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  • 1
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    Appetite stimulation with cannabis‐based medicine and methods for assessment of glomerular filtration in older patients with medical illness: A study protocol
    Wiley ; 2023
    In:  Basic & Clinical Pharmacology & Toxicology Vol. 133, No. 3 ( 2023-09), p. 237-253
    Details
    In: Basic & Clinical Pharmacology & Toxicology, Wiley, Vol. 133, No. 3 ( 2023-09), p. 237-253
    Abstract: Malnutrition in older patients is linked to poor appetite. Cannabis‐based medicine may have orexigenic properties in older patients, but this has to our knowledge never been investigated. In older patients, uncertainty applies to the accuracy of estimated glomerular filtration rate (eGFR) based on creatinine, which is crucial for medication prescribing. In older patients with poor appetite, the study aims (1) to assess the efficacy of Sativex® (8.1‐mg delta‐9‐tetrahydrocannabinol [THC] and 7.5‐mg cannabidiol [CBD] ) to stimulate appetite and (2) to compare the performance of various GFR‐estimates and measured‐GFR (mGFR) for determining gentamicin clearance utilizing population pharmacokinetic (popPK) modelling methods. Methods and objectives This study is composed of two substudies. Substudy 1 is an investigator‐initiated single‐center, double‐blinded, randomized, placebo‐controlled, superiority, cross‐over study. Substudy 1 will recruit 17 older patients with poor appetite, who will also be invited to substudy 2. Substudy 2 is a single‐dose pharmacokinetics study and will recruit 55 patients. Participants will receive Sativex® and placebo in substudy 1 and gentamicin with simultaneous measurements of GFR in substudy 2. The primary endpoints are as follows: Substudy 1—the difference in energy intake between Sativex® and placebo conditions; substudy 2— the accuracy of different eGFR equations compared to mGFR. The secondary endpoints include safety parameters, changes in the appetite hormones, total ghrelin and GLP‐1 and subjective appetite sensations, and the creation of popPK models of THC, CBD, and gentamicin.
    Type of Medium: Online Resource
    ISSN: 1742-7835 , 1742-7843
    URL: Issue
    URL: Article
    DOI: 10.1111/bcpt.v133.3
    DOI: 10.1111/bcpt.13914
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2151592-X
    SSG: 15,3
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  • 2
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    Shoulder rotational profiles in young healthy elite female and male badminton players
    Wiley ; 2014
    In:  Scandinavian Journal of Medicine & Science in Sports Vol. 24, No. 1 ( 2014-02), p. 122-128
    Details
    In: Scandinavian Journal of Medicine & Science in Sports, Wiley, Vol. 24, No. 1 ( 2014-02), p. 122-128
    Abstract: The aim of the present study was to profile shoulder passive range of motion ( ROM ) and isometric strength for external ( ER ) and internal ( IR ) rotation as part of a preseason screening in adolescent national badminton players. Passive external range of motion ( EROM ) and internal range of motion ( IROM ) were examined on the dominant and nondominant shoulder in 31 adolescent national badminton players (12 females and 19 males) with a standard goniometer. Muscle strength was examined with a hand‐held dynamometer in ER and IR . Total range of motion ( TROM  =  EROM + IROM ) was lower on the dominant side compared with the nondominant side in both groups ( P   〈  0.001). Males were generally stronger than females in all strength measurements except for IR on the dominant side ( P   〈  0.01). In females, IR dominant side strength was greater compared with IR on the nondominant side ( P   〈  0.05). TROM was reduced on the dominant side compared with the nondominant side in young elite badminton players, irrespective of gender. No rotational strength differences existed between the dominant and nondominant side in male players, but in female players a higher IR strength on the dominant side was not balanced by a higher ER strength.
