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  • 1
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    Online Resource
    Deep Brain Stimulation Battery Longevity: Comparison of Monopolar Versus Bipolar Stimulation Modes
    Wiley ; 2016
    In:  Movement Disorders Clinical Practice Vol. 3, No. 4 ( 2016-07), p. 359-366
    Details
    In: Movement Disorders Clinical Practice, Wiley, Vol. 3, No. 4 ( 2016-07), p. 359-366
    Abstract: DBS is an effective treatment for movement disorders, but it is relatively complex, invasive, and costly. Little is known about whether stimulation mode alters pulse generator (battery) longevity in routine clinical care. The aim of this study was to compare battery longevity during monopolar versus bipolar stimulation in patients who underwent DBS for movement disorders. Methods We evaluated 2,902 programming adjustments and calculated the average stimulator settings for 393 batteries in 200 unique patients with Parkinson's disease ( PD ) and essential tremor ( ET ). We classified the pulse generators into different stimulation modes (monopolar, bipolar, tripolar, and double monopolar) and compared battery longevity with Kaplan–Meier's survival analyses using the log‐rank test. We exclusively implanted the Medtronic 3387 lead with adjacent electrode contacts separated by 1.5 mm. Results Mean pulse generator longevity was 47.6 ± 1.6 months regardless of diagnosis or stimulation mode. Bipolar stimulation mode was associated with greater longevity than monopolar stimulation (56.1 ± 3.4 vs. 44.2 ± 2.1 months; P = 0.006). This effect was most pronounced when stimulation parameters were at low‐to‐moderate intensity settings. Double monopolar configuration was associated with less pulse generator longevity than conventional stimulation modes (37.8 ± 5.6 vs. 49.7 ± 1.9; P = 0.014). Conclusion Implanted pulse generators initially programmed in bipolar mode provided 1 year of additional battery longevity versus monopolar mode in this large, retrospective series of patients with ET and PD . Given satisfactory efficacy for motor symptoms, bipolar stimulation mode is a feasible alternative programming strategy at the initiation of DBS therapy.
    Type of Medium: Online Resource
    ISSN: 2330-1619 , 2330-1619
    URL: Article
    DOI: 10.1002/mdc3.12285
    Language: English
    Publisher: Wiley
    Publication Date: 2016
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  • 2
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    Acute phosphodiesterase inhibition improves functional muscle ischemia in patients with Becker muscular dystrophy
    Wiley ; 2012
    In:  The FASEB Journal Vol. 26, No. S1 ( 2012-04)
    Details
    In: The FASEB Journal, Wiley, Vol. 26, No. S1 ( 2012-04)
    Abstract: Loss of sarcolemmal nitric oxide synthase (nNOS) engenders ischemia of exercising dystrophin‐deficient muscles of mdx mice and boys with Duchenne muscular dystrophy. We tested if muscle ischemia also occurs in Becker muscular dystrophy (BMD), a milder disease often caused by dystrophin mutations involving the nNOS binding site, and is improved by tadalafil, a phosphodiesterase (PDE5A) inhibitor that enhances cGMP/NO signaling. We measured reflex vasoconstriction (decreased forearm muscle oxygenation [ΔHb0 2 , near infrared spectroscopy] during lower body negative pressure [LBNP] ) at rest and during rhythmic handgrip (HG) in 5 male controls (Ctrls) and 10 men with BMD who underwent a placebo‐controlled cross‐over trial of single‐dose (20 mg) tadalafil. At baseline, HG greatly attenuated vasoconstriction in Ctrls (ΔHb0 2 :−393±89 vs. −91±40 units, p 〈 .01; rest vs. HG) but caused no attenuation in BMD (−381±45 vs. − 374±46). Tadalafil markedly improved ischemia in BMD (ΔHb0 2 :− 439±70 vs. −230±54, rest vs. HG; p=0.014) whereas placebo had no effect. These data provide the first evidence in man that PDE5A inhibition can improve blood flow regulation in dystrophin‐deficient skeletal muscle. Funded by MDA 201149.
