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  • Wiley  (259)
  • 1
    Online Resource
    Online Resource
    The Microbiome Protocols eBook initiative: Building a bridge to microbiome research
    Wiley ; 2024
    In:  iMeta
    Details
    In: iMeta, Wiley
    Type of Medium: Online Resource
    ISSN: 2770-5986 , 2770-596X
    URL: Article
    DOI: 10.1002/imt2.182
    Language: English
    Publisher: Wiley
    Publication Date: 2024
    detail.hit.zdb_id: 3114873-6
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  • 2
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    Efficacy and safety of olmesartan medoxomil‐amlodipine besylate tablet in Chinese patients with essential hypertension: A prospective, single‐arm, multi‐center, real‐world study
    Wiley ; 2023
    In:  The Journal of Clinical Hypertension
    Details
    In: The Journal of Clinical Hypertension, Wiley
    Abstract: There lacks real‐world study with a large sample size assessing olmesartan medoxomil‐amlodipine besylate (OM‐AML) tablet. Therefore, this study aimed to evaluate the efficacy and safety of OM‐AML tablet in patients with essential hypertension. Totally, 1341 patients from 36 medical centers with essential hypertension who took OM‐AML (20/5 mg) tablet were analyzed in the current prospective, single‐arm, multi‐center, real‐world study (SVK study). Seated systolic blood pressure (SeSBP) and seated diastolic blood pressure (SeDBP) at baseline, week (W)4 and W8 were measured. The mean (±SE) change of SeSBP/SeDBP was ‐10.8 ± 0.4/‐6.6 ± 0.3 mmHg at W4 and ‐12.7 ± 0.5/‐7.6 ± 0.3 mmHg at W8, respectively. At W4, 78.8% and 29.0% patients achieved BP target by China and American Heart Association (AHA) criteria; at W8, 84.7% and 36.5% patients reached blood pressure (BP) target by China and AHA criteria, accordingly. Meanwhile, 80.2% and 86.4% patients achieved BP response at W4 and W8, respectively. Home‐measured SeSBP and SeDBP decreased from W1 to W8 (both p   〈  .001). Besides, patients’ and physicians’ satisfaction were elevated at W8 compared with W0 (both p   〈  .001). The medication possession rate was 94.8% from baseline to W4 and 91.3% from baseline to W8. The most common drug‐related adverse events were nervous system disorders (4.6%), vascular disorders (2.6%), and general disorders and administration site conditions (2.3%) by system organ class, which were generally mild and manageable. In conclusion, OM‐AML tablet is one of the best antihypertensive agents in patients with essential hypertension.
    Type of Medium: Online Resource
    ISSN: 1524-6175 , 1751-7176
    URL: Article
    DOI: 10.1111/jch.14700
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2058690-5
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  • 3
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    Room‐Temperature Magnetoelectric Coupling in Atomically Thin ε‐Fe 2 O 3
    Wiley ; 2023
    In:  Advanced Materials Vol. 35, No. 7 ( 2023-02)
    Details
    In: Advanced Materials, Wiley, Vol. 35, No. 7 ( 2023-02)
    Abstract: 2D multiferroics with magnetoelectric coupling combine the magnetic order and electric polarization in a single phase, providing a cornerstone for constructing high‐density information storages and low‐energy‐consumption spintronic devices. The strong interactions between various order parameters are crucial for realizing such multifunctional applications, nevertheless, this criterion is rarely met in classical 2D materials at room‐temperature. Here an ingenious space‐confined chemical vapor deposition strategy is designed to synthesize atomically thin non‐layered ε‐Fe 2 O 3 single crystals and disclose the room‐temperature long‐range ferrimagnetic order. Interestingly, the strong ferroelectricity and its switching behavior are unambiguously discovered in atomically thin ε‐Fe 2 O 3 , accompanied with an anomalous thickness‐dependent coercive voltage. More significantly, the robust room‐temperature magnetoelectric coupling is uncovered by controlling the magnetism with electric field and verifies the multiferroic feature of atomically thin ε‐Fe 2 O 3 . This work not only represents a substantial leap in terms of the controllable synthesis of 2D multiferroics with robust magnetoelectric coupling, but also provides a crucial step toward the practical applications in low‐energy‐consumption electric‐writing/magnetic‐reading devices.