    Type of Medium: Online Resource
    ISSN: 0905-7188 , 1600-0838
    URL: Issue
    URL: Article
    DOI: 10.1111/sms.2014.24.issue-1
    DOI: 10.1111/j.1600-0838.2012.01480.x
    Language: English
    Publisher: Wiley
    Publication Date: 2014
    detail.hit.zdb_id: 2025503-2
    SSG: 31
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  • 3
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    Risk factors during pregnancy and birth‐related complications in HIV ‐positive versus HIV ‐negative women in Denmark, 2002–2014
    Wiley ; 2020
    In:  HIV Medicine Vol. 21, No. 2 ( 2020-02), p. 84-95
    Details
    In: HIV Medicine, Wiley, Vol. 21, No. 2 ( 2020-02), p. 84-95
    Abstract: We aimed to compare risk factors for adverse pregnancy outcomes in women living with HIV ( WLWH ) with those in women of the general population ( WGP ) in Denmark. Further, we estimated risk of pregnancy‐ or birth‐related complications. Methods A retrospective cohort study including all WLWH who delivered a live‐born child from 2002 to 2014 and WGP, matched by origin, age, year and parity, was carried out. We compared risk factors during pregnancy and estimated risk of pregnancy‐ and birth‐related complications using multivariate logistic regression. Results A total of 2334 pregnancies in 304 WLWH and 1945 WGP were included in the study. WLWH had more risk factors present than WGP during pregnancy: previous caesarean section ( CS ) (24.7% versus 16.3%, respectively; P =  0.0001), smoking (14.2% versus 7.5%, respectively; P =  0.0001) and previous perinatal/neonatal death (2.3% versus 0.9%, respectively; P  =   0.03). We found no difference between groups regarding gestational diabetes, hypertensive disorders, low birth weights or premature delivery. More children of WLWH had intrauterine growth retardation ( IUGR ) [adjusted odds ratio ( aOR ) 1.9; 95% confidence interval ( CI ) 1.1–3.2; P =  0.02]. Median gestational age and birth weight were lower in children born to WLWH . WLWH had a higher risk of emergency CS (Em CS ) ( aOR 1.6; 95% CI 1.2–2.1; P =  0.0005) and postpartum haemorrhage ( aOR 1.4; 95% CI 1.0–1.9; P =  0.02) but not infection, amniotomy, failure to progress, low activity‐pulse‐grimace‐appearance‐respiration ( APGAR ) score or signs of asphyxia. Conclusions WLWH had more risk factors present during pregnancy, similar risks of most pregnancy‐ and birth‐related complications but a higher risk of postpartum haemorrhage and Em CS compared with WGP . Children born to WLWH had lower median birth weights and gestational ages and were at higher risk of IUGR .
    Type of Medium: Online Resource
    ISSN: 1464-2662 , 1468-1293
    URL: Issue
    URL: Article
    DOI: 10.1111/hiv.v21.2
    DOI: 10.1111/hiv.12798
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2020341-X
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  • 4
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    Assessment of mode of delivery and predictors of emergency caesarean section among women living with HIV in a matched‐pair setting with women from the general population in Denmark, 2002−2014
    Wiley ; 2017
    In:  HIV Medicine Vol. 18, No. 10 ( 2017-11), p. 736-747
    Details
    In: HIV Medicine, Wiley, Vol. 18, No. 10 ( 2017-11), p. 736-747
    Abstract: We aimed to assess mode of delivery and predictors of emergency caesarean section (Em CS ) in women living with HIV ( WLWH ) in a matched‐pair setting with women from the general population ( WGP ) in Denmark. Further, we analysed birth plan in WLWH . Methods All WLWH giving birth to live‐born children from 2002 to 2014 were included in the study. Data were retrieved from medical records and national registries. WLWH were matched 1:5 by age, birth year, parity and ethnicity to WGP . Multivariate logistic regression was used to estimate predictors. Results We included 389 WLWH and 1945 WGP in the study. At delivery, all WLWH were on antiretroviral therapy and 85.6% had HIV RNA 〈 40 HIV ‐1 RNA copies/ mL . Mean age was 32.7 years [95% confidence interval ( CI ) 32.1–33.2 years]. Mode of delivery differed significantly between WLWH and WGP [vaginal delivery, 33.4% versus 73.3%, respectively; elective caesarean section ( ECS ), 40.6% versus 9.7%, respectively; Em CS , 26% versus 17%, respectively; P 〈 0.0001]. Age 〉 40 years [adjusted odds ratio ( aOR ) 2.3; 95% CI 1.5–3.5], asphyxia ( aOR 3.2; 95% CI 2.4–4.1), delivery during the evening and at night [ aOR 2.3 (95% CI 1.7–3.0) and aOR 2.0 (95% CI 1.5–2.7), respectively], preterm delivery ( aOR 3.8; 95% CI 2.6–5.6) and premature rupture of membranes ( aOR 3.0; 95% CI 2.1–4.4) predicted Em CS . WLWH had a higher risk of Em CS compared with WGP [2002–2006, aOR 2.0 (95% CI 1.2–3.3); 2007–2008, aOR 2.9 (95% CI 1.4–5.9); 2009–2014, aOR 2.6 (95% CI 1.7–3.9)]. After 2007, more than half of WLWH planned to deliver vaginally. Prior caesarean section was associated with ECS ( aOR 11.0; 95% CI 4.5–26.8). No mother‐to‐child transmission occurred. Conclusions Increasing numbers of WLWH deliver vaginally. Despite virological suppression, more WLWH plan and deliver by ECS than WGP . WLWH had a twofold higher risk of Em CS compared with WGP .
