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  • 1
    In: Small, Wiley, Vol. 19, No. 38 ( 2023-09)
    Abstract: Bone is one of the prone metastatic sites of patients with advanced breast cancer. The “vicious cycle” between osteoclasts and breast cancer cells plays an essential role in osteolytic bone metastasis from breast cancer. In order to inhibit bone metastasis from breast cancer, NIR‐II photoresponsive bone‐targeting nanosystems (CuP@PPy‐ZOL NPs) are designed and synthesized. CuP@PPy‐ZOL NPs can trigger the photothermal‐enhanced Fenton response and photodynamic effect to enhance the photothermal treatment (PTT) effect and thus achieve synergistic anti‐tumor effect. Meanwhile, they exhibit a photothermal enhanced ability to inhibit osteoclast differentiation and promote osteoblast differentiation, which reshaped the bone microenvironment. CuP@PPy‐ZOL NPs effectively inhibited the proliferation of tumor cells and bone resorption in the in vitro 3D bone metastases model of breast cancer. In a mouse model of breast cancer bone metastasis, CuP@PPy‐ZOL NPs combined with PTT with NIR‐II significantly inhibited the tumor growth of breast cancer bone metastases and osteolysis while promoting bone repair to achieve the reversal of osteolytic breast cancer bone metastases. Furthermore, the potential biological mechanisms of synergistic treatment are identified by conditioned culture experiments and mRNA transcriptome analysis. The design of this nanosystem provides a promising strategy for treating osteolytic bone metastases.
    Type of Medium: Online Resource
    ISSN: 1613-6810 , 1613-6829
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2168935-0
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  • 2
    In: Acta Geologica Sinica - English Edition, Wiley, Vol. 97, No. 4 ( 2023-08), p. 1150-1162
    Abstract: To better understand the Paleo‐ to Mesoproterozoic tectonic evolution of the Dabie Orogen in the northern margin of Yangtze Block, we present geochronological data for metasedimentary and metavolcanic rocks in the Huwan complex. A total of 385 detrital zircon LA‐ICP‐MS analyses for metasedimentary rocks yielded three 207 Pb/ 206 Pb age populations: 1.50–1.80 Ga, 1.81–1.87 Ga and 1.93–2.0 Ga, providing a maximum depositional timing of ca. 1.50 Ga; while metafelsic volcanic gneisses yielded protolith U‐Pb ages of 1893 ± 54 Ma. The peak ages are remarkably consistent with the tectonothermal events that occurred in the northern Yangtze Block, indicating the presence of Paleo‐ to Mesoproterozoic magmatism in the Dabie Orogen. The age range of 1.93–2.0 Ga correlates with the Paleoproterozoic collision; the age range of 1.81–1.87 Ga coincides with the period of the post‐orogenic extension; and the age range of 1.50–1.80 Ga is interpreted to associate with an extensional regime. Zircon cores with age of 1732–1965 Ma have ε Hf ( t ) values ranging from –11.70 to –2.47, indicating that juvenile crust involved in their magma sources. Owing to the similar age spectra, we proposed that the nucleus of the Dabie Orogen was close to the Yangtze Block since the Paleoproterozoic. The Huwan complex has an intimate affiliation to the Yangtze Block, and implies multiple orogenic cycles. It was not only experienced the Paleo‐Tethys ocean subduction and collision, but also recorded Paleo‐ to Mesoproterozoic tectono‐magmatic events in the Dabie Orogen.
    Type of Medium: Online Resource
    ISSN: 1000-9515 , 1755-6724
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2420386-5
    SSG: 6,25
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