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  • 1
    In: Acute Medicine & Surgery, Wiley, Vol. 8, No. 1 ( 2021-01)
    Abstract: The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2020 (J‐SSCG 2020), a Japanese‐specific set of clinical practice guidelines for sepsis and septic shock created as revised from J‐SSCG 2016 jointly by the Japanese Society of Intensive Care Medicine and the Japanese Association for Acute Medicine, was first released in September 2020 and published in February 2021. An English‐language version of these guidelines was created based on the contents of the original Japanese‐language version. The purpose of this guideline is to assist medical staff in making appropriate decisions to improve the prognosis of patients undergoing treatment for sepsis and septic shock. We aimed to provide high‐quality guidelines that are easy to use and understand for specialists, general clinicians, and multidisciplinary medical professionals. J‐SSCG 2016 took up new subjects that were not present in SSCG 2016 (e.g., ICU‐acquired weakness [ICU‐AW], post‐intensive care syndrome [PICS] , and body temperature management). The J‐SSCG 2020 covered a total of 22 areas with four additional new areas (patient‐ and family‐centered care, sepsis treatment system, neuro‐intensive treatment, and stress ulcers). A total of 118 important clinical issues (clinical questions, CQs) were extracted regardless of the presence or absence of evidence. These CQs also include those that have been given particular focus within Japan. This is a large‐scale guideline covering multiple fields; thus, in addition to the 25 committee members, we had the participation and support of a total of 226 members who are professionals (physicians, nurses, physiotherapists, clinical engineers, and pharmacists) and medical workers with a history of sepsis or critical illness. The GRADE method was adopted for making recommendations, and the modified Delphi method was used to determine recommendations by voting from all committee members. As a result, 79 GRADE‐based recommendations, 5 Good Practice Statements (GPS), 18 expert consensuses, 27 answers to background questions (BQs), and summaries of definitions and diagnosis of sepsis were created as responses to 118 CQs. We also incorporated visual information for each CQ according to the time course of treatment, and we will also distribute this as an app. The J‐SSCG 2020 is expected to be widely used as a useful bedside guideline in the field of sepsis treatment both in Japan and overseas involving multiple disciplines.
    Type of Medium: Online Resource
    ISSN: 2052-8817 , 2052-8817
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2751184-4
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  • 2
    In: Head & Neck, Wiley, Vol. 20, No. 5 ( 1998-08), p. 392-398
    Type of Medium: Online Resource
    ISSN: 1043-3074 , 1097-0347
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 1998
    detail.hit.zdb_id: 2001440-5
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  • 3
    In: Cancer Science, Wiley, Vol. 112, No. 4 ( 2021-04), p. 1579-1588
    Abstract: Traditional observational studies have reported a positive association between higher body mass index (BMI) and the risk of colorectal cancer (CRC). However, evidence from other approaches to pursue the causal relationship between BMI and CRC is sparse. A two‐sample Mendelian randomization (MR) study was undertaken using 68 single nucleotide polymorphisms (SNPs) from the Japanese genome‐wide association study (GWAS) and 654 SNPs from the GWAS catalogue for BMI as sets of instrumental variables. For the analysis of SNP‐BMI associations, we undertook a meta‐analysis with 36 303 participants in the Japanese Consortium of Genetic Epidemiology studies (J‐CGE), comprising normal populations. For the analysis of SNP‐CRC associations, we utilized 7636 CRC cases and 37 141 controls from five studies in Japan, and undertook a meta‐analysis. Mendelian randomization analysis of inverse‐variance weighted method indicated that a one‐unit (kg/m 2 ) increase in genetically predicted BMI was associated with an odds ratio of 1.13 (95% confidence interval, 1.06‐1.20; P value 〈 .001) for CRC using the set of 68 SNPs, and an odds ratio of 1.07 (1.03‐1.11, 0.001) for CRC using the set of 654 SNPs. Sensitivity analyses robustly showed increased odds ratios for CRC for every one‐unit increase in genetically predicted BMI. Our MR analyses strongly support the evidence that higher BMI influences the risk of CRC. Although Asians are generally leaner than Europeans and North Americans, avoiding higher BMI seems to be important for the prevention of CRC in Asian populations.
