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  • Wiley  (6)
  • 1
    Online Resource
    Online Resource
    Influence of layered skull modeling on the frequency sensitivity and target accuracy in simulations of transcranial current stimulation
    Wiley ; 2021
    In:  Human Brain Mapping Vol. 42, No. 16 ( 2021-11), p. 5345-5356
    Details
    In: Human Brain Mapping, Wiley, Vol. 42, No. 16 ( 2021-11), p. 5345-5356
    Abstract: With the development of electrical stimulation technology, especially the emergence of temporally interfering (TI) stimulation, it is necessary to discuss the influence of current frequency on stimulation intensity. Accurate skull modeling is important for transcranial current stimulation (tCS) simulation prediction because of its large role in dispersing current. In this study, we simulated different frequencies of transcranial alternating current stimulation (tACS) and TI stimulation in single‐layer and layered skull model, compared the electric field via error parameters such as the relative difference measure and relative magnification factor. Pearson correlation analysis and t ‐test were used to measure the differences in envelope amplitude. The results showed that the intensity of electric field in the brain generated by per unit of stimulation current will increase with current frequency, and the layered skull model had a better response to frequency. An obvious pattern difference was found between the electric fields of the layered and single‐layer skull individualized models. For TI stimulation, the Pearson correlation coefficient between the envelope distribution of the layered skull model and the single‐layer skull was only 0.746 in the individualized model, which is clearly lower than the correlation coefficient of 0.999 determined from the spherical model. Higher carrier frequencies seemed to be easier to generate a large enough brain electric field envelope in TI stimulation. In conclusion, we recommend using layered skull models instead of single‐layer skull models in tCS (particularly TI stimulation) simulation studies in order to improve the accuracy of the prediction of stimulus intensity and stimulus target.
    Type of Medium: Online Resource
    ISSN: 1065-9471 , 1097-0193
    URL: Issue
    URL: Article
    DOI: 10.1002/hbm.v42.16
    DOI: 10.1002/hbm.25622
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 1492703-2
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  • 2
    Online Resource
    Online Resource
    Hemodynamic response varies across tactile stimuli with different temporal structures
    Wiley ; 2021
    In:  Human Brain Mapping Vol. 42, No. 3 ( 2021-02-15), p. 587-597
    Details
    In: Human Brain Mapping, Wiley, Vol. 42, No. 3 ( 2021-02-15), p. 587-597
    Abstract: Tactile stimuli can be distinguished based on their temporal features (e.g., duration, local frequency, and number of pulses), which are fundamental for vibrotactile frequency perception. Characterizing how the hemodynamic response changes in shape across experimental conditions is important for designing and interpreting fMRI studies on tactile information processing. In this study, we focused on periodic tactile stimuli with different temporal structures and explored the hemodynamic response function (HRF) induced by these stimuli. We found that HRFs were stimulus‐dependent in tactile‐related brain areas. Continuous stimuli induced a greater area of activation and a stronger and narrower hemodynamic response than intermittent stimuli with the same duration. The magnitude of the HRF increased with increasing stimulus duration. By normalizing the characteristics into topographic matrix, nonlinearity was obvious. These results suggested that stimulation patterns and duration within a cycle may be key characters for distinguishing different stimuli. We conclude that different temporal structures of tactile stimuli induced different HRFs, which are essential for vibrotactile perception and should be considered in fMRI experimental designs and analyses.
