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  • 1
    Online Resource
    Online Resource
    Anti‐inflammatory effects of cordycepin: A review
    Wiley ; 2021
    In:  Phytotherapy Research Vol. 35, No. 3 ( 2021-03), p. 1284-1297
    Details
    In: Phytotherapy Research, Wiley, Vol. 35, No. 3 ( 2021-03), p. 1284-1297
    Abstract: Cordycepin is the major bioactive component extracted from Cordyceps militaris . In recent years, cordycepin has received increasing attention owing to its multiple pharmacological activities. This study reviews recent researches on the anti‐inflammatory effects and the related activities of cordycepin. The results from our review indicate that cordycepin exerts protective effects against inflammatory injury for many diseases including acute lung injury (ALI), asthma, rheumatoid arthritis, Parkinson's disease (PD), hepatitis, atherosclerosis, and atopic dermatitis. Cordycepin regulates the NF‐κB, RIP2/Caspase‐1, Akt/GSK‐3β/p70S6K, TGF‐β/Smads, and Nrf2/HO‐1 signaling pathways among others. Several studies focusing on cordycepin derivatives were reviewed and found to down metabolic velocity of cordycepin and increase its bioavailability. Moreover, cordycepin enhanced immunity, inhibited the proliferation of viral RNA, and suppressed cytokine storms, thereby suggesting its potential to treat COVID‐19 and other viral infections. From the collected and reviewed information, this article provides the theoretical basis for the clinical applications of cordycepin and discusses the path for future studies focusing on expanding the medicinal use of cordycepin. Taken together, cordycepin and its analogs show great potential as the next new class of anti‐inflammatory agents.
    Type of Medium: Online Resource
    ISSN: 0951-418X , 1099-1573
    URL: Issue
    URL: Article
    DOI: 10.1002/ptr.v35.3
    DOI: 10.1002/ptr.6890
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 1493490-5
    SSG: 15,3
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  • 2
    Online Resource
    Online Resource
    Mono‐Active Bimetallic Oxide Co 2 AlO 4 with Yolk‐Shell Structure as a Superior Lithium‐Storage Material
    Wiley ; 2019
    In:  ChemElectroChem Vol. 6, No. 13 ( 2019-07), p. 3298-3302
    Details
    In: ChemElectroChem, Wiley, Vol. 6, No. 13 ( 2019-07), p. 3298-3302
    Abstract: The mono‐active bimetallic oxide Co 2 AlO 4 with microsphere morphology and yolk‐shell structure are synthesized and first evaluated as anode materials for lithium ion batteries. The electrochemically inactive Al element disperse well in the material at an atomic‐scale level, which can effectively alleviate volume expansion during the cycling and heighten the electrochemical reaction kinetics. Moreover, the yolk‐shell structure provides adequate buffer space for volume expansion. Benefited from the synergy effect of the yolk‐shell structure and uniformly element Al distribution, the yolk‐shell Co 2 AlO 4 delivers a discharge capacity of 661 mAh g −1 at 1000 mA g −1 after 500 cycles with a capacity retention ratio of 86.4 %, and maintains a high discharge capacity of 548 mAh g −1 at 3200 mA g −1 , showing excellent long‐term cycle performance and rate capability.
    Type of Medium: Online Resource
    ISSN: 2196-0216 , 2196-0216
    URL: Issue
    URL: Article
    DOI: 10.1002/celc.v6.13
    DOI: 10.1002/celc.201900594
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 2724978-5
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  • 3
    Online Resource
    Online Resource
    Anti‐inflammatory activities of natural cyclopeptide RA‐XII in colitis‐associated colon cancer mouse model and its effect on gut microbiome
    Wiley ; 2022
    In:  Phytotherapy Research Vol. 36, No. 6 ( 2022-06), p. 2641-2659
    Details
    In: Phytotherapy Research, Wiley, Vol. 36, No. 6 ( 2022-06), p. 2641-2659
    Abstract: Colorectal cancer (CRC), the third most common cancer globally, is associated with intestinal inflammation that leads to poor prognosis. RA‐XII, a natural cyclopeptide, has previously been reported to possess anti‐tumor activities. Here, the anti‐inflammatory activities of RA‐XII were investigated in colitis‐associated colon cancer mice and a co‐culture in vitro model, in which colon cancer cells HCT116 and macrophages RAW264.7 were grown together to mimic the inflammatory microenvironment of CRC. Changes of inflammatory‐related molecules and protein expressions in cells were evaluated after RA‐XII incubation. Besides, azoxymethane and dextran sulfate sodium‐induced colitis‐associated colon cancer mice were treated with RA‐XII for 24 days, inflammatory parameters and gut microbiome alterations were studied. Our results showed that RA‐XII reversed the inflammatory responses of RAW264.7 cells induced by LPS and modulated the protein expressions of AKT, STAT3/p‐STAT3, P70S6K, NF‐κB and GSK3β and suppressed the expression of LC3A/B in HCT116 cells in co‐culture system. RA‐XII treatment restored the colitis damage in colon, reduced colon tumors numbers and decreased inflammatory factors (IL‐6, IL‐10 and TNF‐α). The role of RA‐XII on regulating gut microbiome was also demonstrated for the first time. In conclusion, our findings provided new scientific evidence for developing RA‐XII as a potent anti‐inflammatory agent for CRC.