    Type of Medium: Online Resource
    ISSN: 0935-9648 , 1521-4095
    URL: Issue
    URL: Article
    DOI: 10.1002/adma.v35.7
    DOI: 10.1002/adma.202209465
    RVK:
    UA 1538
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 1474949-X
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  • 4
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    Furazolidone‐containing triple and quadruple eradication therapy for initial treatment for Helicobacter pylori infection: A multicenter randomized controlled trial in China
    Wiley ; 2018
    In:  Helicobacter Vol. 23, No. 5 ( 2018-10)
    Details
    In: Helicobacter, Wiley, Vol. 23, No. 5 ( 2018-10)
    Abstract: The efficacy of Helicobacter pylori ( H. pylori ) eradication has steadily declined, primarily because of antibiotic resistance. This study aimed to evaluate the efficacy and safety of furazolidone eradication therapies as initial treatments for H. pylori infection. Methods A national, multicenter, open‐label, randomized controlled trial was performed at 16 sites across 13 provinces in China to evaluate the efficacy and safety of furazolidone‐containing therapies for H. pylori infection. Treatment naïve patients were randomly assigned to: esomeprazole 20 mg, bismuth 220 mg, amoxicillin 1000 mg, and furazolidone 100 mg twice daily for 10 and 7 days ( FAB 10 and FAB 7; the same therapy without bismuth ( FA 10 and FA 7). The primary and secondary outcomes were the eradication rate and regimen safety, respectively. Treatment success was assessed by the 13 C urea breath test at least 4 weeks after treatment completion. Results Overall, according to intention‐to‐treat ( ITT ) analysis, the eradication rates for FAB 10 and FAB 7 were 86.6% (95% confidence interval [ CI ], 79.9%‐93.2%) and 83.6% (95% CI , 76.3%‐90.9%) and for FA 10 and FA 7 were 82.4% (95% CI , 74.9%‐89.8%) and 77.6% (95% CI , 69.4%‐85.8%), respectively. According to per‐protocol analysis, the overall eradication rates for FAB 10 and FAB 7 were 94.7% (95% CI , 90.3%‐99.1%) and 90.8% (95% CI , 85.1%‐96.5%) and for FA 10 and FA 7 were 90.6% (95% CI , 84.9%‐96.3%) and 85.1% (95% CI , 78.2%‐92.1%), respectively. The overall prevalence of side effects was 8.1%. Conclusions Furazolidone‐containing therapies, particularly the tested 10‐day quadruple therapy, exhibited satisfactory efficacy and safety. This 10‐day quadruple therapy represents a promising initial treatment strategy for Chinese patients.
