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  • 1
    Online Resource
    Online Resource
    Long noncoding RNA TSPOAP1 antisense RNA 1 negatively modulates type I IFN signaling to facilitate influenza A virus replication
    Wiley ; 2022
    In:  Journal of Medical Virology Vol. 94, No. 2 ( 2022-02), p. 557-566
    Details
    In: Journal of Medical Virology, Wiley, Vol. 94, No. 2 ( 2022-02), p. 557-566
    Abstract: Although the expression of thousands of host long noncoding RNAs (lncRNAs) can be regulated by viral infection, the number of lncRNAs with experimentally verified function is limited. In this study, the expression of host lncRNA TSPOAP1‐AS1 was significantly induced by influenza A virus (IAV) infection in a dose‐ and time‐dependent manner. Polyinosine‐polycytidylic acid (poly (I:C)), a synthetic analog of double‐stranded RNA, also increased TSPOAP1‐AS1 expression. RNA fractionation revealed that TSPOAP1‐AS1 was a nucleocytoplasmic lncRNA, and an increased nuclear/cytoplasmic ratio was detected after IAV infection. The nuclear factor‐κB signaling acting as a critical factor in the transcription of TSPOAP1‐AS1 was determined through the use of pharmacological and genetic approaches. Functionally, overexpression of TSPOAP1‐AS1 resulted in a significant increase in IAV replication. In contrast, the abolition of TSPOAP1‐AS1 by RNA interference restricted viral replication. Furthermore, we demonstrated that TSPOAP1‐AS1 negatively modulated the IAV‐induced Ifnb1 transcription, interferon‐sensitive response element (ISRE) activation, and downstream interferon‐stimulated genes expression. Collectively, our data provides evidence for the host lncRNA utilized by viruses to support its replication.
    Type of Medium: Online Resource
    ISSN: 0146-6615 , 1096-9071
    URL: Issue
    URL: Article
    DOI: 10.1002/jmv.v94.2
    DOI: 10.1002/jmv.25483
    RVK:
    XA 10000
    Language: English
    Publisher: Wiley
    Publication Date: 2022
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    detail.hit.zdb_id: 1475090-9
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  • 2
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    A single nucleotide deletion in the third exon of FT‐D1 increases the spikelet number and delays heading date in wheat ( Triticum aestivum L.)
    Wiley ; 2022
    In:  Plant Biotechnology Journal Vol. 20, No. 5 ( 2022-05), p. 920-933
    Details
    In: Plant Biotechnology Journal, Wiley, Vol. 20, No. 5 ( 2022-05), p. 920-933
    Abstract: The spikelet number and heading date are two crucial and correlated traits for yield in wheat. Here, a quantitative trait locus (QTL) analysis was conducted in F 8 recombinant inbred lines (RILs) derived from crossing two common wheats with different spikelet numbers. A total of 15 stable QTL influencing total spikelet number (TSN) and heading date (HD) were detected. Notably, FT‐D1 , a well‐known flowering time gene in wheat, was located within the finely mapped interval of a major QTL on 7DS ( QTsn/Hd.cau‐7D ). A causal indel of one G in the third exon of FT‐D1 was significantly associated with total spikelet number and heading date. Consistently, CRISPR/Cas9 mutant lines with homozygous mutations in FT‐D1 displayed an increase in total spikelet number and heading date when compared with wild type. Moreover, one simple and robust marker developed according to the polymorphic site of FT‐D1 revealed that this one G indel had been preferentially selected to adapt to different environments. Collectively, these data provide further insights into the genetic basis of spikelet number and heading date, and the diagnostic marker of FT‐D1 will be useful for marker‐assisted pyramiding in wheat breeding.