    Type of Medium: Online Resource
    ISSN: 0951-418X , 1099-1573
    URL: Issue
    URL: Article
    DOI: 10.1002/ptr.v36.6
    DOI: 10.1002/ptr.7482
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 1493490-5
    SSG: 15,3
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  • 4
    Online Resource
    Online Resource
    Preparation of reusable bioreactors using reversible immobilization of enzyme on monolithic porous polymer support with attached gold nanoparticles
    Wiley ; 2014
    In:  Biotechnology and Bioengineering Vol. 111, No. 1 ( 2014-01), p. 50-58
    Details
    In: Biotechnology and Bioengineering, Wiley, Vol. 111, No. 1 ( 2014-01), p. 50-58
    Abstract: Porcine lipase has been reversibly immobilized on a monolithic polymer support containing thiol functionalities prepared within confines of a fused silica capillary and functionalized with gold nanoparticles. Use of gold nanoparticles enabled rejuvenation of the activity of the deactivated reactor simply by stripping the inactive enzyme from the nanoparticles using 2‐mercaptoethanol and subsequent immobilization of fresh lipase. This flow through enzymatic reactor was then used to catalyze the hydrolysis of glyceryl tributyrate (tributyrin). The highest activity was found within a temperature range of 37–40°C. The reaction kinetics is characterized by Michaelis–Menten constant, K m  = 10.9 mmol/L, and maximum reaction rate, V max  = 5.0 mmol/L min. The maximum reaction rate for the immobilized enzyme is 1,000 times faster compared to lipase in solution. The fast reaction rate enabled to achieve 86.7% conversion of tributyrin in mere 2.5 min and an almost complete conversion in 10 min. The reactor lost only less than 10% of its activity even after continuous pumping through it a solution of substrate equaling 1,760 reactor volumes. Finally, potential application of this enzymatic reactor was demonstrated with the transesterification of triacylglycerides from kitchen oil to fatty acid methyl esters thus demonstrating the ability of the reactor to produce biodiesel. Biotechnol. Bioeng. 2014;111: 50–58. © 2013 Wiley Periodicals, Inc.
    Type of Medium: Online Resource
    ISSN: 0006-3592 , 1097-0290
    URL: Issue
    URL: Article
    DOI: 10.1002/bit.v111.1
    DOI: 10.1002/bit.25005
    Language: English
    Publisher: Wiley
    Publication Date: 2014
    detail.hit.zdb_id: 1480809-2
    detail.hit.zdb_id: 280318-5
    SSG: 12
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  • 5
    Online Resource
    Online Resource
    Ubiquitin C‐terminal hydrolase L1 promotes expression of programmed cell death‐ligand 1 in non‐small‐cell lung cancer cells
    Wiley ; 2020
    In:  Cancer Science Vol. 111, No. 9 ( 2020-09), p. 3174-3183
    Details
    In: Cancer Science, Wiley, Vol. 111, No. 9 ( 2020-09), p. 3174-3183
    Abstract: Programmed cell death‐ligand 1 (PD‐L1) expressed on cancer cells can cause immune escape of non‐small‐cell lung cancer (NSCLC). Elucidation of the regulatory mechanisms of the PD‐L1 expression is a prerequisite for establishing new tumor immunotherapy strategies. Ubiquitin C‐terminal hydrolase L1 (UCHL1) is a regulator of cellular signaling transduction that is aberrantly expressed in NSCLC. However, it is not known whether UCHL1 regulates the expression of PD‐L1 in NSCLC cells. In the present study, we found that UCHL1 promotes the expression of PD‐L1 in NSCLC cell lines. In addition, UCHL1 expressed in NSCLC cells inhibited activation of Jurkat cells through upregulation of PD‐L1 expression in in vitro experiments. Moreover, UCHL1 upregulates PD‐L1 expression through facilitating activation of the AKT‐P65 signaling pathway. In conclusion, these results indicated that UCHL1 promoted PD‐L1 expression in NSCLC cells. This finding implied that inhibition of UCHL1 might suppress immune escape of NSCLC through downregulation of PD‐L1 expression in NSCLC cells.
