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  • Wiley  (5)
  • 1
    Online Resource
    Online Resource
    Norepinephrine‐CREB1‐miR‐373 axis promotes progression of colon cancer
    Wiley ; 2020
    In:  Molecular Oncology Vol. 14, No. 5 ( 2020-05), p. 1059-1073
    Details
    In: Molecular Oncology, Wiley, Vol. 14, No. 5 ( 2020-05), p. 1059-1073
    Abstract: The adrenergic system contributes to the stress‐induced onset and progression of cancer. Adrenergic fibers are the primary source of norepinephrine (NE). The underlying mechanisms involved in NE‐induced colon cancer remain to be understood. In this study, we describe the function and regulatory network of NE in the progression of colon cancer. We demonstrate that NE‐induced phosphorylation of cAMP response element‐binding protein 1 (CREB1) promotes proliferation, migration, and invasion of human colon cancer cells. The downstream effector of NE, CREB1, bound to the promoter of miR‐373 and transcriptionally activated its expression. miR‐373 expression was shown to be necessary for NE‐induced cell proliferation, invasion, and tumor growth. We confirmed that proliferation and invasion of colon cancer cells are regulated in vitro and in vivo by miR‐373 through targeting of the tumor suppressors TIMP2 and APC. Our data suggest that NE promotes colon cancer cell proliferation and metastasis by activating the CREB1–miR‐373 axis. The study of this novel signaling axis may provide mechanistic insights into the neural regulation of colon cancer and help in the design of future clinical studies on stress biology in colorectal cancer.
    Type of Medium: Online Resource
    ISSN: 1574-7891 , 1878-0261
    URL: Issue
    URL: Article
    DOI: 10.1002/mol2.v14.5
    DOI: 10.1002/1878-0261.12657
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2322586-5
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  • 2
    Online Resource
    Online Resource
    Effect of Combined Bacillus subtilis on the Sorption of Phenanthrene and 1,2,3‐Trichlorobenzene onto Mineral Surfaces
    Wiley ; 2010
    In:  Journal of Environmental Quality Vol. 39, No. 1 ( 2010-01), p. 236-244
    Details
    In: Journal of Environmental Quality, Wiley, Vol. 39, No. 1 ( 2010-01), p. 236-244
    Abstract: In the natural environment, minerals are often associated with coexisting microorganisms. These interactions have profound impacts on the fate of a wide variety of contaminants. However, little information is available on the sorption of hydrophobic organic compounds (HOC), such as polycyclic aromatic hydrocarbons and chlorinated benzenes, onto the composites of minerals with bacteria, and knowledge of the influence of combined bacteria on HOC sorption to minerals is limited. In our study, sorption isotherms of phenanthrene (Phen) and 1,2,3‐trichlorobenzene (TCB) onto Bacillus subtilis , minerals (kaolinite, montmorillonite, and goethite), and mineral– B. subtilis composites were studied to determine the role of B. subtilis in sorption. For pure mineral systems, the order of Phen and TCB sorption affinity was montmorillonite 〉 kaolinite 〉 goethite. For mineral– B. subtilis composites, the trend was montmorillonite 〉 goethite 〉 kaolinite, consistent with that of their ability to combine with bacteria. The coating of B. subtilis with minerals enhanced the sorption due to the strong sorption of Phen and TCB onto B. subtilis cells and the increase of total organic carbon of minerals. With increasing B. subtilis concentration, sorption of Phen and TCB on pure B. subtilis cells decreased, but sorption on kaolinite surface increased. Sodium azide can greatly reduce sorption capacity but increases sorption linearity for B. subtilis and mineral– B. subtilis composites. Compared with TCB, Phen had higher sorption affinity due to its high hydrophobicity. Our results may be useful for understanding the role of bacteria in regulating the distribution and transport of HOCs in the environment.
    Type of Medium: Online Resource
    ISSN: 0047-2425 , 1537-2537
    URL: Article
    DOI: 10.2134/jeq2009.0113
    Language: English
    Publisher: Wiley
    Publication Date: 2010
    detail.hit.zdb_id: 120525-0
    detail.hit.zdb_id: 2050469-X
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  • 3
    Online Resource
    Online Resource
    The Influence of Blood Collection Tubes in Biomarkers’ Screening by Mass Spectrometry
    Wiley ; 2020
    In:  PROTEOMICS – Clinical Applications Vol. 14, No. 5 ( 2020-09)
    Details
    In: PROTEOMICS – Clinical Applications, Wiley, Vol. 14, No. 5 ( 2020-09)
    Abstract: Mass spectrometry is one of the rapidly developing bio‐analytical techniques in recent years, and it shows that the results of biomarkers’ screening can be influenced by pre‐analytical process. The selection of the blood collection tubes is one of the most significant steps of pre‐analytical process which is often neglected by researchers. So, it is urgent to define the influence of blood collection tubes clearly in biomarkers’ screening. Experimental Design Two types of blood collection tubes, non‐additive tubes and coagulant activator tubes, are used to collect serum samples from patients and healthy controls. All samples are analyzed using matrix‐assisted laser desorption ionization‐time of flight mass spectrum in this study. Results The serum protein profile changes while using coagulant tubes whether for patients or healthy controls. It is found that the effect of coagulant on serum protein of patients is smaller than that of control group. There are 27 significantly different peaks between the control group and the control coagulant group. However, between patient group and patient coagulant group, only one differential peak is obtained. Coagulant changes the expression differences between patients and healthy controls, making the differences expand, shrink or reverse, and most of the polypeptides are small molecule, which will change the results of biomarker's screening. Conclusions and Clinical Relevance This research suggested that different types of blood collection tubes would influence the final laboratory results. So it's important for clinicians to choose the proper tubes to detect biomarkers and make correct diagnoses.
