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  • 1
    Online Resource
    Online Resource
    Gait analysis of patients with Parkinson's disease using a portable triaxial accelerometer
    Wiley ; 2016
    In:  Neurology and Clinical Neuroscience Vol. 4, No. 3 ( 2016-05), p. 93-97
    Details
    In: Neurology and Clinical Neuroscience, Wiley, Vol. 4, No. 3 ( 2016-05), p. 93-97
    Abstract: Gait disturbance is a major problem for Parkinson's disease patients. Aim We examined the nature of parkinsonian gait using a triaxial accelerometer, and elucidated differences as compared with healthy adults. Methods A total of 16 patients with idiopathic Parkinson's disease, 14 healthy young adults and 10 healthy older adults took part in the study. The accelerometer was placed at the level of the L4 spinous process and the participants were instructed to walk along a 30‐m horizontal walkway. Gait speed and acceleration were analyzed on the middle 10 m. Acceleration data were obtained by using the root mean square of acceleration in three directions as the mean acceleration value. Results Gait speed and mean acceleration had a high correlation in healthy young and older adults, but not in the Parkinson's disease patients. Gait speed in the Parkinson's disease patients was significantly slower than that in the healthy older adults ( P 〈 0.05). Evaluations of each component of acceleration showed that the mediolateral component in the patients was significantly high as compared with that in the healthy older adults ( P 〈 0.05), although the vertical and anteroposterior components were not different between the Parkinson's disease patients and healthy adults. Conclusions Gait speed in Parkinson's disease patients is significantly slower than that in healthy older adults. Furthermore, it is suggested that gait in Parkinson's disease patients swings in a more bilateral manner as compared with the gait in normal controls.
    Type of Medium: Online Resource
    ISSN: 2049-4173 , 2049-4173
    URL: Issue
    URL: Article
    DOI: 10.1111/ncn3.2016.4.issue-3
    DOI: 10.1111/ncn3.12043
    Language: English
    Publisher: Wiley
    Publication Date: 2016
    detail.hit.zdb_id: 2706717-8
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  • 2
    Online Resource
    Online Resource
    Simultaneous analysis of the gene expression profiles of cancer and stromal cells in endometrial cancer
    Wiley ; 2014
    In:  Genes, Chromosomes and Cancer Vol. 53, No. 9 ( 2014-09), p. 725-737
    Details
    In: Genes, Chromosomes and Cancer, Wiley, Vol. 53, No. 9 ( 2014-09), p. 725-737
    Abstract: To address the role of cancer‐stroma interactions, we performed gene expression profiling of both cancer and stroma, using matching samples of endometrial cancer (EC), and analyzed the relationship between the gene expression pattern and prognosis in EC. Sixty EC cases were included in this study (38 nonrecurrent and 22 recurrent). Cancer and stroma were separated by performing laser capture microdissection, and microarray analysis was performed separately on cancer and stromal cells. Genes related with progression‐free survival (PFS) in cancer and stroma were analyzed using the Cox regression model, and we established a formula, based on the gene expression pattern of cancer and stroma, to predict recurrence using logistic regression. We estimated the accuracy of the formula using the 0.632 method. All cases were classified based on the 79 selected genes of cancer and stroma related to PFS, based on unsupervised clustering. A total of 143 genes in cancer, and 79 genes in stroma were significantly related with PFS. The estimated area under the curve of receiver operating characteristics curve in cancer and stroma to predict recurrence were 0.800 and 0.758, respectively. Based on the 79 genes of cancer, the 22 recurrent cases were divided into two groups, which generally correlated with the histological grade. In contrast, based on the 79 genes of stroma, the 22 recurrent cases displayed homogeneous gene expression, unrelated to the histological grade. We conclude that gene expression profiles of cancer and stroma can predict the recurrence of EC and stromal that gene expression does not depend on the cancer grade. © 2014 Wiley Periodicals, Inc.