    Type of Medium: Online Resource
    ISSN: 1083-4389 , 1523-5378
    URL: Issue
    URL: Article
    DOI: 10.1111/hel.2018.23.issue-5
    DOI: 10.1111/hel.12496
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2020336-6
    SSG: 12
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  • 5
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    Serum semaphorin 4C as a diagnostic biomarker in breast cancer: A multicenter retrospective study
    Wiley ; 2021
    In:  Cancer Communications Vol. 41, No. 12 ( 2021-12), p. 1373-1386
    Details
    In: Cancer Communications, Wiley, Vol. 41, No. 12 ( 2021-12), p. 1373-1386
    Abstract: To date, there is no approved blood‐based biomarker for breast cancer detection. Herein, we aimed to assess semaphorin 4C (SEMA4C), a pivotal protein involved in breast cancer progression, as a serum diagnostic biomarker. Methods We included 6,213 consecutive inpatients from Tongji Hospital, Qilu Hospital, and Hubei Cancer Hospital. Training cohort and two validation cohorts were introduced for diagnostic exploration and validation. A pan‐cancer cohort was used to independently explore the diagnostic potential of SEMA4C among solid tumors. Breast cancer patients who underwent mass excision prior to modified radical mastectomy were also analyzed. We hypothesized that increased pre‐treatment serum SEMA4C levels, measured using optimized in‐house enzyme‐linked immunosorbent assay kits, could detect breast cancer. The endpoints were diagnostic performance, including area under the receiver operating characteristic curve (AUC), sensitivity, and specificity. Post‐surgery pathological diagnosis was the reference standard and breast cancer staging followed the TNM classification. There was no restriction on disease stage for eligibilities. Results We included 2667 inpatients with breast lesions, 2378 patients with other solid tumors, and 1168 healthy participants. Specifically, 118 patients with breast cancer were diagnosed with stage 0 (5.71%), 620 with stage I (30.00%), 966 with stage II (46.73%), 217 with stage III (10.50%), and 8 with stage IV (0.39%). Patients with breast cancer had significantly higher serum SEMA4C levels than benign breast tumor patients and normal controls ( P 〈 0.001). Elevated serum SEMA4C levels had AUC of 0.920 (95% confidence interval [CI]: 0.900–0.941) and 0.932 (95%CI: 0.911–0.953) for breast cancer detection in the two validation cohorts. The AUCs for detecting early‐stage breast cancer ( n = 366) and ductal carcinoma in situ ( n = 85) were 0.931 (95%CI: 0.916–0.946) and 0.879 (95%CI: 0.832–0.925), respectively. Serum SEMA4C levels significantly decreased after surgery, and the reduction was more striking after modified radical mastectomy, compared with mass excision ( P 〈 0.001). The positive rate of enhanced serum SEMA4C levels was 84.77% for breast cancer and below 20.75% for the other 14 solid tumors. Conclusions Serum SEMA4C demonstrated promising potential as a candidate biomarker for breast cancer diagnosis. However, validation in prospective settings and by other study groups is warranted.
    Type of Medium: Online Resource
    ISSN: 2523-3548 , 2523-3548
    URL: Issue
    URL: Article
    DOI: 10.1002/cac2.v41.12
    DOI: 10.1002/cac2.12233
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2922913-3
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  • 6
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    Plant‐Protein‐Modified TiO 2 (SPI@TiO 2 ) for Photodegradation of Dyes
    Wiley ; 2018
    In:  ChemistrySelect Vol. 3, No. 11 ( 2018-03-22), p. 3127-3132
    Details
    In: ChemistrySelect, Wiley, Vol. 3, No. 11 ( 2018-03-22), p. 3127-3132
    Abstract: TiO 2 photocatalysts modified by soy protein isolate (SPI@TiO 2 ) were successfully prepared via hydrothermal method and characterized by diffuse reflectance UV‐vis spectroscopy, photoluminescence (PL), brunauere emmette teller (BET), scanning electron microscope (SEM), fourier transforming infrared spectrum (FT‐IR), and electrochemical measurements. The photocatalytic activity of the as‐prepared samples was evaluated by testing photocatalytic degradation Rhodamine‐B (RhB). 0.02SPI@TiO 2 showed the highest photocatalytic activity. The improved photocatalytic activity of SPI@TiO 2 composites could be attributed to the existence of SPI, which can reduce the recombination rate of electron–hole and enhance the adsorption of dyes.
