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  • 1
    In: BJOG: An International Journal of Obstetrics & Gynaecology, Wiley, Vol. 129, No. S2 ( 2022-11), p. 40-49
    Abstract: The aim was to assess the expression levels of SLC7A11 and GPX4 in relation to platinum resistance and prognosis in patients with epithelial ovarian cancer (EOC). Design A retrospective cohort study. Setting Women's Hospital, Zhejiang University School of Medicine, Hangzhou, China. Population or Sample We included 192 eligible patients from hospital between January 2002 and December 2018. Methods We retrospectively analysed the medical records of patients with EOC. Surgical specimens of EOC were stained for SLC7A11 and GPX4. Survival analysis was performed using the Kaplan–Meier and Cox regression methods. Main Outcome Measures Clinical end points include platinum‐free interval (PFI), progression‐free survival (PFS) and overall survival (OS). Results Patients with high co‐expression levels of SLC7A11 and GPX4 had a 60‐fold higher risk of platinum resistance compared with those with low co‐expression (risk ratio, 60.46; 95% confidence interval [CI] 22.76–160.58; p   〈  0.001). Moreover, high co‐expression level of SLC7A11 and GPX4 was an independent prognostic factor for poor OS ( p   〈  0.001, hazard ratio [HR] 4.44, 95% CI, 2.77–7.14) and poor PFS ( p   〈  0.001, HR = 5.73, 95% CI, 3.86–8.73). For in vitro experiments, SLC7A11 and GPX4 expression were both upregulated in platinum‐resistant cells compared with their parental ovarian cancer cells, and siRNA‐induced SLC7A11 and GPX4 inhibition decreased platinum resistance. Conclusions High expression levels of SLC7A11 and GPX4 are associated with platinum resistance in EOC patients. High co‐expression of SLC7A11 and GPX4 may be a significant independent prognostic factor and a potential therapeutic target for platinum resistance in EOC patients.
    Type of Medium: Online Resource
    ISSN: 1470-0328 , 1471-0528
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2036469-6
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  • 2
    Online Resource
    Online Resource
    Wiley ; 2011
    In:  Acta Geologica Sinica - English Edition Vol. 85, No. 5 ( 2011-10), p. 1173-1186
    In: Acta Geologica Sinica - English Edition, Wiley, Vol. 85, No. 5 ( 2011-10), p. 1173-1186
    Type of Medium: Online Resource
    ISSN: 1000-9515
    Language: English
    Publisher: Wiley
    Publication Date: 2011
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  • 3
    In: Acta Geologica Sinica - English Edition, Wiley, Vol. 92, No. 4 ( 2018-08), p. 1609-1626
    Abstract: This work extensively investigated global tight sandstone gas, and geologically and geochemically analyzed the tight sandstone gas in China's Ordos, Sichuan, and Tarim basins. We compared typical tight sandstone gas in China with that in North America. We proposed six conditions for the formation of China's tight sandstone gas, and illustrated the geological characteristics of tight sandstone gas. In China, gas‐bearing tight sandstones were mainly deposited in continental lake deltas and marine‐terrigenous facies basin environments, associated with coal‐measure strata, and were mostly buried deeper than 2000 m under a formation pressure of 20–30 MPa, with pressure coefficients varying from overpressure to negative pressure. In other countries, tight gas bearing sandstones were dominantly deposited in marine to marine‐terrigenous facies environments, occurred in coal‐measure strata, and were mostly buried shallower than 2000 m in low‐pressure systems. We systematically analyzed tight sandstone gas in the Ordos, Sichuan, and Tarim basins in terms of chemical compositions, geochemical characteristics of carbon isotopes, origins, and sources. Tight sandstone gas in China usually has a hydrocarbon content of 〉 95%, with CH 41 content 〉 90%, and a generally higher dry coefficient. In the three above‐mentioned large tight sandstone gas regions, δ 13 C1 and δ 13 C 2 mainly ranges from –42‰ to –28‰ and from –28‰ to –21‰, respectively. Type III coal‐measure source rocks that closely coexist with tight reservoirs are developed extensively in these gas regions. The organic petrology of source rocks and the carbon isotope compositions of gas indicate that tight sandstone gas in China is dominantly coal‐derived gas generated by coal‐measure strata. Our analysis of carbon isotope series shows that local isotope reversals are mainly caused by the mixing of gases of different maturities and that were generated at different stages. With increasing maturity, the reversal tendency becomes more apparent. Moreover, natural gas with medium‐low maturity (e.g., Xujiahe Formation natural gas in the Sichuan Basin) presents an apparent reversal at a low‐maturity stage, a normal series at a medium ‐maturity stage, and a reversal tendency again at a high‐maturity stage. Finally, we proposed four conditions for preferred tight sandstone gas “sweep spots,” and illustrated the recoverable reserves, proven reserves, production, and exploration prospects of tight sandstone gas. The geological and geochemical characteristics, origins, sources, and exploration potential of tight sandstone gas in China from our research will be instructive for the future evaluation, prediction, and exploration of tight sandstone gas in China and abroad.
