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  • 1
    In: International Journal of Laboratory Hematology, Wiley, Vol. 44, No. 4 ( 2022-08), p. 759-768
    Abstract: Acute graft‐versus‐host disease (aGVHD) is one of the major complications of allogeneic hematopoietic stem cell transplantation, and the liver, skin, and gastrointestinal tract are the main target organs. The most common type is intestinal aGVHD. Long noncoding RNAs (lncRNAs) have coregulatory functions and participate in a variety of intracellular regulatory processes. We investigated the expression of lncRNAs and their mechanisms in the development of aGVHD. Methods The participants included 15 patients with aGVHD and 4 healthy controls (HCs). To generate profiles of abnormally expressed lncRNAs, peripheral blood mononuclear cell (PBMC) lncRNAs from four patients and four HCs were validated by high‐throughput sequencing and quantitative real‐time‐PCR (qRT‐PCR). A number of databases, including Gene Ontology, Kyoto Encyclopedia of Genes and Genomes, miRanda, TargetScan, and Metascape, were used for bioinformatics analysis. Bioinformatics analysis indicated that overexpression of lnc‐AC145676.2.1‐6‐3 might induce aGVHD via the interleukin (IL)‐1β axis and a downstream miRNA. After the higher levels of lnc‐AC145676.2.1‐6‐3 in other patients were confirmed by qRT‐PCR, serum IL‐1β, IL‐6, and tumor necrosis factor‐α were measured by enzyme linked immunosorbent assays. Results In our study, a large number of lncRNAs were found in PBMCs of patients with intestinal aGVHD, and bioinformatics analysis showed that the upregulated lncRNA lnc‐AC145676.2.1‐6‐3 probably affected the progression of intestinal aGVHD by regulating the hsa‐miR‐3064‐5p/IL‐1β axis. In addition, the changes in lncRNA expression levels were positively correlated with the clinical characteristics of intestinal aGVHD. Conclusion Our results suggest that lncRNAs in PBMCs may become new biomarkers and therapeutic targets for intestinal aGVHD.
    Type of Medium: Online Resource
    ISSN: 1751-5521 , 1751-553X
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2268600-9
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  • 2
    In: Chinese Journal of Chemistry, Wiley
    Abstract: Hypochlorite (ClO – ) is an important reactive oxygen species produced by the immune system to fight off invading pathogens, but its over‐expression can interfere with normal physiological process and induce serious diseases. Although a variety of molecular probes have been reported for detecting ClO – , the development of advanced fluorescent tools with faster response and higher sensitivity to precisely monitor ClO – remains a challenge. In this work, two Hantzsch ester (a derivative of 1,4‐dihydropyridine) derived fluorescent probes MeDHP‐BCl and MeDHP‐PhBCl were constructed based on asymmetric BODIPY‐matrix. These probes exhibit significant fluorescence turn‐on in the ultra‐sensitive (detection limit 〈  1 nmol/L) and ultra‐fast response (≤ 5 s) to ClO – . The reaction has been determined to be a highly selective N ‐chlorination of Hantzsch ester which cannot be activated by various common bioactive species, including nitric oxide (NO) that could oxidize Hantzsch ester under aerobic physiological conditions in most reports. MeDHP‐PhBCl possessed a relatively longer fluorescence emission wavelength and higher quantum yield after activation, while more notably, MeDHP‐BCl displayed lower cytotoxicity and more remarkable fluorescence increment in the response to ClO – , enabling selective and precise visualization of endogenous ClO – over‐expression in living RAW264.7 cells.
    Type of Medium: Online Resource
    ISSN: 1001-604X , 1614-7065
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2144352-X
    SSG: 6,25
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  • 3
    In: Plant, Cell & Environment, Wiley, Vol. 44, No. 10 ( 2021-10), p. 3257-3272
    Abstract: JWB phytoplasma effectors SJP1 and SJP2 stimulate lateral bud outgrowth, at least partly by repressing the ZjBRC1‐controlled auxin efflux channel in Ziziphus jujuba , representing a potential strategy for phytoplasma disease control and new cultivar breeding with varying degrees of shoot branching.