    Type of Medium: Online Resource
    ISSN: 2365-6549 , 2365-6549
    URL: Issue
    URL: Article
    DOI: 10.1002/slct.v3.11
    DOI: 10.1002/slct.201800186
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2844262-3
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  • 7
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    Construction of Hybrid Bi‐microcompartments with Exocytosis‐Inspired Behavior toward Fast Temperature‐Modulated Transportation of Living Organisms
    Wiley ; 2021
    In:  Angewandte Chemie Vol. 133, No. 38 ( 2021-09-13), p. 20963-20970
    Details
    In: Angewandte Chemie, Wiley, Vol. 133, No. 38 ( 2021-09-13), p. 20963-20970
    Abstract: Inspired by the unique characteristics of living cells, the creation of life‐inspired functional ensembles is a rapidly expanding research topic, enabling transformative applications in various disciplines. Herein, we report a facile method for the fabrication of phospholipid and block copolymer hybrid bi‐microcompartments via spontaneous asymmetric assembly at the water/tributyrin interface, whereby the temperature‐mediated dewetting of the inner microcompartments allowed for exocytosis to occur in the constructed system. The exocytosis location and commencement time could be controlled by the buoyancy of the inner microcompartment and temperature, respectively. Furthermore, the constructed bi‐microcompartments showed excellent biocompatibility and a universal loading capacity toward cargoes of widely ranging sizes; thus, the proliferation and temperature‐programmed transportation of living organisms was achieved. Our results highlight opportunities for the development of complex mesoscale dynamic ensembles with life‐inspired behaviors and provide a novel platform for on‐demand transport of various living organisms.
    Type of Medium: Online Resource
    ISSN: 0044-8249 , 1521-3757
    URL: Issue
    URL: Article
    DOI: 10.1002/ange.v133.38
    DOI: 10.1002/ange.202102846
    RVK:
    VA 2100
    RVK:
    VN 5020
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 505868-5
    detail.hit.zdb_id: 506609-8
    detail.hit.zdb_id: 514305-6
    detail.hit.zdb_id: 505872-7
    detail.hit.zdb_id: 1479266-7
    detail.hit.zdb_id: 505867-3
    detail.hit.zdb_id: 506259-7
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  • 8
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    Inherent bioelectrical parameters of hundreds of thousands of single leukocytes based on impedance flow cytometry
    Wiley ; 2022
    In:  Cytometry Part A Vol. 101, No. 8 ( 2022-08), p. 630-638
    Details
    In: Cytometry Part A, Wiley, Vol. 101, No. 8 ( 2022-08), p. 630-638
    Abstract: As label‐free biomarkers, bioelectrical properties of single cells have been widely used in hematology analyzers for 3‐part differential of leukocytes, in which, however, instrument dependent bioelectrical parameters (e.g., DC/AC impedance values) rather than inherent bioelectrical parameters (e.g., diameter D c , specific membrane capacitance C sm and cytoplasmic conductivity σ cy ) were used, leading to poor comparisons among different instruments. In order to address this issue, this study collected inherent bioelectrical parameters from hundreds of thousands of white blood cells based on a home‐developed impedance flow cytometry with corresponding 3‐part differential of leukocytes realized. More specifically, leukocytes were separated into three major subtypes of granulocytes, monocytes and lymphocytes based on density gradient centrifugation. Then these separated cells were aspirated through a constriction‐microchannel based impedance flow cytometry where inherent bioelectrical parameters of D c , C sm and σ cy were quantified as 9.8 ± 0.7 μm, 2.06 ± 0.26 μF/cm 2 , and 0.34 ± 0.05 S/m for granulocytes (n cell  = 134,829); 10.4 ± 1.0 μm, 2.45 ± 0.48 μF/cm 2 , and 0.42 ± 0.08 S/m for monocytes (n cell  = 40,226); 8.0 ± 0.5 μm, 2.23 ± 0.34 μF/cm 2 , and 0.35 ± 0.08 S/m for lymphocytes (n cell  = 129,193). Based on these inherent bioelectrical parameters, neural pattern recognition was conducted, producing a high “classification accuracy” of 93.5% in classifying these three subtypes of leukocytes. These results indicate that as inherent bioelectrical parameters, D c , C sm , and σ cy can be used to electrically phenotype white blood cells in a label‐free manner.