    Type of Medium: Online Resource
    ISSN: 1467-7644 , 1467-7652
    URL: Issue
    URL: Article
    DOI: 10.1111/pbi.v20.5
    DOI: 10.1111/pbi.13773
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2136367-5
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  • 3
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    In vivo ectopic Ngn1 and Neurod1 convert neonatal cochlear glial cells into spiral ganglion neurons
    Wiley ; 2020
    In:  The FASEB Journal Vol. 34, No. 3 ( 2020-03), p. 4764-4782
    Details
    In: The FASEB Journal, Wiley, Vol. 34, No. 3 ( 2020-03), p. 4764-4782
    Type of Medium: Online Resource
    ISSN: 0892-6638 , 1530-6860
    URL: Article
    DOI: 10.1096/fj.201902118R
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 1468876-1
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  • 4
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    High‐efficiency separation of oil sands using ChCl‐based deep eutectic solvents
    Wiley ; 2023
    In:  The Canadian Journal of Chemical Engineering Vol. 101, No. 5 ( 2023-05), p. 2835-2841
    Details
    In: The Canadian Journal of Chemical Engineering, Wiley, Vol. 101, No. 5 ( 2023-05), p. 2835-2841
    Abstract: Deep eutectic solvents (DESs) are a kind of potential lixiviant for extraction processing. Unlike conventional ionic liquids (ILs), DESs are relatively cheap and environmentally friendly. Herein, three different ChCl‐based DESs, namely, choline chloride/urea, choline chloride/ethylene glycol, as well as choline chloride/propandioic acid, were synthesized and used to enhance bitumen recovery from oil sand by petroleum ether extraction. The results showed a multiphase system formed after mixing the components at ~25°C, consisting of sands and clays, a DES layer, and a petroleum ether layer containing the bitumen. These DESs were immiscible with bitumen or petroleum ether. Coupled with a density difference, a clear phase separation was presented between the bitumen–petroleum ether mixture and DES. The DES functioned as a separating agent, keeping the petroleum ether–bitumen mixture and spent sand apart from each other. The results showed that the bitumen recovery was increased by ~12% compared with that without the DESs. We deduced that the enhancement in the separation may result from the reduction of adhesion between bitumen and sand by the DESs. The ChCl‐based DESs and petroleum ether could be readily recycled to reduce industrial costs. After 10 cycles, the bitumen recovery remained above 86%.
    Type of Medium: Online Resource
    ISSN: 0008-4034 , 1939-019X
    URL: Issue
    URL: Article
    DOI: 10.1002/cjce.v101.5
    DOI: 10.1002/cjce.24630
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 240250-6
    detail.hit.zdb_id: 2119520-1
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  • 5
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    Online Resource
    Hormesis effects in tomato plant growth and photosynthesis due to acephate exposure based on physiology and transcriptomic analysis
    Wiley ; 2023
    In:  Pest Management Science Vol. 79, No. 6 ( 2023-06), p. 2029-2039
    Details
    In: Pest Management Science, Wiley, Vol. 79, No. 6 ( 2023-06), p. 2029-2039
    Abstract: Hormesis is a common phenomenon in toxicology described as low‐dose stimulation due to a toxin which causes inhibition at a high dose. Pesticide hormesis in plants has attracted considerable research interest in recent years; however, the specific mechanism has not yet been clarified. Acephate is an organophosphorus insecticide that is used worldwide. Here, hormesis in tomato ( Solanum lycopersicum L.) plant growth and photosynthesis after acephate exposure is confirmed, as stimulation occurred at low stress levels, whereas inhibition occurred after exposure to high concentrations. RESULTS We found that low acephate concentration (5‐fold lower than recommended application dosage) could enhance chlorophyll biosynthesis and stimulate photosynthesis effects, and thus improve S. lycopersicum growth. A high level of acephate (5‐fold higher than recommended application dosage) stress inhibited chlorophyll accumulation, decreased photosystem II efficiency and blocked antioxidant reactions in leaves, increasing reactive oxygen species levels and damaging plant growth. Transcriptomic analysis and quantitative real‐time PCR results revealed that the photosynthesis – antenna proteins pathway played a crucial role in the hormesis effect, and that LHCB7 as well as LHCP from the pathway were the most sensitive to acephate hormesis. CONCLUSION Our results showed that acephate could induce hormesis in tomato plant growth and photosynthesis, and that photosystem II and the photosynthesis – antenna proteins pathway played important roles in hormesis. These results provide novel insights into the scientific and safe application of chemical pesticides, and new guidance for investigation into utilizing pesticide hormesis in agriculture. © 2023 Society of Chemical Industry.
