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  • 1
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    Different impact from betel quid, alcohol and cigarette: Risk factors for pharyngeal and laryngeal cancer
    Wiley ; 2005
    In:  International Journal of Cancer Vol. 117, No. 5 ( 2005-12-10), p. 831-836
    Details
    In: International Journal of Cancer, Wiley, Vol. 117, No. 5 ( 2005-12-10), p. 831-836
    Abstract: The risks of betel quid chewing with or without tobacco, alcohol drinking and cigarette smoking have been well explored in the oral cavity but not in the pharynx and larynx. We conducted a case‐control study to investigate the association of these three risk factors to cancers of the pharynx and larynx in Taiwan. A total cases of 148 pharyngeal cancer, 128 laryngeal cancer and 255 hospital controls, all men, were recruited. Betel quid chewing was a significant independent risk factor (adjusted odds ratio [aOR] = 7.7; 95% confidence interval [CI] = 4.1–15.0) similar to that of alcohol drinking (aOR = 6.6; 95% CI = 3.5–13.0) for pharyngeal cancer, but not for laryngeal cancer (aOR = 1.3; 95% CI = 0.7–2.5) on which cigarette smoking (aOR = 7.1) exerts a stronger significant independent risk than alcohol drinking (aOR = 3.8). For pharyngeal cancers, chewers who consumed 〉 20 quid/day, chewed with inflorescence in the quid or swallowed the betel quid juice were at higher risks; significant dose‐response effects were found in daily quantity of drinking and chewing, and cumulative quantity of drinking. Synergistic effects from the 3 risk factors existed both on the pharynx (aOR = 96.9) and the larynx (aOR = 40.3), and attributed for 93.1% and 92.9% respectively. Our study is the first evidence to show that betel quid chewing without tobacco has different impact on the pharynx (digestive tract) and the larynx (airway), and supports the concept that exposure quantity and direct mucosal contact with the betel quid juice may contribute to carcinogenesis. Our results show an important insight into the impact of betel quid chewing on other sites of the digestive tract other than the oral cavity. © 2005 Wiley‐Liss, Inc.
    Type of Medium: Online Resource
    ISSN: 0020-7136 , 1097-0215
    URL: Issue
    URL: Article
    DOI: 10.1002/ijc.v117:5
    DOI: 10.1002/ijc.21237
    RVK:
    XA 10000
    Language: English
    Publisher: Wiley
    Publication Date: 2005
    detail.hit.zdb_id: 218257-9
    detail.hit.zdb_id: 1474822-8
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  • 2
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    Role of Medicinal Plants for Liver‐Qi Regulation Adjuvant Therapy in Post‐stroke Depression: A Systematic Review of Literature
    Wiley ; 2017
    In:  Phytotherapy Research Vol. 31, No. 1 ( 2017-01), p. 40-52
    Details
    In: Phytotherapy Research, Wiley, Vol. 31, No. 1 ( 2017-01), p. 40-52
    Abstract: Current evidence demonstrated certain beneficial effects of medicinal herbs as an adjuvant therapy for post‐stroke depression (PSD) in China; Chai‐hu (Chinese Thorowax Root, Radix Bupleuri) is an example of a medicinal plant for Liver‐Qi regulation (MPLR) in the treatment of PSD. Despite several narrative reports on the antidepressant properties of MPLR, it appears that there are no systematic reviews to summarize its outcome effects. Therefore, the aim of this review was to assess the effectiveness and safety of MPLR adjuvant therapy in patients with PSD. Seven databases were extensively searched from January 2000 until July 2016. Randomized control trials (RCTs) involving patients with PSD that compared treatment with and without MPLR were taken into account. The pooled effect estimates were calculated based on Cochrane Collaboration's software RevMan 5.3. Finally, 42 eligible studies with 3612 participants were included. Overall, MPLR adjuvant therapy showed a significantly higher effective rate (RR = 1.23; 95% CI = 1.19, 1.27; p   〈  0.00001) compared to those without. Moreover, the administration of MPLR was superior to abstainers regarding Hamilton Depression Scale (HAMD) score changes after 3 weeks (WMD = −4.83; 95% CI = −6.82, −2.83; p   〈  0.00001), 4 weeks (WMD = −3.25; 95% CI = −4.10, −2.40; p   〈  0.00001), 6 weeks (WMD = −4.04; 95% CI = −5.24, −2.84; p   〈  0.00001), 8 weeks (WMD = −4.72; 95% CI = −5.57, −3.87; p   〈  0.00001), and 12 weeks (WMD = −3.07; 95% CI = −4.05, −2.09; p   〈  0.00001). In addition, there were additive benefits in terms of response changes for the National Institutes of Health Stroke Scale (NIHSS) and other self‐rating scores. No frequently occurring or serious adverse events were reported. We concluded that there is supporting evidence that adjuvant therapy with MPLR is effective in reducing the depressive symptoms and enhancing quality of life for patients with PSD. More well‐designed RCTs are necessary to explore the role of MPLR in the treatment of PSD. Copyright © 2016 John Wiley & Sons, Ltd.