    Type of Medium: Online Resource
    ISSN: 1552-4922 , 1552-4930
    URL: Issue
    URL: Article
    DOI: 10.1002/cyto.v101.8
    DOI: 10.1002/cyto.a.24544
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2180639-1
    SSG: 12
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  • 9
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    Incidence, risk factors and mortality of invasive pulmonary aspergillosis in patients with influenza: A systematic review and meta‐analysis
    Wiley ; 2022
    In:  Mycoses Vol. 65, No. 2 ( 2022-02), p. 152-163
    Details
    In: Mycoses, Wiley, Vol. 65, No. 2 ( 2022-02), p. 152-163
    Abstract: An increasing number of cases of invasive pulmonary aspergillosis (IPA) complicating influenza have been described. We performed a meta‐analysis to estimate the incidence, risk factors and outcomes of IPA in patients with influenza. Methods A systematic search was conducted in the PubMed, EMBASE and Cochrane Library databases from their inception to 31 August 2021 for eligible studies. Data on the incidence and risk factors of and mortality due to IPA in influenza patients were pooled using a random‐effects model. Sensitivity analyses restricted to severe influenza requiring intensive care unit (ICU) support and multiple subgroup analyses were performed. Results Fourteen studies involving 6024 hospitalised patients with influenza were included. IPA was estimated to occur in 10% of influenza patients, with a mortality rate of 52%. Similar incidence (11%) and mortality (54%) estimates for IPA were observed in the sensitivity analysis including severe cases requiring ICU support. Subgroup analysis by geographical location showed a similar IPA rate between European (10%) and non‐European (11%) studies. The IPA rate in the subset of nine studies using the modified AspICU criteria was 13%. Most subgroup analyses showed ≥50% mortality in IPA patients. Several predictors for IPA susceptibility were identified, including male sex, smoking history, chronic lung disease, influenza A (H1N1), severe conditions requiring supportive therapy, corticosteroid use before admission, solid organ transplant and haematological malignancy. Conclusions The IPA is common in individuals with severe influenza, and the prognosis is particularly poor. Influenza patients, especially those with high‐risk factors, should be thoroughly screened for IPA.
    Type of Medium: Online Resource
    ISSN: 0933-7407 , 1439-0507
    URL: Issue
    URL: Article
    DOI: 10.1111/myc.v65.2
    DOI: 10.1111/myc.13410
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2020780-3
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  • 10
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    Brucella melitensis 16 M Δ hfq attenuation confers protection against wild‐type challenge in BALB /c mice
    Wiley ; 2013
    In:  Microbiology and Immunology Vol. 57, No. 7 ( 2013-07), p. 502-510
    Details
    In: Microbiology and Immunology, Wiley, Vol. 57, No. 7 ( 2013-07), p. 502-510
    Abstract: Brucellosis is a globally distributed zoonotic disease that causes animal and human diseases. Although effective, the current Brucella vaccines (Rev.1 and M5‐90) have several drawbacks. The first involves residual virulence for animals and humans and the second is the inability to differentiate natural infection from that caused by vaccination. Therefore, Brucella melitensis 16M hfq mutant (16MΔ hfq ) was constructed to overcome these drawbacks. Similarly to Rev.1 and M5‐90, 16MΔ hfq reduces survival in macrophages and mice and induces strong protective immunity in BALB/c mice. Moreover, these vaccines elicit anti‐ Brucella ‐specific IgG1 and IgG2a subtype responses and induce secretion of gamma interferon and interleukin‐4. The Hfq antigen also allows serological differentiation between infected and vaccinated animals. These results show that 16MΔ hfq is an ideal live attenuated vaccine candidate against virulent Brucella melitensis 16M infection. It will be further evaluated in sheep.
    Type of Medium: Online Resource
    ISSN: 0385-5600 , 1348-0421
    URL: Issue
    URL: Article
    DOI: 10.1111/mim.v57.7
    DOI: 10.1111/1348-0421.12065
    Language: English
    Publisher: Wiley
    Publication Date: 2013
    detail.hit.zdb_id: 2102145-4
    SSG: 12
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