    Type of Medium: Online Resource
    ISSN: 1464-2662 , 1468-1293
    URL: Issue
    URL: Article
    DOI: 10.1111/hiv.2017.18.issue-10
    DOI: 10.1111/hiv.12519
    Language: English
    Publisher: Wiley
    Publication Date: 2017
    detail.hit.zdb_id: 2020341-X
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  • 5
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    Incidence of cervical dysplasia and cervical cancer in women living with HIV in D enmark: comparison with the general population
    Wiley ; 2016
    In:  HIV Medicine Vol. 17, No. 1 ( 2016-01), p. 7-17
    Details
    In: HIV Medicine, Wiley, Vol. 17, No. 1 ( 2016-01), p. 7-17
    Abstract: Women living with HIV ( WLWH ) are reportedly at increased risk of invasive cervical cancer ( ICC ). A recent publication found that WLWH in D enmark attend the national ICC screening programme less often than women in the general population. We aimed to estimate the incidence of cervical dysplasia and ICC in WLWH in D enmark compared with that in women in the general population. Methods We studied a nationwide cohort of WLWH and a cohort of 15 age‐matched women per WLWH from the general population for the period 1999–2010. Pathology samples were obtained from The D anish P athology D ata B ank, which contains nationwide records of all pathology specimens. The cumulative incidence and hazard ratios ( HRs ) for time from inclusion to first cervical intraepithelial neoplasia ( CIN )/ ICC and time from first normal cervical cytology result to first CIN / ICC were estimated. Sensitivity analyses were performed to include prior screening outcome, screening intensity and treatment of CIN / ICC in the interpretation of results. Results We followed 1140 WLWH and 17 046 controls with no prior history of ICC or hysterectomy for 9491 and 156 865 person‐years, respectively. Compared with controls, the overall incidences of CIN1 or worse ( CIN1 +), CIN2 + and CIN3 +, but not ICC , were higher in WLWH and predicted by young age and a CD4 count 〈  200 cells/μL. In women with normal baseline cytology, incidences of CIN1 + and CIN2 + were higher in WLWH . However, when we compared subgroups of WLWH and controls where women in both groups were adherent to the national ICC screening programme and had a normal baseline cytology, incidences of CIN and ICC were comparable. Conclusions Overall, WLWH developed more cervical disease than controls. Yet, in WLWH and controls adherent to the national ICC screening programme and with normal baseline cytology, incidences of CIN and ICC were comparable.
    Type of Medium: Online Resource
    ISSN: 1464-2662 , 1468-1293
    URL: Issue
    URL: Article
    DOI: 10.1111/hiv.2016.17.issue-1
    DOI: 10.1111/hiv.12271
    Language: English
    Publisher: Wiley
    Publication Date: 2016
    detail.hit.zdb_id: 2020341-X
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  • 6
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    Quantification of neutrophil chemotaxis: A comparison of stereological and 51 Cr‐labelling methods
    Wiley ; 1995
    In:  APMIS Vol. 103, No. 1-6 ( 1995-01), p. 185-192
    Details
    In: APMIS, Wiley, Vol. 103, No. 1-6 ( 1995-01), p. 185-192
    Abstract: A stereological method has been used to estimate the number of migrated polymorphonuclear leukocytes in a multipore filter assay. The estimates have been compared to those obtained with conventional 51 Cr‐labelling methods. The precision of the estimates in individual subjects with the two methods was similar, and in both cases the contribution to the interindividual variance made by the methods was small compared to the biological variance. However, the 51 Cr‐labelling method resulted in a significant reduction in the fraction of neutrophils that migrated as well as a delay in the chemo‐tactic response. Optimal assay conditions with regard to sample size, cell concentration, incubation time and chemoattractant fMLP concentration have been established for the stereological method and the virtues of the two techniques discussed.