    Type of Medium: Online Resource
    ISSN: 0951-418X , 1099-1573
    URL: Issue
    URL: Article
    DOI: 10.1002/ptr.v31.1
    DOI: 10.1002/ptr.5740
    Language: English
    Publisher: Wiley
    Publication Date: 2017
    detail.hit.zdb_id: 1493490-5
    SSG: 15,3
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  • 3
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    Multifunctional Iron‐Doped Hollow Mesoporous Silica Nanoregulator for Enhanced Tumor Chemodynamic Therapy
    Wiley ; 2023
    In:  Particle & Particle Systems Characterization Vol. 40, No. 9 ( 2023-09)
    Details
    In: Particle & Particle Systems Characterization, Wiley, Vol. 40, No. 9 ( 2023-09)
    Abstract: Chemodynamic therapy (CDT) is a promising method that uses endogenous hydrogen peroxide (H 2 O 2 ) to produce cytotoxic hydroxyl radicals (•OH) via Fenton reaction to kill tumor cells. However, the insufficient contents of H 2 O 2 and the presence of glutathione (GSH) can significantly reduce the therapeutic effect of CDT. Herein, a multifunctional nanoregulator (3‐AT & MA@FHM) that combines Fe‐doped hollow mesoporous silica nanoparticles (Fe‐doped hMSN, or FHM) with 3‐amino‐1,2,4‐triazole (3‐AT) and maleimide (MA) are developed to overcome these challenges. After endocytosis by tumor cells, FHM part of the nanoregulator degrades in a mildly acidic intracellular environment and releases Fe 3+ for CDT. The subsequently released 3‐AT serves as a catalase inhibitor to promote the accumulation of H 2 O 2, while MA acts as a GSH scavenger to decrease the GSH content in tumor cells. This multifunctional nanoplatform simultaneously regulates the contents of H 2 O 2 ‐the substrate for Fenton reaction and GSH‐the main antioxidant, resulting in a significantly enhanced CDT effect. Moreover, organoids are used for safety and toxicity evaluation. The results of organoids experiments showed similar trends to those of cellular experiments, but MIO is more resistant to stress than cells. This study is expected to provide a novel idea for the design of highly efficient CDT nanosystems.
    Type of Medium: Online Resource
    ISSN: 0934-0866 , 1521-4117
    URL: Issue
    URL: Article
    DOI: 10.1002/ppsc.v40.9
    DOI: 10.1002/ppsc.202300054
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 142874-3
    detail.hit.zdb_id: 1481071-2
    detail.hit.zdb_id: 246753-7
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  • 4
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    Seizure After Local Anesthesia for Nasopharyngeal Angiofibroma
    Wiley ; 2007
    In:  The Kaohsiung Journal of Medical Sciences Vol. 23, No. 2 ( 2007-02), p. 97-100
    Details
    In: The Kaohsiung Journal of Medical Sciences, Wiley, Vol. 23, No. 2 ( 2007-02), p. 97-100
    Abstract: We report a young male patient who experienced seizure after local injection of 3 mL 2% lidocaine with epinephrine 1:200,000 around a recurrent nasal angiofibroma. After receiving 100% oxygen via mask and thiamylal sodium, the patient had no residual neurologic sequelae. Seizure immediately following the injection of local anesthetics in the nasal cavity is probably due to injection into venous or arterial circulation with retrograde flow to the brain circulation. Further imaging study or angiography should be done before head and neck surgeries, especially in such highly vascular neoplasm.