    Type of Medium: Online Resource
    ISSN: 1347-9032 , 1349-7006
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2115647-5
    detail.hit.zdb_id: 2111204-6
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  • 4
    In: Pulmonary Circulation, Wiley, Vol. 11, No. 1 ( 2021-01), p. 1-11
    Abstract: Pulmonary arterial hypertension (PAH) remains a disease with a poor prognosis, so early detection and treatment are very important. Sensitive and non‐invasive markers for PAH are urgently required. This study was performed to identify sensitive markers of the clinical severity and prognosis of PAH. Patients diagnosed with PAH (n = 30) and control participants (n = 15) were enrolled in this observational study. Major EPC and MSC markers (including CD34, CD133, VEGFR2, CD90, PDGFRα, and NGFR) in peripheral blood mononuclear cells (PBMNCs) were assessed by flow cytometry. Associations of these markers with hemodynamic parameters (e.g. mean pulmonary arterial pressure, pulmonary vascular resistance, and cardiac index) were assessed. Patients with PAH were followed up for 12 months to assess the incidence of major adverse events, defined as death or lung transplantation. Levels of circulating EPC and MSC markers in PBMNCs were higher in patients with PAH than in control participants. Among the studied markers, nerve growth factor receptor (NGFR) was significantly positively correlated with hemodynamic parameters. During the 12‐month follow‐up period, major‐event‐free survival was significantly higher in patients with PAH who had relatively low frequencies of NGFR positive cells than patients who had higher frequencies. These results suggested that the presence of circulating NGFR positive cells among PBMNCs may be a novel biomarker for the severity and prognosis of PAH.
    Type of Medium: Online Resource
    ISSN: 2045-8940 , 2045-8940
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2638089-4
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  • 5
    Online Resource
    Online Resource
    Wiley ; 1994
    In:  Pediatrics International Vol. 36, No. 3 ( 1994-06), p. 333-335
    In: Pediatrics International, Wiley, Vol. 36, No. 3 ( 1994-06), p. 333-335
    Type of Medium: Online Resource
    ISSN: 1328-8067
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 1994
    detail.hit.zdb_id: 2008621-0
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  • 6
    Online Resource
    Online Resource
    Wiley ; 2011
    In:  Progress in Photovoltaics: Research and Applications Vol. 19, No. 2 ( 2011-03), p. 170-179
    In: Progress in Photovoltaics: Research and Applications, Wiley, Vol. 19, No. 2 ( 2011-03), p. 170-179
    Abstract: Various kinds of photovoltaic (PV) modules have been developed and practically operated as PV systems up to present. Investigation of the long‐term reliability of PV modules is indispensable for the use of PV systems as reliable energy sources. In this study, we show the results of outdoor exposure test in which the performance of 14 PV modules composed of five different kinds made by six different PV manufacturers have been measured since July 2004. The average performance is calculated in each year from 2005 to 2008, and the performance degradation is quantitatively evaluated. The results are that the magnitude of the performance degradation can be clearly classified by the kinds of the PV modules. The performance difference of the single‐crystalline silicon (sc‐Si) modules between 2005 and 2008 is from 1.9% to 2.8%. Polycrystalline silicon (pc‐Si) modules show performance degradation from 0.7% to 1.4%. The performance of an amorphous silicon/crystalline silicon (a‐Si:H/c‐Si) decreased by 0.7%. Although a pair of a‐Si modules had been already exposed to sunlight for about 6 months, the pair of modules show 4.4% of performance degradation. More than half of the performance degradation happened during the initial period from 2005 to 2006. This indicates that it takes about 2 years until the performance of a‐Si modules is stable. The performance is quite stable after 2006. Interestingly, the performance of the cupper indium gallium diselenide modules in 2008 is about 0.8% higher than that in 2005. Copyright © 2010 John Wiley & Sons, Ltd.
