GLORIA

GEOMAR Library Ocean Research Information Access

X

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Online Resource
    Online Resource
    Outcomes of single kidney transplantation from pediatric donors: A single‐center experience
    Wiley ; 2018
    In:  Pediatric Transplantation Vol. 22, No. 5 ( 2018-08)
    Details
    In: Pediatric Transplantation, Wiley, Vol. 22, No. 5 ( 2018-08)
    Abstract: Kidneys from pDD s are increasingly used to narrow the huge gap between incremental demand and static supply. However, there is still controversy on the clinical outcome of SKT from pDD s. We conducted a retrospective cohort study of 452 adult recipients in our center between March 2012 and February 2017. Outcomes of 3 groups, transplants with organs from pDD s (n=50), aDD s (n=207), and LD s (n=195), were compared. The mean age and weight of pDD s were 8.98 years (range 8 months‐17 years) and 30.05 kg (range 8.2‐55 kg), respectively. There was no difference in 1‐year (96.0%, 98.1%, and 99.0%, respectively, P =.277) and 3‐year patient survival (96.0%, 98.1%, and 99.0%, respectively, P =.277) or in 1‐year (96.0%, 96.6%, and 98.5%, P =.307) and 3‐year (96.0%, 96.6% and 97.9%, P =.437) graft survival. SC r, eGFR , and allograft size were similar among the 3 groups at 6th month post‐transplant and thereafter. Incidence of DGF was higher in patients of the aDD group than those in the pDD group (22.7% vs 10.0%, P 〈 .001), but there was no difference in AR and infection. SKT from pDD s to adult recipients is effective and safe with acceptable outcomes, and it will be a promising expansion to the donor pool.
    Type of Medium: Online Resource
    ISSN: 1397-3142 , 1399-3046
    URL: Issue
    URL: Article
    DOI: 10.1111/petr.2018.22.issue-5
    DOI: 10.1111/petr.13196
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2008614-3
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 2
    Online Resource
    Online Resource
    Single kidney transplantation from donors with acute kidney injury: A single‐center experience
    Wiley ; 2019
    In:  Pediatric Transplantation Vol. 23, No. 3 ( 2019-05)
    Details
    In: Pediatric Transplantation, Wiley, Vol. 23, No. 3 ( 2019-05)
    Abstract: Despite a severe shortage of organ supply, patients are reluctant to accept organs from deceased donors with AKI, let alone from pediatric AKI donors. Methods We assessed 70 patients who received kidneys from donors with AKI (10 with pediatric and 60 with adult donors) and 176 contemporaneous patients who received kidneys from non‐AKI donors (41 with pediatric and 135 with adult donors) between March 2012 and February 2017 for retrospectively evaluating the clinical outcomes. Results AKI was defined and staging by the RIFLE criteria and pediatric‐modified RIFLE criteria. Median age was 11.00 years IQR (4.50‐14.00 years), and median weight was 25.00 kg (IQR, 17.00‐45.00 kg) for all pediatric donors. Median follow‐up was 8 months (range, 1‐49 months). Adult AKI group had the highest incidence of DGF (35.0% vs 10%, 9.8%, and 19.3%, P  = 0.011). There was a significant increase in DGF in higher AKI stages (Risk: 20.7%, Injury: 46.7%, Failure: 50.0%; P  = 0.014) among patients with adult donors. No significant differences were noted in 1‐year (100.0%, 95.1%, 98.3%, and 97.8%; P  = 0.751) and 3‐year (100.0%, 95.1%, 98.3%, and 97.8%; P  = 0.751) patient survival, and 1‐year (90.0%, 97.6%, 98.3%, and 95.6%; P  = 0.535) and 3‐year (90.0%, 97.6%, 98.3%, and 95.6%; P  = 0.535) graft survival. Conclusion Transplants procured from donors with AKI, particularly pediatric ones, could achieve excellent intermediate‐term clinical outcomes and thus potentially expand the donor pool.