    Type of Medium: Online Resource
    ISSN: 0140-7791 , 1365-3040
    URL: Issue
    RVK:
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 391893-2
    detail.hit.zdb_id: 2020843-1
    SSG: 12
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  • 4
    Online Resource
    Online Resource
    Wiley ; 2022
    In:  Journal of Advanced Nursing Vol. 78, No. 12 ( 2022-12), p. 4019-4033
    In: Journal of Advanced Nursing, Wiley, Vol. 78, No. 12 ( 2022-12), p. 4019-4033
    Abstract: To systematically review the literature on relationships between communication issues and missed nursing care. Design Systematic review was conducted according to Preferred Reporting Items for Systematic Reviews and Meta‐Analyses 2020 Statement. Data Sources EMBASE, Web of Science, CINAHL, PubMed and Cochrane databases were comprehensively searched from inception to December 2021. Review Methods Screening, data extraction and initial quality assessment were conducted independently by two reviewers. The JBI quality assessment tool was used for study appraisal and the certainty of evidence was assessed using the five Grading of Recommendations Assessment, Development and Evaluation (GRADE) criteria. Discrepancies were settled by consulting a third researcher. Results A total of 18 articles were included. Missed nursing care was common and the status of communication was not optimistic in clinical. Nurses' sociodemographic characteristics and work environment both influenced missed nursing care and communication. Intrateam communication included three parts: doctors‐nurses communication, nurses‐nurses communication and nurses‐patients communication, poor intrateam communication could contribute to missed nursing care. There was an interaction between missed nursing care and communication. Conclusion Promoting efficient intrateam communication, to acknowledge the importance of communication factors in reducing the incidence of missed nursing care in clinics is required. Future research can explore the impact of the internal dimension of communication on missed nursing care and consider interventions aimed at nurses' effective communication. Impact What problem did the study address? This study offers new evidence that the impact of intrateam communication on missed nursing care. What were the main findings? Effective intrateam communication can reduce the incidence of missed nursing care, there is mutual influence between communication and missed nursing care. Where and on whom will the research have an impact? Policymakers can provide positive interventions on communication problems in different populations (e.g. nurses−patients, nurses−nurses and doctors−nurses) to provide high‐quality patient care.
    Type of Medium: Online Resource
    ISSN: 0309-2402 , 1365-2648
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2009963-0
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  • 5
    In: Journal of Clinical Nursing, Wiley, Vol. 32, No. 11-12 ( 2023-06), p. 2533-2546
    Abstract: The aim was to synthesise and discuss predictors of complete oral feeding resumption after feeding tube placement in stroke patients with dysphagia. Design This was a systematic review, following the PRISMA 2020 checklist. Data sources Eight databases (PubMed, Web of Science, Embase, Cochrane, CINAHL, CNKI, WanFang and Vip) were searched for eligible studies from inception up to June 2021. Review methods The JBI Manual for Evidence Synthesis was used to guide this systematic review. Any cross‐sectional survey, longitudinal study, cohort study or case–control study that explored the recovery from tube feeding to complete oral feeding in patients with dysphagia after stroke was included. Qualitative studies, review articles, case reports and conference abstracts were excluded. Two reviewers independently screened and appraised the studies. The Newcastle–Ottawa scale was used for quality assessment. Content analysis was used to categorise factors predicting feeding tube removal in stroke patients with dysphagia. Results This review included a total of 15 studies consisting of 1746 participants, of which 2 were case–control studies and 13 were cohort studies. Four studies were rated as having low risk of bias, and the other 11 had high risk of bias. The factors examined in the studies were categorised into demographic characteristics (age and sex), swallowing function (instrumental assessments and non‐instrumental assessments), stroke characteristics (stroke severity, past stroke history and location of the stroke), functional status (cognitive function and physical function) and clinical measures (body mass index, geriatric nutritional risk index, white blood cell count and C‐reactive protein level). Conclusions The major limitation of this review is the failure to identify predictors of different tube feeding types. Although the current evidence is insufficient to support or oppose the predictive effect of any single factor, these factors are still valuable data for clinical staff that provide information that researchers can use in developing prognostic models. Rigorously designed and high‐quality research is needed to further explore the predictive value of these factors. Registration This review was registered prospectively with PROSPERO [CRD42021272552]. Relevance to clinical practice Healthcare providers should strengthen the monitoring of swallowing function in patients with stroke to promote complete oral feeding resumption. As the predictive value of the identified factors is still uncertain, large, well‐designed, studies are needed to better clarify the importance of these predictors. No Patient or Public Contribution No patient or public was involved in the design, analysis, preparation or writing of this review.