    Type of Medium: Online Resource
    ISSN: 1607-551X , 2410-8650
    URL: Article
    DOI: 10.1016/S1607-551X(09)70383-3
    Language: English
    Publisher: Wiley
    Publication Date: 2007
    detail.hit.zdb_id: 2202782-8
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  • 5
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    Expression of matrix metalloproteinase‐2 and matrix metalloproteinase‐9 in recurrent chronic rhinosinusitis with nasal polyposis
    Wiley ; 2013
    In:  The Kaohsiung Journal of Medical Sciences Vol. 29, No. 1 ( 2013-01), p. 26-31
    Details
    In: The Kaohsiung Journal of Medical Sciences, Wiley, Vol. 29, No. 1 ( 2013-01), p. 26-31
    Abstract: Matrix metalloproteinase (MMP) is involved in the upper airway remodeling process. We hypothesized that MMP had an additive effect on the formation of recurrent nasal polyp. We also investigated the association between the functional promoter polymorphism of MMPs and the intensity of labeling index. Expressions of MMP‐2 and MMP‐9 were assessed via immunohistochemical staining and compared between different groups, including recurrent nasal polyps, nonrecurrent nasal polyps, and control nasal mucosa. Two promoter functional single‐nucleotide polymorphisms (rs3918242 for MMP‐9 and rs243865 for MMP‐2) were selected to correlate with staining intensity. Expression of MMP‐9 was significantly enhanced in gland for recurrent nasal polyp ( p  = 0.016) and nonrecurrent nasal polyp ( p  = 0.005) compared to the control. MMP‐2 positivity was significantly increased in surface epithelium for recurrent nasal polyp ( p  = 0.004) compared to the control ( p  = 0.061). However, there was no significant difference in MMP‐9 and MMP‐2 expressions between recurrent and nonrecurrent nasal polyps. Genetic polymorphism of MMP‐2 and MMP‐9 functional promoters was not associated with the intensity of labeling index. These results suggested that up‐regulation of MMP‐9 in gland and MMP‐2 in surface epithelium was characteristic of both recurrent and nonrecurrent nasal polyps. Pathogenesis of recurrent nasal polyps may involve a mechanism other than MMP.
    Type of Medium: Online Resource
    ISSN: 1607-551X , 2410-8650
    URL: Article
    DOI: 10.1016/j.kjms.2012.08.004
    Language: English
    Publisher: Wiley
    Publication Date: 2013
    detail.hit.zdb_id: 2202782-8
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  • 6
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    Head and neck extranodal lymphoma in a single institute: A 17‐year retrospective analysis
    Wiley ; 2012
    In:  The Kaohsiung Journal of Medical Sciences Vol. 28, No. 8 ( 2012-08), p. 435-441
    Details
    In: The Kaohsiung Journal of Medical Sciences, Wiley, Vol. 28, No. 8 ( 2012-08), p. 435-441
    Abstract: The study's purposes are to identify patient characteristics, treatment response and survival rate, and to describe the important prognostic factors for our patients with extranodal head and neck lymphoma. Furthermore, no study has systemically discussed the overall figure of this disease in Taiwan and we analyzed our data on this topic. A retrospective review was performed for 86 patients with extranodal head and neck lymphoma, diagnosed in Kaohsiung Medical University Hospital, between 1990 and 2007. We evaluated the medical records and analyzed the possible factors affecting treatment outcomes, survival rate, and free‐from‐disease (FFD) survival rate. Forty‐nine male and 37 female patients were included with a male:female ratio of 1.32：1. The most frequent histologic type was diffuse large B cell lymphoma, accounting for 41.9% of the total. The most common primary site involved with extranodal head and neck non‐Hodgkin's lymphoma was a tonsil with 27 cases (31.4%). Stage, international prognostic index (IPI) score, B symptoms, lactate dehydrogenase (LDH) level, and lymph node status significantly affected treatment response. The overall 5‐ and 10‐year survival rates were 68.0% and 57.8%, respectively. The FFD survival rate was 53.6% and 49.3% at 5 and 10 years, respectively. Factors including stage, lymph node status, LDH level, and IPI score produced significant differences in both overall survival and FFD survival. Our analyzed information is similar to other previously presented studies. Stage, IPI score, B symptoms, LDH level, and neck nodal status can be used to evaluate the treatment outcomes. Neck nodal status and stage are the two significant prognostic factors for overall survival.
