GLORIA

GEOMAR Library Ocean Research Information Access

X

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Online Resource
    Online Resource
    Genome assembly and annotation of Periplaneta americana reveal a comprehensive cockroach allergen profile
    Wiley ; 2023
    In:  Allergy Vol. 78, No. 4 ( 2023-04), p. 1088-1103
    Details
    In: Allergy, Wiley, Vol. 78, No. 4 ( 2023-04), p. 1088-1103
    Abstract: One of the most common cockroach types in urban areas, the American cockroach ( Periplaneta americana ), has been reported to impose an increased risk of allergies and asthma. Limited groups of allergens (Per a 1–13) have been identified in this species due to the lack of genome‐related information. Methods To expand the allergen profile of P. americana , genomic, transcriptomic, and proteomic approaches were applied. With the support of a high‐quality genome assembled using nanopore, Illumina, and Hi‐C sequencing techniques, potential allergens were identified based on protein homology. Then, using enzyme‐linked immunosorbent assay, selected allergens were tested in Thai patients allergic to P. americana . Results A chromosomal‐level genome of P. americana (3.06 Gb) has been assembled with 94.6% BUSCO completeness, and its contiguity has been significantly improved (N50 = 151 Mb). A comprehensive allergen profile has been characterized, with seven novel groups of allergens, including enolase (Per a 14), cytochrome C (Per a 15), cofilin (Per a 16), alpha‐tubulin (Per a 17), cyclophilin (Per a 18), porin3 (Per a 19), and peroxiredoxin‐6 (Per a 20), showing IgE sensitivity in enzyme‐linked immunosorbent assay. A new isoallergen of tropomyosin (Per a 7.02) and multiple potential isoallergens of Per a 5 were revealed using bioinformatics and proteomic approaches. Additionally, comparative analysis of P. americana with the closely related Blattodea species revealed the possibility of cross‐reaction. Conclusion The high‐quality genome and proteome of P. americana are beneficial in studying cockroach allergens at the molecular level. Seven novel allergen groups and one isoallergen in Per a 7 were identified.
    Type of Medium: Online Resource
    ISSN: 0105-4538 , 1398-9995
    URL: Issue
    URL: Article
    DOI: 10.1111/all.v78.4
    DOI: 10.1111/all.15531
    RVK:
    XA 10000
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2003114-2
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 2
    Online Resource
    Online Resource
    ATF3 is a neuron‐specific biomarker for spinal cord injury and ischaemic stroke
    Wiley ; 2024
    In:  Clinical and Translational Medicine Vol. 14, No. 4 ( 2024-04)
    Details
    In: Clinical and Translational Medicine, Wiley, Vol. 14, No. 4 ( 2024-04)
    Abstract: Although many molecules have been investigated as biomarkers for spinal cord injury (SCI) or ischemic stroke, none of them are specifically induced in central nervous system (CNS) neurons following injuries with low baseline expression. However, neuronal injury constitutes a major pathology associated with SCI or stroke and strongly correlates with neurological outcomes. Biomarkers characterized by low baseline expression and specific induction in neurons post‐injury are likely to better correlate with injury severity and recovery, demonstrating higher sensitivity and specificity for CNS injuries compared to non‐neuronal markers or pan‐neuronal markers with constitutive expressions. Methods In animal studies, young adult wildtype and global Atf3 knockout mice underwent unilateral cervical 5 (C5) SCI or permanent distal middle cerebral artery occlusion (pMCAO). Gene expression was assessed using RNA‐sequencing and qRT‐PCR, while protein expression was detected through immunostaining. Serum ATF3 levels in animal models and clinical human samples were measured using commercially available enzyme‐linked immune‐sorbent assay (ELISA) kits. Results Activating transcription factor 3 (ATF3), a molecular marker for injured dorsal root ganglion sensory neurons in the peripheral nervous system, was not expressed in spinal cord or cortex of naïve mice but was induced specifically in neurons of the spinal cord or cortex within 1 day after SCI or ischemic stroke, respectively. Additionally, ATF3 protein levels in mouse blood significantly increased 1 day after SCI or ischemic stroke. Importantly, ATF3 protein levels in human serum were elevated in clinical patients within 24 hours after SCI or ischemic stroke. Moreover, Atf3 knockout mice, compared to the wildtype mice, exhibited worse neurological outcomes and larger damage regions after SCI or ischemic stroke, indicating that ATF3 has a neuroprotective function. Conclusions ATF3 is an easily measurable, neuron‐specific biomarker for clinical SCI and ischemic stroke, with neuroprotective properties. Highlights ATF3 was induced specifically in neurons of the spinal cord or cortex within 1 day after SCI or ischemic stroke, respectively. Serum ATF3 protein levels are elevated in clinical patients within 24 hours after SCI or ischemic stroke. ATF3 exhibits neuroprotective properties, as evidenced by the worse neurological outcomes and larger damage regions observed in Atf3 knockout mice compared to wildtype mice following SCI or ischemic stroke.