    Type of Medium: Online Resource
    ISSN: 0892-6638 , 1530-6860
    URL: Issue
    URL: Article
    DOI: 10.1096/fsb2.v26.S1
    DOI: 10.1096/fasebj.26.1_supplement.1092.7
    Language: English
    Publisher: Wiley
    Publication Date: 2012
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  • 3
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    The Effects of Differing Knowledge Transfer Strategies on Group Decision Making and Performance
    Wiley ; 2018
    In:  Journal of Behavioral Decision Making Vol. 31, No. 1 ( 2018-01), p. 115-126
    Details
    In: Journal of Behavioral Decision Making, Wiley, Vol. 31, No. 1 ( 2018-01), p. 115-126
    Abstract: Encouraging reflection on one's existing knowledge in a group setting increases shared understanding, makes information available for problem solving, and makes it easier for members to show and to be shown the merit of others' preferences. However, it is also possible that attempting to constrain the process by which problem solvers manage this reflection process may prevent them from effectively tailoring their approach to different problems. The current research focuses on how the nature of different knowledge transfer strategies impacts problem solving processes and outcomes by examining manipulations of, or constraints to, problem solvers' approach to knowledge transfer. Participants were directed to generate associated knowledge in preparation for answering a series of estimation items, either in a group or individually. We found that groups using a shared reflection process (as opposed to reflecting at an individual member level) were able to give more weight to the inputs of their more expert members and that groups outperformed individuals. We discuss the process of promoting knowledge transfer in a group context relative to an individual context and relate this to the concept of task demonstrability. Copyright © 2017 John Wiley & Sons, Ltd.
    Type of Medium: Online Resource
    ISSN: 0894-3257 , 1099-0771
    URL: Issue
    URL: Article
    DOI: 10.1002/bdm.v31.1
    DOI: 10.1002/bdm.2053
    Language: English
    Publisher: Wiley
    Publication Date: 2018
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  • 4
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    Stejneger's beaked whale strandings in Alaska, 1995–2020
    Wiley ; 2021
    In:  Marine Mammal Science Vol. 37, No. 3 ( 2021-07), p. 843-869
    Details
    In: Marine Mammal Science, Wiley, Vol. 37, No. 3 ( 2021-07), p. 843-869
    Abstract: Presented here is the first comprehensive and updated compilation of history, distribution, and findings of Stejneger's beaked whales ( Mesoplodon stejnegeri ) in Alaska. Stejneger's beaked whales are a poorly understood, elusive, deep‐diving cetacean species found in the North Pacific Ocean. Since Stejneger's beaked whale strandings data in Alaska through 1994 were last published, 35 additional strandings have been documented. Twenty‐seven animals stranded in the Aleutian Islands, seven stranded in Southcentral Alaska, and one animal stranded on St. Lawrence Island. Twenty‐two carcasses were necropsied, but only four were fresh. Seventeen of the 22 died during mass stranding events and cause of death could not be definitively determined. Barotrauma was suspected in three cases and infectious disease possibly complicated by barotrauma occurred in two cases. We documented an expansion of strandings into the northern Bering Sea, characterized a sex bias, examined stomach contents that included macroplastic, and identified parasites not previously associated with Stejneger's beaked whales. Also included are data on the largest known mass stranding of Stejneger's beaked whales, which occurred on Adak Island in 2018. The history, distribution, and findings presented here are central to further our understanding of this species.