    Type of Medium: Online Resource
    ISSN: 1000-9515 , 1755-6724
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2420386-5
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  • 4
    Online Resource
    Online Resource
    Wiley ; 2002
    In:  Magnetic Resonance in Chemistry Vol. 40, No. 11 ( 2002-11), p. 738-742
    In: Magnetic Resonance in Chemistry, Wiley, Vol. 40, No. 11 ( 2002-11), p. 738-742
    Type of Medium: Online Resource
    ISSN: 0749-1581 , 1097-458X
    URL: Issue
    RVK:
    Language: English
    Publisher: Wiley
    Publication Date: 2002
    detail.hit.zdb_id: 1475029-6
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  • 5
    Online Resource
    Online Resource
    Wiley ; 2015
    In:  Acta Geologica Sinica - English Edition Vol. 89, No. s1 ( 2015-09), p. 258-260
    In: Acta Geologica Sinica - English Edition, Wiley, Vol. 89, No. s1 ( 2015-09), p. 258-260
    Type of Medium: Online Resource
    ISSN: 1000-9515
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2015
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  • 6
    In: Acta Geologica Sinica - English Edition, Wiley, Vol. 90, No. 5 ( 2016-10), p. 1821-1837
    Abstract: The Upper Triassic oil accumulations in the Ordos Basin is the most successful tight oil play in China, with average porosity values of less than 10% and permeability values below 1.0 mD. This study investigated the geological characteristics and origin of the tight oil accumulations in the Chang 6 member of the Upper Triassic Yanchang Formation in the Shanbei area based on over 50, 000 petrological, source‐rock analysis, well logging and production data. The tight oil accumulation of the Chang 6 member is distributed continuously in the basin slope and the centre of the basin. The oil‐water relationships are complex. Laumontite dissolution pores are the most important storage spaces, constituting 30%‐60% of total porosity and showing a strong positive relationship with oil production. The pore‐throat diameter is less than 1 µm, and the calculated critical height of the oil column is much larger than the tight sand thickness, suggesting that the buoyancy was probably of limited importance for oil migration. The pressure difference between the source rocks and sandstone reservoirs is inferred to have provided driving force for hydrocarbon migration. Two factors of source‐reservoir configuration and laumontite dissolution contributed to the formation of the Chang 6 tight oil accumulations. Intense hydrocarbon generation and continuous sand bodies close to the hydrocarbon kitchen are the foundation for the large‐scale oil distribution. Dissolution of feldspar‐laumontite during the process of organic matter evolution generated abundant secondary pores and improved the reservoir quality.
    Type of Medium: Online Resource
    ISSN: 1000-9515 , 1755-6724
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2016
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  • 7
    In: Acta Geologica Sinica - English Edition, Wiley, Vol. 94, No. 2 ( 2020-04), p. 418-429
    Abstract: Based on core observation, cast and fluorescent thin sections, FESEM and ESEM, coquina in Da ' anzhai Member of Jurassic in Sichuan Basin were examined systematically. Together with production data and logging evaluation, a method for lacustrine coquina evaluation based on geological theory was established up. In the article, two aspects of the study were elaborated, characteristics of favorable reservoirs, and a “five‐step” evaluation method for favorable coquina reservoir. According to the correlation between porosity and production data, porosity is not effective in finding high quality coquina reservoir of this area. Whereas micro research of reservoir samples from a high productivity well revealed that sparry coquina is the best lithofacies, with the most developed micro storage space of various kinds. After the favorable reservoir was sorted out, a five‐step method evaluating the coquina reservoir was worked out. Correlation of GR value and rock types suggests that GR 〈 30 API is an effective evaluation parameter in identifying profitable reservoir lithofacies. Meanwhile, the combination of profitable reservoir rock thickness and production data revealed that the reservoirs with the highest potentiality are those with thickness of 3–18 m. Fractures are more developed in faults, folds and structural noses in the study area. Organic acid is discharged massively before the peak of hydrocarbon generation, leading to the formation of dissolution pores in the reservoir. The evaluation of organic acid was made by using the source rock indexes. After evaluating the four factors, and compiling their distribution maps, the maps were overlapped to predict favorable reservoir zones, and 7 first class and 9 second class favorable zones of coquina were picked out.