    Type of Medium: Online Resource
    ISSN: 2001-1326 , 2001-1326
    URL: Issue
    URL: Article
    DOI: 10.1002/ctm2.v14.4
    DOI: 10.1002/ctm2.1650
    Language: English
    Publisher: Wiley
    Publication Date: 2024
    detail.hit.zdb_id: 2697013-2
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 3
    Online Resource
    Online Resource
    CPSF4 activates telomerase reverse transcriptase and predicts poor prognosis in human lung adenocarcinomas
    Wiley ; 2014
    In:  Molecular Oncology Vol. 8, No. 3 ( 2014-05), p. 704-716
    Details
    In: Molecular Oncology, Wiley, Vol. 8, No. 3 ( 2014-05), p. 704-716
    Abstract: We discover and identify CPSF4 as a novel hTERT promoter‐regulating factor in lung cancer cells. CPSF4 upregulates hTERT promoter activity, hTERT expression and telomerase activity. Knockdown of CPSF4 inhibits lung cancer growth by downregulating hTERT expression and activity. CPSF4 and hTERT are highly expressed in lung cancer cells and adenocarcinoma tumor tissues. CPSF4 and hTERT overexpression is associated with poor progonsis in lung adenocarcinoma patient.
    Type of Medium: Online Resource
    ISSN: 1574-7891 , 1878-0261
    URL: Article
    DOI: 10.1016/j.molonc.2014.02.001
    Language: English
    Publisher: Wiley
    Publication Date: 2014
    detail.hit.zdb_id: 2322586-5
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 4
    Online Resource
    Online Resource
    W/O Nano‐Emulsions with Olive Leaf Phenolics Improved Oxidative Stability of Sacha Inchi Oil
    Wiley ; 2018
    In:  European Journal of Lipid Science and Technology Vol. 120, No. 5 ( 2018-05)
    Details
    In: European Journal of Lipid Science and Technology, Wiley, Vol. 120, No. 5 ( 2018-05)
    Abstract: Natural phenolic compounds have been drawn a wide attention to replace the synthesis antioxidants due to the food safety issues, while, natural phenolic compounds are usually polyhydroxy derivatives which exhibit hydrophilic capacity, limiting their applications directly in lipid systems. In this work, olive leaf phenolics (OLP) are extracted by ultrasound from five cultivars and the optimal cultivar is chosen to prepare W/O nano‐emulsions of Sacha Inchi oil (SIO, containing more than 90% polyunsaturated fatty acids). The droplet size could reach 2.15 ± 0.13 nm and remaines stable without phase separation during 30‐day storage. Oxidative stabilities of SIO containing 0.02%, 0.05%, and 0.1% OLP (w/w) are evaluated by Rancimat test and accelerated storage test. The release of OLP by preparation of W/O nano‐emulsions is capable of controlling the oxidative progress of SIO, by prolonging the induction time, preventing the production of primary and secondary oxidative products and also the deterioration of polyunsaturated fatty acids and tocopherols. Practical Applications : Sacha Inchi oil (SIO) contains approximately 90% of polyunsaturated fatty acids (PUFAs) associated with poor oxidative stability. Olive leaf phenolics (OLP) are considered as a great and cheap source of natural phenolic compounds. This study aimes to select the optimum source of OLP from five cultivars and to prepare a W/O nano‐emulsion of OLP. By diluting the W/O nano‐emulsion of OLP into SIO, effect of different concentrations OLP on the oxidative stability of SIO is evaluated through thermal oxidative stability and storage oxidative stability in an accelerated storage test. Results indicate that the capacity of OLP to retard the SIO oxidation depends on the incorporated concentration, which means that it is doable to adopt OLP, an abundant and cheap material, to improve the stability of edible oil with high PUFAs in the industry. Olive leaf phenolics are extracted and detected to prepare an efficient and stable W/O nano‐emulsion; By diluting W/O nano‐emulsion into Sacha Inchi oil, oxidative stability of the high content PUFAs oil is improved.