    Type of Medium: Online Resource
    ISSN: 1065-9471 , 1097-0193
    URL: Issue
    URL: Article
    DOI: 10.1002/hbm.v42.3
    DOI: 10.1002/hbm.25243
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 1492703-2
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  • 3
    Online Resource
    Online Resource
    m 6 A‐induced TRIB3 regulates Hippo pathway through interacting with LATS1 to promote the progression of lung adenocarcinoma
    Wiley ; 2024
    In:  Journal of Cellular Physiology Vol. 239, No. 5 ( 2024-05)
    Details
    In: Journal of Cellular Physiology, Wiley, Vol. 239, No. 5 ( 2024-05)
    Abstract: Recent studies have indicated that dysregulation of the Hippo/Yes‐associated protein (YAP) axis is associated with tumor progression and therapy resistance in various cancer types, including lung adenocarcinoma (LUAD). Understanding the regulation of Hippo signaling in LUAD is of great significance. Elevated levels of TRIB3, a pseudo kinase, have been observed in certain lung malignancies and are associated with an unfavorable prognosis. Our research aims to investigate whether increased TRIB3 levels enhance the malignant characteristics of LUAD cells and tumor progression through its interaction with the Hippo signaling pathway. In this study, we reported a positive correlation between elevated expression of TRIB3 and LUAD progression. Additionally, TRIB3 has the ability to enhance TEAD luciferase function and suppress Hippo pathway activity. Moreover, TRIB3 increases total YAP protein levels and promotes YAP nuclear localization. Mechanistic experiments revealed that TRIB3 directly interacts with large tumor suppressor kinase 1 (LATS1), thereby suppressing Hippo signaling. Moreover, the decrease in METTL3‐mediated N6‐methyladenosine modification of TRIB3 results in a substantial elevation of its expression levels in LUAD cells. Collectively, our research unveils a novel discovery that TRIB3 enhances the growth and invasion of LUAD cells by interacting with LATS1 and inhibiting the Hippo signaling pathway. TRIB3 may serve as a potential biomarker for an unfavorable prognosis and a target for novel treatments in YAP‐driven lung cancer.
    Type of Medium: Online Resource
    ISSN: 0021-9541 , 1097-4652
    URL: Issue
    URL: Article
    DOI: 10.1002/jcp.v239.5
    DOI: 10.1002/jcp.31220
    Language: English
    Publisher: Wiley
    Publication Date: 2024
    detail.hit.zdb_id: 1478143-8
    SSG: 12
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  • 4
    Online Resource
    Online Resource
    Hemodynamic effects of size and location of basilar artery fenestrations associated to pathological implications
    Wiley ; 2021
    In:  International Journal for Numerical Methods in Biomedical Engineering Vol. 37, No. 9 ( 2021-09)
    Details
    In: International Journal for Numerical Methods in Biomedical Engineering, Wiley, Vol. 37, No. 9 ( 2021-09)
    Abstract: Fenestration is a rare congenital abnormality that refers to a segmental duplication of arteries. It is still not clear about the role of fenestrations in the etiology and pathological evolution of vascular diseases. This study aims to investigate the hemodynamic influence brought by various sizes and locations of fenestration in basilar artery models. A series presumptive fenestration models were established based on a normal basilar artery model with various sizes and locations. Identical boundary conditions were utilized in the computational fluid dynamics simulations and different flow patterns in the fenestration and bifurcation regions were comprehensively analyzed. Wall shear stress (WSS)‐related parameters such as oscillatory shear index (OSI) and aneurysm formation index (AFI) were computed and compared. The value of WSS on fenestration increased by the fenestration's tortuosity, and nearly‐circular fenestration suffered higher WSS than narrow‐strips one. Also, high OSI and low AFI value mainly occurred in the bifurcation region, indicating a high level of turbulence and high risk of aneurysm formation. The location of fenestration mainly changed the impact force of blood flow on the bifurcation and the disorder characteristics of blood flow, while the size of fenestration changed the WSS distribution on the proximal inner wall and bifurcation region of fenestration. In summary, the nearly‐circular fenestration should be stratified carefully which may results in a high risk inducing unfavorable vascular wall remodeling.