    Type of Medium: Online Resource
    ISSN: 0903-4641 , 1600-0463
    URL: Issue
    URL: Article
    DOI: 10.1111/apm.1995.103.issue-1-6
    DOI: 10.1111/j.1699-0463.1995.tb01094.x
    RVK:
    XA 13160
    Language: English
    Publisher: Wiley
    Publication Date: 1995
    detail.hit.zdb_id: 2098213-6
    SSG: 12
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  • 7
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    Hormonal, immune, and oxidative stress responses to blood flow‐restricted exercise
    Wiley ; 2023
    In:  Acta Physiologica
    Details
    In: Acta Physiologica, Wiley
    Abstract: Heavy‐load free‐flow resistance exercise (HL‐FFRE) is a widely used training modality. Recently, low‐load blood‐flow restricted resistance exercise (LL‐BFRRE) has gained attention in both athletic and clinical settings as an alternative when conventional HL‐FFRE is contraindicated or not tolerated. LL‐BFRRE has been shown to result in physiological adaptations in muscle and connective tissue that are comparable to those induced by HL‐FFRE. The underlying mechanisms remain unclear; however, evidence suggests that LL‐BFRRE involves elevated metabolic stress compared to conventional free‐flow resistance exercise (FFRE). Aim The aim was to evaluate the initial ( 〈 10 min post‐exercise), intermediate (10–20 min), and late ( 〉 30 min) hormonal, immune, and oxidative stress responses observed following acute sessions of LL‐BFRRE compared to FFRE in healthy adults. Methods A systematic literature search of randomized and non‐randomized studies was conducted in PubMed, Embase, Cochrane Central, CINAHL, and SPORTDiscus. The Cochrane Risk of Bias (RoB2, ROBINS‐1) and TESTEX were used to evaluate risk of bias and study quality. Data extractions were based on mean change within groups. Results A total of 12525 hits were identified, of which 29 articles were included. LL‐BFRRE demonstrated greater acute increases in growth hormone responses when compared to overall FFRE at intermediate (SMD 2.04; 95% CI 0.87, 3.22) and late (SMD 2.64; 95% CI 1.13, 4.16) post‐exercise phases. LL‐BFRRE also demonstrated greater increase in testosterone responses compared to late LL‐FFRE. Conclusion These results indicate that LL‐BFRRE can induce increased or similar hormone and immune responses compared to LL‐FFRE and HL‐FFRE along with attenuated oxidative stress responses compared to HL‐FFRE.
    Type of Medium: Online Resource
    ISSN: 1748-1708 , 1748-1716
    URL: Article
    DOI: 10.1111/apha.14030
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2617148-X
    detail.hit.zdb_id: 2219379-0
    SSG: 12
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  • 8
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    Obstetric and neonatal complications in pregnancies conceived after oocyte donation: a systematic review and meta‐analysis
    Wiley ; 2017
    In:  BJOG: An International Journal of Obstetrics & Gynaecology Vol. 124, No. 4 ( 2017-03), p. 561-572
    Details
    In: BJOG: An International Journal of Obstetrics & Gynaecology, Wiley, Vol. 124, No. 4 ( 2017-03), p. 561-572
    Abstract: Oocyte donation pregnancies have increased risk of a range of obstetric and neonatal complications. This article includes Author Insights, a video abstract available at https://vimeo.com/rcog/authorinsights14257 .