    Type of Medium: Online Resource
    ISSN: 1607-551X , 2410-8650
    URL: Article
    DOI: 10.1016/j.kjms.2012.02.014
    Language: English
    Publisher: Wiley
    Publication Date: 2012
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  • 7
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    Vitamin D decreases the secretion of eotaxin and RANTES in nasal polyp fibroblasts derived from Taiwanese patients with chronic rhinosinusitis with nasal polyps
    Wiley ; 2015
    In:  The Kaohsiung Journal of Medical Sciences Vol. 31, No. 2 ( 2015-02), p. 63-69
    Details
    In: The Kaohsiung Journal of Medical Sciences, Wiley, Vol. 31, No. 2 ( 2015-02), p. 63-69
    Abstract: Eosinophils are important inflammatory cells involved in the pathogenesis of chronic rhinosinusitis with nasal polyps (CRSwNP). Vitamin D and its derivatives, in addition to their classic role as regulators of electrolytes homeostasis, have modulatory effects in immunological and inflammatory responses. Such properties suggest that vitamin D might also play a role in inflammatory airway diseases such as CRSwNP. In this study, we investigated the effect of vitamin D derivatives (calcitriol and tacalcitol) on the secretion of eotaxin and Regulated on Activation, Normal T Cell Expressed and Secreted (RANTES), the two major eosinophil chemoattractants, in fibroblasts derived from the polyps of Taiwanese CRSwNP patients. Patients diagnosed with eosinophilic CRSwNP but without malignancies or asthma and undergoing elective endoscopic sinus surgery were recruited. Three primary fibroblast cultures were established using the polyp specimens obtained from these patients. The third to eighth passages of the fibroblasts were used for in vitro studies. Nasal polyp‐derived fibroblasts were stimulated with IL‐1β (10 ng/mL) for 24 hours, followed by replacement with media alone or with calcitriol or tacalcitol (10μM) and incubation for another 24 hours. After the treatments, the levels of secreted eotaxin and RANTES were evaluated by ELISA assays. The results showed that IL‐1β could substantially stimulate the secretion of eotaxin ( p   〈  0.01) and RANTES ( p   〈  0.01) in nasal polyp‐derived fibroblasts. More importantly, this stimulatory effect was significantly suppressed by adding calcitriol ( p  ≤ 0.002 for eotaxin and p  ≤ 0.008 for RANTES) or tacalcitol ( p  ≤ 0.009 for eotaxin and p  ≤ 0.02 for RANTES). Therefore, the inhibitory effect of vitamin D derivatives on eotaxin and RANTES secretion might shed light not only on the disease mechanism, but also on the potential use of vitamin D in pharmacotherapy of Taiwanese patients with CRSwNP.
    Type of Medium: Online Resource
    ISSN: 1607-551X , 2410-8650
    URL: Article
    DOI: 10.1016/j.kjms.2014.11.011
    Language: English
    Publisher: Wiley
    Publication Date: 2015
    detail.hit.zdb_id: 2202782-8
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  • 8
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    Epicardial left ventricular lead implantation for cardiac resynchronization therapy: case report
    Wiley ; 2007
    In:  The FASEB Journal Vol. 21, No. 6 ( 2007-01)
    Details
    In: The FASEB Journal, Wiley, Vol. 21, No. 6 ( 2007-01)
    Type of Medium: Online Resource
    ISSN: 0892-6638 , 1530-6860
    URL: Issue
    URL: Article
    DOI: 10.1096/fsb2.v21.6
    DOI: 10.1096/fasebj.21.6.A1367-b
    Language: English
    Publisher: Wiley
    Publication Date: 2007
    detail.hit.zdb_id: 1468876-1
    SSG: 12
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  • 9
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    Risk of Vocal Palsy After Thyroidectomy with Identification of the Recurrent Laryngeal Nerve
    Wiley ; 2004
    In:  The Kaohsiung Journal of Medical Sciences Vol. 20, No. 9 ( 2004-09), p. 431-436
    Details
    In: The Kaohsiung Journal of Medical Sciences, Wiley, Vol. 20, No. 9 ( 2004-09), p. 431-436