    Type of Medium: Online Resource
    ISSN: 1526-498X , 1526-4998
    URL: Issue
    URL: Article
    DOI: 10.1002/ps.v79.6
    DOI: 10.1002/ps.7381
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2003455-6
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  • 6
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    Postoperative chemotherapy had no prognostic effect on early‐staged young ovarian cancer with unilateral resection
    Wiley ; 2018
    In:  Cancer Medicine Vol. 7, No. 11 ( 2018-11), p. 5488-5496
    Details
    In: Cancer Medicine, Wiley, Vol. 7, No. 11 ( 2018-11), p. 5488-5496
    Abstract: Postoperative chemotherapy has been widely used in the treatment of early‐staged ovarian cancer patients underwent unilateral resection, but the clinical decision mainly depends on the doctor’s experience without a well‐defined guideline. This study used propensity score matching to analyze the effect of postoperative chemotherapy for early‐staged ovarian cancer patients underwent unilateral resection on prognosis. Patients of age 50 or younger than 50 with early‐staged ovarian cancer were explored from the Surveillance, Epidemiology, and End Results program database during 2000‐2018. Propensity score matching was used to randomize the dataset and reduce the selection biases. Univariate and multivariate cox proportional hazards models were utilized to estimate the necessity of chemotherapy. In univariate analysis of matched population, both the overall survival and cancer‐specific survival analysis showed that chemotherapy had no effect on the prognosis of early‐staged young ovarian cancer patients (Overall survival, P =  0.477; Cancer‐specific survival, P  = 0.950). In propensity‐adjusted multivariate analysis, chemotherapy still had no effect on both the overall and cancer‐specific survival probability after excluding the effect of all the confounding factors (HR = 0.863, CI = 0.587‐1.269, P  = 0.455; HR = 1.009, CI = 0.633‐1.607, P  = 0.970). Our study suggested that postoperative chemotherapy is not necessary for early‐staged young ovarian cancer patients with unilateral resection, as indicated by both the overall survival and cancer‐specific survival.
    Type of Medium: Online Resource
    ISSN: 2045-7634 , 2045-7634
    URL: Issue
    URL: Article
    DOI: 10.1002/cam4.2018.7.issue-11
    DOI: 10.1002/cam4.1822
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2659751-2
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  • 7
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    Quantitative analysis of yeast internal architecture using soft X‐ray tomography
    Wiley ; 2011
    In:  Yeast Vol. 28, No. 3 ( 2011-03), p. 227-236
    Details
    In: Yeast, Wiley, Vol. 28, No. 3 ( 2011-03), p. 227-236
    Abstract: We used soft X‐ray tomography (SXT)—a high‐resolution, quantitative imaging technique—to measure cell size and organelle volumes in yeasts. Cell size is a key factor in initiating cell division in yeasts, whereas the number and volume of the organelles have a profound impact on the function and viability of a cell. Consequently, determining these cell parameters is fundamentally important in understanding yeast biology. SXT is well suited to this type of analysis. Specimens are imaged in a near‐native state, and relatively large numbers of cells can be readily analysed. In this study, we characterized haploid and diploid strains of Saccharomyces cerevisiae at each of the key stages in the cell cycle and determined the relationships that exist cellular and organelle volumes. We then compared these results with SXT data obtained from Schizosaccharomyces pombe , the three main phenotypes displayed by the opportunistic yeast pathogen Candida albicans and from a coff1‐22 mutant strain of S. cerevisiae . This comparison revealed that volumetric ratios were invariant, irrespective of yeast strain, ploidy or morphology, leading to the conclusion these volumetric ratios are common in all yeasts. Copyright © 2010 John Wiley & Sons, Ltd.