    Type of Medium: Online Resource
    ISSN: 1000-9515 , 1755-6724
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2020
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  • 8
    Online Resource
    Online Resource
    Wiley ; 2019
    In:  ENERGY & ENVIRONMENTAL MATERIALS Vol. 2, No. 1 ( 2019-03), p. 55-67
    In: ENERGY & ENVIRONMENTAL MATERIALS, Wiley, Vol. 2, No. 1 ( 2019-03), p. 55-67
    Abstract: Electrochemical energy storage and conversion ( EESC ) technology is key to the sustainable development of human society. As an abundant and renewable source, biomass has recently shown widespread applications in EESC , achieving both low environmental impact and high performances. This article provides overview and perspectives on various types of biomass‐derived materials, their preparation, the role in EESC and the desired features, performances and limitations, and future research efforts.
    Type of Medium: Online Resource
    ISSN: 2575-0356 , 2575-0356
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 2945579-0
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  • 9
    Online Resource
    Online Resource
    Wiley ; 2019
    In:  Advanced Science Vol. 6, No. 18 ( 2019-09)
    In: Advanced Science, Wiley, Vol. 6, No. 18 ( 2019-09)
    Abstract: Since the first intercalation of layered silicates by using supercritical CO 2 as a processing medium, considerable efforts have been dedicated to intercalating and exfoliating layered two‐dimensional (2D) materials in various supercritical fluids (SCFs) to yield single‐ and few‐layer nanosheets. Here, recent work in this area is highlighted. Motivating factors for enhancing exfoliation efficiency and product quality in SCFs, mechanisms for exfoliation and dispersion in SCFs, as well as general metrics applied to assess quality and processability of exfoliated 2D materials are critically discussed. Further, advances in formation and application of 2D material–based composites with assistance from SCFs are presented. These discussions address chemical transformations accompanying SCF processing such as doping, covalent surface modification, and heterostructure formation. Promising features, challenges, and routes to expanding SCF processing techniques are described.
    Type of Medium: Online Resource
    ISSN: 2198-3844 , 2198-3844
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 2808093-2
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  • 10
    In: Acta Geologica Sinica - English Edition, Wiley, Vol. 89, No. 3 ( 2015-06), p. 938-971
    Abstract: The new century has witnessed a strategic breakthrough in unconventional oil & gas. Hydrocarbon accumulated in micro‐/nano‐scale pore throat shale systems has become an important domain that could replace current oil & gas resources. Unconventional oil & gas plays an increasingly important role in our energy demand. Tight gas, CBM, heavy oil and asphaltic sand have served as a key domain of exploration & development, with tight oil becoming a ‘bright spot’ domain and shale gas becoming a ‘hotspot’ domain. China has made great breakthroughs in unconventional oil & gas resources, such as tight gas, shale gas, tight oil and CBM, and great progress in oil shale, gas hydrate, heavy oil and oil sand. China has an estimated (223–263)×10 8 t of unconventional oil resources and (890–1260)×10 12 m 3 of gas resources. China has made a breakthrough for progress in unconventional oil & gas study. New progress achieved in fine‐grained sedimentary studies related to continental open lacustrine basin large‐scale shallow‐water delta sand bodies, lacustrine basin central sandy clastic flow sediments and marine‐continental fine‐grained sediments provide a theoretical basis for the formation and distribution of basin central reservoir bodies. Great breakthroughs have been made in unconventional reservoir geology in respect of research methodology & technology, multi‐scale data merging and physical simulation of formation conditions. Overall characterization of unconventional reservoirs via multi‐method and multi‐scale becomes increasingly popular and facilitates the rapid development of unconventional oil & gas geological theory, method and technology. The formation of innovative, continuous hydrocarbon accumulation theory, the establishment of the framework of the unconventional oil & gas geological theory system, and the determination of the implications, geological feature, formation mechanism, distribution rule and core technology of unconventional oil & gas geological study lays a theoretical foundation for extensive unconventional oil & gas exploration and development. Theories and technologies of unconventional oil & gas exploration and development developed rapidly, including some key evaluation techniques such as ‘sweet spot zone’ integrated evaluation and a six‐property evaluation technique that uses hydrocarbon source, lithology, physical property, brittleness, hydrocarbon potential and stress anisotropy, and some key development & engineering technologies including micro‐seismic monitoring, horizontal drilling & completion and “factory‐like” operation pattern, “man‐made reservoir” development, which have facilitated the innovative development of unconventional oil & gas. These breakthroughs define a new understanding in four aspects: ① theoretical innovation; ② key technologies; ③ complete market mechanism and national policy support; and ④ well‐developed ground infrastructure, which are significant for prolonging the life cycle of petroleum industry, accelerating the upgrade and development of theories and technologies and altering the global traditional energy structure.
    Type of Medium: Online Resource
    ISSN: 1000-9515 , 1755-6724
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2015
    detail.hit.zdb_id: 2420386-5
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