    Type of Medium: Online Resource
    ISSN: 0824-0469 , 1748-7692
    URL: Issue
    URL: Article
    DOI: 10.1111/mms.v37.3
    DOI: 10.1111/mms.12780
    Language: English
    Publisher: Wiley
    Publication Date: 2021
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    detail.hit.zdb_id: 2218018-7
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  • 5
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    P2‐430: RELATIONSHIPS BETWEEN LONGITUDINAL RATES OF LEARNING AND MEMORY DECLINE AND DIFFERENT FORMS OF CEREBROVASCULAR PATHOLOGY IN COGNITIVELY UNIMPAIRED BRAIN DONORS
    Wiley ; 2019
    In:  Alzheimer's & Dementia Vol. 15, No. 7S_Part_15 ( 2019-07)
    Details
    In: Alzheimer's & Dementia, Wiley, Vol. 15, No. 7S_Part_15 ( 2019-07)
    Type of Medium: Online Resource
    ISSN: 1552-5260 , 1552-5279
    URL: Article
    DOI: 10.1016/j.jalz.2019.06.2837
    Language: English
    Publisher: Wiley
    Publication Date: 2019
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    detail.hit.zdb_id: 2201940-6
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  • 6
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    TRY plant trait database – enhanced coverage and open access
    Wiley ; 2020
    In:  Global Change Biology Vol. 26, No. 1 ( 2020-01), p. 119-188
    Details
    In: Global Change Biology, Wiley, Vol. 26, No. 1 ( 2020-01), p. 119-188
    Abstract: Plant traits—the morphological, anatomical, physiological, biochemical and phenological characteristics of plants—determine how plants respond to environmental factors, affect other trophic levels, and influence ecosystem properties and their benefits and detriments to people. Plant trait data thus represent the basis for a vast area of research spanning from evolutionary biology, community and functional ecology, to biodiversity conservation, ecosystem and landscape management, restoration, biogeography and earth system modelling. Since its foundation in 2007, the TRY database of plant traits has grown continuously. It now provides unprecedented data coverage under an open access data policy and is the main plant trait database used by the research community worldwide. Increasingly, the TRY database also supports new frontiers of trait‐based plant research, including the identification of data gaps and the subsequent mobilization or measurement of new data. To support this development, in this article we evaluate the extent of the trait data compiled in TRY and analyse emerging patterns of data coverage and representativeness. Best species coverage is achieved for categorical traits—almost complete coverage for ‘plant growth form’. However, most traits relevant for ecology and vegetation modelling are characterized by continuous intraspecific variation and trait–environmental relationships. These traits have to be measured on individual plants in their respective environment. Despite unprecedented data coverage, we observe a humbling lack of completeness and representativeness of these continuous traits in many aspects. We, therefore, conclude that reducing data gaps and biases in the TRY database remains a key challenge and requires a coordinated approach to data mobilization and trait measurements. This can only be achieved in collaboration with other initiatives.
    Type of Medium: Online Resource
    ISSN: 1354-1013 , 1365-2486
    URL: Issue
    URL: Article
    DOI: 10.1111/gcb.v26.1
    DOI: 10.1111/gcb.14904
    Language: English
    Publisher: Wiley
    Publication Date: 2020
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    detail.hit.zdb_id: 2020313-5
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  • 7
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    Tourette syndrome deep brain stimulation: A review and updated recommendations
    Wiley ; 2015
    In:  Movement Disorders Vol. 30, No. 4 ( 2015-04), p. 448-471
    Details
    In: Movement Disorders, Wiley, Vol. 30, No. 4 ( 2015-04), p. 448-471
    Abstract: Deep brain stimulation (DBS) may improve disabling tics in severely affected medication and behaviorally resistant Tourette syndrome (TS). Here we review all reported cases of TS DBS and provide updated recommendations for selection, assessment, and management of potential TS DBS cases based on the literature and implantation experience. Candidates should have a Diagnostic and Statistical Manual of Mental Disorders , Fifth Edition (DSM V) diagnosis of TS with severe motor and vocal tics, which despite exhaustive medical and behavioral treatment trials result in significant impairment. Deep brain stimulation should be offered to patients only by experienced DBS centers after evaluation by a multidisciplinary team. Rigorous preoperative and postoperative outcome measures of tics and associated comorbidities should be used. Tics and comorbid neuropsychiatric conditions should be optimally treated per current expert standards, and tics should be the major cause of disability. Psychogenic tics, embellishment, and malingering should be recognized and addressed. We have removed the previously suggested 25‐year‐old age limit, with the specification that a multidisciplinary team approach for screening is employed. A local ethics committee or institutional review board should be consulted for consideration of cases involving persons younger than 18 years of age, as well as in cases with urgent indications. Tourette syndrome patients represent a unique and complex population, and studies reveal a higher risk for post‐DBS complications. Successes and failures have been reported for multiple brain targets; however, the optimal surgical approach remains unknown. Tourette syndrome DBS, though still evolving, is a promising approach for a subset of medication refractory and severely affected patients. © 2014 International Parkinson and Movement Disorder Society