    Type of Medium: Online Resource
    ISSN: 1438-7697 , 1438-9312
    URL: Issue
    URL: Article
    DOI: 10.1002/ejlt.v120.5
    DOI: 10.1002/ejlt.201700471
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2012720-0
    SSG: 21
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 5
    Online Resource
    Online Resource
    Rhodium(III)‐catalyzed Cleavage of C−C Bond and C−H Bond Cascaded by Michael Addition for the Conversion of α ‐Hydroxy Ketones to Phthalides and Isocoumarins
    Wiley ; 2022
    In:  Asian Journal of Organic Chemistry Vol. 11, No. 4 ( 2022-04)
    Details
    In: Asian Journal of Organic Chemistry, Wiley, Vol. 11, No. 4 ( 2022-04)
    Abstract: A protocol for Rh(III)‐catalyzed cleavage of C−C bond and C−H bond cascaded by Michael addition of α ‐hydroxy ketones was established. The method allows the rapid construction of phthalides and isocoumarins skeleton. A total of 62 phthalides and isocoumarins were obtained with yields up to 91% demonstrating the broad applicability of the protocol. This efficient cascade catalysis can be applied to the total synthesis of the natural products isoochracinic acid and sparstolonin B. The reaction mechanism, especially the dimerization process of the α‐hydroxyketone, is unique. Further studies of the reaction using control experiments, in situ NMR analysis, cyclic voltammogram and isotope tracking experiments have provided insight into the reaction mechanism.
    Type of Medium: Online Resource
    ISSN: 2193-5807 , 2193-5815
    URL: Issue
    URL: Article
    DOI: 10.1002/ajoc.v11.4
    DOI: 10.1002/ajoc.202200024
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2679333-7
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 6
    Online Resource
    Online Resource
    Two New Tirucallane‐Type Triterpenoids from the Stem Barks of Aphanamixis grandifolia and Their Cytotoxic Activities
    Wiley ; 2012
    In:  Chinese Journal of Chemistry Vol. 30, No. 6 ( 2012-06), p. 1356-1360
    Details
    In: Chinese Journal of Chemistry, Wiley, Vol. 30, No. 6 ( 2012-06), p. 1356-1360
    Abstract: Two new tirucallane‐type triterpenoids, 3 α ,24 β ,25‐trihydroxy‐21,21‐dimethoxy‐23‐oxo‐tirucall‐7‐ene ( 1 ) and 3 α ‐acetoxy‐21 β ‐methoxy‐24,25,26,27‐tetranortirucall‐7‐ene‐23(21)‐lactone ( 2 ), were isolated from the stem barks of Aphanamixis grandifolia , and their structures were elucidated on the basis of spectroscopic data analysis including 1D, 2D NMR, IR, and ESI‐MS spectral methods. The two isolates were evaluated for their cytotoxicities using NCI‐H460 and HeLa cell lines.
    Type of Medium: Online Resource
    ISSN: 1001-604X , 1614-7065
    URL: Issue
    URL: Article
    DOI: 10.1002/cjoc.v30.6
    DOI: 10.1002/cjoc.201200100
    Language: English
    Publisher: Wiley
    Publication Date: 2012
    detail.hit.zdb_id: 2144352-X
    SSG: 6,25
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 7
    Online Resource
    Online Resource
    Spirolindemers A and B, Lindenane Sesquiterpenoid Oligomers Equipped with Oxaspiro[4.5]decane from Chloranthus henryi
    Wiley ; 2022
    In:  Chinese Journal of Chemistry Vol. 40, No. 5 ( 2022-03), p. 603-608
    Details
    In: Chinese Journal of Chemistry, Wiley, Vol. 40, No. 5 ( 2022-03), p. 603-608
    Abstract: Spirolindemers A and B, unprecedented lindenane sesquiterpenoid dimer (1) and trimer (2) equipped with oxaspiro[4.5]decane unit, were discovered from the medicinal plant Chloranthus henryi . Their structures including absolute configurations were achieved by HRMS, NMR, ECD, X‐ray diffraction analyses, and quantum chemical calculations. Biogenetically, hetero‐ and homo‐Diels‐Alder additions may dominate the formation of oxaspiro[4.5]decane and spiro[4.5] decane skeletons, respectively. Compound 1 showed anti‐inflammatory activity by inhibiting the expression of iNOS and COX‐2.