    Type of Medium: Online Resource
    ISSN: 2040-7939 , 2040-7947
    URL: Issue
    URL: Article
    DOI: 10.1002/cnm.v37.9
    DOI: 10.1002/cnm.3507
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2540968-2
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  • 5
    Online Resource
    Online Resource
    Single Flexible Janus Nanobelts to Realize Tunable and Enhanced Simultaneous Photoluminescent, Electrical, and Magnetic Trifunctionality
    Wiley ; 2015
    In:  ChemPlusChem Vol. 80, No. 3 ( 2015-03), p. 568-575
    Details
    In: ChemPlusChem, Wiley, Vol. 80, No. 3 ( 2015-03), p. 568-575
    Abstract: Y 2 O 3 :Eu 3+ nanoparticles (NPs), polyaniline (PANI), and Fe 3 O 4 NPs are incorporated into polymethyl methacrylate (PMMA) and electrospun into [Y 2 O 3 :Eu 3+ /PMMA]//[PANI/Fe 3 O 4 /PMMA] Janus nanobelts with Y 2 O 3 :Eu 3+ /PMMA as one half side and PANI/Fe 3 O 4 /PMMA as the other. The morphology and properties of the final products are investigated in detail by X‐ray diffraction (XRD), scanning electron microscopy (SEM), optical microscopy (OM), energy‐dispersive spectrometry (EDS), Hall effect measurements, fluorescence spectroscopy, vibrating sample magnetometry (VSM), and UV/Vis spectroscopy. The results reveal that the [Y 2 O 3 :Eu 3+ /PMMA]//[PANI/Fe 3 O 4 /PMMA] trifunctional Janus nanobelts possess excellent electrical conductivity, magnetism, and fluorescence owing to their special nanostructure. Fluorescence emission peaks of Eu 3+ are observed in the Janus nanobelts. The electrical conductivity reaches the order of 10 −4  S cm −1 . The luminescent intensity, electrical conductivity, and saturation magnetization of the Janus nanobelts can be tuned by adjusting the respective amounts of Y 2 O 3 :Eu 3+ NPs, PANI, and Fe 3 O 4 NPs. The flexible luminescent‐electrical‐magnetic trifunctional Janus nanobelts have many potential applications. More importantly, this design concept and construct technology is of universal significance for the fabrication of other multifunctional nanostructures.
    Type of Medium: Online Resource
    ISSN: 2192-6506 , 2192-6506
    URL: Issue
    URL: Article
    DOI: 10.1002/cplu.v80.3
    DOI: 10.1002/cplu.201402334
    Language: English
    Publisher: Wiley
    Publication Date: 2015
    detail.hit.zdb_id: 2646595-4
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  • 6
    Online Resource
    Online Resource
    Pharmacokinetics of Opicapone and Its Metabolites in Healthy White and Chinese Subjects
    Wiley ; 2021
    In:  Clinical Pharmacology in Drug Development Vol. 10, No. 11 ( 2021-11), p. 1316-1324
    Details
    In: Clinical Pharmacology in Drug Development, Wiley, Vol. 10, No. 11 ( 2021-11), p. 1316-1324
    Abstract: Opicapone (OPC) is a third‐generation catechol‐O‐methyltransferase inhibitor developed to treat Parkinson disease and motor fluctuations. This open‐label, single‐center, phase 1 study aimed to evaluate the pharmacokinetics (PK) of OPC and its metabolites when administered as single and multiple doses in healthy White and Chinese subjects. The study enrolled a total of 30 White and Chinese healthy subjects, equally balanced among groups. The first dose of OPC was administered orally as a single dose of 50 mg on day 1, followed by a 10‐day once‐daily treatment from day 5 to day 14. Plasma concentrations of OPC and its metabolites were measured at 0 to 72 and 0 to 144 hours after dosing for single dose and multiple dose, respectively. Moreover, urine concentrations of OPC and its metabolite were measured 0 to 24 hours after dosing. PK parameters were derived from noncompartmental analysis. Geometric mean ratios and 90% confidence intervals for the main PK parameters were conducted to evaluate the ethnic difference between White and Chinese subjects. The plasma and urine exposure of OPC and its metabolites in Chinese subjects were similar to those in White subjects. These results indicated that ethnicity had no significant impact on PK of OPC between White and Chinese subjects.
    Type of Medium: Online Resource
    ISSN: 2160-763X , 2160-7648
    URL: Issue
    URL: Article
    DOI: 10.1002/cpdd.v10.11
    DOI: 10.1002/cpdd.922
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2649010-9
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