    Type of Medium: Online Resource
    ISSN: 0749-503X , 1097-0061
    URL: Issue
    URL: Article
    DOI: 10.1002/yea.v28.3
    DOI: 10.1002/yea.1834
    RVK:
    WA 15000
    Language: English
    Publisher: Wiley
    Publication Date: 2011
    detail.hit.zdb_id: 1479172-9
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  • 8
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    Protective effect of celastrol on type 2 diabetes mellitus with nonalcoholic fatty liver disease in mice
    Wiley ; 2020
    In:  Food Science & Nutrition Vol. 8, No. 11 ( 2020-11), p. 6207-6216
    Details
    In: Food Science & Nutrition, Wiley, Vol. 8, No. 11 ( 2020-11), p. 6207-6216
    Abstract: To investigate the protective effects of celastrol on mice with type 2 diabetes mellitus (T2DM) and nonalcoholic fatty liver disease (NAFLD), and to explore its underlying mechanism. The levels of low‐density lipoprotein cholesterol (LDL‐C), high‐density lipoprotein cholesterol (HDL‐C), total cholesterol (TC), and triglyceride (TG) in serum were tested. Malondialdehyde (MDA) and superoxide dismutase (SOD), GOT, and GPT in serum were also detected. The histopathological changes of liver tissues were observed by HE staining. The apoptosis cell number of liver tissues was measured by TUNEL staining. Nrf‐2 and HO‐1 protein and mRNA expression were evaluated by IHC, WB, and RT‐PCR assay. Celastrol had effects to depress TG, TC, LDL‐C, GPT, GOT, and MDA concentration and increase HDL‐C and SOD concentration ( p  〈  .05, respectively) with dose‐dependent. Compared with model group, apoptosis cell number was significantly depressed in Cel‐treated groups with dose‐dependent ( p  〈  .05, respectively). Nrf‐2 and HO‐1 mRNA and protein expressions were significantly improved in Cel‐treated groups with dose‐dependent ( p  〈  .05, respectively). Celastrol can inhibit the oxidative stress reaction and liver cell apoptosis via regulation Nrf2/HO‐1 pathway in T2DM mice with NAFLD.
    Type of Medium: Online Resource
    ISSN: 2048-7177 , 2048-7177
    URL: Issue
    URL: Article
    DOI: 10.1002/fsn3.v8.11
    DOI: 10.1002/fsn3.1917
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2703010-6
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  • 9
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    Simultaneous determination of three alkaloids, four ginsenosides and limonin in the plasma of normal and headache rats after oral administration of Wu-Zhu-Yu decoction by a novel ultra fast liquid chromatography-tandem mass spectrometry method: applicatio : Application of 4000Qtrap MS/MS system
    Wiley ; 2013
    In:  Journal of Mass Spectrometry Vol. 48, No. 4 ( 2013-04), p. 519-532
    Details
    In: Journal of Mass Spectrometry, Wiley, Vol. 48, No. 4 ( 2013-04), p. 519-532
    Type of Medium: Online Resource
    ISSN: 1076-5174
    URL: Article
    DOI: 10.1002/jms.3183
    Language: English
    Publisher: Wiley
    Publication Date: 2013
    detail.hit.zdb_id: 1472468-6
    SSG: 11
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  • 10
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    MCPIP1 attenuates the innate immune response to influenza A virus by suppressing RIG‐I expression in lung epithelial cells
    Wiley ; 2018
    In:  Journal of Medical Virology Vol. 90, No. 2 ( 2018-02), p. 204-211
    Details
    In: Journal of Medical Virology, Wiley, Vol. 90, No. 2 ( 2018-02), p. 204-211
    Abstract: The pattern recognition receptor retinoic acid‐inducible gene I (RIG‐I) reportedly plays a key role in sensing influenza A virus (IAV) infection and activating type I interferon (IFN) response. MCP‐1‐induced protein 1 (MCPIP1) can directly degrade cytokine mRNAs, such as IL‐6, IL‐12, IL‐1β, and IL‐2, by functioning as an RNase. Here, we initially observed that MCPIP1 exhibited virus supportive functions later in the course of IAV infection in A549 cells, and negatively regulated IAV‐induced RIG‐I‐dependent innate antiviral response. Exogenous overexpression of MCPIP1 suppressed the expression of RIG‐I, whereas shRNA‐mediated inhibition of endogenous MCPIP1 enhanced RIG‐I expression. The results of experiments with actinomycin D and luciferase assay demonstrated that MCPIP1 reduced RIG‐I expression through destabilizing its mRNA. Various mutants of functional domains of MCPIP1 further confirmed that the inhibitory effect of MCPIP1 on RIG‐I expression required RNase activity but not deubiquitinase activity. Finally, the overexpression of several IAV proteins, which have the ability to inhibit the host IFN response at different levels, induced MCPIP1 expression, especially non‐structural protein 1 (NS1). Conclusively, these data demonstrate the MCPIP1 contributes to attenuate IAV‐induced host antiviral response by suppressing RIG‐I expression.
    Type of Medium: Online Resource
    ISSN: 0146-6615 , 1096-9071
    URL: Issue
    URL: Article
    DOI: 10.1002/jmv.v90.2
    DOI: 10.1002/jmv.24944
    RVK:
    XA 10000
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 752392-0
    detail.hit.zdb_id: 1475090-9
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