    Type of Medium: Online Resource
    ISSN: 1347-9032 , 1349-7006
    URL: Issue
    URL: Article
    DOI: 10.1111/cas.v111.9
    DOI: 10.1111/cas.14529
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2115647-5
    detail.hit.zdb_id: 2111204-6
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  • 6
    Online Resource
    Online Resource
    Multifunctional Separator with Porous Carbon/Multi‐Walled Carbon Nanotube Coating for Advanced Lithium−Sulfur Batteries
    Wiley ; 2018
    In:  ChemElectroChem Vol. 5, No. 1 ( 2018-01-02), p. 71-77
    Details
    In: ChemElectroChem, Wiley, Vol. 5, No. 1 ( 2018-01-02), p. 71-77
    Abstract: An issue associated with lithium−sulfur (Li−S) batteries is polysulfide dissolution, leading to the serious crossover of polysulfide to the Li anode. To address this issue, we report on a multifunctional separator prepared by introducing a porous carbon/multi‐walled carbon nanotube (PC/MWCNT) composite into a commercial separator. It shows that the PC/MWCNT composite is able to enhance the interfacial interaction between the coating and the polysulfide and provides a large surface area for absorbing the polysulfide, thus improving the electrical conductivity. It has been demonstrated that the Li−S cell constructed with the PC/MWCNT composite separator results in a reversible capacity as high as 659 mAh g −1 after 200 cycles at 0.5 C, and the average capacity fading rate of the cell is about 0.138 % per cycle. The performance improvement is attributed to a reduction in the crossover rate of polysulfide through the composite separator as a result of the polysulfide absorption by PC/MWCNT layer.
    Type of Medium: Online Resource
    ISSN: 2196-0216 , 2196-0216
    URL: Issue
    URL: Article
    DOI: 10.1002/celc.v5.1
    DOI: 10.1002/celc.201700986
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2724978-5
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  • 7
    Online Resource
    Online Resource
    Preparation of a surface molecular‐imprinted adsorbent for Ni 2+ based on Penicillium chrysogenum
    Wiley ; 2005
    In:  Journal of Chemical Technology & Biotechnology Vol. 80, No. 4 ( 2005-04), p. 439-444
    Details
    In: Journal of Chemical Technology & Biotechnology, Wiley, Vol. 80, No. 4 ( 2005-04), p. 439-444
    Abstract: A new chitosan molecular‐imprinted adsorbent was prepared from the mycelium of waste biomass. The results showed that an adsorbent using Penicillium chrysogenum mycelium as the core material was better than one derived from peanut coat. The adsorption capacity of the surface‐imprinted adsorbent for Ni 2+ was enhanced by increasing the chitosan concentration in the imprinting process. Epichlorohydrin was better than glutaraldehyde as a cross‐linking agent; the optimal imprinted Ni 2+ concentration for preparing the surface‐imprinted adsorbent was 2 mg (Ni 2+ ) g −1 of mycelium. The adsorption capacity of the surface‐imprinted adsorbent was 42 mg g −1 (at 200 mg dm −3 initial metal ions concentration) and twice that of the mycelium adsorbent. The surface‐imprinted adsorbent can be reused for up to 15 cycles without loss of adsorption capacity. Copyright © 2005 Society of Chemical Industry
    Type of Medium: Online Resource
    ISSN: 0268-2575 , 1097-4660
    URL: Issue
    URL: Article
    DOI: 10.1002/jctb.v80:4
    DOI: 10.1002/jctb.1206
    Language: English
    Publisher: Wiley
    Publication Date: 2005
    detail.hit.zdb_id: 1479465-2
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  • 8
    Online Resource
    Online Resource
    Pre‐buried Interface Strategy for Stable Inverted Perovskite Solar Cells Based on Ordered Nucleation Crystallization
    Wiley ; 2023
    In:  Advanced Functional Materials Vol. 33, No. 45 ( 2023-11)
    Details
    In: Advanced Functional Materials, Wiley, Vol. 33, No. 45 ( 2023-11)
    Abstract: The buried interface has important effect on carrier extraction and nonradiative recombination of perovksite solar cells (PSCs). Herein, to inactivate the buried interfacial defects of perovskite and boost the crystallization quality of perovskite film, 3‐amino‐1‐adamantanol (AAD) serves as a pre‐buried interface modifier on nickel oxide (NiO x ) surface to regulate the nucleation and crystallization process of perovskite precursor. The amino and hydroxyl groups in AAD molecule can synchronously coordinate with nickel ion (Ni 3+ ) in NiO x and lead ion in perovskite, respectively. The dual action favors the ordered arrangement of AAD molecules between NiO x and perovskite, which not only enhances hole extraction in hole transport layer, but also provides active sites for homogeneous nucleation. Furthermore, AAD modifier blocks the unfavorable reaction between Ni 3+ and perovskite, and effectively passivates the buried interfacial defects. The optimal inverted PSCs achieve a champion power conversion efficiency of 22.21% with negligible hysteresis, favorable thermal, optical, and long‐term stability. Thus, this strategy of modulating perovskite nucleation and crystallization by pre‐buried modifier is feasible for achieving efficient and stable inverted perovskite solar cells.
    Type of Medium: Online Resource
    ISSN: 1616-301X , 1616-3028
    URL: Issue
    URL: Article
    DOI: 10.1002/adfm.v33.45
    DOI: 10.1002/adfm.202305013
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2029061-5
    detail.hit.zdb_id: 2039420-2
    SSG: 11
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