    Abstract: The purpose of this study was to assess the risk of vocal palsy after thyroidectomy with identification of recurrent laryngeal nerve (RLN) during surgery. In all, 521 patients treated by the same surgeon were enrolled in this study. Temporary and permanent vocal palsy rates were analyzed for patient groups classified according to surgery for primary benign thyroid disease, thyroid cancer, Graves' disease, and reoperation. Measurement of the vocal palsy rate was based on the number of nerves at risk. Twentysix intentionally sacrificed RLNs were excluded from analysis. Forty patients developed postoperative unilateral vocal palsy. Complete recovery of vocal palsy was documented for 35 of the 37 patients (94.6%) whose RLN integrity had been ensured intraoperatively. Recovery from temporary vocal palsy ranged from 3 days to 4 months (mean, 30.7 days). The overall incidences of temporary and permanent vocal palsy were 5.1% and 0.9%, respectively. The rates of temporary/permanent vocal palsy in groups classified according to underlying disease were 4.0%/0.2% for benign thyroid disease, 2.0%/0.7% for thyroid cancer, 12.0%/1.1% for Graves' disease, and 10.8%/8.1% for reoperation. Surgery for thyroid cancer, Graves' disease, and recurrent goiter were associated with significantly higher vocal palsy rates. Most patients without documented nerve damage during the operation recovered from postoperative vocal palsy. Total lobectomy with routine RLN identification is recommended as a basic procedure in thyroid surgery.
    Type of Medium: Online Resource
    ISSN: 1607-551X , 2410-8650
    URL: Article
    DOI: 10.1016/S1607-551X(09)70181-0
    Language: English
    Publisher: Wiley
    Publication Date: 2004
    detail.hit.zdb_id: 2202782-8
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  • 10
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    Vitamin D decreases the secretion of matrix metalloproteinase‐2 and matrix metalloproteinase‐9 in fibroblasts derived from Taiwanese patients with chronic rhinosinusitis with nasal polyposis
    Wiley ; 2015
    In:  The Kaohsiung Journal of Medical Sciences Vol. 31, No. 5 ( 2015-05), p. 235-240
    Details
    In: The Kaohsiung Journal of Medical Sciences, Wiley, Vol. 31, No. 5 ( 2015-05), p. 235-240
    Abstract: Vitamin D and its derivatives have modulatory effects in immunological and inflammatory responses. Such properties suggest that they might have an impact on chronic inflammatory airway diseases, including nasal polyposis. The aim of this study was to understand the role of vitamin D in chronic rhinosinusitis with nasal polyps (CRSwNP) by investigating its effect on the secretion of matrix metalloproteinase‐2 (MMP‐2) and MMP‐9 in nasal polyp‐derived fibroblasts. Two primary fibroblast cultures were established from nasal polyp tissues obtained during surgery. The nasal polyp‐derived fibroblasts were stimulated with tumor necrosis factor‐α (TNF‐α; 10 ng/mL) for 24 hours, followed by replacement with media alone or with vitamin D derivatives (calcitriol or tacalcitol; 10μM) and incubated for another 24 hours. After the treatments, the levels of MMP‐2 and MMP‐9 secreted were evaluated by both enzyme‐linked immunosorbent assay (ELISA) and Western blot analysis. ELISA results revealed that TNF‐α could substantially stimulate the secretion of MMP‐2 ( p   〈  0.01) and MMP‐9 ( p   〈  0.001) in nasal polyp‐derived fibroblasts. More importantly, such stimulatory effect was significantly suppressed by adding calcitriol ( p  ≤ 0.01 for MMP‐2 and p   〈  0.001 for MMP‐9) or tacalcitol ( p   〈  0.005 for both MMP‐2 and MMP‐9). The ELISA results were also confirmed by Western blot analysis. The inhibitory effect of vitamin D derivatives on MMP‐2 and MMP‐9 secretion could potentiate their application in pharmacotherapy of Taiwanese CRSwNP patients.
    Type of Medium: Online Resource
    ISSN: 1607-551X , 2410-8650
    URL: Article
    DOI: 10.1016/j.kjms.2015.02.001
    Language: English
    Publisher: Wiley
    Publication Date: 2015
    detail.hit.zdb_id: 2202782-8
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