    Type of Medium: Online Resource
    ISSN: 1062-7995 , 1099-159X
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2011
    detail.hit.zdb_id: 2023295-0
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  • 7
    In: Angewandte Chemie, Wiley, Vol. 121, No. 10 ( 2009-02-23), p. 1798-1802
    Abstract: MOF im MOF: Einkristalle eines porösen Kern‐Schale‐Koordinationspolymers (PCP) wurden durch epitaxiales Wachstum in Lösung erzeugt. Synchrotron‐Röntgenbeugungsmessungen offenbarten die strukturellen Beziehungen zwischen dem Kern‐ und Schalenkristall: Ein epitaxiales Wachstum in verdrehter Orientierung gleicht die unterschiedlichen Gitterkonstanten aus. magnified image
    Type of Medium: Online Resource
    ISSN: 0044-8249 , 1521-3757
    URL: Issue
    RVK:
    RVK:
    Language: German
    Publisher: Wiley
    Publication Date: 2009
    detail.hit.zdb_id: 505868-5
    detail.hit.zdb_id: 506609-8
    detail.hit.zdb_id: 514305-6
    detail.hit.zdb_id: 505872-7
    detail.hit.zdb_id: 1479266-7
    detail.hit.zdb_id: 505867-3
    detail.hit.zdb_id: 506259-7
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  • 8
    Online Resource
    Online Resource
    Wiley ; 2010
    In:  Progress in Photovoltaics: Research and Applications Vol. 18, No. 5 ( 2010-08), p. 363-370
    In: Progress in Photovoltaics: Research and Applications, Wiley, Vol. 18, No. 5 ( 2010-08), p. 363-370
    Abstract: In order to disseminate Photovoltaic (PV) technologies into the energy network, the cost down is not only important, but also improving the performance of the PV system is significant issues. Long‐term reliability is one of the most important issues in terms of PV system performance. Previous researches were mainly focused on the reliability of PV modules, but the PV system is composed of a power conditioner, wiring, junction box, and so on. To improve the reliability of PV systems, it is important to accumulate trouble cases focused on all components of PV system. In this paper, we aim at evaluation of the reliability for the PV system on the early stages of PV system's lifetime by using large number of Japanese PV systems' data from the field Test in Japan. New Energy and Industrial Technology Development Organization has been running the “Field test project in Japan” from 1992. In this project, PV system users have cooperated with the collection of monitoring data and reported on the information of maintenance and certain failures of PV systems for 4 years after installation of PV system. Using those reports each year of installation, we evaluated reliability of PV systems by means of parameters such as Mean Time Between Failure, Mean Time To Repair, and the suspension time of PV system. As a result, the main trouble of PV systems was related power conditioner, and a few trouble of PV module was caused by typhoon. Moreover, the trend of the failure rate before FY 2000 of installation was demonstrated as the trend of initial failure in “bathtub curve;” however, the trend of its after FY 2001 of installation was indicated as the accidental failure in “bathtub curve.” Further, the operator simply forgot to restart the power conditioner after maintenance or suspensions of PV system in many trouble cases, and the user did not notice that it had been suspended for a while. These trouble cases can be avoidable easily through the effective alarm such as error message of power conditioner systems with monitoring systems. Thereby, monitoring with the evaluation method of PV systems is one of the important technologies due to the long‐term reliability and stable operation. Copyright © 2010 John Wiley & Sons, Ltd.