    Type of Medium: Online Resource
    ISSN: 1397-3142 , 1399-3046
    URL: Issue
    URL: Article
    DOI: 10.1111/petr.2019.23.issue-3
    DOI: 10.1111/petr.13326
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 2008614-3
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 3
    Online Resource
    Online Resource
    Inducible Activation of FGFR2 in Adult Mice Promotes Bone Formation After Bone Marrow Ablation : FGFR2 PROMOTES BONE FORMATION AFTER BMX
    Wiley ; 2017
    In:  Journal of Bone and Mineral Research Vol. 32, No. 11 ( 2017-11), p. 2194-2206
    Details
    In: Journal of Bone and Mineral Research, Wiley, Vol. 32, No. 11 ( 2017-11), p. 2194-2206
    Type of Medium: Online Resource
    ISSN: 0884-0431
    URL: Article
    DOI: 10.1002/jbmr.3204
    RVK:
    XA 52230
    Language: English
    Publisher: Wiley
    Publication Date: 2017
    detail.hit.zdb_id: 2008867-X
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 4
    Online Resource
    Online Resource
    Antidepressants for polycystic ovary syndrome
    Wiley ; 2013
    In:  Cochrane Database of Systematic Reviews Vol. 2013, No. 6 ( 2013-05-31)
    Details
    In: Cochrane Database of Systematic Reviews, Wiley, Vol. 2013, No. 6 ( 2013-05-31)
    Type of Medium: Online Resource
    ISSN: 1465-1858
    URL: Article
    DOI: 10.1002/14651858.CD008575.pub2
    Language: English
    Publisher: Wiley
    Publication Date: 2013
    detail.hit.zdb_id: 2038950-4
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 5
    Online Resource
    Online Resource
    Psoriasis and risk of chronic kidney diseases: A population‐based cross‐sectional study and Mendelian randomization analysis
    Wiley ; 2023
    In:  Nephrology Vol. 28, No. 11 ( 2023-11), p. 611-619
    Details
    In: Nephrology, Wiley, Vol. 28, No. 11 ( 2023-11), p. 611-619
    Abstract: Conflicting results have been reported regarding the association between psoriasis and risk of chronic kidney diseases (CKD). Furthermore, the causal nature of the possible association remains unexplored. Methods We conducted a population‐based cross‐sectional study using data from National Health and Nutrition Examination Survey (NHANES). Logistic regression analyses were conducted to estimate potential association between psoriasis and CKD risk. Further, we evaluated causality by performing a Mendelian randomization analysis using large‐scale genome‐wide association studies of psoriasis and CKD. Inverse variance‐weighted (IVW) analysis was used as the primary method. Results In the observational study, 16 750 participants were included. Overall, 39 of 429 patients with psoriasis had CKD (9.1%) compared with 1481 of 16 321 without psoriasis (9.1%). In the fully adjusted model, psoriasis was not associated with CKD (OR: 0.77, 95%CI: 0.53–1.10). In the MR analysis, 36 single‐nucleotide polymorphisms (SNPs) were selected as instrumental variables. The IVW analysis reported that genetically predicted psoriasis was associated with a higher risk of CKD (OR: 1.025, 95%CI: 1.001–1.049). After removing 2 SNPs associated with heterogeneity, the association remained (OR: 1.028, 95%CI: 1.006–1.050). Conclusion Genetically predicted psoriasis was associated with a higher risk of CKD. This association may be important for clinicians to monitor kidney function and prescribe potentially nephrotoxic drugs during psoriasis management.
    Type of Medium: Online Resource
    ISSN: 1320-5358 , 1440-1797
    URL: Issue
    URL: Article
    DOI: 10.1111/nep.v28.11
    DOI: 10.1111/nep.14220
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2008235-6
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 6
    Online Resource
    Online Resource
    Tacrolimus variability score outperforms coefficient of variation in predicting clinical outcomes of living kidney transplantation
    Wiley ; 2022
    In:  British Journal of Clinical Pharmacology Vol. 88, No. 1 ( 2022-01), p. 75-83
    Details
    In: British Journal of Clinical Pharmacology, Wiley, Vol. 88, No. 1 ( 2022-01), p. 75-83
    Abstract: Intrapatient variability (IPV) was previously defined as coefficient of variation (CV) or standard deviation of tacrolimus (Tac) exposure while none of them was easily being interpreted and translated into clinical practice after kidney transplantation. Methods We developed a novel Tac variability score (TVS) to evaluate IPV by calculating the frequency of clinically significant changes of Tac trough levels after kidney transplantation. Multivariate Cox proportional analyses were conducted to compare the impact of TVS and CV on transplant outcomes. Results A total of 1343 patients were divided into high TVS ( 〉 0.30) and low TVS ( 〈 0.30) groups, and low CV ( 〈 0.30) and high CV ( 〉 0.30) groups. Univariate analyses showed that high TVS (hazard ratio [HR]: 2.323, 95% confidence interval [CI] : 1.455–3.709) and high CV (HR: 1.606, 95%CI: 1.044–2.471) were associated with inferior graft survival. However, only TVS was an independent predictor for graft failure in multivariate analyses (HR: 1.972, 95%CI: 1.2–3.24), and the correlation maintained in high CV ( P =  .020) and low CV ( P =  .037) subgroups, while CV failed to predict graft loss in neither low ( P =  .387) nor high TVS ( P =  .600) subgroups. In addition, TVS had a higher correlation with graft survival in patients with Tac exposure within the therapeutic range and the correlation was less influenced by mean Tac trough levels. Conclusion TVS is a novel measure of Tac IPV with higher correlation with graft survival and more convenience in clinical use than CV after kidney transplantation.