    Type of Medium: Online Resource
    ISSN: 0885-3185 , 1531-8257
    URL: Issue
    URL: Article
    DOI: 10.1002/mds.v30.4
    DOI: 10.1002/mds.26094
    RVK:
    XA 10000
    Language: English
    Publisher: Wiley
    Publication Date: 2015
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  • 8
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    Habitat prioritization across large landscapes, multiple seasons, and novel areas: An example using greater sage‐grouse in Wyoming
    Wiley ; 2014
    In:  Wildlife Monographs Vol. 190, No. 1 ( 2014-09), p. 1-39
    Details
    In: Wildlife Monographs, Wiley, Vol. 190, No. 1 ( 2014-09), p. 1-39
    Abstract: Sélection de l'habitat abstrait animal est un domaine important et vaste de la recherche en écologie. En particulier, l'étude de la sélection de l'habitat est essentiel dans l'habitat efforts de priorisation pour les espèces préoccupantes de conservation. L'aménagement du paysage pour species qui se passe à des degrés toujours plus en raison de l'appréciation du rôle de modèles échelle du paysage dans la persistance de l'espèce couplé à l'amélioration des ensembles de données pour les espèces et les habitats, et l'empreinte s'étend et s'intensifie de l homme et utilise le paysage. Nous présentons un effort de collaboration à grande échelle pour développer des modèles de sélection de l'habitat à travers de vastes paysages et de multiples saisons pour priorité l'habitat d'une espèce préoccupante de conservation. Tétras des armoises ( Centrocercus urophasianus , ci‐après tétras des armoises) se produire dans des paysages semi‐arides de l'ouest en Amérique du Nord. déclin de la population Gamme échelle de cette espèce ont été documentés, et il est actuellement considéré comme «justifiée mais empêché” de l'inscription en vertu dela Loi sur les espèces en voie de disparition aux États‐Unis. Wyoming devrait demeurer un bastion pour les populations de Tétras des armoises et contient environ 37% des oiseaux restants. Nous avons compilé les données de localisation à partir de 14 études de télémesure uniques (données recueillies 1994–2010) et les données de l'habitat de haute qualité du système, de l'information géographique d'intérêt biologique (SIG) couches dans le Wyoming. Nous avons développé des modèles de sélection de l'habitat pour les tétras des armoises dans le Wyoming pour trois étapes de la vie distincts: 1) la nidification, 2) été, et 3) l'hiver. Nous avons développé des modèles de patch et du paysage à travers 4 degrés, la production de tout l'État et régionale (sud‐ouest, nord‐est, centrales) des modèles pour le Wyoming. Sélection de l'habitat varie selon les régions et les saisons, encore attri de l'habitat préféré tes généralement identifié la vaste littérature sur Tétras des armoises besoins en habitat de saison. Les saisons et les régions, les oiseaux préfèrent les zones avec une plus grande couverture de pourcentage de l'armoise et de routes pavées évitées, l'agriculture et les zones boisées. Oiseaux zones toujours privilégiées avec des précipitations plus abondantes en été et le terrain accidenté éviter en hiver. Sélection pour la couverture d'armoise varier régional avec forte sélection dans la région Nord‐Est, probablement en raison de la disponibilité limitée, tandis que l'évitement des routes revêtues est assez cohérente dans toutes les régions. Nous avons choisi la fonction de sélection des ressources (RSF) seuils pour chaque ensemble de modèles (saisonnière combinaison régional) qui cernait les habitats saisonniers importants pour tétras des armoises. Chaque model ensemble a montré une bonne validation et capacités discriminatoires dans les limites étude de site. Nous avons appliqué les modèles de nidification saison à un nouveau domaine non inclus dans l'élaboration du modèle. Le pourcentage de sites de nidification indépendants qui tombait directement avec dans un habitat important identifié n'était pas trop impressionnant dans la zone roman (49%); cependant, y compris un 500‐m tampon autour des habitats importants capturé 98% des sites de nidification indépendants dans la zone roman. Nous avons également utilisé les arènes et le pic mâle associé compte comme un proxy pour un habitat de nidification à l'extérieur des sites d'étude utilisées pour élaborer des modèles. A 1.5 km tampon autour des importantes limites de l'habitat de nidification inclus 77% des hommes recensés au leks dans le Wyoming en dehors des sites d'étude. Les données n'étaient pas disponibles pour quantitatively tester les performances des modèles d'été et d'hiver en dehors de nos sites d'étude. La collection de modèles présentés ici représente des outils de planification des ressources de gestion à grande échelle qui sont une avancée significative à outils précédents en teefficace de la résolution spatiale et temporelle.