    Type of Medium: Online Resource
    ISSN: 1862-8346 , 1862-8354
    URL: Issue
    URL: Article
    DOI: 10.1002/prca.v14.5
    DOI: 10.1002/prca.201900113
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2317130-3
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  • 4
    Online Resource
    Online Resource
    Platycodin D inhibits proliferation, migration and induces chemosensitization through inactivation of the NF ‐κB and JAK 2/ STAT 3 pathways in multiple myeloma cells
    Wiley ; 2019
    In:  Clinical and Experimental Pharmacology and Physiology Vol. 46, No. 12 ( 2019-12), p. 1194-1200
    Details
    In: Clinical and Experimental Pharmacology and Physiology, Wiley, Vol. 46, No. 12 ( 2019-12), p. 1194-1200
    Abstract: Multiple myeloma ( MM ) is a malignancy characterized by the proliferation of malignant plasma cells. Platycodin D ( PLD ) is a triterpenoid saponin that exerts anti‐tumour activity through multiple mechanisms. However, the role of PLD in MM remains unknown. Here, we investigated the effect of PLD on MM cell lines NCI ‐H929 and U266B1, and elucidated the underlying molecular mechanism. Cell Counting Kit‐8 assay showed that the proliferation of NCI ‐H929 and U266B1 cells was significantly decreased after PLD treatment. Transwell assay confirmed that PLD treatment suppressed migration of NCI ‐H929 and U266B1 cells. Flow cytometry results indicated that the apoptotic rates of bortezomib ( BTZ )‐treated NCI ‐H929 and U266B1 cells were markedly increased after PLD treatment. Western blot analysis revealed that bcl‐2 expression was decreased, while bax expression was increased in PLD ‐treated NCI ‐H929 and U266B1 cells compared with that in BTZ ‐treated cells. Furthermore, PLD treatment blocked the activation of nuclear factor‐kappa B ( NF ‐κB) and Janus kinase 2 ( JAK 2)/signal transducer and activator of transcription 3 ( STAT 3) signalling pathways in NCI ‐H929 cells. Taken together, these data showed that PLD inhibited proliferation and migration, and enhanced chemosensitization to BTZ through inactivation of the NF ‐κB and JAK 2/ STAT 3 pathways in MM cell lines. These findings indicated that PLD might serve as a novel therapeutic agent for the treatment of MM .
    Type of Medium: Online Resource
    ISSN: 0305-1870 , 1440-1681
    URL: Issue
    URL: Article
    DOI: 10.1111/cep.v46.12
    DOI: 10.1111/1440-1681.13145
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 2020033-X
    SSG: 15,3
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  • 5
    Online Resource
    Online Resource
    Arsenic Distribution and Adsorption Behavior in the Sediments of the Daliao River System in China
    Wiley ; 2013
    In:  Water Environment Research Vol. 85, No. 8 ( 2013-08), p. 687-695
    Details
    In: Water Environment Research, Wiley, Vol. 85, No. 8 ( 2013-08), p. 687-695
    Abstract: This study investigated the arsenic (As) distribution and adsorption behavior in sediments of the Daliao River System (DRS). Results indicated that the total As was 2.6–83.1 mg kg −1 in the sediments of the DRS. The pseudo‐first order model and intra‐particle diffusion model give a good fit of the experimental kinetics data for As, indicating that particle diffusion mechanism may not be the rate controlling step while this mechanism is involved. By comparing the zero equilibrium As concentration (EAsC o ) with the actual As concentration in the overlying water of the DRS, all the sediments showed a trend of releasing As. Arsenic exhibited strong adsorption on sediment at pH 4.5–7. Arsenic retention by sediment was much enhanced by Ca 2+ compared to Na + . More As was desorbed by phosphate at low and high pH extremes. The added or sorbed As was mainly transferred to the specifically sorbed fraction and amorphous Fe (Al) oxyhydroxides bound fraction, indicating Fe oxides are a major sorbent of As in sediment.
    Type of Medium: Online Resource
    ISSN: 1061-4303 , 1554-7531
    URL: Article
    DOI: 10.2175/106143012X13560205144894
    RVK:
    AR 10100
    Language: English
    Publisher: Wiley
    Publication Date: 2013
    detail.hit.zdb_id: 1098976-6
    detail.hit.zdb_id: 2051010-X
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