interactions remain poorly understood. This study aimed to determine the influence of XRCC5 / 6 polymorphisms on breast cancer risk, and their interactions with cigarette smoking, alcohol consumption, and sleep satisfaction. Methods The study included 1039 patients with breast cancer and 1040 controls. Four single‐nucleotide polymorphisms of XRCC5 and two of XRCC6 were genotyped. Information about smoking, alcohol consumption, and sleep satisfaction was collected through questionnaires. Odds ratios (OR) and related 95% confidence intervals (95% CI) were assessed using unconditional logistic regression models. Gene‐environment interactions were analyzed using logistic regression with multiplicative interaction models. Results XRCC5 rs16855458 was associated with increased breast cancer risk in the co‐dominant ( p trend  = 0.003) and dominant (CA + AA vs. CC, OR = 1.29, 95% CI = 1.07–1.56, p  = 0.008) genetic models after Bonferroni correction. The CG + GG genotype of XRCC6 rs2267437 was associated with an increased risk of estrogen receptor‐negative/progesterone receptor‐negative (ER−/PR−) breast cancer (CG + GG vs. CC: OR = 1.54, 95% CI = 1.12–2.13, p  = 0.008) after Bonferroni correction. Moreover, an antagonistic interaction between XRCC5 rs16855458 and alcohol consumption ( p interaction  = 0.017), and a synergistic interaction between XRCC6 rs2267437 and sleep satisfaction were associated with breast cancer risk ( p interaction  = 0.0497). However, these interactions became insignificant after Bonferroni correction. Conclusion XRCC5 rs16855458 was associated with breast cancer risk, and XRCC6 rs2267437 was associated with the risk of ER−/PR− breast cancer. Breast cancer risk associated with XRCC5 and XRCC6 polymorphisms might vary according to alcohol consumption and sleep satisfaction, respectively, and merit further investigation.
    Type of Medium: Online Resource
    ISSN: 2045-7634 , 2045-7634
    URL: Issue
    URL: Article
    DOI: 10.1002/cam4.v10.8
    DOI: 10.1002/cam4.3847
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2659751-2
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