    Type of Medium: Online Resource
    ISSN: 1001-604X , 1614-7065
    URL: Issue
    URL: Article
    DOI: 10.1002/cjoc.v40.5
    DOI: 10.1002/cjoc.202100743
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2144352-X
    SSG: 6,25
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 8
    Online Resource
    Online Resource
    Sarcaglarols A—D, Lindenane−Monoterpene Heterodimers from Sarcandra glabra Based on Molecular Networks
    Wiley ; 2021
    In:  Chinese Journal of Chemistry Vol. 39, No. 1 ( 2021-01), p. 129-136
    Details
    In: Chinese Journal of Chemistry, Wiley, Vol. 39, No. 1 ( 2021-01), p. 129-136
    Abstract: Sarcaglarols A—D ( 1 — 4 ), two pairs of lindenane−monoterpene heterodimers fused by a 1,2‐dioxane moiety, were discovered and isolated from the leaves of Sarcandra glabra guided by MS/MS molecular networking‐based strategy. Their planar structures, absolute configurations of basic skeleton and flexible polyhydric side chain were established by analysis of HRESIMS, NMR spectroscopic data, ECD spectrum, and the X‐ray diffraction study of isopropylidene derivatives. An intermolecular [2+2+2] cycloaddition may play a key role in the biosynthesis pathway of the 1,2‐dioxane moiety fused lindenane−monoterpene heterodimer skeleton, which can be recognized as the biogenetic precursors of our previous reported lindenane−normonoterpene conjugates. In addition, compounds 1 , 3 and 4 exhibited moderate inhibitory effects of lipid accumulation in free fatty acid‐exposed L02 cells.
    Type of Medium: Online Resource
    ISSN: 1001-604X , 1614-7065
    URL: Issue
    URL: Article
    DOI: 10.1002/cjoc.v39.1
    DOI: 10.1002/cjoc.202000456
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2144352-X
    SSG: 6,25
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 9
    Online Resource
    Online Resource
    Oxygen permeation through a CO2-tolerant mixed conducting oxide (Pr0.9La0.1)2(Ni0.74Cu0.21Ga0.05)O4+δ
    Wiley ; 2012
    In:  AIChE Journal Vol. 58, No. 8 ( 2012-08), p. 2473-2478
    Details
    In: AIChE Journal, Wiley, Vol. 58, No. 8 ( 2012-08), p. 2473-2478
    Type of Medium: Online Resource
    ISSN: 0001-1541
    URL: Article
    DOI: 10.1002/aic.12742
    Language: English
    Publisher: Wiley
    Publication Date: 2012
    detail.hit.zdb_id: 2020333-0
    detail.hit.zdb_id: 240008-X
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
  • 10
    Online Resource
    Online Resource
    Antioxidant capacities of heat‐treated wheat germ and extruded compounded bran
    Wiley ; 2022
    In:  Cereal Chemistry Vol. 99, No. 3 ( 2022-05), p. 582-592
    Details
    In: Cereal Chemistry, Wiley, Vol. 99, No. 3 ( 2022-05), p. 582-592
    Abstract: Pure wheat bran and wheat germ are the by‐products of sieved flour. Pure wheat bran contains a substantial amount of dietary fiber, vitamins B and D, and other nutrients; lipases in the wheat germ induce lipid oxidation and break down vitamins. The present study used heat treatment to stabilize the wheat germ and then compounded it with the extruded pure wheat bran and compared it with the extruded bran. The antioxidant capacity and soluble polyphenols of the compounded wheat bran and extruded wheat bran were subsequently measured, to select a method to improve the antioxidant capacity of wheat bran. Findings The optimized heating temperature of wheat germ was 110°C. The half‐maximal inhibitory concentration value of the total antioxidant capacity showed that the compounded wheat bran had a higher antioxidant capacity than the extruded wheat bran. It was hypothesized that the operations of extrusion and heat treatment increased the antioxidant capacity of compounded wheat bran. In addition, after the extrusion treatment, a variety of flavonoid glycosides in the wheat bran was released while the content of various phenolic acid types was decreased. However, the content of the phenolic acid types and flavonoids in the compounded wheat bran was increased. Hence, compounded wheat bran is more suitable for producing functional foods. Conclusion The results of this study revealed that extruded pure wheat bran and heat‐treated wheat germ can effectively increase the antioxidant capacity and the content of the phenolic acid types and flavonoids; hence, it is more suitable for producing functional foods. Significance and novelty This study developed a fast and inexpensive detection method that uses a combination of heat and extrude to process compounded wheat bran, which provides the optimal process method for extending the yield and shelf life of wheat bran products.
    Type of Medium: Online Resource
    ISSN: 0009-0352 , 1943-3638
    URL: Issue
    URL: Article
    DOI: 10.1002/cche.v99.3
    DOI: 10.1002/cche.10520
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2016053-7
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    Online Resource
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...