In:
ANZ Journal of Surgery, Wiley, Vol. 88, No. 5 ( 2018-05)
Abstract:
To investigate the impact of intraoperative blood transfusion on the long‐term outcomes of liver transplantation for hepatocellular carcinoma. Method Adult patients who had non‐salvage liver transplantation at our centre between January 2005 and December 2012 for hepatocellular carcinomas that were within the University of California, San Francisco criteria and could not be resected or ablated were divided into groups with and without intraoperative blood transfusion. Comparisons were made between groups. Results Ninety‐nine patients were included in the study. Sixty‐two (62.6%) patients received intraoperative blood transfusion. Patients without transfusion were younger (54 versus 56 years; P = 0.04) and had a lower Model for End‐stage Liver Disease score (11 versus 14; P 〈 0.001). Most of them had stage‐I tumours (64.9 versus 37.1%; P = 0.007) and fewer of them had postoperative complications of grade IIIA or above in the Clavien‐Dindo classification (21.6 versus 48.4%; P = 0.008). The groups were comparable in hospital mortality (3.2 versus 2.7%; P = 1.00), 5‐year overall survival (90.8 versus 89.2%; P = 0.611) and 5‐year disease‐free survival (90.5 versus 89.2%; P = 0.835). On multivariate analysis, postoperative complications of grade IIIA or above were associated with worse survival (hazard ratio, 7.108; 95% confidence interval, 1.455–34.712; P = 0.015). Conclusion Intraoperative blood transfusion was shown to have no significant impact on the long‐term outcomes of liver transplantation for hepatocellular carcinoma, whereas postoperative complications of grade IIIA or above were associated with worse recipient survival.
Type of Medium:
Online Resource
ISSN:
1445-1433
,
1445-2197
DOI:
10.1111/ans.2018.88.issue-5
Language:
English
Publisher:
Wiley
Publication Date:
2018
detail.hit.zdb_id:
2095927-8
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