In:
Annals of the New York Academy of Sciences, Wiley, Vol. 936, No. 1 ( 2001-06), p. 526-530
Abstract:
A bstract : We found a novel genetic abnormality, heterozygous C→T nucleotide substitution at position −1138 bp in the 5′‐flanking region of the fibrinogen Aα gene, in patients with hypofibrinogenemia. Luciferase reporter assay using the pGL3‐basic vector and CHO cells indicates that the transcriptional activity of a vector incorporated with −1138T was reduced to one‐third that of a vector incorporated with −1138C. These results suggest that the region adjacent to the −1138C bp of the 5′‐flanking region of the fibrinogen Aα gene is one of the most crucial sites for the transcription of the fibrinogen Aα gene.
Type of Medium:
Online Resource
ISSN:
0077-8923
,
1749-6632
DOI:
10.1111/nyas.2001.936.issue-1
DOI:
10.1111/j.1749-6632.2001.tb03539.x
Language:
English
Publisher:
Wiley
Publication Date:
2001
detail.hit.zdb_id:
2834079-6
detail.hit.zdb_id:
211003-9
detail.hit.zdb_id:
2071584-5
SSG:
11
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