    Type of Medium: Online Resource
    ISSN: 1470-0328 , 1471-0528
    URL: Issue
    URL: Article
    DOI: 10.1111/bjo.2017.124.issue-4
    DOI: 10.1111/1471-0528.14257
    Language: English
    Publisher: Wiley
    Publication Date: 2017
    detail.hit.zdb_id: 2036469-6
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  • 9
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    Near‐normalization of glycaemic control with glucagon‐like peptide‐1 receptor agonist treatment combined with exercise in patients with type 2 diabetes
    Wiley ; 2017
    In:  Diabetes, Obesity and Metabolism Vol. 19, No. 2 ( 2017-02), p. 172-180
    Details
    In: Diabetes, Obesity and Metabolism, Wiley, Vol. 19, No. 2 ( 2017-02), p. 172-180
    Abstract: To investigate the effects of exercise in combination with a glucagon‐like peptide‐1 receptor agonist ( GLP‐1RA ), liraglutide, or placebo for the treatment of type 2 diabetes. Methods Thirty‐three overweight, dysregulated and sedentary patients with type 2 diabetes were randomly allocated to 16 weeks of either exercise and liraglutide or exercise and placebo. Both groups had three supervised 60‐minute training sessions per week including spinning and resistance training. Results Glycated haemoglobin ( HbA1c ) levels dropped by a mean ± standard deviation of 2.0% ± 1.2% (from 8.2% ± 1.4%) in the exercise plus liraglutide group vs 0.3% ± 0.9% (from 8.0% ± 1.2%) in the exercise plus placebo group ( P 〈 .001), and body weight was reduced more with liraglutide (−3.4 ± 2.9 kg vs −1.6 ± 2.3 kg; P 〈 .001). Compared with baseline, similar reductions were seen in body fat (exercise plus liraglutide: −2.5% ± 1.4% [ P 〈 .001]; exercise plus placebo: −2.2% ± 1.9% [ P 〈 .001]) and similar increases were observed in maximum oxygen uptake (exercise plus liraglutide: 0.5 ± 0.5 L O 2 /min [ P 〈 .001]; exercise plus placebo: 0.4 ± 0.4 L O 2 /min [ P = .002]). Greater reductions in fasting plasma glucose (−3.4 ± 2.3 mM vs −0.3 ± 2.6 mM , P 〈 .001) and systolic blood pressure (−5.4 ± 7.4 mm Hg vs −0.6 ± 11.1 mm Hg , P 〈 .01) were seen with exercise plus liraglutide vs exercise plus placebo. The two groups experienced similar increases in quality of life during the intervention. Conclusions In obese patients with type 2 diabetes, exercise combined with GLP‐1RA treatment near‐normalized HbA1c levels and caused a robust weight loss when compared with placebo. These results suggest that a combination of exercise and GLP‐1RA treatment is effective in type 2 diabetes.
    Type of Medium: Online Resource
    ISSN: 1462-8902 , 1463-1326
    URL: Issue
    URL: Article
    DOI: 10.1111/dom.2017.19.issue-2
    DOI: 10.1111/dom.12797
    Language: English
    Publisher: Wiley
    Publication Date: 2017
    detail.hit.zdb_id: 2004918-3
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  • 10
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    Impaired lipolysis in propionic acidemia: A new metabolic myopathy?
    Wiley ; 2020
    In:  JIMD Reports Vol. 53, No. 1 ( 2020-05), p. 16-21
    Details
    In: JIMD Reports, Wiley, Vol. 53, No. 1 ( 2020-05), p. 16-21
    Abstract: The objective of this study was to investigate the fat and carbohydrate metabolism in a patient with propionic acidemia (PA) during exercise by means of indirect calorimetry and stable isotope technique. A 34‐year‐old patient with PA performed a 30‐minute submaximal cycle ergometer test. Data were compared to results from six gender‐ and age‐matched healthy controls. Main findings are that the patient with PA had impaired lipolysis, blunted fatty acid oxidation, compensatory increase in carbohydrate utilization, and low work capacity. Our findings indicate that PA should be added to the list of metabolic myopathies.
    Type of Medium: Online Resource
    ISSN: 2192-8312 , 2192-8312
    URL: Issue
    URL: Article
    DOI: 10.1002/jmd2.v53.1
    DOI: 10.1002/jmd2.12113
    Language: English
    Publisher: Wiley
    Publication Date: 2020
    detail.hit.zdb_id: 2672872-2
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