    Type of Medium: Online Resource
    ISSN: 0962-1067 , 1365-2702
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2006661-2
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  • 6
    In: Journal of Microscopy, Wiley, Vol. 284, No. 1 ( 2021-10), p. 74-82
    Abstract: Clear and complete microstructural imaging of the root canal isthmus is an important part of pathological investigations in research and clinical practice. X‐ray micro‐computed tomography (μCT) is a widely used non‐destructive imaging technique, which allows for distortion‐free three‐dimensional (3D) visualisation. While absorption μCT typically has poor contrast resolution for observing the root canal isthmus, especially for weak‐absorbing tissues, propagation‐based X‐ray phase‐contrast imaging (PBI) is a powerful imaging method, which in its combination with μCT (PB‐PCμCT) enables high‐resolution and high‐contrast microstructural imaging of the weak‐absorbing tissues in samples. To investigate the feasibility and ability of PB‐PCμCT in microstructural imaging of the root canal isthmus, conventional absorption μCT and PB‐PCμCT experiments were performed. The two‐dimensional (2D) and 3D comparison results demonstrated that, compared to absorption μCT, PB‐PCμCT has the ability to image the root canal isthmus more clearly and completely, and thus, it has great potential to serve as a valuable tool for biomedical and preclinical studies on the root canal isthmus.
    Type of Medium: Online Resource
    ISSN: 0022-2720 , 1365-2818
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2007259-4
    SSG: 11
    SSG: 12
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  • 7
    In: Sustainable Development, Wiley
    Abstract: To cope with global climate change and realize sustainable development, China has invested heavily in the construction of information infrastructure and technological infrastructure (IT) in recent years. In this research, we first find out the effect of IT on CO 2 emissions and how IT impacts CO 2 emissions, considering an expanded endogenous growth model. Then, using the dynamic spatial lag model and the system generalized method of moments (SGMM), this study investigates the impact of IT on CO 2 emissions and their mechanisms in 30 provinces of China from 2005 to 2019. The results are: (1) CO 2 emissions have a spatial lag effect, a temporal lag effect, and a spatio‐temporal lag effect. (2) IT reduces local CO 2 emissions. (3) IT promotes the decrease of CO 2 emissions in local areas over the short and long terms. In the long term, IT promotes the decrease of CO 2 emissions in the surrounding regions. Both in the short and long terms, the direct effect is greater than the indirect effect. (4) IT reduces CO 2 emissions through optimizing the energy consumption structure (ENS) and enhancing the level of green technology innovation (GI). This study provides a theoretical basis for realizing the dual carbon goals of emissions peak and carbon neutrality.
    Type of Medium: Online Resource
    ISSN: 0968-0802 , 1099-1719
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2021120-X
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  • 8
    In: Advanced Materials, Wiley, Vol. 34, No. 39 ( 2022-09)
    Abstract: Efforts to enable fast charging and high energy density lithium‐ion batteries (LIBs) are hampered by the trade‐off nature of the traditional electrode design: increasing the areal capacity usually comes with sacrificing the fast charge transfer. Here a single‐layer chunky particle electrode design is reported, where red‐phosphorus active material is embedded in nanochannels of vertically aligned graphene (red‐P/VAG) assemblies. Such an electrode design addresses the sluggish charge transfer stemming from the high tortuosity and inner particle/electrode resistance of traditional electrode architectures consisting of randomly stacked active particles. The vertical ion‐transport nanochannels and electron‐transfer conductive nanowalls of graphene confine the direction of charge transfer to minimize the transfer distance, and the incomplete filling of nanochannels in the red‐P/VAG composite buffers volume change locally, thus avoiding the variation of electrodes thickness during cycling. The single‐layer chunky particle electrode displays a high areal capacity (5.6 mAh cm −2 ), which is the highest among the reported fast‐charging battery chemistries. Paired with a high‐loading LiNi 0.6 Co 0.2 Mn 0.2 O 2 (NCM622) cathode, a pouch cell shows stable cycling with high energy and power densities. Such a single‐layer chunky particle electrode design can be extended to other advanced battery systems and boost the development of LIBs with fast‐charging capability and high energy density.