    Type of Medium: Online Resource
    ISSN: 0084-0173 , 1938-5455
    URL: Issue
    URL: Article
    DOI: 10.1002/wmon.v190.1
    DOI: 10.1002/wmon.1014
    Language: English
    Publisher: Wiley
    Publication Date: 2014
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    detail.hit.zdb_id: 2067304-8
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  • 9
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    Interseasonal movements of greater sage‐grouse, migratory behavior, and an assessment of the core regions concept in Wyoming
    Wiley ; 2012
    In:  The Journal of Wildlife Management Vol. 76, No. 5 ( 2012-07), p. 1062-1071
    Details
    In: The Journal of Wildlife Management, Wiley, Vol. 76, No. 5 ( 2012-07), p. 1062-1071
    Abstract: Animals can require different habitat types throughout their annual cycles. When considering habitat prioritization, we need to explicitly consider habitat requirements throughout the annual cycle, particularly for species of conservation concern. Understanding annual habitat requirements begins with quantifying how far individuals move across landscapes between key life stages to access required habitats. We quantified individual interseasonal movements for greater sage‐grouse ( Centrocercus urophasianus ; hereafter sage‐grouse) using radio‐telemetry spanning the majority of the species distribution in Wyoming. Sage‐grouse are currently a candidate for listing under the United States Endangered Species Act and Wyoming is predicted to remain a stronghold for the species. Sage‐grouse use distinct seasonal habitats throughout their annual cycle for breeding, brood rearing, and wintering. Average movement distances in Wyoming from nest sites to summer‐late brood‐rearing locations were 8.1 km (SE = 0.3 km; n  = 828 individuals) and the average subsequent distances moved from summer sites to winter locations were 17.3 km (SE = 0.5 km; n  = 607 individuals). Average nest‐to‐winter movements were 14.4 km (SE = 0.6 km; n  = 434 individuals). We documented remarkable variation in the extent of movement distances both within and among sites across Wyoming, with some individuals remaining year‐round in the same vicinity and others moving over 50 km between life stages. Our results suggest defining any of our populations as migratory or non‐migratory is innappropriate as individual strategies vary widely. We compared movement distances of birds marked using Global Positioning System (GPS) and very high frequency (VHF) radio marking techniques and found no evidence that the heavier GPS radios limited movement. Furthermore, we examined the capacity of the sage‐grouse core regions concept to capture seasonal locations. As expected, we found the core regions approach, which was developed based on lek data, was generally better at capturing the nesting locations than summer or winter locations. However, across Wyoming the sage‐grouse breeding core regions still contained a relatively high percentage of summer and winter locations and seem to be a reasonable surrogate for non‐breeding habitat when no other information exists. We suggest that conservation efforts for greater sage‐grouse implicitly incorporate seasonal habitat needs because of high variation in the amount of overlap among breeding core regions and non‐breeding habitat. © 2012 The Wildlife Society.
    Type of Medium: Online Resource
    ISSN: 0022-541X , 1937-2817
    URL: Issue
    URL: Article
    DOI: 10.1002/jwmg.v76.5
    DOI: 10.1002/jwmg.337
    Language: English
    Publisher: Wiley
    Publication Date: 2012
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    detail.hit.zdb_id: 2066663-9
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  • 10
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    Abstracts from the Food Allergy and Anaphylaxis Meeting 2016
    Wiley ; 2017
    In:  Clinical and Translational Allergy Vol. 7, No. S1 ( 2017-3)
    Details
    In: Clinical and Translational Allergy, Wiley, Vol. 7, No. S1 ( 2017-3)
    Type of Medium: Online Resource
    ISSN: 2045-7022
    URL: Article
    DOI: 10.1186/s13601-017-0142-2
    Language: English
    Publisher: Wiley
    Publication Date: 2017
    detail.hit.zdb_id: 2630865-4
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