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  • 1
    Online Resource
    Online Resource
    Pathological and Immunohistochemical Study of Experimental Peste Des Petits Ruminants Virus Infection in Goats
    Wiley ; 2004
    In:  Journal of Veterinary Medicine, Series B Vol. 51, No. 4 ( 2004-05), p. 153-159
    Details
    In: Journal of Veterinary Medicine, Series B, Wiley, Vol. 51, No. 4 ( 2004-05), p. 153-159
    Abstract: Peste des petits ruminants (PPR) is an emerging, economically important viral disease of goats and sheep in the Indian subcontinent. In the present investigation, 15 hill goats were experimentally infected with 2 ml of 10% splenic suspension of a virulent isolate of PPR virus (PPR/Izatnagar/94) that had caused heavy mortality ( 〉 75%) in goats during 1994 outbreaks in northern India. More than 86% (13 of 15) animals died between 9 and 13 days post inoculation at the height of temperature or when temperatures were declining. Necropsy findings included congestion of gastrointestinal tract (GIT), nasal sinuses, consolidation of antero‐ventral lobes of lungs, engorged spleen, and occasionally oedematous lymph nodes. Histopathological examination of major organs of GIT revealed degeneration and necrosis of labial mucosa, severe mucosal and submucosal congestion, degeneration and necrosis of intestinal epithelium and lymphoid cell depletion from Peyer's patches along with presence of syncytia at times. Lungs showed broncho‐interstitial changes and presence of intracytoplasmic and intranuclear eosinophilic inclusions in alveolar macrophages and syncytial cells. These changes in lungs were frequently complicated with serofibrinous pneumonia (57%, eight of 14). Lymphocytolysis and occasional syncytia formation were evident in the lymphoid tissues. Immunohistochemical (IHC) findings included presence of PPR virus antigen in the labial, intestinal, and bronchiolar epithelial cells, pneumocytes, macrophages and syncytial cells in lungs, and lymphoid (intact and necrotic) and reticular cells in lymphoid organs. The findings of the study indicated the highly virulent nature of the PPR virus isolate (PPR/Izatnagar/94), causing 100% mortality and characteristic pathological changes in the target organs such as lungs, intestines and lymphoid tissues. The results of the IHC study suggested that indirect immunoperoxidase could be an alternative method in the absence of more sophisticated methods of laboratory diagnosis of PPR virus infection in goats.
    Type of Medium: Online Resource
    ISSN: 0931-1793
    URL: Issue
    URL: Article
    DOI: 10.1111/jvb.2004.51.issue-4
    DOI: 10.1111/j.1439-0450.2004.00747.x
    Language: English
    Publisher: Wiley
    Publication Date: 2004
    detail.hit.zdb_id: 2271118-1
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  • 2
    Online Resource
    Online Resource
    Highly Facile, Regio‐ and Stereoselective Synthesis of Spiropyrrolidine‐5‐aza‐2‐oxindole Derivatives through Multicomponent 1,3‐Dipolar Cycloaddition Reaction and Their In‐Vitro and In‐Silico Biological Studies
    Wiley ; 2021
    In:  ChemistrySelect Vol. 6, No. 35 ( 2021-09-21), p. 9407-9414
    Details
    In: ChemistrySelect, Wiley, Vol. 6, No. 35 ( 2021-09-21), p. 9407-9414
    Abstract: Highly facile one pot synthesis of an assortment of novel spiropyrrolidine 5‐aza‐2‐oxindole derivatives via 1, 3‐di polar cycloaddition reaction has been reported. The underlying concept of Huisgen reaction was applied wherein the azomethine ylides (1,3‐dipoles), generated in‐situ from isatin‐derived compounds and cyclic / acyclic α‐amino acids through the thermal decarboxylation, reacted with exo ‐cyclic benzylidine derivatives (dipolarophiles) of 5‐aza‐2‐oxindole afforded plethora of spiropyrrolidine 5‐aza‐2‐oxindoles in excellent yield. High regio‐ and stereo selectivity were accomplished employing this methodology and optimum yield was obtained when reaction carried out under methanol reflux in presence of triethylamine. Furthermore, the compounds were tested for their in‐vitro biological potency as anti‐microbial and anti‐mycobacterial. Antibacterial screening result reveals that out of fifteen compounds four compounds emerged with moderate to reasonable activity against gram negative E. coli and P. aeruginosa . Antifungal screening resulted in identification of two compounds as moderate antifungal agents against A. niger . Antimycobacterial activity results revealed that the four compounds displayed good to moderate in‐vitro activity with MIC= 12.5  μg/mL against H37Rv strain as compared to standard pyrazinamide (MIC= 3.12  μg/mL). Additionally, molecular docking study was carried out to understand the possible binding modes of the synthesized derivatives within the active site of antibacterial (PDB ID : 3ACX), antifungal (PDB ID : 1IYL) and antimycobacterial (PDB ID : 4TZT) target proteins and were found to display good docking energies. Besides, ADMET properties of the synthesized compounds have shown drug likeness with good oral absorption and moderate BBB permeability.