    Type of Medium: Online Resource
    ISSN: 0306-5251 , 1365-2125
    URL: Issue
    URL: Article
    DOI: 10.1111/bcp.v88.1
    DOI: 10.1111/bcp.14876
    RVK:
    XA 33650
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 1498142-7
    SSG: 15,3
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 7
    Online Resource
    Online Resource
    Adult genitourinary sarcoma: Clinical characteristics and survival in a series of patients treated at a high‐volume institution
    Wiley ; 2017
    In:  International Journal of Urology Vol. 24, No. 6 ( 2017-06), p. 425-431
    Details
    In: International Journal of Urology, Wiley, Vol. 24, No. 6 ( 2017-06), p. 425-431
    Abstract: To report our institutional experience in the management of adult genitourinary sarcoma. Methods This was a retrospective analysis of data on adult genitourinary sarcoma treated at the West China Hospital, Sichuan University, Chengdu, Sichuan, China from 1985 to 2010. Clinicopathological parameters were analyzed to determine their impact on overall, recurrence‐free and metastasis‐free survivals. Results A total of 46 women and 142 men were included, with a median age of 42 years. Of these, 152 cases were high‐grade. The most common site was the paratesticular region. Surgical resection was carried out in 155 patients (82.4%), with negative margin in 106. After a minimum follow up of 5 years, 20 patients (11.6%) survived disease‐free, 14 (8.1%) were alive with disease and 138 (80.2%) died of disease. Survival rates at 1, 3 and 5 years were 91.3%, 64.0% and 47.7%. In univariate analyses, liposarcoma, high grade, metastasis at diagnosis, a lack of surgical resection and positive margin were predictive of unfavorable survival. In multivariate analyses, high grade, a lack of surgical resection and chemotherapy were independent predictors of poor survival. Conclusions Adult genitourinary sarcoma is an aggressive malignancy, usually presenting at advanced stage, with a high incidence of recurrence and metastasis. Complete resection and selective combination of chemotherapy and radiotherapy might constitute the optimal treatment for this disease.
    Type of Medium: Online Resource
    ISSN: 0919-8172 , 1442-2042
    URL: Issue
    URL: Article
    DOI: 10.1111/iju.2017.24.issue-6
    DOI: 10.1111/iju.13345
    Language: English
    Publisher: Wiley
    Publication Date: 2017
    detail.hit.zdb_id: 2009793-1
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 8
    Online Resource
    Online Resource
    Expanding the donor pool: Kidney transplantation from serum HBV DNA or HBeAg ‐positive donors to HBsAg ‐negative recipients
    Wiley ; 2023
    In:  Liver International
    Details
    In: Liver International, Wiley
    Abstract: HBsAg‐positive (HBsAg[+]) donors are rarely accepted for kidney transplantation (KT), especially when the donor is also HBV DNA‐positive (HBV DNA[+] ) or HBeAg‐positive (HBeAg[+]) serologically. This study aimed to report kidney transplant outcomes from HBsAg(+) donors to HBsAg(−) recipients. Methods Consecutive cases were retrospectively identified from 1 July 2017 to 31 December 2020. KTs from HBsAg(−)/HBcAb‐positive (HBcAb[+]) donors to HBcAb(−) recipients were selected as the control group. The primary outcomes were de novo HBV infection (DNH), graft and patient survival. Results We identified 105 HBsAg(−) recipients who received HBsAg(+) kidneys and 516 HBcAb(−) recipients who received HBcAb(+) kidneys. A higher DNH rate was observed after receiving HBsAg(+) kidneys than after receiving HBcAb(+) kidneys after a median follow‐up of 23.0 months (4/105[3.8%] vs. 2/516[0.4%] , p  = .009). All four infected recipients receiving HBsAg(+) kidneys had HBsAg clearance after treatment. Graft and patient survival were comparable between the groups ( p  = .630, p  = .910). The DNH rates were 0/22(0%), 3/70(4.3%) and 1/13(7.7%) after receiving HBsAg(+), HBV DNA(+) and HBeAg(+) kidneys, respectively ( p  = .455). The DNH rate was lower if the donor had received antiviral treatment (4/42[9.5%] vs. 0/63[0%] , p  = .023). HBsAb(−) recipients had a higher DNH incidence than HBsAb(+) recipients (3/25[12.0%] vs. 1/80[1.3%] , p  = .041). Conclusions The use of HBsAg(+) donors contributed to comparable graft and patient survival, but HBV DNA(+) or HBeAg(+) donors and HBsAb(−) recipients maybe associated with a higher risk of HBV infection. These findings help expand the donor pool and emphasize the role of donor antiviral treatment and recipient HBV immunity in establishing optimal prophylactic regimens.