    Type of Medium: Online Resource
    ISSN: 1062-7995 , 1099-159X
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2010
    detail.hit.zdb_id: 2023295-0
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  • 9
    Online Resource
    Online Resource
    Wiley ; 2014
    In:  Progress in Photovoltaics: Research and Applications Vol. 22, No. 9 ( 2014-09), p. 949-957
    In: Progress in Photovoltaics: Research and Applications, Wiley, Vol. 22, No. 9 ( 2014-09), p. 949-957
    Abstract: The performance of photovoltaic (PV) modules is generally rated under standard test conditions (STC). However, the performance of thin‐film photovoltaic modules is not unique even under STC, because of the “metastability”. The effects of the light soaking and thermal annealing shall be incorporated into an appropriate energy rating standard. In this study, the change in I–V characteristics of thin‐film PV modules caused by the metastability was examined by repeated indoor measurements in addition to round‐robin outdoor measurements. The investigated thin‐film modules were copper indium gallium (di)selenide (CIGS), a‐Si : H, and a‐Si : H/µc‐Si : H (tandem) modules. The increase in the performance of the CIGS module between the initial and final indoor measurements was approximately 8%. Because of light‐induced degradation, the indoor performance of the a‐Si : H and a‐Si : H/µc‐Si : H modules decreased by approximately 35% and 20%, respectively. The performance was improved by about 4–6% under high temperature conditions after the initial degradation. The results suggest that the performance of thin‐film silicon modules can seasonally vary by approximately 4–6% only due to thermal annealing and light soaking effects. The effect of solar spectrum enhanced the outdoor performance of the a‐Si : H module by about 10% under low air mass conditions, although that of the a‐Si : H/µc‐Si : H modules showed a little increase. The currents of these a‐Si : H/µc‐Si : H modules may be limited by the bottom cells. Therefore, it is required to optimize the effect of solar spectrum in addition to the effects of light soaking and thermal annealing, in order to achieve the best performance for thin‐film silicon tandem modules. Copyright © 2013 John Wiley & Sons, Ltd.
    Type of Medium: Online Resource
    ISSN: 1062-7995 , 1099-159X
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2014
    detail.hit.zdb_id: 2023295-0
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  • 10
    Online Resource
    Online Resource
    Wiley ; 2017
    In:  Clinical Anatomy Vol. 30, No. 6 ( 2017-09), p. 753-760
    In: Clinical Anatomy, Wiley, Vol. 30, No. 6 ( 2017-09), p. 753-760
    Abstract: This study was designed specifically to determine the normal acetabular orientation and femoral head covering, and whether these are affected by age or sex. Computed tomographic images of normal Japanese hip joints were used (males 60, females 60; mean age 48.3 years, range 15–79 years). Male and female age profiles were matched. The reconstructed 3‐D pelvic images were aligned in the anatomical pelvic coordinate system. The acetabular orientation angles and femoral covering angles were measured in the sagittal, coronal, and horizontal planes. In the sagittal plane, the acetabular orientation angle was operative anteversion (O‐av), and the femoral covering angles were the anterior and posterior center‐edge angles (ACE and PCE). In the coronal plane, they were the Sharp angle (SA) and the lateral center‐edge angle (LCE). In the horizontal plane, they were anatomical anteversion (A‐av) and the anterior and posterior sector angles (ASA and PSA). The O‐av, SA, and A‐av were smaller in the male than the female acetabulum ( P   〈  0.01). SA in both males and females was inversely correlated with age ( P   〈  0.01). Both male PCE and PSA were significantly smaller than those of females, while male ASA was larger than female ASA ( P   〈  0.05). The male acetabulum is directed further outward and downward than the female one. However, this does not indicate that the male acetabulum covers the femoral head more, because there is no significant sex difference in the LCE. Femoral coverage is more posteriorly biased in females than in males owing to pelvic inclination. Clin. Anat. 30:753–760, 2017. © 2017Wiley Periodicals, Inc.
    Type of Medium: Online Resource
    ISSN: 0897-3806 , 1098-2353
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2017
    detail.hit.zdb_id: 2004511-6
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