    Type of Medium: Online Resource
    ISSN: 1045-2257 , 1098-2264
    URL: Issue
    URL: Article
    DOI: 10.1002/gcc.v53.9
    DOI: 10.1002/gcc.22182
    Language: English
    Publisher: Wiley
    Publication Date: 2014
    detail.hit.zdb_id: 1018988-9
    detail.hit.zdb_id: 1492641-6
    SSG: 12
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  • 3
    Online Resource
    Online Resource
    Stem Cell Factor and/or Endothelin‐3 Dependent Immortal Melanoblast and Melanocyte Populations Derived From Mouse Neural Crest Cells
    Wiley ; 2000
    In:  Pigment Cell Research Vol. 13, No. s8 ( 2000-06), p. 73-80
    Details
    In: Pigment Cell Research, Wiley, Vol. 13, No. s8 ( 2000-06), p. 73-80
    Abstract: Stem cell factor (SCF) and endothelin‐3 (ET3) are both necessary for melanocyte development. In order to obtain immortal cell populations of melanoblasts that can survive without feeder cells, we first obtained an immortal cell population of neural crest cells (NCCs) from Sl/+ and +/+ mice of strain WB by incubating with a culture medium supplemented with SCF and ET3, and then we designated them as NCC‐SE3 cells. NCC‐SE3 cells were bipolar, polygonal, or round in shape and possessed melanosomes of stages I–III (mainly stage I). They were positive to dihydroxyphenylalanine (DOPA) reaction and expressed KIT (a receptor tyrosine kinase), tyrosinase, tyrosinase‐related protein‐1 (TRP1), tyrosinase‐related protein‐2 (TRP2), and endothelin‐B receptor (ETR B ) as determined by immunostaining. We next cultured NCC‐SE3 cells by changing culture medium from the one supplemented with SCF+ET3 to the one supplemented with SCF or ET3. NCC‐SE3 cells cultured with ET3 alone, designated as NCC‐E3 cells, were bipolar in shape and had mainly stage II melanosomes and expressed the same proteins as did NCC‐SE3 cells. However, NCC‐SE3 cells cultured with SCF alone, designated as NCC‐S4.1 cells, were polygonal in shape and had mainly stage I melanosomes. They are thought to be more immature because they were positive to KIT, TRP1, and TRP2, but not to ETR B , tyrosinase, and DOPA reaction. When 12‐ O ‐tetradecanoyl phorbol‐13‐acetate and cholera toxin were added to the culture medium, NCC‐S4.1 cells changed shape from polygonal to bipolar and became DOPA‐positive. This suggests that NCC‐S4.1 cells are melanoblasts that have the potential to differentiate into melanocytes. These cell populations will be extremely useful to study factors that affect melanocyte development and melanogenesis.
    Type of Medium: Online Resource
    ISSN: 0893-5785 , 1600-0749
    URL: Article
    DOI: 10.1034/j.1600-0749.13.s8.14.x
    Language: English
    Publisher: Wiley
    Publication Date: 2000
    detail.hit.zdb_id: 2425880-5
    detail.hit.zdb_id: 2027000-8
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  • 4
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    Online Resource
    Intra‐ and inter‐investigator reliabilities of oral moisture measured using an oral moisture‐checking device
    Wiley ; 2020
    In:  Journal of Oral Rehabilitation Vol. 47, No. 4 ( 2020-04), p. 480-484
    Details
    In: Journal of Oral Rehabilitation, Wiley, Vol. 47, No. 4 ( 2020-04), p. 480-484
    Abstract: Oral mucosal moisture determined using oral moisture‐checking devices is used as a mouth dryness evaluation method. Such devices are capable of evaluating the state of mouth dryness in a simple manner and have applicability in a wide range of subjects; however, their intra‐ and inter‐investigator reliabilities have not yet been clarified. Objective This study aims to investigate the intra‐ and inter‐investigator reliabilities of measuring oral moisture using an oral moisture‐checking device for a wide range of age groups. Methods Intra‐ and inter‐investigator reliabilities were investigated in 28 young subjects and 19 older subjects aged ≥65 years. Three trained investigators independently measured oral mucosal moisture values using an oral moisture‐checking device. Intra‐investigator reliability was assessed using the coefficient of variation (CV) and intraclass correlation coefficient (ICC) (1.1), and inter‐investigator reliability was assessed using ICC (2.1). Results Mean CV was 0.015 and 0.016, mean ICC (1.1) was 0.806 and 0.877, and ICC (2.1) was 0.873 and 0.829 in the young and older subjects, respectively. Conclusion In young subjects, the mean values of ICC (1.1) and ICC (2.1) of the oral moisture‐checking device were 0.806 and 0.873, respectively, whereas in older subjects, these values were 0.877 and 0.829, respectively. Thus, this confirms that the examination of oral mucosal moisture using the oral moisture‐checking device has sufficient intra‐ and inter‐investigator reliabilities for a wide range of age groups.
    Type of Medium: Online Resource
    ISSN: 0305-182X , 1365-2842
    URL: Issue
    URL: Article
    DOI: 10.1111/joor.2019.47.issue-4
    DOI: 10.1111/joor.12919
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2007587-X
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