    Type of Medium: Online Resource
    ISSN: 1478-3223 , 1478-3231
    URL: Article
    DOI: 10.1111/liv.15703
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2124684-1
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 9
    Online Resource
    Online Resource
    miR‐17‐92 ameliorates renal ischemia reperfusion injury
    Wiley ; 2018
    In:  The Kaohsiung Journal of Medical Sciences Vol. 34, No. 5 ( 2018-05), p. 263-273
    Details
    In: The Kaohsiung Journal of Medical Sciences, Wiley, Vol. 34, No. 5 ( 2018-05), p. 263-273
    Abstract: There is limited information on the role of miR‐17‐92 in renal tubular pathophysiology. Therefore, the present study was performed to determine whether miR‐17‐92 plays a role in ischemia‐reperfusion injury (IRI)‐induced acute kidney injury. We originally demonstrated that miR‐17‐92 is up‐regulated following IRI in vivo. To explore the roles of miR‐17‐92 in the IRI process, we first generated a renal proximal tubule‐specific miR‐17‐92 deletion (PT‐miR‐17‐92 −/− ) knockout mouse model with Cre driven by the Kap promoter. We found that PT‐deficient miR‐17‐92 mice had more severe renal dysfunction and renal structures than their littermates. Compared with sham‐operated mice, both wide‐type (WT) mice and PT‐miR‐17‐92 −/− mice showed increased serum levels of creatinine and urea. However, the levels of serum urea and creatinine in PT‐miR‐17‐92 −/− mice after the IRI operation were significantly higher than the levels in WT mice. In addition, PT‐miR‐17‐92 −/− mice showed higher levels of serum potassium and phosphonium after the IRI operation. Histological analysis revealed that PT‐miR‐17‐92 −/− mice had substantial histopathologic changes, such as tubular dilation and tubular necrosis. Overexpression of miR‐17‐92 could partially reverse the side‐effects of IRI on the proximal tubules in vivo. Furthermore, we employed a quantitative proteomic strategy and identified 16 proteins as potential targets of miR‐17‐92. Taken together, our findings suggested that miR‐17‐92 may ameliorates IRI‐induced acute kidney injury. Our results indicate that pharmacologic modulation of these miRNAs may have therapeutic potential for acute kidney injury.
    Type of Medium: Online Resource
    ISSN: 1607-551X , 2410-8650
    URL: Article
    DOI: 10.1016/j.kjms.2017.09.003
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2202782-8
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 10
    Online Resource
    Online Resource
    Impact of remaining kidney volume to body weight ratio on renal function in living kidney donors
    Wiley ; 2016
    In:  The Kaohsiung Journal of Medical Sciences Vol. 32, No. 4 ( 2016-04), p. 185-190
    Details
    In: The Kaohsiung Journal of Medical Sciences, Wiley, Vol. 32, No. 4 ( 2016-04), p. 185-190
    Abstract: To investigate whether the ratio of remnant kidney volume to body weight (V/W ratio) can impact renal function in donors, 45 living kidney donors were enrolled. Kidney volume was analyzed by magnetic resonance imaging. Renal function was compared between donors with a V/W ratio of 〈 2.0 mL/kg ( n  = 23) or ≥ 2.0 mL/kg ( n  = 22). Donors in both V/W groups showed similar serum creatinine levels and estimated glomerular filtration rates (eGFRs) at 7 days and 1 year, whereas donors with a V/W ratio of 〈 2.0 mL/kg had significantly higher 24‐hour urine protein levels at 1 year (0.54 ± 0.23 g/d vs. 0.33 ± 0.19 g/d, p  = 0.028). Multivariate analysis revealed no correlation between the V/W ratio and eGFR at 7 days or 1 year, and a V/W ratio of 〈 2 mL/kg was not associated with an increased incidence of eGFR 〈 60 mL/min/1.73 m 2 at 1 year (risk ratio 1.73, 95% confidence interval 0.10–29.47). The V/W ratio correlated inversely with 24‐hour urine protein ( r  = −0.377, p  = 0.021) at 1 year, and donors with a V/W ratio of 〈 2.0 mL/kg were more likely to show 24‐hour urine protein 〉 300 mg (risk ratio 1.70, 95% confidence interval 1.08–2.67) at 1 year. Donors with lower V/W ratios have higher 24‐hour urinary protein levels at 1 year after transplantation. These findings suggest that the V/W ratio may be useful for kidney selection.
    Type of Medium: Online Resource
    ISSN: 1607-551X , 2410-8650
    URL: Article
    DOI: 10.1016/j.kjms.2016.01.003
    Language: English
    Publisher: Wiley
    Publication Date: 2016
    detail.hit.zdb_id: 2202782-8
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...