    Type of Medium: Online Resource
    ISSN: 2365-6549 , 2365-6549
    URL: Issue
    URL: Article
    DOI: 10.1002/slct.v6.35
    DOI: 10.1002/slct.202102118
    Language: English
    Publisher: Wiley
    Publication Date: 2021
    detail.hit.zdb_id: 2844262-3
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  • 3
    Online Resource
    Online Resource
    Molecular characterization and identification of markers associated with yield traits in mulberry using ISSR markers
    Wiley ; 2006
    In:  Plant Breeding Vol. 125, No. 3 ( 2006-06), p. 298-301
    Details
    In: Plant Breeding, Wiley, Vol. 125, No. 3 ( 2006-06), p. 298-301
    Abstract: Mulberry ( Morus indica L.) is an important tree crop being exploited for feeding the silk‐producing insect Bombyx mori L. In order to identify parents suitable for breeding to raise high‐yielding varieties for the non‐traditional areas of Kerala, India and also to identify markers associated with leaf yield attributing traits, the present study was undertaken with 44 mulberry genotypes. Variability on morpho‐biometric traits and molecular markers, generated with 12 selected ISSR primers, was estimated. Significant differences between genotypes were observed for all the traits. The dendrogram generated with morpho‐biometric characters clustered the genotypes into three distinct groups and one isolate, while the same using Inter simple sequence repeat (ISSR) markers clustered the genotypes into five groups and six isolates. The greater resolving power of the ISSR markers was evident form the dendrograms. Using step‐wise multiple regression analysis, a number of markers associated with number of branches, total shoot length, leaf weight, internodal distance, leaf chlorophyll, protein, leaf moisture percentage were identified. These markers could be of much use in Marker assisted selection (MAS) breeding programmes in mulberry, especially when no genetic information in terms of linkage maps and Quantitative Trait Locis (QTLs) is available a plant with high heterozygosity and a long juvenile period.
    Type of Medium: Online Resource
    ISSN: 0179-9541 , 1439-0523
    URL: Issue
    URL: Article
    DOI: 10.1111/pbr.2006.125.issue-3
    DOI: 10.1111/j.1439-0523.2006.01212.x
    Language: English
    Publisher: Wiley
    Publication Date: 2006
    detail.hit.zdb_id: 2020488-7
    SSG: 12
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  • 4
    Online Resource
    Online Resource
    PHYSIOLOGICAL ECOLOGY OF GELIDIELLA ACEROSA (FORSSKAL) FELDMANN ET HAMEL 1
    Wiley ; 1973
    In:  Journal of Phycology Vol. 9, No. 3 ( 1973-09), p. 333-335
    Details
    In: Journal of Phycology, Wiley, Vol. 9, No. 3 ( 1973-09), p. 333-335
    Type of Medium: Online Resource
    ISSN: 0022-3646
    URL: Article
    DOI: 10.1111/j.1529-8817.1973.tb04102.x
    RVK:
    WA 15000
    Language: English
    Publisher: Wiley
    Publication Date: 1973
    detail.hit.zdb_id: 281226-5
    detail.hit.zdb_id: 1478748-9
    SSG: 12
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  • 5
    Online Resource
    Online Resource
    Synthesis, characterization and antibacterial evaluation of N ‐( 2‐Morpholinoethyl )‐3‐phenylquinoxalin‐2‐amine derivatives
    Wiley ; 2023
    In:  Journal of Heterocyclic Chemistry Vol. 60, No. 4 ( 2023-04), p. 566-575
    Details
    In: Journal of Heterocyclic Chemistry, Wiley, Vol. 60, No. 4 ( 2023-04), p. 566-575
    Abstract: A series of substituted N ‐(2‐Morpholinoethyl)‐3‐phenylquinoxalin‐2‐amines (5a–j) (5ab , 5ac) were synthesized in good yield and characterized for their structural confirmation. The pure quinoxaline products were screened for their in‐vitro antibacterial activity against Salmonella paratyphi, a well‐known food borne pathogen. The preliminary results revealed that among the series, compounds 5a , 5c , 5d , 5e , 5f , 5h , 5ab and 5ac bearing bromo, fluoro, methoxy, methyl groups at para position on phenyl ring which inturn substituted at third position of quinoxaline and methyl, benzoyl groups at sixth position on the quinoxaline were emerged as potential candidates by displaying antisalmonella activity. Among the potential candidates, compounds 5c , 5e , 5f and 5ac were effective against Salmonella whereas compounds 5a , 5f and 5ac effectively inhibited the biofilm formation of Salmonella .
    Type of Medium: Online Resource
    ISSN: 0022-152X , 1943-5193
    URL: Issue
    URL: Article
    DOI: 10.1002/jhet.v60.4
    DOI: 10.1002/jhet.4608
    RVK:
    VA 5200
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2042274-X
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  • 6
    Online Resource
    Online Resource
    PHYSIOLOGICAL ECOLOGY OF GELIDIELLA ACEROSA (FORSSKAL) FELDMANN ET HAMEL1
    Wiley ; 1973
    In:  Journal of Phycology Vol. 9, No. 3 ( 1973-09), p. 333-335
    Details
    In: Journal of Phycology, Wiley, Vol. 9, No. 3 ( 1973-09), p. 333-335
    Type of Medium: Online Resource
    ISSN: 0022-3646 , 1529-8817
    URL: Issue
    URL: Article
    DOI: 10.1111/jpy.1973.9.issue-3
    DOI: 10.1111/j.0022-3646.1973.00333.x
    RVK:
    WA 15000
    Language: English
    Publisher: Wiley
    Publication Date: 1973
    detail.hit.zdb_id: 281226-5
    detail.hit.zdb_id: 1478748-9
    SSG: 12
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