    Type of Medium: Online Resource
    ISSN: 0935-9648 , 1521-4095
    URL: Issue
    RVK:
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 1474949-X
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  • 9
    In: Advanced Materials, Wiley, Vol. 35, No. 33 ( 2023-08)
    Abstract: Excitonic resonance in atomically thin semiconductors offers a favorite platform to study 2D nanophotonics in both classical and quantum regimes and promises potentials for highly tunable and ultra‐compact optical devices. The understanding of charge density dependent exciton‐trion conversion is the key for revealing the underlaying physics of optical tunability. Nevertheless, the insufficient and inefficient light‐matter interactions hinder the observation of trionic phenomenon and the development of excitonic devices for dynamic power‐efficient electro‐optical applications. Here, by engaging an optical cavity with atomically thin transition metal dichalcogenides (TMDCs), greatly enhanced exciton‐trion conversion is demonstrated at room temperature (RT) and achieve electrical modulation of reflectivity of ≈40% at exciton and 7% at trion state, which correspondingly enables a broadband large phase tuning in monolayer tungsten disulfide. Besides the absorptive conversion, ≈100% photoluminescence conversion from excitons to trions is observed at RT, illustrating a clear physical mechanism of an efficient exciton‐trion conversion for extraordinary optical performance. The results indicate that both excitons and trions can play significant roles in electrical modulation of the optical parameters of TMDCs at RT. The work shows the real possibility for realizing electrical tunable and multi‐functional ultra‐thin optical devices using 2D materials.
    Type of Medium: Online Resource
    ISSN: 0935-9648 , 1521-4095
    URL: Issue
    RVK:
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 1474949-X
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  • 10
    In: Thoracic Cancer, Wiley, Vol. 10, No. 10 ( 2019-10), p. 1904-1912
    Abstract: Tumor mutation burden (TMB) is an important determinant and biomarker for response of targeted therapy and prognosis in patients with lung cancer. The present study aimed to determine whether radiomics signature could non‐invasively predict the TMB status and driver mutations in patients with resectable early stage lung adenocarcinoma (LUAD). Methods A total of 61pulmonary nodules (PNs) from 51 patients post‐operatively diagnosed LUAD were enrolled for analysis. Two datasets were divided according to two‐thirds of patients from different commercial Comprehensive Genomic Profiling (CGP) panels: a training cohort including 41 PNs and a testing cohort including rest 20PNs. We sequenced all tumor specimens and paired blood cells using next generation sequencing (NGS), so as to detect TMB status and somatic mutations. We collected 718 quantitative 3D radiomics features extracted from segmented volumes of each PNs and 78 clinical and pathological features retrieved from medical records as well. Support vector machine methods were performed to establish the predictive model. Results We established an efficient fusion‐positive tumor prediction model that predicts TMB status and EGFR/TP53 mutations of early stage LUAD. The radiomics signature yielded a median AUC value of 0.606, 0.604, and 0.586 respectively. Combining radiomics with the clinical information can further improve the prediction performance, which the median AUC values are 0.671 for TMB, 0.697 and 0.656 for EGFR/TP53 respectively. Conclusion It is feasible and effective to facilitate TMB and somatic driver mutations prediction by using the radiomics signature and NGS data in early stage LUAD.
    Type of Medium: Online Resource
    ISSN: 1759-7706 , 1759-7714
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 2559245-2
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